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Impact of Enhanced Recovery Implementation in Women Undergoing Abdominal Sacrocolpopexy.

Int J Gynaecol Obstet 2022 May 22. Epub 2022 May 22.

Department of Obstetrics and Gynecology, Mayo Clinic -, Rochester, Minnesota, USA.

Objective: Assess the effect of Enhanced Recovery After Surgery with and without liposomal bupivacaine (LB) on opioid use, hospital length of stay (LOS), costs, and morbidity of women undergoing sacrocolpopexy.

Methods: Retrospective cohort of women who underwent abdominal sacrocolpopexy between April 1, 2009, and November 30, 2017. Costs for relevant health care services were determined by assigning 2017 charges multiplied by 2017 Medicare Cost Report's cost to charge ratios. Read More

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Impact of gender differences on hemostasis in patients after coronary artery bypass grafts surgeries in the context of tranexamic acid administration.

J Cardiothorac Surg 2022 May 21;17(1):123. Epub 2022 May 21.

Department of Anesthesiology, Fuwai Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Xicheng District, Beijing, 100037, China.

Background: Sex differences present in the blood management of patients after coronary artery bypass grafts (CABG) surgeries. Tranexamic acid (TXA) performed well in maintaining hemostasis during and after surgeries. However, the impact of sex differences on blood control after CABG in patients who received TXA was not investigated. Read More

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A Risk Calculator for Post-Operative Urinary Retention (POUR) Following Vaginal Pelvic Floor Surgery: Multivariable Prediction Modelling.

BJOG 2022 May 21. Epub 2022 May 21.

Division of Female Pelvic Medicine and Reconstructive Surgery, Department of Obstetrics and Gynecology, Mount Sinai Hospital, University of Toronto, Toronto, ON, Canada.

Objective: To determine the peri-operative characteristics associated with an increased risk of post-operative urinary retention (POUR) following vaginal pelvic floor surgery.

Design: A retrospective cohort study using multivariable prediction modelling.

Setting: A tertiary referral urogynaecology unit. Read More

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The role of maternal physical activity on in vitro fertilization outcomes: a systematic review and meta-analysis.

Arch Gynecol Obstet 2022 May 21. Epub 2022 May 21.

Second Department of Obstetrics and Gynecology, Medical School, National and Kapodistrian University of Athens, "Aretaieio" University Hospital, Athens, Greece.

Purpose: This systematic review is designed to summarize the evidence concerning the impact of maternal physical activity on the reproductive outcomes following assisted reproduction techniques (ART), namely in vitro fertilization (IVF)/intracytoplasmic sperm injection (ICSI).

Methods: We searched for eligible studies on PubMed, EMBASE databases and the Cochrane Library from their inception until September 2021. Our primary outcomes were live birth rate and miscarriage, while secondary ones included clinical pregnancy and implantation rates. Read More

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Increased risk of obstetric anal sphincter injury in women undergoing vaginal delivery after caesarean section: A systematic review and meta-analysis.

BJOG 2022 May 21. Epub 2022 May 21.

Department of Obstetrics and Gynecology, Herlev University Hospital, Herlev, Denmark.

Background: There is increased focus on obstetric anal sphincter injury (OASI) and there are several well-established risk factors such as birth weight, instrumental delivery and median episiotomy. Some studies have found increased risk of OASI in women delivering vaginally after a previous caesarean section (VBAC).

Objective: To evaluate whether there is increased prevalence of OASI in VBAC compared to primiparous women. Read More

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Serum and cervico-vaginal glycodelin concentrations as predictors of successful implantation after embryo transfer.

Taiwan J Obstet Gynecol 2022 May;61(3):464-471

Department of Obstetrics and Gynaecology, Ain Shams University, Cairo, Egypt.

Objective: Evaluation of glycodelin (Gd) concentrations in serum and cervico-vaginal secretions as a predictor for implantation after ICSI.

Materials And Methods: Prospective study on 50 women undergoing ICSI where long protocol ovarian stimulation was used. Serum and cervico-vaginal lavage Gd concentrations were measured then rates of biochemical and clinical pregnancy were detected and predictive value was evaluated using logistic regression analysis. Read More

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Ovulation triggering with hCG alone, GnRH agonist alone or in combination? A randomized controlled trial in advanced-age women undergoing IVF/ICSI cycles.

Hum Reprod 2022 May 20. Epub 2022 May 20.

Reproductive Medical Center, International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, China.

Study Question: Is a dual ovulation trigger with a combination of GnRH agonist (GnRHa) and hCG superior to single hCG and/or single GnRHa trigger in improving treatment outcomes in advanced-age women (aged ≥ 35 years) undergoing IVF/ICSI treatment?

Summary Answer: Co-administration of GnRHa and hCG as a dual trigger increases the number of good-quality embryos but it is not associated with a higher number of oocytes retrieved, compared with single hCG or GnRHa trigger.

What Is Known Already: Many studies have demonstrated that a dual trigger has positive impact on oocyte maturation, retrieval rate and pregnancy rate without increasing the risk of ovarian hyperstimulation syndrome (OHSS) in some groups of IVF patients, when compared with single hCG trigger. Few studies have however been conducted to compare a dual trigger with a single GnRHa trigger, and insufficient evidence exists to support which trigger can achieve the best outcomes in IVF patients aged ≥35 years. Read More

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Dietary practices after primary treatment for ovarian cancer: A qualitative analysis from the OPAL Study.

J Acad Nutr Diet 2022 May 17. Epub 2022 May 17.

QIMR Berghofer Medical Research Institute, Population Health Department, Brisbane, Queensland, Australia;; Adjunct Professor, Queensland University of Technology, School of Public Health and Social Work, Brisbane, Queensland, Australia.

Background: Little is known about dietary practices of women who have completed primary treatment for ovarian cancer, many of whom will go on to experience cancer recurrence and have further treatment. Knowledge of dietary practices is needed to optimize care.

Objective: To identify dietary practices after primary treatment for ovarian cancer and evaluate how these practices differ by disease recurrence and treatment status. Read More

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Mitochondrial and glucose metabolic dysfunctions in granulosa cells induce impaired oocytes of polycystic ovary syndrome through Sirtuin 3.

Free Radic Biol Med 2022 May 17. Epub 2022 May 17.

Women's Hospital, School of Medicine, Zhejiang University, Hangzhou, 310006, China. Electronic address:

Mitochondrial function and glucose metabolism play important roles in bidirectional signaling between granulosa cells (GCs) and oocytes. However, the factors associated with mitochondrial function and glucose metabolism of GCs in polycystic ovary syndrome (PCOS) are poorly understood, and their potential downstream effects on oocyte quality are still unknown. The aim of this study was to investigate whether there are alterations in mitochondrial-related functions and glucose metabolism in ovarian GCs of women with PCOS and the role of Sirtuin 3 (SIRT3) in this process. Read More

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Procalcitonin kinetics following abdominal aortic surgery and its value for postoperative intestinal ischaemia detection.

Vascular 2022 May 20:17085381221102812. Epub 2022 May 20.

Central European Institute of Technology, 37748Masaryk University, Brno, Czech Republic.

Objective: The purpose of our study was to describe perioperative kinetics of procalcitonin (PCT) in patients undergoing aortic surgery, to compare the kinetics in the open abdominal aortic aneurysm (AAA) repair and aortobifemoral bypass for aortoiliac occlusive disease (AIOD), and to evaluate the ability of PCT to detect intestinal ischaemia.

Methods: A prospective non-randomized observational cohort study in 80 patients (62 men and 18 women) undergoing elective aortic surgery was performed. Serum PCT was measured at baseline and defined intraoperative and postoperative timepoints up to postoperative day 7. Read More

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Surgical anatomy of the vaginal introitus.

Neurourol Urodyn 2022 May 20. Epub 2022 May 20.

Department of Obstetrics & Gynecology, Gold Coast University Hospital, Southport, Queensland, Australia.

Aim: The vaginal introitus is the entrance to the vagina, encompassing the anterior and posterior vestibules and the perineum. The surgical anatomy of the vaginal introitus, the lowest level of the vagina, has not been subject to a recent comprehensive examination and description. Vaginal introital surgery (perineorrhaphy) should be a key part of surgery for a majority of pelvic organ prolapse. Read More

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The Association Between Serum Estradiol Levels on hCG Trigger Day and Live Birth Rates in Non-PCOS Patients: A Retrospective Cohort Study.

Front Endocrinol (Lausanne) 2022 3;13:839773. Epub 2022 May 3.

Hebei Key Laboratory of Infertility and Genetics, Hebei Clinical Research Center for Birth Defects, Department of Reproductive Medicine, Second Hospital of Hebei Medical University, Shijiazhuang, China.

Objective: To retrospectively analyze the association of serum estradiol (E2) levels on human chorionic gonadotropin (hCG) trigger day and live birth rates (LBRs) in women undergoing fresh embryo transfer and not exhibiting polycystic ovary syndrome.

Design: Retrospective cohort study.

Methods: Analysis of 13,950 patients who had fresh embryo transfer between December 2013 and December 2019. Read More

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Changes in Sex Steroids and Relation With Menopausal Complaints in Women Undergoing Risk-reducing Salpingo-oophorectomy.

J Endocr Soc 2022 Jun 25;6(6):bvac069. Epub 2022 Apr 25.

Department of Laboratory Medicine, The Netherlands Cancer Institute, Amsterdam, The Netherlands.

Context: Risk-reducing salpingo-oophorectomy (RRSO) is performed in BRCA1 or 2 mutant carriers to minimize ovarian cancer risk. Although studies have been performed investigating sex steroid levels, menopausal complaints, and sexual functioning in relation to RRSO, their exact relationship remains unknown.

Objectives: To investigate the impact of RRSO on serum sex steroid levels and their association with menopausal complaints and sexual functioning. Read More

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Hypertriglyceridemia-induced pancreatitis after egg retrieval for in vitro fertilization and fenofibrate cessation.

Clin Case Rep 2022 May 12;10(5):e05874. Epub 2022 May 12.

Department of Medicine Greenwich Hospital Yale-New Haven Health System Greenwich Connecticut USA.

A 36-year-old woman with prior hypertriglyceridemia-induced pancreatitis presented with a recurrence of pancreatitis after beginning in vitro fertilization (IVF). Her primary care physician had discontinued fenofibrate due to concerns for teratogenicity. This case illustrates the importance of fibrate therapy for high-risk women undergoing IVF, despite limited evidence regarding its teratogenicity. Read More

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Utility values and its time to deterioration in breast cancer patients after diagnosis and during treatments.

Qual Life Res 2022 May 19. Epub 2022 May 19.

Biostatistics Unit, Department of Clinical Research and Innovation & Department of Human and Social Sciences, Centre Léon Bérard, Lyon, France.

Background: The potential effects of breast cancer (BC) on health-related quality of life (HRQoL) should be considered in clinical and policy decision-making, as the economic burden of BC management is currently assessed. In the last decades, time-to-HRQoL score deterioration (TTD) has been proposed as an approach to the analysis of longitudinal HRQoL in oncology. The main objectives of the current study were to investigate the evolution of the utility values in BC patients after diagnosis and during follow-ups and to evaluate the TTD in utility values among women in all stages of BC. Read More

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Impact of hyperuricemia on coronary blood flow and in-hospital mortality in patients with acute myocardial infarction undergoing percutaneous coronary intervention.

J Cardiol 2022 May 16. Epub 2022 May 16.

Department of Cardiology and Nephrology, Mie University Graduate School of Medicine, Tsu, Japan.

Background: Although serum uric acid (UA) is considered as a risk factor for cardiovascular disease, few data exist regarding the relationship between hyperuricemia, coronary blood flow, and subsequent outcome in patients with acute myocardial infarction (AMI). The purpose of our study is to assess whether hyperuricemia is associated with suboptimal coronary flow and increased risk of mortality in patients with AMI after percutaneous coronary intervention (PCI).

Methods: Using the Rural AMI registry data, 989 consecutive patients with AMI who underwent emergent PCI and had UA measurement at admission were analyzed. Read More

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Effect of Physician Consultation on Satisfaction With Hearing Aid Use: A Randomized Clinical Trial.

JAMA Otolaryngol Head Neck Surg 2022 May 19. Epub 2022 May 19.

Division of Otolaryngology-Head and Neck Surgery, University of British Columbia, Vancouver, British Columbia, Canada.

Importance: Hearing loss is one of the most common chronic disabilities in older adults, yet reported rates of users' satisfaction with hearing aids are low. Some believe that physicians can provide patients who are pursuing a hearing aid fitting an impartial opinion that will improve hearing aid satisfaction.

Objective: To determine whether a physician consultation increased or decreased patients' satisfaction with hearing aids compared with patients undergoing hearing aid fitting with a dispensing audiologist alone. Read More

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Cleavage-stage versus blastocyst-stage embryo transfer in assisted reproductive technology.

Cochrane Database Syst Rev 2022 05 19;5:CD002118. Epub 2022 May 19.

Repromed Fertility Specialists, Auckland, New Zealand.

Background: Advances in embryo culture media have led to a shift in in vitro fertilisation (IVF) practice from cleavage-stage embryo transfer to blastocyst-stage embryo transfer. The rationale for blastocyst-stage transfer is to improve both uterine and embryonic synchronicity and enable self selection of viable embryos, thus resulting in better live birth rates.

Objectives: To determine whether blastocyst-stage (day 5 to 6) embryo transfer improves the live birth rate (LBR) per fresh transfer, and other associated outcomes, compared with cleavage-stage (day 2 to 3) embryo transfer. Read More

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Pharmacokinetics of Vaginal vs Buccal Misoprostol for Labor Induction at Term.

Clin Transl Sci 2022 May 19. Epub 2022 May 19.

Indiana University School of Medicine, Indianapolis, IN, USA.

The IMPROVE study (NCT02408315) compared the efficacy and safety of vaginal and buccal administration of misoprostol for full-term, uncomplicated labor induction. This report compares the pharmacokinetics of misoprostol between vaginal and buccal routes. Women ≥ 14 years of age undergoing induction of labor ≥ 37 weeks gestation without significant complications were randomized to vaginal or buccal misoprostol 25 µg followed by 50 µg doses every 4 hrs. Read More

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Long-term Effect of Face-to-Face vs Virtual Reality Cardiopulmonary Resuscitation (CPR) Training on Willingness to Perform CPR, Retention of Knowledge, and Dissemination of CPR Awareness: A Secondary Analysis of a Randomized Clinical Trial.

JAMA Netw Open 2022 May 2;5(5):e2212964. Epub 2022 May 2.

Department of Cardiology, Radboud University Medical Center, Nijmegen, the Netherlands.

Importance: Increased bystander cardiopulmonary resuscitation (CPR) is essential to improve survival after cardiac arrest. Although most studies focus on technical CPR skills, the randomized Lowlands Saves Lives trial prespecified a follow-up survey on other important aspects that affect the widespread performance of CPR.

Objective: To investigate bystander willingness to perform CPR on a stranger, theoretical knowledge retention, and dissemination of CPR awareness 6 months after undergoing short face-to-face and virtual reality (VR) CPR trainings. Read More

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Ovarian stimulation strategies for intrauterine insemination in couples with unexplained infertility: a systematic review and individual participant data meta-analysis.

Hum Reprod Update 2022 May 18. Epub 2022 May 18.

Department of Obstetrics and Gynaecology, Monash University, Clayton, VIC 3168, Australia.

Background: Intrauterine insemination with ovarian stimulation (IUI-OS) is a first-line treatment for unexplained infertility. Gonadotrophins, letrozole and clomiphene citrate (CC) are commonly used agents during IUI-OS and have been compared in multiple aggregate data meta-analyses, with substantial heterogeneity and no analysis on time-to-event outcomes. Individual participant data meta-analysis (IPD-MA) is considered the gold standard for evidence synthesis as it can offset inadequate reporting of individual studies by obtaining the IPD, and allows analyses on treatment-covariate interactions to identify couples who benefit most from a particular treatment. Read More

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Influence of breast cancer prognostic factors on oocyte in vitro maturation outcomes performed for urgent fertility preservation.

Hum Reprod 2022 May 19. Epub 2022 May 19.

Department of Reproductive Medicine & Fertility Preservation, Hôpital Jean Verdier, Bondy, France.

Study Question: Do breast cancer (BC) characteristics influence IVM of oocytes outcomes in patients undergoing fertility preservation (FP)?

Summary Answer: Scarff-Bloom-Richardson (SBR) III grade, triple-negative BC and HER2 overexpression are independent predictors of fewer oocytes or poor IVM outcomes in young women seeking FP.

What Is Known Already: SBR grade, triple-negative status and overexpression of HER2, as well as a high Ki67 proliferation index are all established prognostic factors for BC, influencing patients' therapeutic management. Yet there are also concerns about the potential impact of cancer status on ovarian reserve and function. Read More

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Quality of Infertility Care Services and Emotional Health of South Asian Women.

Psychol Res Behav Manag 2022 9;15:1131-1146. Epub 2022 May 9.

Obstetrics and Gynecology, Maternity and Children Hospital Ha'il, Ha'il, Kingdom of Saudi Arabia.

Background: Treatment tolerability and treatment environment are two major spheres of infertility care that may associate with women's emotional health and coping mechanisms.

Aim: The present study aimed at assessing the relationship between infertility treatment quality and various aspects of emotion-focus coping, problem-focus coping, and avoidance coping mechanisms.

Method: The study was completed by using standardized tools and data from this descriptive, cross-sectional, correlational study were collected from 350 women undergoing infertility treatments in private reproductive healthcare centers in Quetta, Pakistan. Read More

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Comparative study of the usefulness of adjunctive tomosynthesis in breast cancer screening by mammography and ultrasound in Japan.

Breast Cancer 2022 May 18. Epub 2022 May 18.

Musashimurayama Hospital, Tokyo, Japan.

Introduction: There are few studies have conducted digital breast tomosynthesis (DBT) in addition to digital mammography (2DDM) and ultrasound (US) for screening. The purpose of this study is to determine the possibility of synergistic effects of DBT and US screening for Japanese.

Methods: 5023 examinations of the opportunistic screening using 2DDM and US (2D group: 2581) or 2DDM and US plus DBT (3 group: 2442) were performed at our facility from May 1, 2017 to March 31, 2019. Read More

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Comparison of Outcomes Between BRCA Pathogenic Variant Carriers Undergoing Breast-Conserving Surgery Versus Mastectomy.

Ann Surg Oncol 2022 May 18. Epub 2022 May 18.

Breast Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

Introduction: Although outcomes are similar following breast-conserving surgery (BCS) or mastectomy among sporadic breast cancer patients, data are mixed for women with a germline BRCA mutation. We sought to compare outcomes among a modern cohort of BRCA mutation carriers undergoing BCS versus mastectomy.

Methods: Women with a BRCA mutation and an index breast cancer from 2006-2015 were retrospectively identified from institutional databases. Read More

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Cervical versus utero-ovarian ligament injection of the tracer for the pelvic sentinel lymph node mapping in gynecologic oncology: a prospective observational study.

Gynecol Obstet Invest 2022 May 18. Epub 2022 May 18.

Objective: In gynecologic oncology, the consolidated injection site for the pelvic sentinel lymph node mapping is the cervix. However, in apparent early-stage ovarian cancer, current trials map the pelvic area injecting the tracers in the utero-ovarian ligament. A different injection site is proposed based on a possible different lymphatic ovarian drainage through the utero-ovarian ligament and uterus and consequently a different pelvic sentinel lymph node mapping than the cervix; however, this was never proven. Read More

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Outcomes of embryo vitrification at different developmental stages: Evaluation of 2412 warming cycles.

Medicine (Baltimore) 2022 May 13;101(19):e29233. Epub 2022 May 13.

Center for Reproductive Medicine, Provincial Hospital Affiliated to Shandong University, Jinan 250021, China.

Introduction: Advances in cell culture media have led to a shift from cleavage stage embryo transfer to blastocyst stage transfer. Extended embryo culture to the blastocyst stage provides some theoretical advantages and disadvantages. There has been controversy. Read More

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Immediate versus delayed postabortal insertion of contraceptive implant.

Cochrane Database Syst Rev 2022 05 18;5:CD013565. Epub 2022 May 18.

Obstetrics and Gynaecology, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand.

Background: Contraceptive implants are one of the most effective contraceptive methods, providing a long duration of pregnancy protection and a high safety profile. Hence this method is suitable for optimizing the interpregnancy interval, especially for women undergoing abortion. Women who have had abortions are at high risk of rapid repeat pregnancies. Read More

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Prognostic impact of preoperative Geriatric Nutritional Risk Index in oral squamous cell carcinoma.

Oral Dis 2022 May 18. Epub 2022 May 18.

Department of Oral and Maxillofacial Surgery, School of Dentistry, Aichi-Gakuin University, 2-11, Suemori-dori, Chikusa-ku, Nagoya, Aichi, Japan.

Objectives: To investigate the prognostic impact of preoperative Geriatric Nutritional Risk Index (GNRI) values in older adults undergoing radical surgery for oral squamous cell carcinoma (OSCC).

Subjects And Methods: This retrospective study included 61 patients ≥ 65 years old with OSCC (43 men, 18 women; age: 72.1±5. Read More

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Anastomotic Leak Rate and Prolonged Postoperative Paralytic Ileus in Patients Undergoing Laparoscopic Surgery for Colo-Rectal Cancer After Placement of No-Coil Endoanal Tube.

Surg Innov 2022 May 17:15533506221090995. Epub 2022 May 17.

Science of Health Department, General Surgery Unit, University "Magna Graecia" Medical School, Catanzaro, Italy.

Background: Colorectal cancer (CRC) is the second most common gastrointestinal tumor in men and the third in women. Left-hemicolectomy (LC) and low anterior resection (LAR) are considered the gold standard curative treatment. In this retrospective study, we evaluated the presence or absence of post-operative complications, in all patients who underwent Video-laparoscopic (VLS) LAR/LC with No Coil trans-anal tube positioning, and compared the data with the current literature on the topic. Read More

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