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Understanding abortion seeking care outside of formal health care settings in Cape Town, South Africa: a qualitative study.

Reprod Health 2021 Sep 23;18(1):190. Epub 2021 Sep 23.

Ibis Reproductive Health, 1736 Franklin St, Oakland, CA, USA.

Background: Although abortion was legalized in South Africa in 1996, barriers to safe, legal abortion services remain, and women continue to seek abortions outside of the formal healthcare sector. This study explored the decision-making processes that women undertake when faced with an unintended pregnancy, the sources of information used to make their decisions and the factors that contribute to their seeking of informal sector abortion in Cape Town, South Africa.

Methods: We conducted 15 semi-structured in-depth interviews in English with women who had accessed an abortion outside of the formal health care sector. Read More

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September 2021

Long-Term Follow-Up Results of Mechanical Wrist Traction as Non-Invasive Treatment for Carpal Tunnel Syndrome.

Front Neurol 2021 6;12:668549. Epub 2021 Sep 6.

Department of Medical and Clinical Psychology, Centre of Research on Psychology in Somatic Diseases, Tilburg University, Tilburg, Netherlands.

For patients with carpal tunnel syndrome (CTS), the only long-term effective treatment option is carpal tunnel release surgery. Up to one-third report recurrent symptoms, and 12% needs repeated surgery. This study aimed to evaluate the long-term effects of mechanical traction as a non-invasive treatment option for CTS compared to care as usual. Read More

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September 2021

A Survey of Potentially Modifiable Patient-Level Factors Associated with Self-Report and Objectively Measured Adherence to Adjuvant Endocrine Therapies After Breast Cancer.

Patient Prefer Adherence 2021 15;15:2039-2050. Epub 2021 Sep 15.

Department of Psychology, University of Calgary, Calgary, AB, Canada.

Purpose: Despite the efficacy of adjuvant endocrine therapy (AET) in reducing breast cancer recurrence and mortality, suboptimal AET adherence is common and hence an important clinical issue among breast cancer survivors. Delineating potentially modifiable patient-level factors associated with AET adherence may support the development of successful adherence-enhancing interventions.

Patients And Methods: The present study included 133 breast cancer survivors prescribed AET recruited from a cancer pharmacy. Read More

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September 2021

Perceived versus Patient-Reported Significance of Surgeon Gender in Breast Reconstruction.

Plast Reconstr Surg 2021 Oct;148(4):720-728

From the Department of Surgery, Section of Plastic and Reconstructive Surgery, Michigan Medicine; Department of Biostatistics, University of Michigan; and Consulting for Statistics, Computing and Analytics Research, University of Michigan Office of Research.

Background: Previous investigators demonstrated that female patients often prefer female providers. However, these studies have not determined whether there are gender preferences for breast reconstruction surgeons or whether the effects of surgeon gender impacts patient-reported outcomes.

Methods: Adult women were crowdsourced using Amazon Mechanical Turk to characterize societal preferences for the gender of breast and plastic surgeons in a hypothetical scenario. Read More

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October 2021

Comparison of Clinical Outcomes and Safety Associated With Chlorthalidone vs Hydrochlorothiazide in Older Adults With Varying Levels of Kidney Function.

JAMA Netw Open 2021 Sep 1;4(9):e2123365. Epub 2021 Sep 1.

Ottawa Hospital Research Institute, Division of Nephrology, Department of Medicine, University of Ottawa, Ottawa, Canada.

Importance: Thiazide diuretics are commonly prescribed for the treatment of hypertension, a disease highly prevalent among older individuals and in those with chronic kidney disease. How specific thiazide diuretics compare in regard to safety and clinical outcomes in these populations remains unknown.

Objective: To compare safety and clinical outcomes associated with chlorthalidone or hydrochlorothiazide use among older adults with varying levels of kidney function. Read More

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September 2021

Young Sexual Minority Adolescent Experiences of Self-expression and Isolation on Social Media: Cross-sectional Survey Study.

JMIR Ment Health 2021 Sep 15;8(9):e26207. Epub 2021 Sep 15.

Wellesley Centers for Women, Wellesley College, Wellesley, MA, United States.

Background: Early adolescent years are marked by pervasive self- and peer-regulation regarding gender and sexuality norms, which can affect the mental well-being of sexual minority youth. During this developmental period, social media use is also emerging as a dominant mode of communication with peers, allowing for both risk and resilient behaviors that can impact well-being.

Objective: This exploratory study aims to examine how sexual minorities in middle school use social media, who they are connected to and for what purposes, and the associations between these behaviors and mental well-being compared with their heterosexual peers. Read More

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September 2021

Neurokinin 3 Receptor Antagonists Compared With Serotonin Norepinephrine Reuptake Inhibitors for Non-Hormonal Treatment of Menopausal Hot Flushes: A Systematic Qualitative Review.

Adv Ther 2021 Sep 12. Epub 2021 Sep 12.

School of Medicine, University of St Andrews, Medical and Biological Sciences Building, North Haugh, St Andrews, KY16 9TF, UK.

Introduction: Hot flushes/flashes (HFs) or other vasomotor symptoms affect between 45 and 97% of women during menopause. Hormone replacement therapy (HRT) is effective at alleviating menopausal symptoms, but some women cannot or prefer not to take HRT. Since current non-hormonal options have suboptimal efficacy/tolerability, there is a pressing need for an effective, well-tolerated alternative. Read More

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September 2021

Preference for and Efficacy of a PrEP Decision Aid for Women with Substance Use Disorders.

Patient Prefer Adherence 2021 1;15:1913-1927. Epub 2021 Sep 1.

Yale School of Medicine, AIDS Program, New Haven, CT, USA.

Background: Women with substance use disorders (SUDs) are a key population for HIV prevention with pre-exposure prophylaxis (PrEP), though uptake is limited by awareness of PrEP, misestimation of personal HIV risk, and minimally integrated HIV prevention and addiction treatment services. Patient-centered decision aids (DA) could address these barriers to PrEP, but no extant DA for PrEP has been published, including for women with SUDs.

Methods: We developed a patient-centered PrEP DA for women in addiction treatment. Read More

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September 2021

A survey to evaluate knowledge, perceptions and attitudes toward COVID-19 vaccinations among rheumatologists in Germany.

Rheumatol Int 2021 Sep 8. Epub 2021 Sep 8.

Department of Rheumatology and Clinical Immunology, Kliniken Essen-Mitte, Essen, Germany.

The objective is to evaluate the attitude of rheumatologists regarding the use of COVID-19 vaccination in patients with inflammatory rheumatic diseases (IRDs). From February 2nd until March 15th, 2021, rheumatologists from Germany were asked to participate anonymously in a survey addressing their attitude with respect to COVID-19 vaccinations of IRD patients. The survey was completed by 214 participants (107 men, 103 women, 4 unspecified). Read More

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September 2021

Evaluation of Watchful Waiting and Tumor Behavior in Patients With Basal Cell Carcinoma: An Observational Cohort Study of 280 Basal Cell Carcinomas in 89 Patients.

JAMA Dermatol 2021 Sep 8. Epub 2021 Sep 8.

Radboud Institute for Health Sciences, Department of Dermatology, Radboud University Medical Center, Nijmegen, the Netherlands.

Importance: Few studies have examined watchful waiting (WW) in patients with basal cell carcinoma (BCC), although this approach might be suitable in patients who might not live long enough to benefit from treatment.

Objective: To evaluate reasons for WW and to document the natural course of BCC in patients who chose WW and reasons to initiate later treatment.

Design, Setting, And Participants: An observational cohort study was performed at a single institution between January 2018 and November 2020 studying patients with 1 or more untreated BCC for 3 months or longer. Read More

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September 2021

Jail as a Point of Contraceptive Care Access: Needs and Preferences Among Women in an Urban Jail.

J Midwifery Womens Health 2021 Aug 31. Epub 2021 Aug 31.

Department of Gynecology and Obstetrics, Johns Hopkins School of Medicine, Baltimore, Maryland.

Introduction: Individuals who are incarcerated in the United States often struggle to access family planning care because of the common practice of jails not providing contraceptives on site. However, less is known about the contraceptive needs and preferences, including the desirability of intrauterine devices and implants, among those who are incarcerated.

Methods: Cross-sectional, in-person surveys were administered to 148 reproductive-age women (aged 18-48) incarcerated at an urban jail in Utah to identify women's contraceptive needs and preferences while incarcerated. Read More

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Cervical cancer screening using HPV tests on self-samples: attitudes and preferences of women participating in the VALHUDES study.

Arch Public Health 2021 Aug 30;79(1):155. Epub 2021 Aug 30.

Unit of Cancer Epidemiology, Belgian Cancer Centre, Sciensano, J. Wytsmanstreet 14, B1050, Brussels, Belgium.

Background: Interventions to reach women who do not participate regularly in screening may reduce the risk of cervical cancer. Self-collection of a vaginal specimen has been shown to increase participation. The relative clinical accuracy of human papillomavirus (HPV) testing on first-void urine (with Colli-Pee) and on vaginal self-samples versus on cervical clinician-collected samples is being investigated in the VALHUDES trial. Read More

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Do you want to receive bad news through your patient accessible electronic health record? A national survey on receiving bad news in an era of digital health.

Health Informatics J 2021 Jul-Sep;27(3):14604582211035817

University of Skövde, Sweden.

Despite the fact that patient accessible electronic health records (PAEHRs) have been around for many years in several countries, there is a lack of research investigating patient's preferences for receiving bad news, including through PAEHRs. Little is also known about the characteristics of the patients who prefer to receive bad news through the PAEHR in terms of, for example medical diagnosis, age and educational level. This study, based on a national patient survey in Sweden ( = 2587), investigated this. Read More

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Fatigue as the limiting factor for vaginal birth in patients with multiple sclerosis.

Neuro Endocrinol Lett 2021 Aug 28;42(4):222-228. Epub 2021 Aug 28.

Department of Neurology, Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava, Slovakia.

Objectives: Multiple sclerosis (MS) is a chronic autoimmune and neurodegenerative disease. This study evaluated pregnancy-related issues in patients with MS in one perinatological centre.

Material And Methods: A single-centre, retrospective study of the perinatal period in patients with MS admitted at the Dpt. Read More

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Pain response and symptoms in photorefractive keratectomy: mechanical de-epithelization compared with transepithelial ablation.

Arq Bras Oftalmol 2021 Aug 18. Epub 2021 Aug 18.

Departamento de Oftalmologia, Escola Paulista e Medicina, Universidade Federal de São Paulo, São Paulo, SP, Brazil.

Purpose: To compare postoperative pain and discomfort between mechanical and transepithelial photorefractive keratectomies.

Methods: This prospective comparative study included 190 eyes of 95 patients with hyperopia (up to +4.00 D), astigmatism (up to -5. Read More

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I Do It, but I Decide With Whom.

Front Psychol 2021 5;12:673617. Epub 2021 Aug 5.

Department of Sociology, University of Barcelona, Barcelona, Spain.

Social interactions and communication shape the desires and preferences of men and women. While it is true that some men have modified their behavior due to feminist women, the same happened with some women, who changed attraction patterns thanks to new alternative masculinities (NAM). This study examines the latter, focusing on social interactions mediated by language, as a crucial element to impact and change the desires of people. Read More

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Patient Satisfaction with Virtual-Based Prenatal Care: Implications after the COVID-19 Pandemic.

Matern Child Health J 2021 Aug 19. Epub 2021 Aug 19.

Department of Newborn Medicine, Brigham and Women's Hospital, Boston, MA, USA.

Objective: The objective of this study was to identify factors related to satisfaction with virtual visits during pregnancy in an effort to prioritize intervention targets for pregnant women during the COVID-19 pandemic.

Methods: The study relied on data obtained from pregnant women (N = 416) who participated in the Perinatal Experiences and COVID-19 Effects (PEACE) Study from May 21 to November 22, 2020. Using a cross-sectional design, this study examined factors including COVID-19 related experiences and prenatal care changes in association with patient satisfaction of virtual prenatal care. Read More

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Treatment Adherence to Nucleos(t)ide Analogs in Chinese Patients with Hepatitis B Virus-Related Hepatocellular Carcinoma: A Single-Center Cross-Sectional Study.

Patient Prefer Adherence 2021 10;15:1729-1738. Epub 2021 Aug 10.

Department of Pharmacy, Shanghai Ninth People's Hospital, Shanghai JiaoTong University School of Medicine, Shanghai, 200011, People's Republic of China.

Purpose: Chronic hepatitis B virus (HBV) infection is a crucial risk factor in the occurrence and development of hepatocellular carcinoma (HCC). Antiviral therapy is very important for patients with HBV-related HCC. To maintain undetectable level of HBV DNA, patients must take nucleos(t)ide analogues (NUCs) appropriately and regularly. Read More

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Lived experience perspectives on labeling and defining long-standing anorexia nervosa.

J Eat Disord 2021 Aug 14;9(1):101. Epub 2021 Aug 14.

InsideOut Institute, Charles Perkins Centre, The University of Sydney, Sydney, NSW, 2006, Australia.

Objective: Since efforts to stage anorexia nervosa (AN) revealed the existence of various presentations, research into the long-standing subgroup has increased. A change in treatment has been proposed with the intention to use more effective evidence-based methods that target symptoms of the long-standing presentation and improve prognosis. A barrier in achieving this goal in both research and clinical contexts is the lack of a consistent label and definition. Read More

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Success rate to complete optimal 20 + 2 ISUOG planes for foetal ultrasonographic structural screening during early second trimester pregnancy in Thailand.

Ultrasound J 2021 Aug 14;13(1):36. Epub 2021 Aug 14.

Department of Obstetrics and Gynecology, Faculty of Medicine, Srinakharinwirot University, Ongkharak, 26120, Nakornnayok, Thailand.

Objective: To compare the success rates of obtaining optimal 20 + 2 (2 overview + 20 planes) International Society of Ultrasound in Obstetrics and Gynaecology (ISUOG) planes for foetal ultrasound structural screening between pregnant women at gestational age (GA) 18-20 weeks and 20-22 weeks 6 days METHODS: A prospective descriptive study was conducted. Singleton pregnant women at GA 18-22 weeks + 6 days attending antenatal clinic between December 2019 and March 2020 were invited to participate in the study. Women whose foetuses had obvious structural anomalies were excluded. Read More

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Continuous versus intermittent extended adjuvant letrozole for breast cancer: final results of randomized phase III SOLE (Study of Letrozole Extension) and SOLE Estrogen Substudy.

Ann Oncol 2021 Oct 10;32(10):1256-1266. Epub 2021 Aug 10.

International Breast Cancer Study Group, Bern, Switzerland; IEO European Institute of Oncology, IRCCS, Milan, Italy.

Background: Late recurrences in postmenopausal women with hormone receptor-positive breast cancers remain an important challenge. Avoidance or delayed development of resistance represents the main objective in extended endocrine therapy (ET). In animal models, resistance was reversed with restoration of circulating estrogen levels during interruption of letrozole treatment. Read More

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October 2021

"Whilst you are here…" Acceptability of providing advice about screening and early detection of other cancers as part of the breast cancer screening programme.

Health Expect 2021 Aug 8. Epub 2021 Aug 8.

School of Cancer & Pharmaceutical Sciences, Cancer Prevention Group, King's College London, London, UK.

Objectives: This research aimed to assess women's willingness to receive advice about cervical and bowel cancer screening participation and advice on cancer symptom awareness when attending breast cancer screening.

Methods: Women (n = 322) aged 60-64 years, living in the United Kingdom, who had previously taken part in breast cancer screening were recruited via a market research panel. They completed an online survey assessing willingness to receive advice, the potential impact of advice on breast screening participation, prospective acceptability and preferences for mode and timing of advice. Read More

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Burden and Quality of Life Among Female and Male Patients with Heart Failure in Europe: A Real-World Cross-Sectional Study.

Patient Prefer Adherence 2021 30;15:1693-1706. Epub 2021 Jul 30.

Novartis Pharma AG, Basel, Switzerland.

Purpose: To characterize symptoms, clinical burden, and health-related quality of life (HRQoL) among women and men with heart failure (HF) with a left ventricular ejection fraction (LVEF) of ≤60% in Europe.

Patients And Methods: A real-world cross-sectional study was conducted in France, Germany, Italy, Spain, and United Kingdom from June to November 2019. Patient record forms were completed by 257 cardiologists and 158 general practitioners for consecutive patients with HF. Read More

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Women who prefer "lesbian" to "queer": generational continuity and discontinuity.

J Lesbian Stud 2021 Aug 4:1-20. Epub 2021 Aug 4.

Centre for People, Organisation and Work, RMIT University, Melbourne, VIC, Australia.

The legitimacy of the term and identity "lesbian" has long been contested, but has come under renewed scrutiny, with some suggesting it is exclusionary and dated. Along with these suggestions is the implication of a generational divide. Supposedly, older women-unaware of contemporary queer discourses-are more likely use the term "lesbian," whereas younger women are more likely to choose queer affiliated identities. Read More

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Oral Misoprostol alone versus oral misoprostol followed by oxytocin for labour induction in women with hypertension in pregnancy (MOLI): protocol for a randomised controlled trial.

BMC Pregnancy Childbirth 2021 Jul 29;21(1):537. Epub 2021 Jul 29.

Department of Women's and Children's Health, Liverpool Women's Hospital, University of Liverpool, Crown Street, Liverpool, L8 7SS, UK.

Background: Every year approximately 30,000 women die from hypertensive disease in pregnancy. Magnesium sulphate and anti-hypertensives reduce morbidity, but delivery is the only cure. Low dose oral misoprostol, a prostaglandin E1 analogue, is a highly effective method for labour induction. Read More

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Willingness to vaccinate against Covid-19: A qualitative study involving older adults from Southern Switzerland.

Vaccine X 2021 Aug 15;8:100108. Epub 2021 Jul 15.

Institute of Public Health, Università della Svizzera italiana, Switzerland.

Background: The Covid-19 pandemic is causing unprecedented disruption and suffering to people across the globe, with a disproportionate toll on the elderly. The development and equitable distribution of a vaccine seems to be the most promising and sustainable route ahead. The goal of this study was to explore older adults' attitudes towards and beliefs regarding the Covid-19 vaccination in Southern Switzerland. Read More

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Breast health screening: a UK-wide questionnaire.

BMJ Nutr Prev Health 2021 4;4(1):206-212. Epub 2021 May 4.

Department of Chemistry and Biosciences, University of Bradford, Bradford, UK.

Background: Currently, there is an unmet clinical need in identifying and screening women at high risk of breast cancer, where tumours are often aggressive and treatment intervention is too late to prevent metastasis, recurrence and mortality. This has been brought into sharp focus by the SARS-CoV-2 global pandemic, constantly changing hospital policies and surgical guidelines in reducing access to established screening and treatment regimens. Nipple aspirate fluid (NAF), is thought to provide a unique window into the biological processes occurring within the breast, particularly in the context of a developing neoplasm. Read More

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Epidemiological factors influencing gender preference among mothers attending under-five immunization clinic: A cross-sectional comparative study.

J Educ Health Promot 2021 31;10(1):190. Epub 2021 May 31.

Department of Community Medicine, Seth G.S. Medical College and KEM Hospital, Mumbai, Maharashtra, India.

Background: Sex ratio is an important social indicator measuring the status and equality of female in society. The falling sex ratio of our country is a demographic disaster that is waiting to happen and is a matter of grave concern. Perception of gender by mothers or families has long-term implications on how children are nurtured during their lives. Read More

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Optimizing Fertility in Primary Ovarian Insufficiency: Case Report and Literature Review.

Front Genet 2021 23;12:676262. Epub 2021 Jun 23.

Mary Elizabeth Conover Foundation, Inc, McLean, VA, United States.

Primary ovarian insufficiency (POI) is a clinical spectrum of ovarian dysfunction. Overt POI presents with oligo/amenorrhea and hypergonadotropic hypogonadism before age 40 years. Overt POI involves chronic health problems to include increased morbidity and mortality related to estradiol deficiency and the associated osteoporosis and cardiovascular disease as well as psychological and psychiatric disorders related to the loss of reproductive hormones and infertility. Read More

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Differential adherence to peer and nurse components of a supportive care package-The appeal of peer support may be related to women's health and psychological status.

Patient Educ Couns 2021 Jun 29. Epub 2021 Jun 29.

Peter MacCallum Cancer Centre, 305 Grattan St, Melbourne, VIC 3000, Australia; Swinburne University of Technology, Hawthorn, VIC 3122, Australia. Electronic address:

Objective: Knowledge of factors associated with intervention non-adherence may provide insights into the clinical utility of non-pharmacologic interventions.

Methods: This study compared complete and incomplete adherers to two separate components of a novel intervention package for women undergoing curative intent radiotherapy for gynaecological cancer on socio-demographic, clinical and pre-radiotherapy patient-reported outcomes data.

Results: Adherence to the tailored specialist nurse consultations was satisfactory (71% participated in all available sessions, 19% participated in all but one). Read More

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