20,432 results match your criteria women preeclampsia

Clinical risk factors for preeclampsia in twin pregnancies.

PLoS One 2021 15;16(4):e0249555. Epub 2021 Apr 15.

Department of Obstetrics and Gynecology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.

Background: Preeclampsia is a common obstetric complication. The rate of preeclampsia is increased in twin pregnancies. The aim of this study was to assess the clinical risk factors for developing preeclampsia in twin pregnancies. Read More

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TIGIT and CD155 as Immune-Modulator Receptor and Ligand on CD4 T cells in Preeclampsia Patients.

Immunol Invest 2021 Apr 15:1-16. Epub 2021 Apr 15.

Stem Cell Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.

One of the main characteristics of preeclampsia (PE) is systemic inflammation. CD4 FoxP3 cells play a critical role in both fetomaternal tolerance and successful pregnancy. T-cell immunoglobulin, as well as immunoreceptor tyrosine-based inhibitory motif (ITIM) domain (TIGIT)/CD155 pathway, possesses critical parts in the development of normal pregnancy by promoting regulatory T (Treg) cells. Read More

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Gestational Folate and Folic Acid Intake among Women in Canada at Higher Risk of Pre-Eclampsia.

J Nutr 2021 Apr 13. Epub 2021 Apr 13.

OMNI Research Group, Clinical Epidemiology Program, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada.

Background: Periconceptional folic acid (FA) supplementation is recommended to prevent neural tube defects; however, the extent to which recommendations are met through dietary sources and supplements is not clear.

Objectives: Our objective was to evaluate the dietary and supplemental intakes of FA in a Canadian pregnancy cohort and to determine the proportions of pregnant women exceeding the Estimated Average Requirement (EAR) and Tolerable Upper Intake Level (UL).

Methods: FACT (the Folic Acid Clinical Trial) was an international multicenter, randomized, double-blinded, placebo-controlled, phase III trial investigating FA for the prevention of pre-eclampsia in high-risk pregnancies. Read More

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Childbirth and motherhood in women with motor disability due to a rare condition: an exploratory study.

Orphanet J Rare Dis 2021 Apr 13;16(1):176. Epub 2021 Apr 13.

Child Psychiatry, Hopital Pitié Salpêtrière APHP and Sorbonne Université, Paris, France.

Background: Rare diseases may result in motor impairment, which in turn may affect parenthood. Our purpose was to evaluate perinatal outcomes, parenting needs, mother-infant interactions and infant development in a set of volunteer women with motor impairment due to a rare disease. In a parenting support institution, we recruited a consecutive series of 22 volunteer pregnant women or young mothers, recorded perinatal outcomes, and followed mother-infant interaction and relationship and infant development up to 14 months postpartum. Read More

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Fetal Heart Rate Decelerations in Women with Sleep-Disordered Breathing.

Reprod Sci 2021 Apr 13. Epub 2021 Apr 13.

Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, University of Michigan, Ann Arbor, MI, USA.

Emerging literature has shown that women with sleep-disordered breathing (SDB) have increased risk for gestational hypertension/preeclampsia and gestational diabetes. Case reports suggest an association between maternal apnea and fetal heart rate deceleration but data are lacking on how maternal sleep impacts fetal health. Since decelerations may be associated with adverse outcomes, we sought to determine whether fetal heart rate decelerations were associated with SDB. Read More

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The Involvement of MicroRNAs in SARS-CoV-2 Infection Comorbid with HIV-Associated Preeclampsia.

Curr Hypertens Rep 2021 Apr 13;23(4):20. Epub 2021 Apr 13.

Optics and Imaging Centre, Doris Duke Medical Research Institution, College of Health Sciences, University of KwaZulu-Natal, Durban, KwaZulu-Natal, South Africa.

Purpose Of Review: This review investigated the potential role of microRNAs (miRNAs) in the synergy of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, preeclampsia (PE), and human immunodeficiency virus (HIV) infection. Maternal health is a great concern when treating pregnant women fighting this triad of diseases, which is highly prevalent in South Africa. MicroRNAs are involved in fine-tuning of physiological processes. Read More

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Cellular immune responses in the pathophysiology of preeclampsia.

J Leukoc Biol 2021 Apr 13. Epub 2021 Apr 13.

Perinatology Research Branch, Division of Obstetrics and Maternal-Fetal Medicine, Division of Intramural Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, U.S. Department of Health and Human Services (NICHD/NIH/DHHS), Bethesda, Maryland, Detroit, Michigan, USA.

Preeclampsia, defined as new-onset hypertension accompanied by proteinuria occurring at 20 weeks of gestation or later, is a leading cause of perinatal morbidity and mortality worldwide. The pathophysiology of this major multi-systemic syndrome includes defective deep placentation, oxidative stress, endothelial dysfunction, the presence of an anti-angiogenic state, and intravascular inflammation, among others. In this review, we provide a comprehensive overview of the cellular immune responses involved in the pathogenesis of preeclampsia. Read More

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MicroRNA‑524‑5p regulates the proliferation and invasion of HTR‑8/SVneo trophoblasts by targeting NUMB in the Notch signaling pathway.

Mol Med Rep 2021 Jun 13;23(6). Epub 2021 Apr 13.

Department of Obstetrics, Hainan General Hospital, Hainan Affiliated Hospital of Hainan Medical University, Haikou, Hainan 570311, P.R. China.

Preeclampsia is a pregnancy disorder that is primarily associated with maternal and neonatal or fetal morbidity and mortality. The discovery of dysregulated microRNAs (miRs) and their roles in preeclampsia has provided new insight into the mechanisms involved in pregnancy‑related disorders. In the present study, quantitative PCR demonstrated that the expression levels of miR‑524‑5p were lower in patients with preeclampsia than those in normal pregnant women. Read More

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Length of stay in the ward following a preeclamptic pregnancy.

J Hum Hypertens 2021 Apr 12. Epub 2021 Apr 12.

Department of Obstetrics & Gynaecology, The University of Auckland, Auckland, New Zealand.

To date, data on postpartum management of preeclampsia including the optimal time for discharge are limited. The aims of this study were to investigate the appropriate time for discharge after delivery, and factors that could affect the time for discharge. Data on 210 preeclamptic women including the severity or time of onset and days in the ward after delivery were collected and analysed. Read More

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The expression of ATP-sensitive potassium channels in human umbilical arteries with severe pre-eclampsia.

Sci Rep 2021 Apr 12;11(1):7955. Epub 2021 Apr 12.

Department of Obstetrics, The Affiliated Hospital of Southwest Medical University, No.8 Kangcheng Road, Luzhou, 646000, Sichuan Province, China.

The aim of this study is to establish the expression of ATP-sensitive potassium channels(KATP) in human umbilical arteries with severe pre-eclampsia. Real-time quantitative PCR and western blotting were used to detect the mRNA and protein expression levels of KATP channel subunits Kir6.1 and SUR2B in human umbilical arteries from normal pregnant and those with severe pre-eclampsia, early onset severe pre-eclampsia and late onset severe pre-eclampsia. Read More

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Comparison of maternal and neonatal outcomes between acute fatty liver of pregnancy and hemolysis, elevated liver enzymes and low platelets syndrome: a retrospective cohort study.

BMC Pregnancy Childbirth 2021 Apr 12;21(1):293. Epub 2021 Apr 12.

Department of Obstetrics and Gynecology, Mackay Memorial Hospital, No. 92, Section 2, Zhong-Shan North Road, 10449, Taipei, Taiwan.

Background: Acute fatty liver of pregnancy (AFLP) and hemolysis, elevated liver enzymes and low platelets (HELLP) syndrome are two uncommon disorders that mimic each other clinically, but are distinct pathophysiologically. This study aimed to compare maternal and neonatal outcomes between AFLP and HELLP syndrome.

Methods: This retrospective cohort study was performed at a tertiary referral center in Taiwan between June 2004 and April 2020. Read More

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Risk factors for pregnancy morbidity in women with antiphospholipid syndrome.

J Reprod Immunol 2021 Mar 29;145:103315. Epub 2021 Mar 29.

Obstetrics and Gynecology Department, Peking University People's Hospital, Beijing, China. Electronic address:

Antiphospholipid syndrome (APS) increases the risk of obstetric complications, but risk factors for pregnancy morbidity in women with APS remain incompletely characterized. This retrospective study included pregnant women with APS and a control group without APS admitted to Peking University People's Hospital between January 2013 and September 2019. Clinical data were extracted from medical records. Read More

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Renal and cardiovascular repercussions in preeclampsia and their impact on fluid management: a literature review.

Braz J Anesthesiol 2021 Apr 9. Epub 2021 Apr 9.

Universidade de São Paulo (USP), Hospital das Clínicas, Faculdade de Medicina, São Paulo, SP, Brazil.

Preeclampsia is a multifactorial condition associated with significant morbidity and mortality. Fluid therapy in these patients is challenging since volume expansion may precipitate pulmonary edema, and fluid restriction may worsen renal function. Furthermore, cardiac impairment may introduce an additional component to the hemodynamic management. Read More

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Obstructive sleep apnea syndrome is associated with maternal complications in pregnant women.

Ginekol Pol 2021 Apr 12. Epub 2021 Apr 12.

Bursa Yüksek İhtisas Training and Researh Hospital, Turkey.

Objectives: This study was performed to evaluate the relationship between obstructive sleep apnea syndrome and pregnancy complications.

Material And Methods: A total of 500 women (18-45 years) who had delivered (vaginal delivery or caesarean section) between January 2017 and March 2017 in our clinic were included in the study. Patients at high risk for obstructive sleep apnea syndrome were identified using the Stop Bang questionnaire. Read More

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The Effect of Mild Gestational Diabetes Mellitus Treatment on Adverse Pregnancy Outcomes: A Systemic Review and Meta-Analysis.

Front Endocrinol (Lausanne) 2021 26;12:640004. Epub 2021 Mar 26.

Faculty of Nursing and Health Sciences, Nord University, Bodø, Norway.

Objectives: It is uncertain whether the treatment of mild gestational diabetes mellitus (GDM) improves pregnancy outcomes. The aim of this systemic review and meta-analysis was to investigate the effect of mild GDM treatment on adverse pregnancy outcomes.

Methods: A comprehensive literature search was conducted on the databases of PubMed, Scopus, and Google Scholar to retrieve studies that compared interventions for the treatment of mild GDM with usual antenatal care. Read More

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The presence of lupus nephritis additionally increases the risk of preeclampsia among pregnant women with systemic lupus erythematosus.

Lupus 2021 Apr 12:9612033211004716. Epub 2021 Apr 12.

Department of Molecular Medicine and Surgery, Karolinska Institute, Solna, Sweden.

Introduction: Pregnant women with systematic lupus erythematosus (SLE) have an increased risk of obstetric complications, such as preeclampsia and premature births. Previous studies have suggested that renal involvement could further increase the risk for adverse obstetric outcomes. The aim of this study was to compare the obstetric outcomes in a Swedish cohort of patients with SLE with and without lupus nephritis (LN). Read More

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PlGF (Placental Growth Factor) Testing in Clinical Practice: Evidence From a Canadian Tertiary Maternity Referral Center.

Hypertension 2021 Apr 12:HYPERTENSIONAHA12117047. Epub 2021 Apr 12.

Department of Obstetrics and Gynaecology, Division of Maternal-Fetal Medicine, Sinai Health System, Toronto, Canada. (K.M., J.W.S., M.C.A., S.R.H., R.C.W., S.C., J.C.K.).

There is little evidence evaluating angiogenic growth factor testing in real-world obstetric settings. This investigation evaluated maternal and perinatal pregnancy outcomes associated with maternal PlGF (placental growth factor) levels in real-world clinical care of high-risk pregnancies. From March 2017 to December 2019, 979 pregnant women with suspected risk of placental dysfunction, hypertensive disorders of pregnancy, or fetal growth restriction completed PlGF testing between 20+0 and 35+6 weeks of gestation. Read More

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Preconceptional maternal weight loss and hypertensive disorders in pregnancy: a systematic review and meta-analysis.

Eur J Clin Nutr 2021 Apr 9. Epub 2021 Apr 9.

Department Obstetrics and Gynecology, Erasmus MC, University Medical Center, Rotterdam, The Netherlands.

Background: Hypertensive disorders of pregnancy (HDP), including pregnancy-induced hypertension (PIH), Preeclampsia (PE), Hemolysis Elevated Liver enzymes and Low Platelets (HELLP) and chronic hypertension, are leading causes of maternal and perinatal morbidity and mortality. Although the pathophysiology of HDP is complex, preconceptional weight reduction in obese women might reduce these complications. We conducted a systematic review and meta-analysis to investigate the effectiveness of preconceptional weight loss by lifestyle intervention or bariatric surgery in overweight and obese women and the reduction of the risk of HDP. Read More

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CopenFast trial: Faster-acting insulin Fiasp versus insulin NovoRapid in the treatment of women with type 1 or type 2 diabetes during pregnancy and lactation - a randomised controlled trial.

BMJ Open 2021 Apr 9;11(4):e045650. Epub 2021 Apr 9.

Center for Pregnant Women with Diabetes, Rigshospitalet, Copenhagen, Denmark.

Introduction: Faster-acting insulin aspart (Fiasp) is approved for use in pregnancy and lactation, but no clinical study has evaluated its effects during this life stage in women with pre-existing diabetes. The aim of the CopenFast trial is to evaluate the effect of Fiasp compared with insulin aspart (NovoRapid) on maternal glycaemic control during pregnancy, delivery and lactation and on fetal growth and infant health.

Methods And Analysis: An open-label randomised controlled trial of pregnant women with type 1 or type 2 diabetes including women on multiple daily injection (MDI) therapy or insulin pump therapy. Read More

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Severe Preeclampsia is Associated with Functional and Structural Cardiac Alterations: A Case-control Study.

Z Geburtshilfe Neonatol 2021 Apr 9. Epub 2021 Apr 9.

Department of Cardiology, Pamukkale University, Denizli, Turkey.

Background: The aim of the current study is to compare electrocardiographic and echocardiographic changes in patients with severe preeclampsia (PE) and those with uncomplicated pregnancies.

Methods: This is a case-controlled prospective study consisting of 21 pregnant women with severe preeclampsia and a control group consisting of age- and gestational age-matched 24 healthy pregnant women. All patients underwent electrocardiographic and echocardiographic investigation. Read More

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Intrahepatic Cholestasis of Pregnancy and Associated Adverse Maternal and Fetal Outcomes: A Retrospective Case-Control Study.

Gastroenterol Res Pract 2021 25;2021:6641023. Epub 2021 Mar 25.

The Third School of Clinical Medicine, Southern Medical University, Guangzhou, 510000 Guangdong, China.

Objective: Intrahepatic cholestasis of pregnancy (ICP) is a common pregnancy-related liver disease and is associated with an increased risk of adverse neonatal outcomes. Ursodeoxycholic acid (UDCA) is the most effective treatment. This study was aimed at investigating the adverse outcomes of ICP and evaluating the effects of treatment with UDCA in patients with ICP. Read More

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The relationship between polymorphisms of microRNA and preeclampsia: A protocol for meta-analysis and bioinformatics prediction.

Medicine (Baltimore) 2021 Apr;100(14):e25477

Key Laboratory of Birth Defects and Related Diseases of Women and Children, Ministry of Education.

Background: Preeclampsia has genetic correlation. Many studies have shown that microRNA (miRNA) polymorphism is highly associated with preeclampsia, but the results are inconsistent. The purpose of this study is to systematically evaluate the relationship between miRNA polymorphism and preeclampsia. Read More

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Maternal Mortality in the United States: Recent Trends, Current Status, and Future Considerations.

Obstet Gynecol 2021 Apr 8. Epub 2021 Apr 8.

Department of Obstetrics and Gynaecology and the School of Population and Public Health, University of British Columbia, and the Children's and Women's Hospital of British Columbia, Vancouver, British Columbia, Canada; CHU de Québec-Université Laval Research Center, Quebec City, Quebec, Canada; the Division of Clinical Epidemiology, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden; the Perinatal Epidemiology Research Unit, Departments of Pediatrics and Obstetrics and Gynaecology, Dalhousie University and the IWK Health Centre, Halifax, Nova Scotia, Canada; the Department of Obstetrics and Gynaecology, King Saud University, Riyadh, Saudi Arabia; the Division of Epidemiology and Biostatistics, Department of Obstetrics, Gynecology, and Reproductive Sciences, Rutgers Robert Wood Johnson Medical School, New Brunswick, New Jersey; and the Epidemiology Branch, Division of Intramural Population Health Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, Maryland.

Rigorous studies carried out by the National Center for Health Statistics show that previously reported increases in maternal mortality rates in the United States were an artifact of changes in surveillance. The pregnancy checkbox, introduced in the revised 2003 death certificate and implemented by the states in a staggered manner, resulted in increased identification of maternal deaths and in reported maternal mortality rates. This Commentary summarizes the findings of the National Center for Health Statistics reports, describes temporal trends and the current status of maternal mortality in the United States, and discusses future concerns. Read More

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Association of thyroid function during pregnancy with the risk of preeclampsia and gestational diabetes mellitus.

Endocr Pract 2021 Apr 5. Epub 2021 Apr 5.

Department of Clinical Epidemiology, Obstetrics and Gynecology Hospital of Fudan University, Shanghai, China. Electronic address:

Objective: To estimate the association of maternal thyroid dysfunction with the risk of gestational hypertension and diabetes. Whether the association would be affected by gestational age at diagnosis and thyroid autoimmunity was further explored.

Methods: A cohort study of 41647 participants was conducted. Read More

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Serum Copper Level and Its Relation with Blood Pressure and Urinary Protein Level in Preeclampsia.

Mymensingh Med J 2021 Apr;30(2):473-477

Dr Saima Haque Lisa, Assistant Professor, Department of Physiology, Parkview Medical College, Sylhet, Bangladesh; E-mail:

Preeclampsia is a multifactorial disease of unknown etiology and is associated with oxidative stress. Some studies observed that alteration of essential trace element may contribute to the development of preeclampsia. The aim of the study was to assess the serum copper (Cu) level and its relation with blood pressure and urinary protein level in preeclampsia. Read More

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A Misleading Presentation of Pheochromocytoma in Pregnancy: A Case Report.

Medeni Med J 2021 26;36(1):69-74. Epub 2021 Mar 26.

All India Institute of Medical Sciences, Department of Pathology, Bhubaneswar, India.

Pheochromocytoma is a catecholamine-secreting adrenal tumor and also a rare cause of secondary hypertension in pregnancy. Its low prevalence, nonspecific clinical presentation, and symptoms similar to preeclampsia generate a diagnostic challenge during pregnancy. A 23-year-old hypertensive pregnant woman at 36th gestational week of her first pregnancy was admitted with severe hypertension (210/150 mmHg), headache and proteinuria that made us presume the case as severe preeclampsia. Read More

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Assessing the relationship between pregravid body mass index and risk of adverse maternal pregnancy and neonatal outcomes: prospective data in Southwest China.

Sci Rep 2021 Apr 7;11(1):7591. Epub 2021 Apr 7.

Department of Medical Data-Science, Graduate School of Medicine, Wakayama Medical University, Wakayama, Japan.

The relevance of pregestational body mass index (BMI) on adverse pregnancy outcomes remained unclear in Southwest China. This study aimed to investigate the overall and age-category specific association between pre-gestational BMI and gestational diabetes mellitus (GDM), preeclampsia, cesarean delivery, preterm delivery, stillbirth, macrosomia, and small-for-gestational age (SGA) or large-for-gestational age (LGA) neonates in Southwest China. Furthermore, it explores the relative importance of influence of pregravid BMI and maternal age on pregnancy outcomes. Read More

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Protocol for a randomized controlled trial of pre-pregnancy lifestyle intervention to reduce recurrence of gestational diabetes: Gestational Diabetes Prevention/Prevención de la Diabetes Gestacional.

Trials 2021 Apr 7;22(1):256. Epub 2021 Apr 7.

Weight Control and Diabetes Research Center, The Miriam Hospital, Providence, USA.

Background: Gestational diabetes mellitus (GDM) is associated with several maternal complications in pregnancy, including preeclampsia, preterm labor, need for induction of labor, and cesarean delivery as well as increased long-term risks of type 2 diabetes, metabolic syndrome, and cardiovascular disease. Intrauterine exposure to GDM raises the risk for complications in offspring as well, including stillbirth, macrosomia, and birth trauma, and long-term risk of metabolic disease. One of the strongest risk factors for GDM is the occurrence of GDM in a prior pregnancy. Read More

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Maternal lipid levels in preeclampsia: singleton vs. twin pregnancies.

J Matern Fetal Neonatal Med 2021 Apr 7:1-8. Epub 2021 Apr 7.

Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing, PR China.

Objective: To compare the maternal lipid levels in preeclampsia (PE) patients between singleton and twin pregnancies.

Methods: In this retrospective study, pregnant women with PE were divided into singleton group ( = 702) and twin group ( = 198). Serum lipids which include total cholesterol (TC), triglyceride (TG), low-density lipoprotein cholesterol (LDL-C), and high-density lipoprotein cholesterol (HDL-C) were measured and the TC/HDL-C ratio, TG/HDL-C ratio, and LDL-C/HDL-C ratio were calculated and compared between the two groups. Read More

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Neurology of Preeclampsia and Related Disorders: an Update in Neuro-obstetrics.

Curr Pain Headache Rep 2021 Apr 7;25(6):40. Epub 2021 Apr 7.

Department of Neurology, Columbia University Vagelos College of Physicians and Surgeons, New York, NY, USA.

Purpose Of Review: Preeclampsia and related hypertensive disorders of pregnancy affect up to 10% of pregnancies. Neurological complications are common and neurologists often become involved in the care of obstetric patients with preeclampsia. Here, we review the definition(s), epidemiology, clinical features, and pathophysiology of preeclampsia, focusing on maternal neurological complications and headache as a common presenting symptom of preeclampsia. Read More

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