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The Role of ApoE Expression and Variability of Its Glycosylation in Human Reproductive Health in the Light of Current Information.

Int J Mol Sci 2021 Jul 4;22(13). Epub 2021 Jul 4.

Department of Laboratory Diagnostics, Division of Laboratory Diagnostics, Faculty of Pharmacy, Wroclaw Medical University, Borowska Street 211A, 50-556 Wroclaw, Poland.

Apolipoprotein E (ApoE), a 34-kDa glycoprotein, as part of the high-density lipoprotein (HDL), has antioxidant, anti-inflammatory and antiatherogenic properties. The variability of ApoE expression in the course of some female fertility disorders (endometriosis, POCS), and other gynecological pathologies such as breast cancer, choriocarcinoma, endometrial adenocarcinoma/hyperplasia and ovarian cancer confirm the multidirectional biological function of ApoE, but the mechanisms of its action are not fully understood. It is also worth taking a closer look at the associations between ApoE expression, the type of its genotype and male fertility disorders. Read More

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Vasectomy interest and awareness among patients and their partners in prenatal clinics in the United States.

BMJ Sex Reprod Health 2021 Jul 16. Epub 2021 Jul 16.

Department of Obstetrics and Gynecology, John H Stroger Hospital of Cook County, Chicago, Illinois, USA.

Objective: Although vasectomy is safer, more effective and less expensive than tubal ligation, rates of permanent contraception are consistently higher in women than in men. We sought to explore vasectomy interest and awareness in patients and their partners during prenatal visits, a time when contraceptive counselling is typically performed.

Methods: Anonymous surveys were distributed between January and July 2019 to a cross-sectional, convenience sample of pregnant women and their partners, if available, presenting for outpatient prenatal care at two hospitals (one public, one private) serving different patient populations in Chicago, Illinois, USA. Read More

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Delivery of home-based postpartum contraception in Southwest Trifinio, Guatemala: reach, adoption, and implementation in a cluster-randomized trial.

Contraception 2021 Jul 13. Epub 2021 Jul 13.

University of Colorado, Anschutz Medical Campus, Aurora, CO, USA. Electronic address:

Objective: The objective of this analysis was to present our secondary outcomes (reach, adoption, implementation, maintenance domains) of a prospective trial to test the efficacy of a home-based intervention to increase postpartum contraceptive uptake.

Methods: We executed a cluster-randomized trial to determine if provision of contraception in the home setting increased uptake of postpartum methods. We collected secondary outcomes on how our implementation strategies of revising professional roles and changing service sites performed in terms of the number of people our study enrolled of all women eligible (reach), how it was accepted by the providers (adoption), what methods were used to conduct the study (implementation), and preliminary results on whether or not the intervention will be continued (maintenance). Read More

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Gender Differences in Atherosclerotic Vascular Disease: From Lipids to Clinical Outcomes.

Front Cardiovasc Med 2021 28;8:707889. Epub 2021 Jun 28.

Laboratory of Angiopathology, Institute of General Pathology and Pathophysiology, Moscow, Russia.

Cardiovascular diseases (CVDs) are one of the main reasons of death and morbidity in the world. Both women and men have high rates of cardiovascular morbidity and mortality, although gender-related differences in mortality and morbidity rates are observed in different age groups of the population. In the large cohort of cardiovascular disease, ischemic heart disease (IHD), heart failure (HF), systemic hypertension, and valvular heart disease are particularly common in the population. Read More

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Women doctors in female urology: current status and implications for future workforce.

BJU Int 2021 Jul 14. Epub 2021 Jul 14.

Urology department, The Austin Hospital, University of Melbourne, Victoria.

Introduction: Throughout the medical workforce, including in Urology, there has been increasing female doctor representation. This increase has been attributed to the perceived increased interest in urologists pursuing female urology as a sub-specialisation. This study aims to objectively determine the percentage of female trainees and consultants who are interested in their career being focussed on female urology in order to facilitate the improved planning for the future of this subspecialty. Read More

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Production and characterization of a human antisperm monoclonal antibody against CD52g for topical contraception in women.

EBioMedicine 2021 Jul 10;69:103478. Epub 2021 Jul 10.

Department of Medicine, Boston University School of Medicine, 670 Albany St. Rm 516, Boston, MA 02118, United States. Electronic address:

Background: Approximately 40% of human pregnancies are unintended, indicating a need for more acceptable effective contraception methods. New antibody production systems make it possible to manufacture reagent-grade human monoclonal antibodies (mAbs) for clinical use. We used the Nicotiana platform to produce a human antisperm mAb and tested its efficacy for on-demand topical contraception. Read More

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The Associations of HIV Pre-Exposure Prophylaxis Interest and Sexual Risk Behaviors Among Young Black Women.

AIDS Patient Care STDS 2021 Jul;35(7):263-270

School of Social Work, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.

The uptake of pre-exposure prophylaxis (PrEP) is low among young Black cisgender heterosexual women, although this subgroup faces a higher burden of new HIV diagnoses. This study explored the association between sexual risk and prevention behaviors, and oral PrEP and vaginal PrEP ring interest among young Black women (YBW). A sample of YBW ( = 208) 18-25 years of age completed a self-administered questionnaire assessing sexual risk and prevention behaviors, HIV and sexually transmitted infection (STI) testing, and PrEP interest from June to December 2018. Read More

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Use of Fertility Awareness-Based Methods for Pregnancy Prevention Among Ghanaian Women: A Nationally Representative Cross-Sectional Survey.

Glob Health Sci Pract 2021 06 30;9(2):318-331. Epub 2021 Jun 30.

School of Public Health, Kwame Nkrumah University of Science and Technology, Ghana.

Few studies in low- and middle-income countries have examined the use of fertility awareness-based methods (FABMs) for pregnancy prevention. Understanding the prevalence of FABM use among Ghanaian contraceptors and the characteristics and practices of users is essential. Our 2018 nationally representative survey of Ghanaian women included detailed questions on the use of rhythm and Standard Days Method/Cycle Beads (SDM). Read More

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The SWIM study: Ethnic minority women's ideas and preferences for a tailored intervention to promote national cancer screening programmes-A qualitative interview study.

Health Expect 2021 Jul 7. Epub 2021 Jul 7.

Department of Public Health Programmes, Randers Regional Hospital, Randers, Denmark.

Background: Ethnic minority women from non-Western countries are less likely than the native women to participate in screening programmes for cervical cancer, breast cancer and colorectal cancer. This social inequality can result in loss of possibility for prevention, delayed diagnosis and treatment and, ultimately, lower chance of survival. Developing a tailored intervention might be the solution to reduce social inequalities in cancer screening, and a key feature in intervention research is to consult the target group. Read More

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Establishing and Evaluating a Study Questionnaire on Knowledge and Attitudes of Healthcare Professionals Towards Recreational and Medical Cannabis Across Europe.

Clin Drug Investig 2021 Jul 7. Epub 2021 Jul 7.

Clinical Pharmacology, Karolinska University Hospital, Stockholm, Sweden.

Background And Objective: The present survey was a preliminary to a European research project on the attitude and knowledge of healthcare professionals towards the use of medical cannabis. The objective was to evaluate the readability, understandability, and relevance of a first version of the study questionnaire before preparing the finalized questionnaire, which will be subsequently proposed to European healthcare professionals on a large scale.

Methods: A cross-sectional study was conducted between December 2019 and May 2020. Read More

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YouTube as a source of information on breast cancer in the Arab world.

Support Care Cancer 2021 Jul 5. Epub 2021 Jul 5.

Department of Hematology-Oncology, Faculty of Medicine, Saint-Joseph University of Beirut, Beirut, Lebanon.

Background: The general population is increasingly using YouTube as a source of information on breast cancer, the most frequent cancer among women. Arabs are the most interested population in breast cancer on YouTube. The transmission of accurate information is important to reduce mortality rates. Read More

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The study of 2-dimensional computed tomography scans of the glenoid anatomy in relation to reverse shoulder arthroplasty in the Southern Chinese population.

JSES Int 2021 Jul 3;5(4):714-721. Epub 2021 Apr 3.

Chief of Service, Department of Orthopaedics and Traumatology, North District Hospital, Sheung Shui, Hong Kong S.A.R.

Background: Reverse shoulder arthroplasty is becoming an increasingly common surgical procedure in Hong Kong, as well as in many other countries worldwide. The aim of this study is to describe the glenoid anatomy in the Southern Chinese population. We are interested to know whether commercially available glenoid implants are suitable for this population and whether there are any steps or precautions we can take during surgery to optimize the clinical outcome for these patients. Read More

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Heart and Head: Profiles and Predictors of Self-Assessed Cognitive and Affective Empathy in a Sample of Medical and Health Professional Students.

Front Psychol 2021 16;12:632996. Epub 2021 Jun 16.

Department of Life, Health and Environmental Sciences, University of L'Aquila, L'Aquila, Italy.

For medical and health professions, students learning to respond to others' distress with well-regulated empathy is an important developmental skill linked to positive health outcomes and professionalism. Our study aimed to investigate the sociodemographic, psychological, and psychosocial differences between medical (MS) and health professional (HPS) students and their empathic abilities, since both populations share common stressors, namely, dealing with suffering people. Additionally, we were interested in assessing the psychological and psychosocial predictors of empathy of MS compared to HPS. Read More

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Catharsis Through Cinema: An Italian Qualitative Study on Watching Tragedies to Mitigate the Fear of COVID-19.

Front Psychiatry 2021 16;12:622174. Epub 2021 Jun 16.

Emili Sagol Creative Arts Therapies Research Center, University of Haifa, Haifa, Israel.

Among different ways of coping with the unsettling situation of the COVID-19 pandemic, a very peculiar one has been identified: a more frequent request, by the general population, of movies or TV series related to the very theme of viruses, contagions, and epidemics. The aim of the present study was to explore this peculiar phenomenon, in order to identify people's emotions and cognitions during and after the process, and to better understand the possible psychological function cinema can have during moments of intense and generalized crisis like the present COVID-19 pandemic. Fifteen Italian adults took part in the study - eight women and seven men (average age = 30 years, SD = 10. Read More

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Sexual Functioning of Transgender Females Post-Vaginoplasty: Evaluation, Outcomes and Treatment Strategies for Sexual Dysfunction.

Sex Med Rev 2021 Jul 1. Epub 2021 Jul 1.

Department of Urology, SUNY Upstate Medical University, Syracuse, NY, USA.

Introduction: Transfeminine genital reconstructive surgery is an important part of gender affirmation for many transgender women. Sexual health post-vaginoplasty is an important aspect of quality of life that can have a significant impact on overall well-being.

Objectives: The objective of this review is to provide a summary of the literature on the sexual outcomes of transgender females post-vaginoplasty and identify treatment strategies for those experiencing sexual dysfunction. Read More

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Differential associations between fatigue and psychobiological stress measures in women with depression and women with somatic symptom disorder.

Psychoneuroendocrinology 2021 Jun 25;132:105343. Epub 2021 Jun 25.

Outpatient Unit for Research, Teaching and Practice, Faculty of Psychology, University of Vienna, Vienna, Austria.

Objective: Medically unexplained fatigue is a burdensome, widespread symptom, and a frequent complaint in depressive disorders (DDs) as well as somatic symptom disorder (SSD). Heightened stress levels are a likely cause of fatigue, although the temporal associations, as well as the role of the stress-reactive hypothalamic-pituitary-adrenal (HPA) axis, are not yet completely understood. We were interested in the differences between DD and SSD regarding general, mental, and physical fatigue, as well as associations between psychobiological stress measures (representing different time frames) and fatigue in these groups. Read More

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A Signature of Four Circulating microRNAs as Potential Biomarkers for Diagnosing Early-Stage Breast Cancer.

Int J Mol Sci 2021 Jun 6;22(11). Epub 2021 Jun 6.

Department of Anatomy, Cell Biology and Physiological Sciences, Faculty of Medicine, American University of Beirut, Beirut 1107 2020, Lebanon.

Breast cancer (BC) is the most predominant type of cancer among women. The aim of this study is to find new biomarkers that can help in early detection of BC, especially for those who are too young to be screened using mammography as per guidelines. Using microRNA microarray, we previously showed dysregulation of 74 microRNAs in tumors from early BC patients as compared with normal adjacent tissues, which we were interested in studying in blood circulation. Read More

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Knowledge, Attitudes, and Practices of Spanish Midwives and Midwifery Students toward Oral Healthcare during Pregnancy.

Int J Environ Res Public Health 2021 06 4;18(11). Epub 2021 Jun 4.

Department of Psiquiatry, Radiology, Public Health, Nursing and Medicine, University of Santiago de Compostela, 15782 A Coruña, Spain.

Pregnancy can affect the mother's oral health, increasing their susceptibility to oral diseases that have been associated with harmful effects on the newborn. Despite the severity of oral diseases during pregnancy, the demand for dental care during the gestational period is low, which may improve with the participation of midwives in promoting oral health activities. The objectives of this study were: (i) to determine the knowledge, attitudes, and practices of Spanish midwives and midwifery students regarding oral health in pregnant women; and (ii) to identify the barriers faced by these healthcare professionals in addressing oral health promotion during pregnancy. Read More

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Postpartum heavy episodic drinking: A survey to inform development of a text messaging intervention.

Drug Alcohol Rev 2021 Jun 30. Epub 2021 Jun 30.

Johns Hopkins Bloomberg School of Public Health, Baltimore, USA.

Introduction: Text messaging interventions (TMI) are promising for addressing heavy episodic drinking (HED) in non-treatment-seeking postpartum women. Their anonymous delivery can overcome fear of consequences that often prevents postpartum women from seeking treatment for HED. We assessed feasibility and acceptability of text messaging to inform the development of a tailored TMI for postpartum HED. Read More

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Attitudes toward a mindfulness-based intervention from African American women living with HIV: A qualitative study.

SAGE Open Med 2021 16;9:20503121211025144. Epub 2021 Jun 16.

Department of Health Promotion Education and Behavior, South Carolina SmartState Center for Healthcare Quality (CHQ), Arnold School of Public Health, University of South Carolina, Columbia, SC, USA.

Introduction: Mindfulness-based interventions train participants to pay attention to their own emotions in the current moment without judging themselves. This study aims to assess the attitudes toward a mindfulness-based stress reduction intervention among African American women living with HIV.

Methods: We collected qualitative data from three focus group discussions with 18 African American women living with HIV who were purposely recruited from the Palmetto Health-USC Immunology Center in South Carolina, United States. Read More

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The experiences of postnatal women and healthcare professionals of a brief weight management intervention embedded within the national child immunisation programme.

BMC Pregnancy Childbirth 2021 Jun 29;21(1):462. Epub 2021 Jun 29.

The Centre for Lifestyle Medicine and Behaviour, School of Sport, Exercise and Health Sciences, Loughborough University, Loughborough, Leicestershire, LE11 3TU, UK.

Background: After childbirth, most women do not lose the extra weight gained during pregnancy. This is important because postnatal weight retention contributes to the development of obesity in later life. Research shows that postnatal women living with overweight would prefer to weigh less, are interested in implementing weight loss strategies, and would like support. Read More

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What women want: General population perspectives and access to preconception expanded carrier screening.

Prenat Diagn 2021 Jun 27. Epub 2021 Jun 27.

Myriad Women's Health, San Francisco, California, USA.

Objective: Expanded carrier screening (ECS) assesses the risk of individuals and couples of having a child affected with a set of genetic conditions. Carriers have options available to optimize pregnancy outcomes based on personal values and preferences. The greatest range of options is available prior to pregnancy, therefore professional societies recommend this screening be performed preconception. Read More

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Hand Osteoarthritis: investigating Pain Effects of estrogen-containing therapy (HOPE-e): a protocol for a feasibility randomised placebo-controlled trial.

Pilot Feasibility Stud 2021 Jun 24;7(1):133. Epub 2021 Jun 24.

Centre for Osteoarthritis Pathogenesis Versus Arthritis, Kennedy Institute of Rheumatology, NDORMS, University of Oxford, Oxford, UK.

Background: Hand osteoarthritis (OA) is a common condition, causing pain, stiffness and reduced quality of life. Incidence is higher amongst women, particularly around the age of the menopause. Whilst the relationship between sex hormones and OA has been studied in vitro, in epidemiological studies and in clinical trials of hormone replacement therapy (HRT), this study is the first to investigate the effect of estrogen-containing therapy on hand pain in post-menopausal women with symptomatic hand OA in a randomised study design. Read More

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Discomfort and relieving factors among patients with bladder cancer undergoing office-based cystoscopy.

Urol Oncol 2021 Jun 20. Epub 2021 Jun 20.

Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC; Department of Urology, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC. Electronic address:

Objective: To evaluate the degree of discomfort among patients with bladder cancer undergoing office-based cystoscopy and identify factors and interventions that influence discomfort and anxiety.

Methods: We conducted a survey of the Bladder Cancer Advocacy Network Patient Survey Network (BCAN PSN) to investigate the degree of discomfort associated with office-based cystoscopy and prevalence of interventions used to reduce discomfort. All patients had undergone at least one previous cystoscopy. Read More

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Strategies for Recruiting and Retaining Women and Minorities in Orthopaedics: AOA Critical Issues Symposium.

J Bone Joint Surg Am 2021 Jun 21. Epub 2021 Jun 21.

Department of Orthopaedic Surgery, University of Minnesota, Minneapolis, Minnesota.

Abstract: Despite considerable attention being paid to the lack of diversity in orthopaedic surgery over the last decade, there has been very little actual change in the racial and gender demographics. This article discusses mechanisms for improving the diversity of interested programs, including reviewing potential barriers to racial and gender-based diversity programs. Read More

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Patient Experience in Virtual Visits Hinges on Technology and the Patient-Clinician Relationship: A Large Survey Study With Open-ended Questions.

J Med Internet Res 2021 Jun 21;23(6):e18488. Epub 2021 Jun 21.

Office of Patient Experience, Clinical Transformation, Cleveland Clinic, Cleveland, OH, United States.

Background: Patient satisfaction with in-person medical visits includes patient-clinician engagement. However, communication, empathy, and other relationship-centered care measures in virtual visits have not been adequately investigated.

Objective: This study aims to comprehensively consider patient experience, including relationship-centered care measures, to assess patient satisfaction during virtual visits. Read More

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Impact of dedicated women's outreach workers (WOWs) on recruitment of women in ACTG clinical studies.

HIV Res Clin Pract 2021 Apr 18;22(2):37-45. Epub 2021 Jun 18.

Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.

Background: Despite efforts by the AIDS Clinical Trials Group (ACTG) to enroll representative numbers of diverse women, participation in ACTG studies in the United States remains largely white and male. To address this gap in women's participation in ACTG research, a one-year pilot study of dedicated women's outreach workers (WOWs) was proposed.

Objectives: included demonstrating that targeted recruitment efforts can expand community awareness of ACTG research and ensuring successful enrollment of women at the respective clinical research sites. Read More

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Understanding family planning outcomes in northwestern Nigeria: analysis and modeling of social and behavior change factors.

BMC Public Health 2021 06 17;21(1):1168. Epub 2021 Jun 17.

Department of Global Community Health and Behavioral Sciences, School of Public Health and Tropical Medicine, Tulane University, New Orleans, Louisiana, 70112, USA.

Background: Northwestern Nigeria faces a situation of high fertility and low contraceptive use, driven in large part by high-fertility norms, pro-natal cultural and religious beliefs, misconceptions about contraceptive methods, and gender inequalities. Social and behavior change (SBC) programs often try to shift drivers of high fertility through multiple channels including mass and social media, as well as community-level group, and interpersonal activities. This study seeks to assist SBC programs to better tailor their efforts by assessing the effects of intermediate determinants of contraceptive use/uptake and by demonstrating their potential impacts on contraceptive use, interpersonal communication with partners, and contraceptive approval. Read More

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Analysis of Media Outlets on Women's Health: Thematic and Quantitative Analyses Using Twitter.

Front Public Health 2021 31;9:644284. Epub 2021 May 31.

Department Preventive Medicine and Public Health, School of Medicine, University of Navarra, Pamplona, Spain.

Media outlets influence social attitudes toward health habits. The analysis of tweets has become a tool for health researchers. The objective of this study was to investigate the distribution of tweets about women's health and the interest generated among Twitter users. Read More

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The UPTAKE study: a cross-sectional survey examining the insights and beliefs of the UK population on COVID-19 vaccine uptake and hesitancy.

BMJ Open 2021 06 15;11(6):e048856. Epub 2021 Jun 15.

Department of Gastroenterology and Haematology, Royal Wolverhampton Hospitals NHS Trust, Wolverhampton, UK.

Objective: A key challenge towards a successful COVID-19 vaccine uptake is vaccine hesitancy. We examine and provide novel insights on the key drivers and barriers towards COVID-19 vaccine uptake.

Design: This study involved an anonymous cross-sectional online survey circulated across the UK in September 2020. Read More

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