30,048 results match your criteria women advanced


Pregnancy exposure to phthalates and DNA methylation in male placenta - An epigenome-wide association study.

Environ Int 2022 Jan 13;160:107054. Epub 2022 Jan 13.

University Grenoble Alpes, Inserm, CNRS, Team of Environmental Epidemiology applied to Development and Respiratory Health, Institute for Advanced Biosciences, Grenoble, France.

Background: Exposure to phthalates during pregnancy may alter DNA methylation in the placenta, a crucial organ for the growth and development of the fetus.

Objectives: We studied associations between urinary concentrations of phthalate biomarkers during pregnancy and placental DNA methylation.

Methods: We measured concentrations of 11 phthalate metabolites in maternal spot urine samples collected between 22 and 29 gestational weeks in 202 pregnant women. Read More

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January 2022

Prenatal Exposure to Teratogenic Medications in the Era of Risk Evaluation and Mitigation Strategies (REMS).

Am J Obstet Gynecol 2022 Jan 12. Epub 2022 Jan 12.

Department of Pharmaceutical Outcomes and Policy, College of Pharmacy, University of Florida; Department of Epidemiology, College of Medicine and College of Public Health and Health Professions, University of Florida; Center for Drug Evaluation and Safety (CoDES), University of Florida. Electronic address:

Background: Prevention of prenatal exposures to teratogenic drugs is a significant clinical and public health concern. With the enactment of the FDA Amendment Act in 2007, the Food and Drug Administration has begun to require manufacturers to implement Risk Evaluation and Mitigation Strategies (REMS) to prevent prenatal exposures. Among 12 REMS drugs, several had predecessor risk mitigation plans (e. Read More

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January 2022

Installing oncofertility programs for breast cancer in limited versus optimum resource settings: Empirical data from 39 surveyed centers in Repro-Can-OPEN Study Part I & II.

J Assist Reprod Genet 2022 Jan 15. Epub 2022 Jan 15.

Oncofertility Consortium, Michigan State University, 965 Wilson Road, Room A626B, East Lansing, MI, 48824-1316, USA.

Purpose: As a further step to elucidate the actual diverse spectrum of oncofertility practices for breast cancer around the globe, we present and discuss the comparisons of oncofertility practices for breast cancer in limited versus optimum resource settings based on data collected in the Repro-Can-OPEN Study Part I & II.

Methods: We surveyed 39 oncofertility centers including 14 in limited resource settings from Africa, Asia & Latin America (Repro-Can-OPEN Study Part I), and 25 in optimum resource settings from the United States, Europe, Australia and Japan (Repro-Can-OPEN Study Part II). Survey questions covered the availability of fertility preservation and restoration options offered to young female patients with breast cancer as well as the degree of utilization. Read More

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January 2022

Plasma metabolomic profiles for colorectal cancer precursors in women.

Eur J Epidemiol 2022 Jan 15. Epub 2022 Jan 15.

Department of Nutrition, Harvard T.H. Chan School of Public Health, 667 Huntington Avenue, Kresge 906A, Boston, MA, 02115, USA.

How metabolome changes influence the early process of colorectal cancer (CRC) development remains unknown. We conducted a 1:2 matched nested case-control study to examine the associations of pre-diagnostic plasma metabolome (profiled using LC-MS) with risk of CRC precursors, including conventional adenomas (n = 586 vs. 1141) and serrated polyps (n = 509 vs. Read More

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January 2022

Trends in treatment patterns and costs of care among patients with advanced stage cervical cancer.

Gynecol Oncol 2022 Jan 11. Epub 2022 Jan 11.

Fred Hutchinson Cancer Research Center, Seattle, WA, USA.

Background: Current treatments for recurrent or metastatic cervical cancer (r/mCC) do not offer satisfactory clinical benefits, with most patients progressing beyond first-line (1L) treatment. With new treatments under investigation, understanding current treatment patterns, the impact of newly approved therapies, and total costs of care for r/mCC are important.

Methods: A retrospective analysis of a US commercial insurance claims database to identify adult patients with r/mCC between 2015 and Q1-2020; defining 1L treatment as the first administration of systemic treatment without concomitant chemoradiation or surgery. Read More

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January 2022

Maternal advanced age, single parenthood, and ART increase the risk of child morbidity up to five years of age.

BMC Pediatr 2022 Jan 14;22(1):39. Epub 2022 Jan 14.

Department of Obstetrics and Gynecology, and Department of Biomedical and Clinical Sciences, Linköping University, SE-581 85, Linköping, Sweden.

Background: Advanced maternal age, single status and use of assisted reproductive technology (ART) are increasing in mothers in high-income countries, and all are known risk factors for negative obstetric outcomes. Less is known about their long-term consequences for childhood morbidity. Thus, the aim of this study was to investigate morbidity up to five years of age, in the children of older, single, and/or ART-treated mothers. Read More

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January 2022

Comparison of efficacy and safety between simultaneous integrated boost intensity-modulated radiotherapy and standard-dose intensity-modulated radiotherapy in locally advanced esophageal squamous cell carcinoma: a retrospective study.

Strahlenther Onkol 2022 Jan 14. Epub 2022 Jan 14.

Department of Radiation Oncology, The Fourth Hospital of Hebei Medical University, 050011, Shijiazhuang, China.

Objective: This study aimed to evaluate the efficacy and safety of simultaneous integrated boost intensity-modulated radiotherapy (SIB-IMRT) versus standard-dose intensity-modulated radiotherapy (SD-IMRT) in the treatment of locally advanced esophageal squamous cell carcinoma.

Methods: From July 2003 to March 2014, 1748 patients in a single center who received definitive chemoradiotherapy were included in the analysis. A total of 109 patients who underwent SIB-IMRT and fulfilled all inclusion and exclusion criteria were identified as the study group. Read More

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January 2022

Diagnosis of Choroidal Disease With Deep Learning-Based Image Enhancement and Volumetric Quantification of Optical Coherence Tomography.

Transl Vis Sci Technol 2022 Jan;11(1):22

Department of Ophthalmology, Graduate School of Medicine, Osaka University, Suita, Osaka, Japan.

Purpose: The purpose of this study was to quantify choroidal vessels (CVs) in pathological eyes in three dimensions (3D) using optical coherence tomography (OCT) and a deep-learning analysis.

Methods: A single-center retrospective study including 34 eyes of 34 patients (7 women and 27 men) with treatment-naïve central serous chorioretinopathy (CSC) and 33 eyes of 17 patients (7 women and 10 men) with Vogt-Koyanagi-Harada disease (VKH) or sympathetic ophthalmitis (SO) were imaged consecutively between October 2012 and May 2019 with a swept source OCT. Seventy-seven eyes of 39 age-matched volunteers (26 women and 13 men) with no sign of ocular pathology were imaged for comparison. Read More

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January 2022

Trends in the incidence of head and neck cancer by subsite between 1993 and 2015 in Japan.

Cancer Med 2022 Jan 14. Epub 2022 Jan 14.

Division of Cancer Information and Control, Department of Preventive Medicine, Aichi Cancer Center Research Institute, Nagoya, Japan.

Background: Tobacco use and alcohol consumption are still important risk factors for head and neck cancer (HNC) in developing countries, even though decreasing in tobacco prevalence. Recently, an increased incidence of oropharyngeal cancer due to human papilloma virus (HPV) infection has attracted attention in advanced countries, including the United States and Europe. However, few studies have evaluated trends in the incidence of HNC by subsite in Japan. Read More

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January 2022

Effects of smartphone mirroring-based telepresence exercise on body composition and physical function in obese older women.

Aging Clin Exp Res 2022 Jan 14. Epub 2022 Jan 14.

Medical Big Data Research Center, Seoul National University College of Medicine, Seoul, Republic of Korea.

Aims: This study aimed to develop a smartphone mirroring-based telepresence exercise program that can be performed at home while allowing for real-time feedback by instructors.

Methods: For this randomized controlled trial, 29 obese older women aged 66-87 years with ≥ 30% body fat were recruited at a senior citizen center. The intervention group was provided with the smartphone mirroring-based telepresence exercise program, in which participants exercised in their homes for 20-40 min three times a week for 12 weeks. Read More

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January 2022

Prevalence and characteristics of antidepressant prescribing in adults with comorbid depression and type 2 diabetes mellitus: A systematic review and meta-analysis.

Health Sci Rev (Oxf) 2021 ;1:None

Epidemiology and Applied Clinical Research Department, Division of Psychiatry, University College London (UCL), London, United Kingdom.

Background: Treatment guidelines do not provide specific recommendations for antidepressant prescribing in people with type 2 diabetes mellitus (T2DM). It is important to understand the prevalence of antidepressant prescribing and associated patient characteristics, to recognise safety issues or inequalities related to treatment access.

Methods And Results: Seven databases were searched using terms related to depression, T2DM and antidepressant medication. Read More

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January 2021

Diagnostic Benefit of the Detection of Mitotic Figures in Endometriotic Lesions.

Geburtshilfe Frauenheilkd 2022 Jan 10;82(1):85-92. Epub 2022 Jan 10.

Department of Obstetrics and Gynecology, Technische Universität Dresden, Dresden, Germany.

Endometriosis is a chronic disease which is diagnosed by surgical intervention combined with a histological work-up. Current international and national recommendations do not require the histological determination of the proliferation rate. The diagnostic and clinical importance of the mitotic rate in endometriotic lesions still remains to be elucidated. Read More

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January 2022

Palliative Prognostic Index Validation in Hospitalized Advanced Cancer Patients in Indonesia Tertiary Hospitals.

Acta Med Indones 2021 Oct;53(4):442-449

1. Division of Psychosomatic and Pallliative, Department of Internal Medicine, Faculty of Medicine Universitas Indonesia - dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia. 2. Clinical Epidemiology Unit, Department of Internal Medicine, Faculty of Medicine Universitas Indonesia - dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia..

Background: Accurate prediction of survival is important for advanced cancer patients to determine medical interventions plan the patient's lives and prepare for their death. The palliative prognostic index (PPI) is most popular scores used worldwide to predict life expectancy in advanced cancer palliative patients. The purpose of this study was to test validity and the performance of PPI in Cipto Mangunkusumo Hospital as a Tertiary Referral Nasional Hospital. Read More

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October 2021

A Multicentre Retrospective Study of Fulvestrant Use and Efficacy in Advanced/Metastatic Breast Cancer.

Clin Oncol (R Coll Radiol) 2022 Jan 10. Epub 2022 Jan 10.

North Middlesex University Hospital NHS Trust, London, UK.

Aims: Fulvestrant is a selective oestrogen receptor (ER) degrader used in postmenopausal women with hormone receptor-positive advanced breast cancer. The study aim was to analyse demographics and outcomes of UK patients treated with fulvestrant monotherapy at nine representative centres.

Materials And Methods: Medical records of 459 patients with locally advanced or metastatic ER-positive, HER2-negative breast cancer treated with fulvestrant between August 2011 and November 2018 at nine UK centres were reviewed. Read More

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January 2022

Response capability of hospitals to an incident caused by mass gatherings in southeast Iran.

Injury 2022 Jan 6. Epub 2022 Jan 6.

Non-Communicable Diseases Research Center, Ilam University of Medical Sciences, Ilam, Iran. Electronic address:

Background And Objectives: Hospitals are expected to provide a safe environment for patients, visitors, and employees during emergencies and disasters, as well as provide health care to disaster survivors. The aim of this study was to evaluate the response capability of hospitals to an incident caused by mass gatherings (MG) in Kerman province.

Methods: This cross-sectional study was performed among hospitals of Kerman city in 2021. Read More

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January 2022

An in-Vivo Daily Self-Report Approach to the Assessment of Outcomes of Two Psychotherapies for Women With Posttraumatic Stress Disorder.

Behav Ther 2022 Jan 21;53(1):11-22. Epub 2021 May 21.

University of Connecticut, School of Medicine.

Emotion regulation and interpersonal psychotherapies that do not require trauma memory processing have been shown to be effective in treating posttraumatic stress disorder (PTSD). This study used a novel method to assess in vivo outcomes in a randomized clinical trial with women (N = 147; ages 18-54; 61% of color; 94% low income) with full (79%) or partial (21%) PTSD. Participants were assigned to affect regulation or interpersonal therapy, or wait-list, and completed daily self-reports for 2 to 4 weeks at baseline and up to 30 days at posttest. Read More

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January 2022

Consumption of Olive Oil and Risk of Total and Cause-Specific Mortality Among U.S. Adults.

J Am Coll Cardiol 2022 Jan;79(2):101-112

Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA. Electronic address:

Background: Olive oil consumption has been shown to lower cardiovascular disease risk, but its associations with total and cause-specific mortality are unclear.

Objectives: The purpose of this study was to evaluate whether olive oil intake is associated with total and cause-specific mortality in 2 prospective cohorts of U.S. Read More

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January 2022

Optimal individualization of patient-oriented ovarian stimulation in Japanese assisted reproductive technology clinics, a review for unique setting with advanced-age patients.

J Obstet Gynaecol Res 2022 Jan 13. Epub 2022 Jan 13.

Department of Obstetrics and Gynecology, Saitama Medical University, Saitama, Japan.

Ovarian stimulation is a key issue in assisted reproductive technology (ART) treatment. ART practice in Japan is unique with various types of ovarian stimulation protocols, which may contribute to lower pregnancy rates compared to other countries. This review aims to clarify optimal individualized ovarian stimulation for improving the pregnancy rate per one oocyte retrieval cycle in Japan. Read More

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January 2022

Changes in CD163+, CD11b+, and CCR2+ peripheral monocytes relate to Parkinson's disease and cognition.

Brain Behav Immun 2022 Jan 10. Epub 2022 Jan 10.

DANDRITE & Department of Biomedicine, Aarhus University, Aarhus, Denmark. Electronic address:

Alpha-synuclein pathology is associated with immune activation and neurodegeneration in Parkinson's disease. The immune activation involves not only microglia but also peripheral immune cells, such as mononuclear phagocytes found in blood and infiltrated in the brain. Understanding peripheral immune involvement is essential for developing immunomodulatory treatment. Read More

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January 2022

Cumulative Advanced Breast Cancer Risk Prediction Model Developed in a Screening Mammography Population.

J Natl Cancer Inst 2022 Jan 13. Epub 2022 Jan 13.

Department of Public Health Sciences, University of California, Davis, CA, USA.

Background: Estimating advanced breast cancer risk in women undergoing annual or biennial mammography could identify women who may benefit from less or more intensive screening. We developed an actionable model to predict cumulative six-year advanced cancer (prognostic pathologic stage II or higher) risk according to screening interval.

Methods: We included 931,186 women aged 40-74 years in the Breast Cancer Surveillance Consortium undergoing 2,542,382 annual (prior mammogram within 11-18 months) or 752,049 biennial (prior within 19-30 months) screening mammograms. Read More

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January 2022

Delays in the presentation and diagnosis of women with breast cancer in Yogyakarta, Indonesia: A retrospective observational study.

PLoS One 2022 13;17(1):e0262468. Epub 2022 Jan 13.

Leeds Institute of Health Sciences, School of Medicine, Faculty of Medicine and Health, University of Leeds, Leeds, United Kingdom.

Purpose: To investigate factors associated with delays in presentation and diagnosis of women with confirmed breast cancer (BC).

Methods: A cross-sectional study nested in an ongoing prospective cohort study of breast cancer patients at Dr Sardjito Hospital, Yogyakarta, Indonesia, was employed. Participants (n = 150) from the main study were recruited, with secondary information on demographic, clinical, and tumor variables collected from the study database. Read More

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January 2022

Interventions for Women Veterans with Mental Health Care Needs: Findings from a Scoping Review.

Issues Ment Health Nurs 2022 Jan 13:1-12. Epub 2022 Jan 13.

School of Nursing, University of Wisconsin-Madison, Madison, Wisconsin, USA.

Experts have prioritized research on women veterans' mental health and the delivery of gender-sensitive care. The purpose of this study was to conduct a scoping review of the literature to summarize interventions for women veterans with mental health care needs designed in the Department of Veterans Affairs (VA). We identified 1,073 articles; eight were eligible for full review and represented seven unique interventions. Read More

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January 2022

Executive functioning and serum lipid fractions in Parkinson's disease-a possible sex-effect: the PACOS study.

J Neural Transm (Vienna) 2022 Jan 13. Epub 2022 Jan 13.

Department of Surgical and Medical Sciences Advanced Technologies "G.F. Ingrassia", University of Catania, Via Santa Sofia 78, 95123, Catania, Italy.

The association between dyslipidemia and cognitive performance in Parkinson's disease (PD) patients still needs to be clarified. Aim of the study was to evaluate the presence of possible associations between serum lipids fractions and executive dysfunction also exploring the sex-specific contribute of lipids level on cognition. Patients from the PACOS cohort, who underwent a complete serum lipid profile measures (total cholesterol-TC, low-density lipoprotein cholesterol-LDL, high-density lipoprotein cholesterol-HDL and triglycerides-TG) were selected. Read More

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January 2022

Next Level Health: a holistic health and wellbeing program to empower New Zealand women.

Health Promot Int 2022 Jan 12. Epub 2022 Jan 12.

Department of Pathophysiology & Molecular Medicine, University of Otago, Mein St, Newtown, Wellington 6021, New Zealand.

Improving equity in women's health requires gender-specific and empowering approaches. However, health programs often disempower women by adopting a 'one-size-fits-all' approach that emphasizes diet, exercise and weight loss over other important aspects like sleep and mental wellbeing. This article reports on the design of Next Level Health (NLH), a program that aims to empower women through developing a wide range of health behaviors to support their holistic wellbeing. Read More

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January 2022

A randomized controlled trial on the effect of blue-blocking glasses compared to partial blue-blockers on melatonin profile among nulliparous women in third trimester of the pregnancy.

Neurobiol Sleep Circadian Rhythms 2022 May 29;12:100074. Epub 2021 Dec 29.

Department of Psychosocial Science, Faculty of Psychology, University of Bergen, Bergen, Norway.

Objective: In pregnancy melatonin regulates circadian rhythms, induce sleep, and has a neuroprotective positive effect on fetal development. Artificial blue light in the evening delays and suppresses melatonin production. Thus, we investigated the effect of blocking blue light on the melatonin profile. Read More

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Post-Marketing Surveillance of a generic Oxaliplatin (Alvoxal) in Iranian Patients with Cancer.

Curr Ther Res Clin Exp 2022 29;96:100657. Epub 2021 Nov 29.

Medical Department, Orchid Pharmed Company, Tehran, Iran.

Background: CRC is the second and third most common cancer in women and men, respectively. The national comprehensive cancer network guidelines recommend oxaliplatin-based chemotherapy as a preferred regimen for patients with advanced or metastatic colon cancer. Oxaliplatin is also used in the off-label treatment of gastric cancer. Read More

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November 2021

Surgical treatment of advanced anterior wall and apical vaginal prolapse using the anchorless self-retaining support implant: long-term follow-up.

Int Urogynecol J 2022 Jan 13. Epub 2022 Jan 13.

"La Sapienza" Univ.-Polo Pontino, ICOT-Latina, Italy.

Introduction And Hypothesis: Following health notification by the FDA in 2008 of serious complications with transvaginal mesh for anterior pelvic organ prolapse, there has been a return to native tissue repairs. Earlier work with a self-retaining support (SRS) implant showed a high anatomical success rate with minimal implant-related complications over a medium-term follow-up. It is proposed that post-implant complications are more a consequence of the method of mesh anchoring rather than the implant itself. Read More

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January 2022

Changes in Visceral and Ectopic Adipose Tissue Stores Across Pregnancy and their Relationship to Gestational Weight Gain.

J Nutr 2022 Jan 11. Epub 2022 Jan 11.

Department of Medicine, Knight Cardiovascular Institute, Oregon Health & Science University, 3181 SW Sam Jackson Park Road, Portland, OR, 97239, USA.

Background: Excessive gestational weight gain has been associated with increased total body fat (TBF), metabolic syndrome and abdominal obesity. However, little is known about the relationship of gestational weight gain with changes in metabolically active visceral or ectopic (hepatic and skeletal muscle) lipid stores.

Objectives: In a prospective study of 50 healthy pregnant women, we assessed whether changes in weight were associated with changes in total, visceral, and ectopic lipid stores. Read More

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January 2022

Optimizing the colorectal cancer screening programme using faecal immunochemical test (FIT) in Flanders, Belgium from the "interval cancer" perspective.

Br J Cancer 2022 Jan 12. Epub 2022 Jan 12.

Research Department, Belgian Cancer Registry, Brussels, Belgium.

Background: Interval cancer (IC) is a critical issue in colorectal cancer (CRC) screening. We identified factors associated with ICs after faecal immunochemical test (FIT) screening and explored the impact of lowering FIT cut-off or shortening screening interval on FIT-ICs in Flanders.

Methods: FIT participants diagnosed with a CRC during 2013-2018 were included. Read More

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January 2022

Synthesis, Physicochemical Characterization and In vitro Evaluation of Biodegradable PLGA Nanoparticles entrapped to Folic acid for Targeted Delivery of Kaempferitrin.

Biotechnol Appl Biochem 2022 Jan 12. Epub 2022 Jan 12.

Molecular Oncology Lab, Department of Biochemistry, Periyar University, Salem, Tamil Nadu, 636011, India.

Polymeric nanoparticles are widely studied in the treatment of colorectal cancer. Kaempferitrin loaded non-toxic and biodegradable poly (D, L lactic-co-glycolic acid) PLGA nanoparticles (NPs) developed by solvent emulsion evaporation method by improving its solubility and bioavailability. In order to improve the delivery of kaempferitrin (KM) to cancerous cells, folic acid (FA) combined kaempfertrin PLGA NPs were prepared. Read More

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January 2022