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Pragmatic, Data-Driven Method to Determine Cutoffs for CSF Biomarkers of Alzheimer Disease Based on Validation Against PET Imaging.

Neurology 2022 May 26. Epub 2022 May 26.

Cognitive Neurology Center, Lariboisiere - Fernand Widal Hospital, AP-HP, Université de Paris, Paris, France.

Objective: To elaborate a new algorithm to establish a standardized method to define cuff-offs for CSF biomarkers of Alzheimer's disease (AD) by validating the algorithm against CSF classification derived from PET imaging.

Methods: Low and high levels of CSF phosphorylated tau were first identified to establish optimal cut-offs for CSF amyloid-β peptide (Aβ) biomarkers. These Aβ cut-offs were then used to determine cut-offs for CSF tau and phosphorylated tau markers. Read More

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Early career Black women in school-based mental health fields: Understanding their experiences of workplace discrimination.

J Sch Psychol 2022 Jun 8;92:49-65. Epub 2022 Mar 8.

William and Mary, United States of America.

This study aimed to understand school mental health providers' experiences with racism and other forms of discrimination (i.e., gendered-based discrimination) at work, with an exclusive focus on early career Black women. Read More

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Evidence for the effectiveness of immunologic therapies in women with subfertility and/or undergoing assisted reproduction.

Fertil Steril 2022 Jun;117(6):1144-1159

Nuffield Department of Women's and Reproductive Health, University of Oxford, Oxford, United Kingdom. Electronic address:

Implantation is a critical step in the establishment of a successful pregnancy, depending on a complex immune-endocrine dialogue between the developing embryo and maternal endometrium. Research suggests that altered immunity in the maternal decidua results in implantation impairment and failure. Immunomodulatory drugs have, thus, been widely used in assisted conception to aid embryo implantation, despite an absence of consensus on their effectiveness and safety. Read More

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Immune determinants of endometrial receptivity: a biological perspective.

Fertil Steril 2022 Jun;117(6):1107-1120

Robinson Research Institute and Adelaide Medical School, The University of Adelaide, Adelaide, South Australia, Australia.

Immune cells are essential for endometrial receptivity to embryo implantation and early placental development. They exert tissue-remodeling and immune regulatory roles-acting to promote epithelial attachment competence, regulate the differentiation of decidual cells, remodel the uterine vasculature, control and resolve inflammatory activation, and suppress destructive immunity to paternally inherited alloantigens. From a biological perspective, the endometrial immune response exerts a form of "quality control"-it promotes implantation success when conditions are favorable but constrains receptivity when physiological circumstances are not ideal. Read More

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Becoming a Parent During Cardiovascular Training.

J Am Coll Cardiol 2022 May;79(21):2119-2126

Division of Cardiovascular Medicine, University of Florida College of Medicine, Malcom Randall VA Medical Center, Gainesville, Florida, USA.

Background: Specialty training in cardiovascular diseases is consistently perceived to have adverse job conditions and interfere with family life. There is a dearth of universal workforce support for trainees who become parents during training.

Objectives: This study sought to identify parental policies across cardiovascular training programs internationally. Read More

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Gender Differences in Takotsubo Syndrome.

J Am Coll Cardiol 2022 May;79(21):2085-2093

University of Foggia, Department of Medical and Surgical Sciences, Foggia, Italy.

Background: Male sex in takotsubo syndrome (TTS) has a low incidence and it is still not well characterized.

Objectives: The aim of the present study is to describe TTS sex differences.

Methods: TTS patients enrolled in the international multicenter GEIST (GErman Italian Spanish Takotsubo) registry were analyzed. Read More

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Affective disorders: eliminate WArning signs and REstore functioning-AWARE-a randomised controlled multimodule intervention study, presentation of design and intervention.

BMJ Open 2022 May 26;12(5):e058839. Epub 2022 May 26.

Research Unit, North Zealand Psychiatric Center, Hillerod, Copenhagen, Denmark.

Introduction: Affective disorders are associated with impaired overall functioning and quality of life (QoL). Despite different medical and psychological treatment options, the prognosis remains largely unchanged. Consequently, the field needs new intervention strategies especially targeting patient groups with impaired functioning. Read More

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Mediator or moderator? The role of obesity in the association between age at menarche and blood pressure in middle-aged and elderly Chinese: a population-based cross-sectional study.

BMJ Open 2022 May 26;12(5):e051486. Epub 2022 May 26.

Department of Emergency and Critical Care Nursing, School of Nursing, Wannan Medical College, Wuhu, Anhui, China.

Objective: We investigated the moderation/mediation between the age of menarche and obesity parameters in predicting blood pressure (BP) in middle-aged and elderly Chinese.

Design: Our study is a population-based cross-sectional study.

Setting: Participants in this study came from the China Health and Retirement Longitudinal Study (CHARLS). Read More

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Cross-sectional study of COVID-19 knowledge, beliefs and prevention behaviours among adults in Senegal.

BMJ Open 2022 May 26;12(5):e057914. Epub 2022 May 26.

Department of Health, Human Performance and Recreation, University of Arkansas College of Education and Health Professions, Fayetteville, Arkansas, USA.

Objectives: The aim of the study was to explore COVID-19 beliefs and prevention behaviours in a francophone West African nation, Senegal.

Design: This was a cross-sectional analysis of survey data collected via a multimodal observational study.

Participants: Senegalese adults aged 18 years or older (n=1452). Read More

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Preferences of Australian healthcare providers regarding education on long-term health after hypertensive disorders of pregnancy: a qualitative study.

BMJ Open 2022 May 26;12(5):e055674. Epub 2022 May 26.

Discipline of Women's Health, University of New South Wales Faculty of Medicine and Health, Sydney, New South Wales, Australia.

Objectives: To explore Australian healthcare providers' (HCPs') preferred content, format and access to education regarding long-term health after hypertensive disorder of pregnancy (HDP), in order to guide the development of education programmes.

Design And Setting: A qualitative study using a framework analysis was undertaken. Registered HCP who were practising in Australia and previously completed a survey about long-term health after HDP were invited to participate. Read More

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Analysis of female enrollment in clinical trials for alcohol and substance use disorders: Is it time for sex-informed pharmacotherapy?

Contemp Clin Trials 2022 May 23:106784. Epub 2022 May 23.

Mary Horrigan Connors Center for Women's Health and Gender Biology, Department of Psychiatry, Brigham and Women's Hospital, United States of America; Harvard Medical School, Boston, MA, United States of America. Electronic address:

Background: Women represent an increasing number of individuals with alcohol and substance use disorders (ASUDs), and sex-differences might affect results of interventional clinical trials (CTs). We aim at assessing the proportion of women and the reporting of sex-stratified and female-specific data in CTs for ASUDs.

Methods: We extracted data from ClinicalTrials. Read More

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Helicobacter pylori acquisition rates and the associated risk factors amongst newlywed couples; a prospective cohort study in Tehran, Iran.

Microbes Infect 2022 May 23:104974. Epub 2022 May 23.

Cancer Research Center, Cancer Institute of Iran, Tehran University of Medical Sciences, Tehran, Iran; Cancer Biology Research Center, Cancer Institute of Iran, Tehran University of Medical Sciences, Tehran, Iran. Electronic address:

Background: The rates and routes of Helicobacter pylori transmission, in a high prevalent country like Iran, with gastric cancer as the leading cause of male cancer mortality is of essence. Here, we have studied the H. pylori-associated risk factors and the likelihood of interspousal transmission. Read More

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Breast arterial calcification and Epicardial adipose tissue volume but not density are independently associated with cardiovascular risk.

Int J Cardiol 2022 May 23. Epub 2022 May 23.

Monash University, Melbourne, Victoria, Australia, Wellington Rd, Clayton, Australia, 3800; Monash Cardiovascular Research Centre, Monash Health, Melbourne, Victoria, Australia, 246 Clayton Rd, Clayton, Australia, 3168; Victorian Heart Institute, Melbourne, Victoria, Australia, Blackburn Rd, Clayton, Australia, 3800; Baker Heart and Diabetes Institute, Melbourne, Victoria, Australia, 75 Commercial Rd, Melbourne, Australia, 3004. Electronic address:

Background: Mammographically detected breast arterial calcification (BAC) has been proposed as surrogate marker for coronary artery disease (CAD) in women. Epicardial adipose tissue (EAT) and peri-coronary adipose tissue (PCAT) are inflammatory fat depots linked to atherogenesis. BAC has demonstrated association with inflammation, therefore we aimed to determine the association between BAC, EAT and PCAT. Read More

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Association between comorbidities and left and right atrial dysfunction in patients with paroxysmal atrial fibrillation: Analysis of AF-RISK.

Int J Cardiol 2022 May 23. Epub 2022 May 23.

CARIM School for Cardiovascular Diseases, Maastricht University, Maastricht University Medical Center, Maastricht, the Netherlands.; Department of Cardiology, Maastricht University, Maastricht University Medical Center, Maastricht, the Netherlands.; Department of Cardiology, Radboud University Medical Centre, Nijmegen, the Netherlands.; Centre for Heart Rhythm Disorders, University of Adelaide and Royal Adelaide Hospital, Adelaide, Australia.; Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.. Electronic address:

Background: To identify the association between comorbidities and left atrial (LA) and right atrial (RA) function in patients with paroxysmal atrial fibrillation (AF).

Methods: This is a cross-sectional study. Speckle-tracking echocardiography was performed in 344 patients with paroxysmal AF at baseline, and available in 298 patients after 1-year follow-up. Read More

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Associations between prenatal exposure to polybrominated diphenyl ethers and physical growth in a seven year cohort study.

Chemosphere 2022 May 23:135049. Epub 2022 May 23.

Department of Clinical Epidemiology and Biostatistics, Shanghai Children's Medical Center, School of Medicine, Shanghai Jiao Tong University, Shanghai, China. Electronic address:

Although evidence suggests that prenatal exposure to polybrominated diphenyl ethers (PBDEs) alter offspring's physical growth, most studies rely upon physical growth at a single timepoint, and little is known regarding their longitudinal effects over time. In the current study, we determined the associations between prenatal PBDEs exposure and child physical growth by following up 207 mother-child pairs from the Laizhou Wan Birth Cohort (LWBC) from pregnancy until the children were seven years old. Child physical growth including weight, height, and body mass index (BMI) was assessed at birth, and at one, two and seven years of age. Read More

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Re-Sternotomy Coronary Artery Bypass 1999-2018: Insights from the STS Adult Cardiac Surgery Database.

Ann Thorac Surg 2022 May 23. Epub 2022 May 23.

Dept. of Cardiothoracic Surgery, Hadassah Hebrew University Medical Center, Jerusalem, Israel.

Background: We sought to quantify the risk trend of re-sternotomy coronary artery bypass grafting (CABG)over the past two decades.

Methods: We compared the outcomes of 194,804 consecutive re-sternotomy CABG cases and 1,445,894 randomly-selected first-time CABG cases (50% of total) reported to the STS Adult Cardiac Surgery Database between 1999-2018. Primary outcomes were in-hospital mortality and overall morbidity. Read More

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Gender Representation Among Presenters in Ophthalmology Subspecialties in 2019: A Retrospective Review.

Am J Ophthalmol 2022 May 23. Epub 2022 May 23.

University of Utah Health John A Moran Eye Center, Salt Lake City, Utah, United States.

Purpose: To describe gender representation at eight national ophthalmology conferences, stratified by role, session category, and sub-specialty.

Design: Retrospective cross-sectional study.

Study Population: 3,817 presenters at the 2019 American Academy of Ophthalmology subspecialty days, American Society of Cataract and Refractive Surgery, American Glaucoma Society, American Society of Retina Specialists, American Society of Ophthalmic Plastic and Reconstructive Surgery, American Association for Pediatric Ophthalmology and Strabismus, North American Neuro-Ophthalmology Society, and American Uveitis Society meetings. Read More

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Evaluation of viral load in patients with Ebola virus disease in Liberia: a retrospective observational study.

Lancet Microbe 2022 May 23. Epub 2022 May 23.

Laboratory of Virology, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT, USA. Electronic address:

Background: Viral load in patients with Ebola virus disease affects case fatality rate and is an important parameter used for diagnostic cutoffs, stratification in randomised controlled trials, and epidemiological studies. However, viral load in Ebola virus disease is currently estimated using numerous different assays and protocols that were not developed or validated for this purpose. Here, our aim was to conduct a laboratory-based re-evaluation of the viral loads of a large cohort of Liberian patients with Ebola virus disease and analyse these data in the broader context of the west Africa epidemic. Read More

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Video-assisted informed consent in a clinical trial of resuscitation of extremely preterm infants: Lessons learned.

Am J Perinatol 2022 May 26. Epub 2022 May 26.

Department of Pediatrics, Oregon Health & Science University, Portland, United States.

Objective: Obtaining informed consent for clinical trials is challenging in acute clinical settings. For the VentFirst randomized clinical trial (assisting ventilation during delayed cord clamping for infants <29 weeks' gestation), we created an informational video that sites could choose to use to supplement the standard in-person verbal and written consent. Using a post-consent survey, we sought to describe the impact of the video on subject recruitment, satisfaction with the consent process, and knowledge about the study. Read More

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Practical Prediction Model for Ovarian Insufficiency after Radiation.

Rev Bras Ginecol Obstet 2022 May 26. Epub 2022 May 26.

Gynecology Department, Universidade Estadual Paulista "Júlio de Mesquita Filho", Botucatu, SP, Brazil.

Objective:  The present study aimed to develop a useful mathematical model that predicts the age at which premature ovarian insufficiency might occur after teletherapy radiation. A diagnosis of premature or early menopause has physical and psychological consequences, so women may need support and long-term medical follow-up.

Methods:  To correlate ovarian radiation dose with ovarian function, we used the formula described by Wallace et al. Read More

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Colposcopic multimodal fusion for the classification of cervical lesions.

Phys Med Biol 2022 May 26. Epub 2022 May 26.

Affiliated Hospital of Weifang Medical University, 2428 Yuhe Road, Kuiwen District, Weifang City, Shandong Province, Weifang, Shandong, 261031, CHINA.

Objective: Cervical cancer is one of the two biggest killers of women and early detection of cervical precancerous lesions can effectively improve the survival rate of patients. Manual diagnosis by combining colposcopic images and clinical examination results is the main clinical diagnosis method at present. Developing an intelligent diagnosis algorithm based on artificial intelligence is an inevitable trend to solve the objectification of diagnosis and improve the quality and efficiency of diagnosis. Read More

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Moderators of cognitive behavioural therapy treatment effects and predictors of outcome in the CODES randomised controlled trial for adults with dissociative seizures.

J Psychosom Res 2022 Apr 19;158:110921. Epub 2022 Apr 19.

King's College London, Department of Biostatistics and Health Informatics, Institute of Psychiatry, Psychology and Neuroscience, UK. Electronic address:

Objective: We explored moderators of cognitive behavioural therapy (CBT) treatment effects and predictors of outcome at 12-month follow-up in the CODES Trial (N = 368) comparing CBT plus standardised medical care (SMC) vs SMC-alone for dissociative seizures (DS).

Methods: We undertook moderator analyses of baseline characteristics to determine who had benefited from being offered CBT 12 months post-randomisation. Outcomes included: monthly DS frequency, psychosocial functioning (Work and Social Adjustment Scale - WSAS), and health-related quality of life (Mental Component Summary (MCS) and Physical Component Summary (PCS) SF-12v2 scores). Read More

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Developing multi-language maternal health education videos for refugee and migrant women in southeast Melbourne.

Midwifery 2022 May 14;111:103369. Epub 2022 May 14.

Monash Centre for Health Research and Implementation, Monash University, Melbourne, Australia.

Problem: In Australia, many women from refugee and migrant backgrounds experience significant health disparities and barriers to care and poor health literacy negatively influences their maternal and infant health outcomes. Improving health literacy improves these outcomes yet can be time consuming and difficult to provide within the confines of current models of maternity care.

Introduction: Each year, more than 9000 women give birth across Monash Health's three maternity sites within one large public health service, located in Melbourne. Read More

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Midwives' experiences of supporting women's mental health: A mixed-method study.

Midwifery 2022 May 11;111:103368. Epub 2022 May 11.

School of Healthcare Sciences, Cardiff University, Cardiff, CF24 0AB, United Kingdom.

Objective: To explore midwives' skills, knowledge and experiences of supporting women's mental health.

Research Design And Setting: This paper reports the second phase of a larger project, the 'Mothers' Mood Study', which recruited women and midwives to explore their experiences of perinatal mental health and service provision and focuses on midwives' experiences of supporting women with perinatal mental health problems. This paper reports on midwives' experiences through self-administered questionnaires and focus groups. Read More

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Factor structure and psychometric properties of a Korean translation of the Body Appreciation Scale-2.

Authors:
Minsun Lee

Body Image 2022 May 23;42:11-24. Epub 2022 May 23.

Dept. of Fashion Design, Konkuk University Glocal Campus, 268 Chungwon-daero, Chungju, Chungcheongbuk-do 27478, South Korea. Electronic address:

The applicability of the Body Appreciation Scale-2 (BAS-2) in a Korean context is still unexplored, even though awareness of the importance of a positive body image has increased in South Korea. The current study examined the factor structure and psychometric properties of a Korean translation of the BAS-2, specifically to (1) translate and culturally adapt the BAS-2 to Korea, (2) confirm its unidimensional construct, and (3) identify its associations with body image and psychological outcomes across sex with a Korean sample. Data from 839 Korean adult men (n = 415) and women (n = 424) were randomly split into two subsamples. Read More

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Monitoring of lamotrigine concentrations in mothers, colostrum, and breastfed newborns during the early postpartum period.

Biomed Pharmacother 2022 May 23;151:113167. Epub 2022 May 23.

Department of Clinical Pharmacology, Faculty of Medicine, University of Ostrava, Syllabova 19, 703 00 Ostrava, Czech Republic; Department of Clinical Pharmacology, Institute of Laboratory Medicine, University Hospital Ostrava, 17. listopadu 1790, 700 30 Ostrava, Czech Republic.

Objective: To analyse the concentrations of lamotrigine in maternal serum, colostrum, and serum of breastfed newborns, and to evaluate the effect of comedication with enzyme-inducing antiseizure medication and valproic acid.

Methods: This cohort study collected data from 158 women and 143 breastfed newborns. Maternal serum, milk (i. Read More

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Increased risk of death immediately after discharge from compulsory care for substance abuse.

Drug Alcohol Depend 2022 May 10;236:109492. Epub 2022 May 10.

Department of Public Health Sciences, Stockholm University, SE-106 91 Stockholm, Sweden.

Background: In Sweden, approximately 1000 persons per year are committed to compulsory care for substance abuse for a maximum duration of six months. People admitted to compulsory care are known to suffer high mortality risks, but whether the risk of dying is further heightened immediately after discharge is not known.

Methods: Individual data from Swedish national registers were used to follow all persons discharged from a six months compulsory care episode in the period 2000-2017 (N = 7, 929). Read More

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Cardiometabolic measures and cognition in early menopause - Analysis of baseline data from a randomized controlled trial.

Maturitas 2022 Apr 29;162:58-65. Epub 2022 Apr 29.

Division of Geriatrics, Department of Medicine, University of Wisconsin School of Medicine and Public Health, Madison Geriatric Research Education and Clinical Center (GRECC), United States.

Objective: The relationships between cardiometabolic indices and cognition were examined in recently menopausal women.

Methods: Cross-sectional analysis of baseline data from the KEEPS (Kronos Early Estrogen Prevention Study)-Cognitive ancillary study (n = 621). Cognitive performance was assessed by the Modified Mini Mental Status (3MS) score (primary outcome). Read More

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