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Letter to the editor regarding the article ''Rossi A, Magri F, Michelini S, et al. New onset of alopecia areata in a patient with SARS-COV-2 infection: Possible pathogenetic correlations? J Cosmet Dermatol. 2021 Mar 19. doi: 10.1111/jocd.14080".

J Cosmet Dermatol 2021 Apr 14. Epub 2021 Apr 14.

Department of Dermatology, American University of Beirut Medical Center, Beirut, Lebanon.

We read with interest the recent report titled "New onset of alopecia areata in a patient with SARS-COV-2 infection: Possible pathogenetic correlations?" by Rossi et al. The authors report on a 29-year-old woman who developed alopecia areata/totalis one month after recovering from SARS-Cov-2 infection and ponder the underlying mechanistic pathways. Read More

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Low ferritin levels appear to be associated with worsened health in male repeat blood donors.

Vox Sang 2021 Apr 14. Epub 2021 Apr 14.

Finnish Red Cross Blood Service (FRCBS), Helsinki, Finland.

Background And Objectives: Frequent blood donation depletes iron stores of blood donors. Iron depletion may lead to anaemia, but the health effects of iron depletion without anaemia in healthy blood donors are not well understood. We studied in the FinDonor cohort whether worsening of self-rated health of blood donors during the study period was associated with biomarkers for iron levels or other self-reported changes in lifestyle. Read More

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Study of the Prevalence of Glaucoma in Kazakhstan.

Klin Monbl Augenheilkd 2021 Apr 14. Epub 2021 Apr 14.

Ophthalmology, Kazakh Scientific Research Institute of Eye Diseases, Almaty, Kazakhstan.

Background: Glaucoma is one of the leading causes of permanent visual disability around the world. However, the available literature lacks data on the prevalence of glaucoma in Central Asia, particularly in the Republic of Kazakhstan.

Objective: The study was aimed at assessing the prevalence of glaucoma in the population of the Republic of Kazakhstan over 40 years old in 2019. Read More

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Outcome of Surgical Interventions and Deliveries in Patients with Bleeding of Unknown Cause: An Observational Study.

Thromb Haemost 2021 Apr 14. Epub 2021 Apr 14.

Department of Haematology, Erasmus University Medical Centre, Rotterdam, The Netherlands.

Background:  The most optimal management for patients with bleeding of unknown cause (BUC) is unknown, as limited data are available.

Objective:  Evaluate management and outcome of surgical procedures and deliveries in patients with BUC.

Materials And Methods:  All patients ≥12 years of age, referred to a tertiary center for a bleeding tendency, were included. Read More

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[Surgical treatment of urethral prolapse].

Aktuelle Urol 2021 Apr 14. Epub 2021 Apr 14.

Helios Krankenhaus St. Josefshospital, Klinik für Urologie und Kinderurologie, Krefeld Uerdingen.

Urethral prolapses in humans are rare. Urethral caruncula are more frequent. Caruncula originate from the dorsal external layer of the urethral meatus. Read More

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Complicated Monochorionic-Diamniotic Twins in a Pregnant Woman with COVID-19 in the Second Trimester.

Am J Perinatol 2021 Apr 14. Epub 2021 Apr 14.

Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, University of California, Los Angeles, California.

Objective:  A majority of studies evaluating the risk of vertical transmission and adverse outcomes in pregnancies with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are mostly based on third-trimester infections. There is limited data available on pregnancy sequelae of maternal infection in the first or second trimester.

Study Design:  We present a patient with monochorionic-diamniotic twins that develops coronavirus disease 2019 infection at 15 weeks of gestation. Read More

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Mother-Infant Dyads with COVID-19 at an Urban, Safety-Net Hospital: Clinical Manifestations and Birth Outcomes.

Am J Perinatol 2021 Apr 14. Epub 2021 Apr 14.

Department of Pediatrics, Boston Medical Center, Boston University School of Medicine, Boston, Massachusetts.

Objective:  This study aimed to describe maternal characteristics and clinical outcomes of infants born to mothers with positive severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) tests during pregnancy at an urban, safety-net hospital in Boston.

Study Design:  We abstracted electronic chart data from 75 pregnant women with positive SARS-CoV-2 tests at any stage of gestation until 72 hours after birth who delivered consecutively between March 31 and August 6, 2020 at our center. We collected clinical data on maternal and infant characteristics, including testing, signs, and symptoms of coronavirus disease 2019 (COVID-19), delivery outcomes, newborn care practices (skin-to-skin care, location of care, and breastfeeding) and 30-day postdischarge infant emergency room visits and readmissions. Read More

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Establishment of Early Pregnancy Related Thyroid Hormone Models and Reference Intervals for Pregnant Women in China Based on Real World Data.

Horm Metab Res 2021 Apr 14;53(4):272-279. Epub 2021 Apr 14.

Department of Obstetrics and Gynecology, Peking Union Medical College & Chinese Academy of Medical Science, Beijing, P. R. China.

Thyroid hormone reference intervals are crucial for diagnosing and monitoring thyroid dysfunction during early pregnancy, and the dynamic change trend of thyroid hormones during pregnancy can assist clinicians to assess the thyroid function of pregnant women. This study aims to establish early pregnancy related thyroid hormones models and reference intervals for pregnant women. We established two derived databases: derived database* and derived database#. Read More

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An Autopsy Case of Spontaneous Coronary Artery Dissection With Eosinophilic Coronary Periarteritis and Degeneration of Medial Smooth Muscles.

Am J Forensic Med Pathol 2021 Apr 13. Epub 2021 Apr 13.

From the Department of Forensic Medicine, Nagoya City University Graduate School of Medical Sciences, Nagoya Department of Anatomic Pathology, Hirosaki University Graduate School of Medicine, Hirosaki Department of Legal Medicine, University of Yamanashi Graduate School of Medicine, Chuo, Japan.

Abstract: A 45-year-old woman with no known medical history died suddenly shortly after complaining of anterior chest discomfort. The autopsy revealed a dissection at the anterior descending branch of the left coronary artery, and eosinophilic adventitial inflammation was observed both in the right coronary artery and in the vicinity of the dissection. Furthermore, there was degeneration of the tunica media in the right coronary artery, and this was thought to be a predissection lesion. Read More

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Facial Skin Biophysical Profile of Women in Malaysia: Significance of Facial Skincare Product Use.

Skin Pharmacol Physiol 2021 Apr 14:1-12. Epub 2021 Apr 14.

Discipline of Pharmaceutical Technology, School of Pharmaceutical Sciences, Universiti Sains Malaysia, Penang, Malaysia.

Introduction: At present, there is a lack of baseline data on the facial skin biophysical profile of women in Malaysia. The implications related to the daily habits and facial skincare product use on the skin biophysical condition are, thus, unknown. In this study, we aim to evaluate facial skin biophysical parameters of Malaysian women and examine the influence of demographic characteristics, daily habits, and facial skincare product use on these parameters. Read More

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High-Risk Periods for Adult Traumatic Brain Injuries: A Nationwide Population-Based Study.

Neuroepidemiology 2021 Apr 14:1-8. Epub 2021 Apr 14.

Department of Neurosurgery, Tampere University Hospital and Tampere University, Tampere, Finland.

Introduction: There is minimal existing available information on nationwide seasonal peaks in traumatic brain injuries (TBIs). This lack of information is an impediment to the effective development of prevention programs, societal policies, and hinders the resourcing of medical emergency services. Our current aim is to study nationwide population-based high-risk periods TBI over a 15-year study period in Finland. Read More

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Influence of the competing risk of death on estimates of disease recurrence in trials of adjuvant endocrine therapy for early-stage breast cancer: A secondary analysis of MA.27, MA.17 and MA.17R.

Eur J Cancer 2021 Apr 11;149:117-127. Epub 2021 Apr 11.

Princess Margaret Cancer Centre, Toronto, Ontario, Canada. Electronic address:

Background: Many women diagnosed with early-stage hormone-sensitive breast cancer die of causes other than their breast cancer. These competing risks can create challenges in analysing and clearly communicating data on risk of breast cancer recurrence or death. Here, we quantify the impact of competing risks on estimates of disease recurrence and benefit from therapy. Read More

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The contribution of non-drug factors to fetal malformation in anti-seizure-medication-treated pregnancy.

Epilepsy Behav 2021 Apr 11;118:107941. Epub 2021 Apr 11.

Royal Brisbane and Women's Hospital and School of Medicine and Biomedical Science, University of Queensland, Brisbane, Queensland 4027, Australia.

Purpose: To assess the possible contribution of factors in additional to intrauterine anti-seizure medication (ASM) exposure in the occurrence of fetal malformation in women with ASM-treated epilepsy.

Results: Logistic regression analysis showed that maternal age over 31 years, family histories of fetal malformation, and conception after assisted fertility treatment, and also dosage of valproate, carbamazepine, and topiramate, made statistically significant (P<0.05) contributions to the fetal malformation rate in 2223 pregnancies in Australian women with epilepsy. Read More

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Three concomitant locked finger metacarpophalangeal joints caused by degenerative metacarpal heads: case report.

Hand Surg Rehabil 2021 Apr 11. Epub 2021 Apr 11.

Department of Orthopedic surgery, Pontchaillou University Hospital, 2 rue Henri Le Guilloux, 35033, Rennes, France. Electronic address:

A locked metacarpophalangeal joint (LMCP) is a rare condition often confused with trigger finger. Its causes are numerous and typically divided into two broad categories: acquired LMCP in younger patients, and degenerative LMCP in older patients. This pathology usually affects only one MCP. Read More

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Perception of Gender Discrimination Among Spine Surgeons Across Latin America: A Web-Based Survey.

Spine J 2021 Apr 11. Epub 2021 Apr 11.

University of Cambridge, UK.

Background Context: Female physicians rarely choose spine surgery as their specialty. While the specialty's nature and its associated lifestyle are potential barriers, gender-related issues may play an important part.

Purpose: To evaluate the gender discrimination among spine surgeons across Latin America. Read More

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Stress urinary incontinence after urethral diverticulum repair without concomitant anti-incontinence procedure.

Urology 2021 Apr 11. Epub 2021 Apr 11.

Department of Urology, UT Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX, 75390-9110. Electronic address:

Objective: To review the rates of persistent and de novo stress urinary incontinence (SUI) following urethral diverticulum (UD) repairs performed without concomitant SUI surgical procedures.

Methods: Following IRB approval, charts of women who underwent UD excision by three FPMRS surgeons were reviewed. Data collected from the electronic medical record included demographic information, preoperative symptoms and evaluation (validated questionnaires [UDI-6, QoL]), imaging studies, operative details, post-operative symptoms, and subsequent surgical interventions. Read More

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Patient-derived organoids model cervical tissue dynamics and viral oncogenesis in cervical cancer.

Cell Stem Cell 2021 Apr 8. Epub 2021 Apr 8.

Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences (KNAW) and University Medical Center (UMC) Utrecht, Uppsalalaan 8, 3584 CT Utrecht, the Netherlands; Oncode Institute, Jaarbeursplein 6, 3521 AL Utrecht, the Netherlands; Princess Máxima Center for Pediatric Oncology, Heidelberglaan 25, 3584 CS Utrecht, the Netherlands. Electronic address:

Cervical cancer is a common gynecological malignancy often caused by high-risk human papillomavirus. There is a paucity of human-derived culture systems to study the cervical epithelium and the cancers derived thereof. Here we describe a long-term culturing protocol for ecto- and endocervical epithelia that generates 3D organoids that stably recapitulate the two tissues of origin. Read More

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Withdrawal method inquiries and user experiences: an analysis of content posted on four gendered forums on Reddit.

Contraception 2021 Apr 11. Epub 2021 Apr 11.

Section of Family Planning, Department of Obstetrics and Gynecology, Keck School of Medicine of the University of Southern California. Electronic address:

Objectives: Limited research and guidance on the use of "withdrawal" or coitus interruptus for contraception lead to inconsistent or even inaccurate physician recommendations regarding its use. Consequently, patients rely on online communities to learn about this commonly used contraceptive method. To identify knowledge gaps and concerns between men and women, as well as explore how they use withdrawal, we examined withdrawal-related posts on the popular internet discussion forum, Reddit. Read More

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Metabolic Syndrome in Obesity: Treatment Success and Adverse Pregnancy Outcomes with Ovulation Induction in Polycystic Ovary Syndrome.

Am J Obstet Gynecol 2021 Apr 11. Epub 2021 Apr 11.

Department of Obstetrics and Gynecology, University of Oklahoma Health Sciences Center, Oklahoma City, OK; Department of Biostatistics and Epidemiology, University of Oklahoma Health Sciences Center.

Objective: Obesity is common in women with polycystic ovary syndrome (PCOS). PCOS and obesity are associated with reduced fertility. Metabolic syndrome's (MetS) effect on infertility treatment success and pregnancy outcomes in women with PCOS undergoing ovulation induction (OI) has not been investigated. Read More

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The IMPACT trial: human papillomavirus, cervical cytology and histopathological results from the baseline and 1-year follow-up phase.

Am J Obstet Gynecol 2021 Apr 11. Epub 2021 Apr 11.

Ventana Medical Systems Inc./Roche Tissue Diagnostics, Tucson, AZ.

Background: An increase in human papillomavirus (HPV) test volumes is expected in the near future as HPV-based screening protocols are expected to become more broadly adopted.

Objective: The IMproving Primary screening And Colposcopy Triage (IMPACT) trial, a prospective, multicenter US cervical cancer screening trial, was conducted to obtain FDA approvals for the new high-throughput cobas HPV for use on the cobas 6800/8800 Systems (cobas HPV) for detecting cervical precancer and cancer (cervical intraepithelial neoplasia of grade 2 or worse [≥CIN2] and grade 3 or worse, [≥CIN3]). Here the baseline demographics, HPV, cervical cytology and histolpathologic results are presented. Read More

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Two cases of neural tube defects with dolutegravir use at conception in south Brazil.

Braz J Infect Dis 2021 Apr 11:101572. Epub 2021 Apr 11.

Hospital de Clínicas de Porto Alegre, Porto Alegre, RS, Brazil; Federal University of Rio Grande do Sul, School of Medicine, Porto Alegre, RS, Brazil. Electronic address:

Dolutegravir (DTG) is amongst the most prescribed antiretrovirals worldwide and is recommended as first line regimen in most HIV treatment guidelines. Its use, although infrequently, had been associated to an increased chance of neural tube defects (NTD) in Botswana, Africa. Herein we describe two cases of NTD in women who conceived while taking DTG as part of their antiretroviral treatment in the city of Porto Alegre, Brazil. Read More

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Single-cell transcriptomics identifies gene expression networks driving differentiation and tumorigenesis in the human fallopian tube.

Cell Rep 2021 Apr;35(2):108978

Women's Cancer Research Program at the Samuel Oschin Comprehensive Cancer Center, Cedars-Sinai Medical Center, Los Angeles, CA, USA; Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Cedars-Sinai Medical Center, Los Angeles, CA, USA; Center for Bioinformatics and Functional Genomics, Cedars-Sinai Medical Center, Los Angeles, CA, USA. Electronic address:

The human fallopian tube harbors the cell of origin for the majority of high-grade serous "ovarian" cancers (HGSCs), but its cellular composition, particularly the epithelial component, is poorly characterized. We perform single-cell transcriptomic profiling of around 53,000 individual cells from 12 primary fallopian specimens to map their major cell types. We identify 10 epithelial subpopulations with diverse transcriptional programs. Read More

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Case 11-2021: A 39-Year-Old Woman with Fever, Flank Pain, and Inguinal Lymphadenopathy.

N Engl J Med 2021 Apr;384(15):1448-1456

From the Departments of Medicine (R.C.C., A.M.N.), Radiology (M.S.), Pediatrics (A.M.N.), and Pathology (A.R.S.), Massachusetts General Hospital, and the Departments of Medicine (R.C.C., A.M.N.), Radiology (M.S.), Pediatrics (A.M.N.), and Pathology (A.R.S.), Harvard Medical School - both in Boston.

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Clinical features and follow-up of pediatric patients hospitalized for COVID-19.

Pediatr Pulmonol 2021 Apr 14. Epub 2021 Apr 14.

Medicine Research Center, Ningbo City First Hospital, Ningbo, Zhejiang Province, China.

Objective: This report summarizes the clinical features and 1-month follow-up observations for pediatric patients who were hospitalized with coronavirus disease 2019 (COVID-19) in Wuhan Women and Children's Hospital.

Methods: The 1-month follow-up data included clinical manifestations and results from serum severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) IgG and IgM tests, reverse-transcription polymerase chain reaction (RT-PCR) for SARS-CoV-2, lung computed tomography (CT) scans, and laboratory tests.

Results: Between January 20 and March 15, 2020, 127 patients aged 0-15 years were hospitalized for COVID-19 treatment, including 3 severe cases and 124 mild or moderate cases. Read More

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Pregnancy outcomes following different protocols of controlled ovarian hyperstimulation in couples undergoing intrauterine insemination.

Clin Exp Pharmacol Physiol 2021 Apr 14. Epub 2021 Apr 14.

Department of Obstetrics and Gynecology, College of Medicine, Hawler Medical University, Erbil, 44001, Kurdistan, Iraq.

Clomiphene citrate (CC), letrozole, and cetrorelix acetate are frequently used agents in controlled ovarian hyperstimulation (COH). However, these three agents have not yet been compared to one another regarding their pregnancy outcomes. The present study was designed to retrospectively compare pregnancy outcomes among the three aforementioned agents. Read More

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The association of osteochemometrics and bone mineral density in humans.

Am J Phys Anthropol 2021 Apr 14. Epub 2021 Apr 14.

Centre for Functional Ecology, Laboratory of Forensic Anthropology, Department of Life Sciences, Calçada Martim de Freitas, University of Coimbra, Coimbra, Portugal.

Objectives: Even though much is known about bone mineral and matrix composition, studies about their relationship with several bone properties and its alterations related to bone diseases such as osteoporosis are practically non-existent in humans. Thus, the development of methods to understand the effects of bone properties at a microscopic level is paramount. This research aimed to evaluate whether Fourier transform infrared-attenuated total reflectance (FTIR-ATR) band intensity ratios correlate with femoral bone mass, bone mineral content (BMC) (total and femoral neck), bone mineral per unit area (BMD) (total, femoral neck, greater trochanter, intertrochanteric region, and Ward's area) and the area (total and femoral neck). Read More

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Stakeholder collaboration in long-term care of older people in Lithuania.

Health Soc Care Community 2021 Apr 14. Epub 2021 Apr 14.

ISM University of Management and Economics, Vilnius, Lithuania.

Demographic situation, changes in the role of women in society and growing demand for long-term care (LTC) of older people have challenged the ability to meet the growing LTC needs in most developed countries. In countries where responsibility for LTC is still largely laid on families, it is, however, even more critical and calls for improvements in formal LTC systems. More intensive stakeholder collaboration in LTC policy development, organising and delivery are of primary importance in improving LTC systems. Read More

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Policy foundations for transformation: a gender analysis of adolescent health policy documents in South Africa.

Health Policy Plan 2021 Apr 14. Epub 2021 Apr 14.

School of Public Health, University of the Western Cape, Bellville, Robert Sobukwe Rd, Western Cape 7535, South Africa.

The Sustainable Development Goals (SDGs) and the United Nations Global Strategy (2016-30) emphasize that all women, children and adolescents 'survive, thrive and transform'. A key element of this global policy framework is that gender equality is a stand-alone goal as well as a cross-cutting priority. Gender inequality and intersecting social and structural determinants shape health systems, including the content of policy documents, with implications for implementation. Read More

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[Time trend in inequalities in smoking and abusive alcohol consumption in Brazil's state capitals].

Cad Saude Publica 2021 7;37(4):e00050120. Epub 2021 Apr 7.

Programa de Pós-graduação em Epidemiologia, Universidade Federal de Pelotas, Pelotas, Brasil.

This was a time trend study aimed at assessing inequalities in smoking and abusive alcohol consumption, considering schooling as a proxy for socioeconomic status, according to sex and region of Brazil. The study used data from the Risk and Protective Factors Surveillance System for Chronic Non-Comunicable Diseases Through Telephone Interview (Vigitel) survey collected from 2006 to 2017. The outcomes were abusive alcohol consumption and smoking. Read More

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The therapeutic itinerary of health workers diagnosed with COVID-19.

Rev Lat Am Enfermagem 2021 9;29:e3413. Epub 2021 Apr 9.

Universidade Federal Fluminense, Escola de Enfermagem Aurora de Afonso Costa, Niterói, RJ, Brazil.

Objective: to analyze the therapeutic itinerary of health workers diagnosed with COVID-19.

Method: qualitative study conducted with 132 health workers diagnosed with COVID-19. Data were collected using a semi-structured form sent through the social media and processed with the Interface de R pour Analyses Multidimensionnelles de Textes et de Questionnaires, according to the Descending Hierarchical Classification. Read More

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