1,248 results match your criteria within-subject correlation

Reproducibility of Brain Volume Changes in Longitudinal Voxel-Based Morphometry Between Non-Accelerated and Accelerated Magnetic Resonance Imaging.

J Alzheimers Dis 2021 Jul 21. Epub 2021 Jul 21.

Department of Radiology, Graduate School of Medicine, University of Tokyo, Bunkyo-ku, Tokyo, Japan.

Background: Scan acceleration techniques, such as parallel imaging, can reduce scan times, but reliability is essential to implement these techniques in neuroimaging.

Objective: To evaluate the reproducibility of the longitudinal changes in brain morphology determined by longitudinal voxel-based morphometry (VBM) between non-accelerated and accelerated magnetic resonance images (MRI) in normal aging, mild cognitive impairment (MCI), and Alzheimer's disease (AD).

Methods: Using data from the Alzheimer's Disease Neuroimaging Initiative (ADNI) 2 database, comprising subjects who underwent non-accelerated and accelerated structural T1-weighted MRI at screening and at a 2-year follow-up on 3. Read More

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B -Corrected T1 Mapping in Lung Cancer: Repeatability, Reproducibility, and Identification of Histological Types.

J Magn Reson Imaging 2021 Jul 22. Epub 2021 Jul 22.

Siemens Healthineers Digital Technology Co., Ltd, Shanghai, China.

Background: T1 mapping can potentially quantitatively assess the intrinsic properties of tumors. B correction can reduce the magnetic field inhomogeneity.

Purpose: To assess the repeatability and reproducibility of B -corrected T1 mapping for lung cancer and the ability to identify pathological types. Read More

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Reproducibility of Retinal Nerve Fiber Layer and Macular Ganglion Cell Layer Thickness Measurements by Optical Coherence Tomography in Myopic Eyes.

J Glaucoma 2021 Jul 20. Epub 2021 Jul 20.

Department of Ophthalmology, Kim's Eye Hospital, Seoul, Republic of Korea Seoul Delight Eye Clinic, Cheonan, Republic of Korea Department of Ophthalmology, Chungnam National University Hospital, Daejeon, Republic of Korea.

Prcis: In myopic eyes, reproducibility of circumpapillary retinal nerve fiber layer (RNFL) and macular ganglion cell-inner plexiform layer thickness measurement by optical coherence tomography showed excellent reproducibility except for the temporal quadrant RNFL thickness measurement.

Purpose: To evaluate the long-term reproducibility of circumpapillary retinal nerve fiber layer (RNFL) and macular ganglion cell-inner plexiform layer (GCIPL) thickness measurements using optical coherence tomography (OCT) in myopic eyes.

Methods: Sixty-five eyes with moderate-to-high myopia (spherical equivalent <-3. Read More

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Acute effects of high-intensity interval training and moderate-intensity continuous exercise on BDNF and irisin levels and neurocognitive performance in late middle-aged and older adults.

Behav Brain Res 2021 Jul 15;413:113472. Epub 2021 Jul 15.

Institute of Physical Education, Health and Leisure Studies, National Cheng Kung University, Taiwan.

The purposes of the present study were (1) to explore and compare the acute effects of high-intensity interval training (HIIT) and moderate-intensity continuous exercise (MICE) on neurocognitive performance and molecular biomarkers in late middle-aged and older adults, and (2) to examine the relationships of HIIT/MICE exercise-induced neurocognitive changes with changes in circulating irisin and BDNF levels elicited by different acute exercise modes. Using a within-subject design, twenty-one participants completed an acute bout of 30 min of HIIT, MICE, or a non-exercise-intervention (REST) session in a counterbalanced order. The neuropsychological [i. Read More

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Ann Stat 2020 Oct 19;48(5):2622-2645. Epub 2020 Sep 19.

Department of Statistics, the Pennsylvania State University, University Park, PA 16802-2111, USA.

This paper concerns statistical inference for longitudinal data with ultrahigh dimensional covariates. We first study the problem of constructing confidence intervals and hypothesis tests for a low dimensional parameter of interest. The major challenge is how to construct a powerful test statistic in the presence of high-dimensional nuisance parameters and sophisticated within-subject correlation of longitudinal data. Read More

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October 2020

Associations of air pollution and greenness with the nasal microbiota of healthy infants: A longitudinal study.

Environ Res 2021 Jul 10;202:111633. Epub 2021 Jul 10.

University of Basel Children's Hospital (UKBB), Basel, Switzerland; Division of Paediatric Respiratory Medicine and Allergology, Department of Paediatrics, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland; Division of Respiratory Medicine, University Children's Hospital Zurich and Childhood Research Center, University of Zurich, Zurich, Switzerland. Electronic address:

Background: Air pollution and greenness are associated with short- and long-term respiratory health in children but the underlying mechanisms are only scarcely investigated. The nasal microbiota during the first year of life has been shown to be associated with respiratory tract infections and asthma development. Thus, an interplay between greenness, air pollution and the early nasal microbiota may contribute to short- and long-term respiratory health. Read More

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Circadian periodicity affects The Type of ventricular arrhythmias and efficacy of Implantable defibrillator therapies.

J Cardiovasc Electrophysiol 2021 Jul 12. Epub 2021 Jul 12.

Ospedale Monaldi, Napoli.

Introduction: Factors influencing malignant arrhythmia onset are not fully understood. We explored circadian periodicity of ventricular arrhythmias (VAs) in patients with implantable cardioverter and cardiac resynchronization defibrillators (ICD/CRT-D).

Methods: Time, morphology (monomorphic/polymorphic), and mode of termination (anti-tachycardia pacing [ATP] or shock) of VAs stored in a database of remote monitoring data were adjudicated. Read More

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Agreement Between Swept-Source Optical Biometry and Scheimpflug-based Topography Measurements of Posterior Corneal Curvature.

Bulent Kose

J Cataract Refract Surg 2021 Jun 23. Epub 2021 Jun 23.

Department of Ophthalmology, Osmangazi Aritmi Hospital, Bursa, Turkey.


Purpose: To evaluate agreement of posterior corneal curvature parameters between a swept-source optical coherence tomography (SS-OCT) based biometry (IOLMaster 700; Carl Zeiss Meditec AG, Jena, Germany) and Scheimpflug topography (Pentacam HR; OCULUS, Wetzlar, Germany) in healthy, myopic eyes.

Setting: Department of Ophthalmology, Osmangazi Aritmi Hospital, Bursa, Turkey. Read More

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Development of a protocol to assess within-subject, regional white matter hyperintensity changes in aging and dementia.

J Neurosci Methods 2021 Jun 24;360:109270. Epub 2021 Jun 24.

Sanders-Brown Center on Aging, University of Kentucky, Lexington, KY 40506, USA; Departments of Neurology, University of Kentucky, Lexington, KY 40506, USA; Departments of Behavioral Science, University of Kentucky, Lexington, KY 40536, USA. Electronic address:

Background: White matter hyperintensities (WMH), associated with both dementia risk and progression, can individually progress, remain stable, or even regress influencing cognitive decline related to specific cerebrovascular-risks. This study details the development and validation of a registration protocol to assess regional, within-subject, longitudinal WMH changes (ΔWMH) that is currently lacking in the field.

New Method: 3D-FLAIR images (baseline and one-year-visit) were used for protocol development and validation. Read More

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Gender-specific associations between psychological distress and injecting risk behaviours among people who inject drugs in Montreal, Canada.

Int J Drug Policy 2021 Jun 18:103319. Epub 2021 Jun 18.

Université de Montréal Hospital Research Centre (CRCHUM), 900 Rue Saint Denis, Montréal (Québec), Canada H2X 0A9; Department of Family and Emergency Medicine, Faculty of Medicine, Université de Montréal. 2900 boul. Édouard-Montpetit, Montréal (Québec), Canada H3C 3J7. Electronic address:

Background: Psychological distress is common among people who inject drugs (PWID) and may be associated with HCV-related risk behaviours. Previous studies have documented increased vulnerability to both psychological distress and HCV infection among female relative to male PWID. It is, however, unclear whether behavioural responses to distress differ by gender. Read More

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Deep Cross-User Models Reduce the Training Burden in Myoelectric Control.

Front Neurosci 2021 24;15:657958. Epub 2021 May 24.

Department of Electrical and Computer Engineering, Institute of Biomedical Engineering, University of New Brunswick, Fredericton, NB, Canada.

The effort, focus, and time to collect data and train EMG pattern recognition systems is one of the largest barriers to their widespread adoption in commercial applications. In addition to multiple repetitions of motions, including exemplars of confounding factors during the training protocol has been shown to be critical for robust machine learning models. This added training burden is prohibitive for most regular use cases, so cross-user models have been proposed that could leverage inter-repetition variability supplied by other users. Read More

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Comparing School-Aged Refraction Measurements Using the 2WIN-S Portable Refractor in Relation to Cycloplegic Retinoscopy: A Cross-Sectional Study.

J Ophthalmol 2021 21;2021:6612476. Epub 2021 May 21.

He Eye Specialist Hospital, Shenyang, China.

Purpose: To assess the repeatability and agreement of refractive measurements using 2WIN-S photoscreening with the gold-standard cycloplegic retinoscope refraction.

Design: Single centre, cross-sectional study.

Methods: Spherical, cylindrical, axis, and spherical equivalent of 194 bilateral eyes of 97 children were assessed using a retinoscope and 2WIN-S. Read More

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Decoding Spatial Memory Retrieval in Cubical Space Using fMRI Signals.

Front Neural Circuits 2021 18;15:624352. Epub 2021 May 18.

Department of Neurosurgery, Tianjin Medical University General Hospital, Tianjin, China.

The way spatial memory retrieval is represented in the brain remains unclear to date. Previous studies have displayed a hippocampus-centered navigation network using functional magnetic resonance imaging (fMRI) analysis. There have been some studies on the representation of navigation behavior by signal distribution patterns, but only in the hippocampus and adjacent structures. Read More

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Assessing the Reliability of Intraocular Pressure Measurements Using Rebound Tonometry.

J Glaucoma 2021 May 27. Epub 2021 May 27.

Department of Ophthalmology and Visual Sciences, West Virginia University, 1 Medical Center Drive, Morgantown, WV, 26506 Southern Eye Group, 3290 Dauphin Street #500, Mobile, AL, 36606 Mid-Atlantic Permanente Medical Group, 7141 Security Boulevard, Baltimore, MD, 21244 Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, 4420 Bayard Street, Suite 600, Pittsburgh, PA, 15260.

Precis: In a trio of prospective studies, the iCare rebound tonometer demonstrated significantly lower test-retest variability than Goldmann tonometry with good inter-operator and inter-device reproducibility, supporting its value in monitoring intraocular pressure changes over time.

Purpose: To characterize intra- and inter-operator and inter-device reliability of intraocular pressure (IOP) measurements with rebound tonometry ([RT], ic100, iCare USA, Inc, Raleigh, NC).

Methods: Three prospective cross-sectional studies were conducted in distinct sample of adult patients with established glaucoma, suspected glaucoma, or no glaucoma at the West Virginia University Eye Institute. Read More

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Machine learning to extract muscle fascicle length changes from dynamic ultrasound images in real-time.

PLoS One 2021 26;16(5):e0246611. Epub 2021 May 26.

School of Mechanical Engineering, Georgia Institute of Technology, Atlanta, Georgia, United States of America.

Background And Objective: Dynamic muscle fascicle length measurements through B-mode ultrasound have become popular for the non-invasive physiological insights they provide regarding musculoskeletal structure-function. However, current practices typically require time consuming post-processing to track muscle length changes from B-mode images. A real-time measurement tool would not only save processing time but would also help pave the way toward closed-loop applications based on feedback signals driven by in vivo muscle length change patterns. Read More

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The reliability of an abbreviated fat tolerance test: A comparison to the oral glucose tolerance test.

Clin Nutr ESPEN 2021 Jun 21;43:428-435. Epub 2021 Mar 21.

Department of Nutritional Sciences, Oklahoma State University, 301 Human Sciences, Oklahoma State University, Stillwater, OK 74078, Stillwater, OK, USA. Electronic address:

Background & Aims: Postprandial lipemia (PPL) is predictive of cardiovascular disease risk, but the current method for assessing PPL is a burdensome process. Recently, the validity of an abbreviated fat tolerance test (AFTT) has been demonstrated. As a continuation of this research, the purpose of this study was to determine the reliability of the AFTT and compare it to the reliability of the oral glucose tolerance test (OGTT). Read More

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Monitoring Individual Sleep and Nocturnal Heart Rate Variability Indices: The Impact of Training and Match Schedule and Load in High-Level Female Soccer Players.

Front Physiol 2021 26;12:678462. Epub 2021 Apr 26.

Portugal Football School, Portuguese Football Federation (FPF), Oeiras, Portugal.

Purpose: To describe individual sleep habits and nocturnal heart rate variability (HRV) responses, and to explore intra-individual associations of workload with sleep and nocturnal HRV indices in high-level female soccer players throughout a 2-week competitive period.

Materials And Methods: The study followed a descriptive, observational design. Thirty-four high-level female soccer players (aged 20. Read More

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Variable selection methods for identifying predictor interactions in data with repeatedly measured binary outcomes.

J Clin Transl Sci 2020 Nov 16;5(1):e59. Epub 2020 Nov 16.

Department of Medicine, Division of Rheumatology and Immunology, Medical University of South Carolina, Charleston, SC, USA.

Introduction: Identifying predictors of patient outcomes evaluated over time may require modeling interactions among variables while addressing within-subject correlation. Generalized linear mixed models (GLMMs) and generalized estimating equations (GEEs) address within-subject correlation, but identifying interactions can be difficult if not hypothesized . We evaluate the performance of several variable selection approaches for clustered binary outcomes to provide guidance for choosing between the methods. Read More

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November 2020

Test-retest reliability of tone- and 40 Hz train-evoked gamma oscillations in female rats and their sensitivity to low-dose NMDA channel blockade.

Psychopharmacology (Berl) 2021 Aug 4;238(8):2325-2334. Epub 2021 May 4.

Department of Pharmaceutical Sciences, Bill Gatton College of Pharmacy, East Tennessee State University, VA Building 7, Room 324, Maple Ave, Johnson City, TN, 37604, USA.

Rationale: Schizophrenia patients consistently show deficits in sensory-evoked broadband gamma oscillations and click-evoked entrainment at 40 Hz, called the 40-Hz auditory steady-state response (ASSR). Since such evoked oscillations depend on cortical N-methyl D-aspartic acid (NMDA)-mediated network activity, they can serve as pharmacodynamic biomarkers in the preclinical and clinical development of drug candidates engaging these circuits. However, there are few test-retest reliability data in preclinical species, a prerequisite for within-subject testing paradigms. Read More

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Cost and healthcare utilization analysis of culturally sensitive, shared medical appointment model for Latino children with type 1 diabetes.

Pediatr Diabetes 2021 Aug 6;22(5):816-822. Epub 2021 May 6.

Barbara Davis Center, University of Colorado Denver, Aurora, Colorado, USA.

Objective: This study evaluated costs and healthcare utilization associated with a culturally-sensitive, medical and education program for pediatric Latino patients with type 1 diabetes.

Research Design And Methods: Program participants included Latino children ages 1-20 years old diagnosed with type 1 diabetes (n = 57). Control subjects with type 1 diabetes were matched by age, sex, and zip code to intervention participants from the Colorado All Payer Claims Database. Read More

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Occupational stress, burnout, and organizational readiness for change: A longitudinal study among HIV HCPs in China.

Psychol Health Med 2021 Apr 19:1-12. Epub 2021 Apr 19.

Guangxi Center of Disease Control and Prevention, Nanning, Guangxi, China.

Literature suggests that organizational readiness for change (ORC) could facilitate adaptation and implementation of new projects or practices in clinical settings. Limited data are available regarding the longitudinal associations between ORC and psychosocial conditions of HCPs. Using six waves of longitudinal data collected between 2013 and 2016 from 357 HIV HCPs in Guangxi, China, we identify sociodemographic and occupational characteristics that impact ORC and examine how occupational stress and burnout affect ORC adjusting for potential cofounders. Read More

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Comparison of A-Scan ultrasonography and the Lenstar optical biometer in Guinea pig eyes.

Exp Eye Res 2021 Jun 20;207:108578. Epub 2021 Apr 20.

Tianjin Key Laboratory of Retinal Functions and Diseases, Tianjin International Joint Research and Development Centre of Ophthalmology and Vision Science, Eye Institute and School of Optometry, Tianjin Medical University Eye Hospital, Tianjin, China. Electronic address:

Objective: To compare the biometric parameters provided by A-scan ultrasonography and the Lenstar optical biometer in guinea pig eyes, including anterior segment depth (ASD), lens thickness (LT), vitreous chamber depth (VCD), and axial length (AL), and differences of them between treated form deprivation (FD) eyes and untreated fellow eyes after 4 weeks of FD.

Methods: Three-week-old guinea pigs (N = 41) were subjected to biometric measurements before monocular FD (baseline) and after a 4-week FD. Statistical analyses including within-subject standard deviation (SD), coefficient of variation (CV), and intraclass correlation coefficient (ICC), used to evaluate repeatability for both the A-scan ultrasonography and the Lenstar individually, and correlation and Bland-Altman analyses were used to assess agreement between the two methods. Read More

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Sulfur amino acid restriction, energy metabolism and obesity: a study protocol of an 8-week randomized controlled dietary intervention with whole foods and amino acid supplements.

J Transl Med 2021 04 15;19(1):153. Epub 2021 Apr 15.

Department of Nutrition, Institute of Basic Medical Sciences, University of Oslo, Sognsvannveien 9, 0372, Oslo, Norway.

Background: Dietary sulfur amino acid (SAA) restriction is an established animal model for increasing lifespan and improving metabolic health. Data from human studies are limited. In the study outlined in this protocol, we will evaluate if dietary SAA restriction can reduce body weight and improve resting energy expenditure (REE) and parameters related to metabolic health. Read More

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Postoperative changes in vertical ground reaction forces, walking barefoot and with ankle-foot orthoses in children with Cerebral Palsy.

Clin Biomech (Bristol, Avon) 2021 Apr 23;84:105336. Epub 2021 Mar 23.

Faculty of Medicine, Institute of Health and Society, University of Oslo, Oslo, Norway; Division of Orthopaedic Surgery, Department of Research, Oslo University Hospital, Oslo, Norway.

Background: Children with cerebral palsy often have problems to support the body centre of mass, seen as increased ratio between excessive vertical ground reaction forces during weight acceptance and decreased forces below bodyweight in late stance. We aimed to examine whether increasing ankle range of motion through surgery and restraining motion with ankle-foot orthoses postoperatively would have impact on the vertical ground reaction force in weight acceptance and late stance.

Methods: Ground reaction forces were recorded from 24 children with bilateral and 32 children with unilateral cerebral palsy, each measured walking barefoot before and after triceps surae lengthening. Read More

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The impact of baseline glomerular filtration rate on subsequent changes of glomerular filtration rate in patients with chronic kidney disease.

Sci Rep 2021 Apr 12;11(1):7894. Epub 2021 Apr 12.

Institute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University, Room 501, No. 17, Xu-Zhou Road, Taipei, 100, Taiwan.

Higher baseline glomerular filtration rate (GFR) may yield subsequent steeper GFR decline, especially in patients with diabetes mellitus (DM). However, this correlation in patients with chronic kidney disease (CKD) and the presence or absence of DM remains controversial. We conducted a longitudinal cohort study in a single medical center between 2011 and 2018. Read More

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Evaluation of Reproducibility of Brain Volumetry between Commercial Software, Inbrain and Established Research Purpose Method, FreeSurfer.

J Clin Neurol 2021 Apr;17(2):307-316

Department of Radiology, Konkuk University Medical Center, Konkuk University School of Medicine, Seoul, Korea.

Background And Purpose: We aimed to determine the intermethod reproducibility between the commercial software Inbrain (MIDAS IT) and the established research-purpose method FreeSurfer, as well as the effect of MRI resolution and the pathological condition of subjects on their intermethod reproducibility.

Methods: This study included 45 healthy volunteers and 85 patients with mild cognitive impairment (MCI). In 43 of the 85 patients with MCI, three-dimensional, T1-weighted MRI data were obtained at an in-plane resolution of 1. Read More

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Neurophysiological Indices of Audiovisual Speech Processing Reveal a Hierarchy of Multisensory Integration Effects.

J Neurosci 2021 Jun 6;41(23):4991-5003. Epub 2021 Apr 6.

School of Engineering, Trinity Centre for Biomedical Engineering and Trinity College Institute of Neuroscience, Trinity College Dublin, Dublin 2, Ireland

Seeing a speaker's face benefits speech comprehension, especially in challenging listening conditions. This perceptual benefit is thought to stem from the neural integration of visual and auditory speech at multiple stages of processing, whereby movement of a speaker's face provides temporal cues to auditory cortex, and articulatory information from the speaker's mouth can aid recognizing specific linguistic units (e.g. Read More

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Genetic evidence for a large overlap and potential bidirectional causal effects between resilience and well-being.

Neurobiol Stress 2021 May 14;14:100315. Epub 2021 Mar 14.

Department of Biological Psychology, Vrije Universiteit Amsterdam, the Netherlands.

Resilience and well-being are strongly related. People with higher levels of well-being are more resilient after stressful life events or trauma and vice versa. Less is known about the underlying sources of overlap and causality between the constructs. Read More

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Cumulative Effects of Thyroid Hormones Over 10 Years and Risk of General and Abdominal Obesity.

Horm Metab Res 2021 May 23;53(5):335-340. Epub 2021 Mar 23.

Endocrine Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

We aimed to assess if changes in thyrotropin (TSH) and free thyroxine (FT4) over 10 years of follow-up would be associated with changes in body mass index (BMI) and waist circumference (WC) or risk of obesity. We enrolled 2317 out of 4179 participants in Tehran Thyroid Study with serum TSH between 0.1-10 mU/l and without history of thyroid medication or surgery. Read More

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Repeatability and reproducibility of apparent diffusion coefficient and fat fraction measurement of focal myeloma lesions on whole body magnetic resonance imaging.

Br J Radiol 2021 Apr 18;94(1120):20200682. Epub 2021 Mar 18.

The Royal Marsden Hospital Foundation NHS Trust and The Institute of Cancer Research, London, UK.

Objective: To assess intra- and inter-reader variability of apparent diffusion coefficient (ADC) and fat fraction (FF) measurement in focal myeloma bone lesions and the influence of lesion size.

Methods: 22 myeloma patients with focal active disease on whole body MRI were included. Two readers outlined a small (5-10 mm) and large lesion (>10 mm) in each subject on derived ADC and FF maps; one reader performed this twice. Read More

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