2,315 results match your criteria will elaborate

Evaluating causality of cellular senescence in non-alcoholic fatty liver disease.

JHEP Rep 2021 Aug 1;3(4):100301. Epub 2021 May 1.

Department of Internal and Vascular Medicine, Amsterdam University Medical Centers, location AMC, Amsterdam, the Netherlands.

Cellular senescence is a state of irreversible cell cycle arrest that has important physiological functions. However, cellular senescence is also a hallmark of ageing and has been associated with several pathological conditions. A wide range of factors including genotoxic stress, mitogens and inflammatory cytokines can induce senescence. Read More

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Surgical site infection prevention and management in immunocompromised patients: a systematic review of the literature.

World J Emerg Surg 2021 Jun 10;16(1):33. Epub 2021 Jun 10.

General, Emergency and Trauma Surgery Department, Pisa University Hospital, Via Paradisa 1, 56100, Pisa, Italy.

Background: Immunocompromised patients are at higher risk of surgical site infection and wound complications. However, optimal management in the perioperative period is not well established. Present systematic review aims to analyse existing strategies and interventions to prevent and manage surgical site infections and other wound complications in immunocompromised patients. Read More

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Systematic Review on Local Ancestor Inference From a Mathematical and Algorithmic Perspective.

Front Genet 2021 24;12:639877. Epub 2021 May 24.

State Key Laboratory of Agrobiotechnology, China Agricultural University, Beijing, China.

Genotypic data provide deep insights into the population history and medical genetics. The local ancestry inference (LAI) (also termed local ancestry deconvolution) method uses the hidden Markov model (HMM) to solve the mathematical problem of ancestry reconstruction based on genomic data. HMM is combined with other statistical models and machine learning techniques for particular genetic tasks in a series of computer tools. Read More

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Adipose Extracellular Vesicles: Messengers From and to Macrophages in Regulating Immunometabolic Homeostasis or Disorders.

Front Immunol 2021 24;12:666344. Epub 2021 May 24.

Key Laboratory of Infection and Immunity of Shandong Province, Department of Immunology, School of Basic Medical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, China.

Adipose tissue is comprised of heterogenous cell populations that regulate both energy metabolism and immune reactions. Macrophages play critical roles in regulating immunometabolic homeostasis or disorders through cooperation with adipocytes, adipose tissue-derived stem cells (ADSCs) or other cells in adipose tissue. Extracellular vesicles (EVs) are recently recognized as efficient messengers for intercellular communication. Read More

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Study on the mechanism of regulating the hypothalamic cortical hormone releasing hormone/corticotropin releasing hormone type I receptor pathway by vibro-annular abdominal massage under the brain-intestine interaction in the treatment of insomnia.

Medicine (Baltimore) 2021 May;100(19):e25854

Nursing College of Changchun University of Chinese Medicine, Changchun, China.

Background: Insomnia is a common disease associated with different nervous system stress response and endocrine disorders. It has been reported previously that abdominal vibration and ring massage therapy can significantly improve the symptoms of insomnia patients, enhance the activity of neurons. In addition, functional MRI (resting state brain functional magnetic resonance imaging [Rs_fMRI]) of the resting state brain test has proved that the functional connection between hypothalamus and parahippocampal gyrus could be significantly enhanced after abdominal massage treatment. Read More

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Genetic evaluation in children with short stature.

Curr Opin Pediatr 2021 Jun 7. Epub 2021 Jun 7.

Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland, USA.

Purpose Of Review: Short stature is a common clinical manifestation in children. Yet, a cause is often unidentifiable in the majority of children with short stature by a routine screening approach. The purpose of this review is to describe the optimal genetic approach for evaluating short stature, challenges of genetic testing, and recent advances in genetic testing for short stature. Read More

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Structure and Dynamics of Meprin β in Complex with a Hydroxamate-Based Inhibitor.

Int J Mol Sci 2021 May 26;22(11). Epub 2021 May 26.

Fraunhofer Institute for Cell Therapy and Immunology, Department of Drug Design and Target Validation, Weinbergweg 22, 06120 Halle (Saale), Germany.

The astacin protease Meprin β represents an emerging target for drug development due to its potential involvement in disorders such as acute and chronic kidney injury and fibrosis. Here, we elaborate on the structural basis of inhibition by a specific Meprin β inhibitor. Our analysis of the crystal structure suggests different binding modes of the inhibitor to the active site. Read More

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The Cellular and Chemical Biology of Endocytic Trafficking and Intracellular Delivery-The GL-Lect Hypothesis.

Ludger Johannes

Molecules 2021 May 31;26(11). Epub 2021 May 31.

Cellular and Chemical Biology Department, Institut Curie, PSL Research University, U1143 INSERM, UMR3666 CNRS, 26 rue d'Ulm, CEDEX 05, 75248 Paris, France.

Lipid membranes are common to all forms of life. While being stable barriers that delimitate the cell as the fundamental organismal unit, biological membranes are highly dynamic by allowing for lateral diffusion, transbilayer passage via selective channels, and in eukaryotic cells for endocytic uptake through the formation of membrane bound vesicular or tubular carriers. Two of the most abundant fundamental fabrics of membranes-lipids and complex sugars-are produced through elaborate chains of biosynthetic enzymes, which makes it difficult to study them by conventional reverse genetics. Read More

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Structural Plasticity of LL-37 Indicates Elaborate Functional Adaptation Mechanisms to Bacterial Target Structures.

Int J Mol Sci 2021 May 14;22(10). Epub 2021 May 14.

Institute of Microbiology and Infection, College of Medical and Dental Sciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK.

The human cathelicidin LL-37 is a multifunctional peptide of the human innate immune system. Among the various functions of LL-37, its antimicrobial activity is important in controlling the microorganisms of the human body. The target molecules of LL-37 in bacteria include membrane lipids, lipopolysaccharides (LPS), lipoteichoic acid (LTA), proteins, DNA and RNA. Read More

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National Registry of Interstitial Lung Disease from Pakistan.

Cureus 2021 Apr 25;13(4):e14684. Epub 2021 Apr 25.

Pulmonology, Gulab Devi Chest Hospital, Lahore, PAK.

Introduction Interstitial lung disease (ILD) is a heterogeneous group of over 200 parenchymal lung diseases with a myriad of etiologies. Interstitial lung disease registries from around the world show varying prevalence and incidence of these diseases. The aim of this study was to determine the epidemiology and characteristics of ILD in Pakistan. Read More

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Intention to Use Behavioral Health Data From a Health Information Exchange: Mixed Methods Study.

JMIR Ment Health 2021 May 27;8(5):e26746. Epub 2021 May 27.

School of Health and Applied Human Sciences, College of Health and Human Services, University of North Carolina Wilmington, Wilmington, NC, United States.

Background: Patients with co-occurring behavioral health and chronic medical conditions frequently overuse inpatient hospital services. This pattern of overuse contributes to inefficient health care spending. These patients require coordinated care to achieve optimal health outcomes. Read More

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Animal and Human Models of Tissue Repair and Fibrosis: An Introduction.

Methods Mol Biol 2021 ;2299:277-290

Laboratory of Tissue Repair and Regeneration, Faculty of Dentistry, University of Toronto, Toronto, ON, Canada.

Reductionist cell culture systems are not only convenient but essential to understand molecular mechanisms of myofibroblast activation and action in carefully controlled conditions. However, tissue myofibroblasts do not act in isolation and the complexity of tissue repair and fibrosis in humans cannot be captured even by the most elaborate culture models. Over the past five decades, numerous animal models have been developed to study different aspects of myofibroblast biology and interactions with other cells and extracellular matrix. Read More

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January 2021

Discovery of Plasma Membrane-Associated RNAs through APEX-seq.

Cell Biochem Biophys 2021 May 24. Epub 2021 May 24.

Key Laboratory of RNA Biology, Institute of Biophysics, Chinese Academy of Sciences, 100101, Beijing, China.

In addition to nucleic acids, a variety of other biomolecules have also been found on the plasma membrane. Although researchers have realized that RNA has the ability to bind to membrane vesicles in vitro, little is known about whether and how RNA connects to the plasma membrane of the cell. The combination of high-throughput sequencing and in situ labeling methods provides an innovative approach for large-scale identification of subcellular RNAs. Read More

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Neurorehabilitation From a Distance: Can Intelligent Technology Support Decentralized Access to Quality Therapy?

Front Robot AI 2021 5;8:612415. Epub 2021 May 5.

Rehabilitation Engineering Laboratory, Department of Health Sciences and Technology, ETH Zurich, Switzerland.

Current neurorehabilitation models primarily rely on extended hospital stays and regular therapy sessions requiring close physical interactions between rehabilitation professionals and patients. The current COVID-19 pandemic has challenged this model, as strict physical distancing rules and a shift in the allocation of hospital resources resulted in many neurological patients not receiving essential therapy. Accordingly, a recent survey revealed that the majority of European healthcare professionals involved in stroke care are concerned that this lack of care will have a noticeable negative impact on functional outcomes. Read More

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Intraoperative molecular imaging clinical trials: a review of 2020 conference proceedings.

J Biomed Opt 2021 May;26(5)

Perelman School of Medicine, Univ. of Pennsylvania, United States.

Significance: Surgery is often paramount in the management of many solid organ malignancies because optimal resection is a major factor in disease-specific survival. Cancer surgery has multiple challenges including localizing small lesions, ensuring negative surgical margins around a tumor, adequately staging patients by discriminating positive lymph nodes, and identifying potential synchronous cancers. Intraoperative molecular imaging (IMI) is an emerging potential tool proposed to address these issues. Read More

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OpenAnnotate: a web server to annotate the chromatin accessibility of genomic regions.

Nucleic Acids Res 2021 May 17. Epub 2021 May 17.

Ministry of Education Key Laboratory of Bioinformatics, Bioinformatics Division at the Beijing National Research Center for Information Science and Technology, Center for Synthetic and Systems Biology, Department of Automation, Tsinghua University, Beijing 100084, China.

Chromatin accessibility, as a powerful marker of active DNA regulatory elements, provides valuable information for understanding regulatory mechanisms. The revolution in high-throughput methods has accumulated massive chromatin accessibility profiles in public repositories. Nevertheless, utilization of these data is hampered by cumbersome collection, time-consuming processing, and manual chromatin accessibility (openness) annotation of genomic regions. Read More

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Multi-Level Neuromorphic Devices Built on Emerging Ferroic Materials: A Review.

Front Neurosci 2021 28;15:661667. Epub 2021 Apr 28.

School of Electrical and Computer Engineering, Purdue University, West Lafayette, IN, United States.

Achieving multi-level devices is crucial to efficiently emulate key bio-plausible functionalities such as synaptic plasticity and neuronal activity, and has become an important aspect of neuromorphic hardware development. In this review article, we focus on various ferromagnetic (FM) and ferroelectric (FE) devices capable of representing multiple states, and discuss the usage of such multi-level devices for implementing neuromorphic functionalities. We will elaborate that the analog-like resistive states in ferromagnetic or ferroelectric thin films are due to the non-coherent multi-domain switching dynamics, which is fundamentally different from most memristive materials involving electroforming processes or significant ion motion. Read More

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A Review of the Literature Organized Into a New Database: RHeference.

Transfus Med Rev 2021 Apr 20;35(2):70-77. Epub 2021 Apr 20.

Univ Paris Est Creteil, INSERM, IMRB, Creteil, France; EFS Ile-de-France Créteil, Creteil, France; Laboratory of Excellence GR-Ex, Paris, France. Electronic address:

Hundreds of articles containing heterogeneous data describe D variants or add to the knowledge of known alleles. Data can be difficult to find despite existing online blood group resources and genetic and literature databases. We have developed a modern, elaborate database for D variants, thanks to an extensive literature search with meticulous curation of 387 peer-reviewed articles and 80 abstracts from major conferences and other sources. Read More

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Putting self-regulated learning in context: Integrating self-, co-, and socially shared regulation of learning.

Med Educ 2021 May 14. Epub 2021 May 14.

Department of Educational Development and Research, Faculty of Health, Medicine and Life Science, Maastricht University, Maastricht, The Netherlands.

Processes involved in the regulation of learning have been researched for decades, because of its impact on academic and workplace performance. In fact, self-regulated learning is the focus of countless studies in health professions education and higher education in general. While we will always need competent individuals who are able to regulate their own learning, developments in healthcare require a shift from a focus on the individual to the collective: collaboration within and between healthcare teams is at the heart of high-quality patient care. Read More

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Mitochondria: A critical hub for hepatic stellate cells activation during chronic liver diseases: Mitochondria in hepatic stellate cells.

Hepatobiliary Pancreat Dis Int 2021 Apr 28. Epub 2021 Apr 28.

Department of Pharmacology, the Blue Lab, Molecular Medicine and Toxicology Division, Saveetha Dental College, Saveetha Institute of Medical and Technical Sciences (SIMATS), Chennai 600077, Tamil Nadu, India. Electronic address:

Background: Upon liver injury, quiescent hepatic stellate cells (qHSCs), reside in the perisinusoidal space, phenotypically transdifferentiate into myofibroblast-like cells (MFBs). The qHSCs in the normal liver are less fibrogenic, migratory, and also have less proliferative potential. However, activated HSCs (aHSCs) are more fibrogenic and have a high migratory and proliferative MFBs phenotype. Read More

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Recent Advances in Peripheral Opioid Receptor Therapeutics.

Curr Pain Headache Rep 2021 May 10;25(7):46. Epub 2021 May 10.

Department of Anesthesiology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

Purpose Of Review: Although opioids are excellent analgesics, they are associated with severe short- and long-term side effects that are especially concerning for the treatment of chronic pain. Peripherally acting opioid receptor agonists promise to mitigate the more serious centrally mediated side effects of opioids, and the goal of this paper is to identify and elaborate on recent advances in these peripheral opioid receptor therapeutics.

Recent Findings: Peripheral opioid receptor agonists are effective analgesics that at the same time circumvent the problem of centrally mediated opioid side effects by (1) preferentially targeting peripheral opioid receptors that are often the source of the pain and (2) their markedly diminished permeability or activity across the blood-brain barrier. Read More

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Subclinical Hypothyroidism in Geriatric Population and Its Association With Heart Failure.

Cureus 2021 Apr 5;13(4):e14296. Epub 2021 Apr 5.

Neurology, California Institute of Behavioral Neurosciences & Psychology, Fairfield, USA.

Heart failure (HF) is one of the most common causes of hospitalization in the geriatric age group, above 65 years. It is associated with high morbidity, mortality, and bad prognosis. Subclinical hypothyroidism (SCH) is a common condition present in this age group that significantly affects the cardiovascular system. Read More

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Violent emotions and the violence of life.

Avner Bergstein

Int J Psychoanal 2020 Oct 4;101(5):863-878. Epub 2020 Sep 4.

Israel Psychoanalytic Society, Jerusalem, Israel.

The paper discusses the violence of emotions and the violent retaliation against the mind as a way of protecting oneself against overwhelming pain. Leaning on Bion's thinking, it is suggested that violence may be an outcome of a quantity of excitation that the individual is unable to elaborate mentally. This violence is often dormant, covered by a veneer of civilization. Read More

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October 2020

Role of hydrogen in traumatic brain injury: a narrative review.

Med Gas Res 2021 Jul-Sep;11(3):114-120

Department of Neurosurgery & Brain and Nerve Research Laboratory, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu Province, China.

Traumatic brain injury (TBI) is a serious global public health problem. Survivors of TBI often suffer from long-term disability, which puts a heavy burden on society and families. Unfortunately, up to now, there is no efficacious treatment for TBI patients in clinical practice. Read More

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Climate change during the COVID-19 outbreak: scoping future perspectives.

Environ Sci Pollut Res Int 2021 May 2. Epub 2021 May 2.

Department of Economics and Business Administration, Art & Social Sciences Division, University of Education Lahore (Faisalabad Campus), Faisalabad, Pakistan.

Neither war nor recession or any kind of prior disaster has been considered a prelude to the looming threat of climate change over the past era as coronavirus (hereafter COVID-19) has in only a few months. Although numerous studies have already been published on this topic, there has not been compelling evidence critically assessing the impact of COVID-19 by and on climate change. The present study fills this gap by taking a more holistic approach to elaborate factors, e. Read More

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Delineation of mechanistic approaches employed by plant growth promoting microorganisms for improving drought stress tolerance in plants.

Microbiol Res 2021 Aug 22;249:126771. Epub 2021 Apr 22.

Department of Agronomy, Institute of Food and Agricultural Sciences, University of Florida, Gainesville, FL, 32611, USA. Electronic address:

Drought stress is expected to increase in intensity, frequency, and duration in many parts of the world, with potential negative impacts on plant growth and productivity. The plants have evolved complex physiological and biochemical mechanisms to respond and adjust to water-deficient environments. The physiological and biochemical mechanisms associated with water-stress tolerance and water-use efficiency have been extensively studied. Read More

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Stakeholder Views on the Idea of Medicines Reuse in the UK.

Pharmacy (Basel) 2021 Apr 16;9(2). Epub 2021 Apr 16.

Department of Biomedical Engineering, School of Biological Sciences, University of Reading, Whiteknights, Reading RG6 6AY, UK.

People's views about medicines reuse are being examined in a handful of qualitative studies and this commentary adds to that work by drawing on our own discussions with groups of stakeholders in the UK in the past two years. The reuse of medicines within the community pharmacy setting is not permitted in the UK but our multidisciplinary team anticipates that this position will change in the coming years as medication shortages and worries about environmental waste and financial losses from the destruction of unused medicines are brought to the fore. Indeed, for many stakeholders, the issue of waste is a strong feature of conversations about medicines reuse. Read More

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The European Paediatric Rare Tumours Network - European Registry (PARTNER) project for very rare tumors in children.

Pediatr Blood Cancer 2021 Apr 29:e29072. Epub 2021 Apr 29.

Hematology-Oncology Division, Department of Women's and Children's Health, Padova University Hospital, Padua, Italy.

The PARTNER project (Paediatric Rare Tumours Network - European Registry) was launched in 2016. PARTNER aims to create a European Registry dedicated to children and adolescents with very rare tumors (VRT). It links existing national registries and provides a registry for those countries in which a VRT registry has not yet been created. Read More

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Review on the Vascularization of Organoids and Organoids-on-a-hip.

Front Bioeng Biotechnol 2021 12;9:637048. Epub 2021 Apr 12.

Department of Cell Biology, Third Military Medical University, Chongqing, China.

The use of human cells for the construction of 3D organ models based on cell self-assembly and engineering design has recently increased in popularity in the field of biological science. Although the organoids are able to simulate the structures and functions of organs , the 3D models have difficulty in forming a complex vascular network that can recreate the interaction between tissue and vascular systems. Therefore, organoids are unable to survive, due to the lack of oxygen and nutrients, as well as the accumulation of metabolic waste. Read More

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Covid-19 Dynamic Monitoring and Real-Time Spatio-Temporal Forecasting.

Front Public Health 2021 8;9:641253. Epub 2021 Apr 8.

Center for Informatics, Federal University of Pernambuco, Recife, Brazil.

Periodically, humanity is often faced with new and emerging viruses that can be a significant global threat. It has already been over a century post-the Spanish Flu pandemic, and we are witnessing a new type of coronavirus, the SARS-CoV-2, which is responsible for Covid-19. It emerged from the city of Wuhan (China) in December 2019, and within a few months, the virus propagated itself globally now resulting more than 50 million cases with over 1 million deaths. Read More

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