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FOXD3 suppresses epithelial-mesenchymal transition through direct transcriptional promotion of SMAD7 in esophageal squamous cell carcinoma.

Mol Carcinog 2021 Sep 22. Epub 2021 Sep 22.

Laboratory of Pathology, Hebei Cancer Institute, The Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei, China.

The transcription factor forkhead box D3 (FOXD3) is an important member of the FOX family, which can maintain the pluripotent properties of cell clusters, neural crest, and trophoblastic progenitor cells in vivo. It has been shown that FOXD3 could affect proliferation, migration, and angiogenesis of various tumors and its deletion and overexpression in organisms will undoubtedly have important influence on the change of cell fate and the occurrence of tumors. However, the underlying functions and molecular mechanisms of FOXD3 in esophageal squamous cell carcinoma (ESCC) have not been fully clarified. Read More

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September 2021

Neuronal development in the cochlea of a nonhuman primate model, the common marmoset.

Dev Neurobiol 2021 Sep 21. Epub 2021 Sep 21.

Department of Otorhinolaryngology, Head and Neck Surgery, Keio University School of Medicine, 35 Shinanomachi Shinjuku-ku, Tokyo, 160-8582, Japan.

Precise cochlear neuronal development is vital to hearing ability. Understanding the developmental process of the spiral ganglion is useful for studying hearing loss aimed at aging or regenerative therapy. Although inter-species differences have been reported between rodents and humans, to date, most of our knowledge about the development of cochlear neuronal development has been obtained from rodent models because of the difficulty in using human fetal samples in this field. Read More

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September 2021

Optimizing spatial properties of a new checkerboard-like visual stimulus for user-friendly SSVEP-based BCIs.

J Neural Eng 2021 Sep 20. Epub 2021 Sep 20.

State Key Laboratory on Integrated Optoelectronics, Institute of Semiconductors, Chinese Academy of Sciences, No.A35, QingHua East Road, Haidian District, Beijing P R China , Beijing, 100083, CHINA.

Low-frequency steady-state visual evoked potential (SSVEP)-based brain-computer interface (BCI) systems with high performance are prone to cause visual discomfort and fatigue. High-frequency SSVEP-based BCI systems can alleviate the discomfort, but always obtain lower performance. This study optimized the spatial properties of a proposed checkerboard-like visual stimulus toward high-performance and user-friendly SSVEP-based BCI systems. Read More

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September 2021

Acceptance and commitment therapy for older people with treatment-resistant generalised anxiety disorder: the FACTOID feasibility study.

Health Technol Assess 2021 Sep;25(54):1-150

Division of Psychiatry, Faculty of Brain Sciences, University College London, London, UK.

Background: Generalised anxiety disorder, characterised by excessive anxiety and worry, is the most common anxiety disorder among older people. It is a condition that may persist for decades and is associated with numerous negative outcomes. Front-line treatments include pharmacological and psychological therapy, but many older people do not find these treatments effective. Read More

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September 2021

Recommendations for uniform definitions used in newborn screening for severe combined immunodeficiency.

J Allergy Clin Immunol 2021 Sep 16. Epub 2021 Sep 16.

Department of Pediatrics, Laboratory for Pediatric Immunology, Leiden University Medical Center, Leiden, The Netherlands. Electronic address:

Background: Public health newborn screening (NBS) programs continuously evolve, taking advantage of international shared learning. NBS for severe combined immunodeficiency (SCID) has recently been introduced in many countries. However, comparison of screening outcomes has been hampered by use of disparate terminology and imprecise or variable case definitions for non-SCID conditions with T-cell lymphopenia. Read More

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September 2021

Detailed clinical features and genotype-phenotype correlation in an OTOF-related hearing loss cohort in Japan.

Hum Genet 2021 Sep 18. Epub 2021 Sep 18.

Department of Microbiology, Sapporo Medical University School of Medicine, Sapporo, Japan.

Mutations in the OTOF gene are a common cause of hereditary hearing loss and the main cause of auditory neuropathy spectrum disorder (ANSD). Although it is reported that most of the patients with OTOF mutations have stable, congenital or prelingual onset severe-to-profound hearing loss, some patients show atypical clinical phenotypes, and the genotype-phenotype correlation in patients with OTOF mutations is not yet fully understood. In this study, we aimed to reveal detailed clinical characteristics of OTOF-related hearing loss patients and the genotype-phenotype correlation. Read More

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September 2021

Expression and functional characterization of the mannose receptor (MR) from Nile tilapia (Oreochromis niloticus) in response to bacterial infection.

Dev Comp Immunol 2021 Sep 13;126:104257. Epub 2021 Sep 13.

School of Life Sciences, South China Normal University, Institute of Modern Aquaculture Science and Engineering, Guangdong Provincial Key Laboratory for Healthy and Safe Aquaculture, Guangzhou 510631, PR China. Electronic address:

Mannose receptor (MR) as a member of the pattern recognition receptors (PRRs) plays an important role in the immune response. In mammals, the role of MR in the regulation of phagocytosis is clarified; however, its contribution to opsonize phagocytosis remains unclear in bony fish. In this study, the expression pattern of Nile tilapia mannose receptor gene (OnMR) was investigated and its regulation of the phagocytosis of monocytes/macrophages to pathogenic bacteria was identified. Read More

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September 2021

Repeat hepatectomy for recurrent colorectal liver metastases: A comparative analysis of short- and long-term results.

Hepatobiliary Pancreat Dis Int 2021 Aug 27. Epub 2021 Aug 27.

Digestive Surgery Division, Department of Gastroenterology, University of São Paulo School of Medicine, São Paulo, Brazil.

Background: Liver recurrence after resection of colorectal liver metastases (CRLM) is frequent. Repeat hepatectomy has been shown to have satisfactory perioperative results. However, the long-term outcomes and the benefits for patients with early recurrence have not been clarified. Read More

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Curled cation structures accelerate the dynamics of ionic liquids.

Phys Chem Chem Phys 2021 Sep 15. Epub 2021 Sep 15.

Department of Chemistry, Saarland University, Campus B2.2, 66123, Saarbrücken, Germany.

Ionic liquids are modern liquid materials with potential and actual implementation in many advanced technologies. They combine many favourable and modifiable properties but have a major inherent drawback compared to molecular liquids - slower dynamics. In previous studies we found that the dynamics of ionic liquids are significantly accelerated by the introduction of multiple ether side chains into the cations. Read More

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September 2021

Analysis of furans and pyridines from new generation heated tobacco product in Japan.

Environ Health Prev Med 2021 Sep 13;26(1):89. Epub 2021 Sep 13.

Department of Environmental Health, National Institute of Public Health, 2-3-6 Minami, Wako, Saitama, 351-0197, Japan.

Background: In recent years, heated tobacco products (HTPs), which are widely used in Japan, have been sold by various brands using additives such as flavors. It has been reported that the components of mainstream smoke are different from those of conventional cigarettes. In this study, we established an analytical method for furans and pyridines in the mainstream smoke, which are characteristic of HTPs and particularly harmful among the generated components, and investigated the amount of component to which the smokers are exposed. Read More

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September 2021

A Japanese Patient with Anti-PM/Scl and Centromere Antibody-Positive Scleroderma-Amyopathic Dermatomyositis Overlap Syndrome Who Developed Renal Crisis.

Mod Rheumatol Case Rep 2021 Sep 10. Epub 2021 Sep 10.

The First Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health, Japan.

Anti-PM/Scl antibodies are associated with the overlap syndrome of systemic sclerosis and dermatomyositis/polymyositis (SSc-DM/PM), and are found in 50% of SSc-DM/PM cases in Europe and the United States, whereas they are rare in Japan. We report a case of an 80-year-old Japanese female with SSc-amyopathic dermatomyositis (ADM) overlap syndrome, who developed scleroderma renal crisis (SRC), a complication of SSc. She had positive antinuclear antibodies in a discrete-speckled and nucleolar pattern and anticentromere antibodies and anti-PM/Scl antibodies were confirmed by ELISA and immunoprecipitation, respectively. Read More

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September 2021

Interleukin-21 in Viral Infections.

Hironobu Asao

Int J Mol Sci 2021 Sep 1;22(17). Epub 2021 Sep 1.

Department of Immunology, Faculty of Medicine, Yamagata University, 2-2-2 Iida-nishi, Yamagata City 990-9585, Japan.

Interleukin (IL)-21 is a cytokine that affects the differentiation and function of lymphoid and myeloid cells and regulates both innate and adaptive immune responses. In addition to regulating the immune response to tumor and viral infections, IL-21 also has a profound effect on the development of autoimmune and inflammatory diseases. IL-21 is produced mainly from CD4 T cells-in particular, follicular helper T (Tfh) cells-which have a great influence on the regulation of antibody production. Read More

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September 2021

[On the acupoint and its specificity].

Bing Zhu

Zhongguo Zhen Jiu 2021 Sep;41(9):943-50

Institute of Acupuncture and Moxibustion, China Academy of Chinese medical Sciences, Beijing 100700, China.

Although acupuncture has spanned thousands of years in the history of traditional medicine, still some basic questions are not clarified. Acupuncture is the theory based on long time medical practice of the ancient sage, combined with objectivesymptom and medical expertise from diseases, and being applied for the instruction in clinic. In this way, acupoint is discovered by doctors in the practice of disease treatment other than a natural occurrence in the healthy population. Read More

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September 2021

Acts as a Pro-carcinogenic Bacterium in Colorectal Cancer: From Association to Causality.

Front Cell Dev Biol 2021 20;9:710165. Epub 2021 Aug 20.

Department of Oncological and Endoscopic Surgery, The First Affiliated Hospital of Harbin Medical University, Harbin, China.

Colorectal cancer (CRC) is a common cancer worldwide with complex etiology. (), an oral symbiotic bacterium, has been linked with CRC in the past decade. A series of gut microbiota studies show that CRC patients carry a high abundance of in the tumor tissue and fecal, and etiological studies have clarified the role of as a pro-carcinogenic bacterium in various stages of CRC. Read More

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Effect and Safety of Therapeutic Regimens for Patients With Germline BRCA Mutation-Associated Breast Cancer: A Network Meta-Analysis.

Front Oncol 2021 20;11:718761. Epub 2021 Aug 20.

Department of Biochemistry and Molecular Biology, Mudanjiang Medical University, Mudanjiang, China.

Purpose: Breast cancer type 1 susceptibility (BRCA) mutations not only increase breast cancer (BC) risk but also result in poor survival and prognosis for BC patients. This study will analyze the effect and safety of therapeutic regimens for the treatment of BC patients with germline BRCA (gBRCA) mutations by network meta-analysis.

Methods: Public databases were searched from inception to 29 April 2021. Read More

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Modelling spinal locomotor circuits for movements in developing zebrafish.

Elife 2021 Sep 2;10. Epub 2021 Sep 2.

Biology, Brain and Mind Research Institute, Centre for Neural Dynamics, University of Ottawa, Ottawa, Canada.

Many spinal circuits dedicated to locomotor control have been identified in the developing zebrafish. How these circuits operate together to generate the various swimming movements during development remains to be clarified. In this study, we iteratively built models of developing zebrafish spinal circuits coupled to simplified musculoskeletal models that reproduce coiling and swimming movements. Read More

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September 2021

Destruction or Reconstruction: A Subtle Liaison between the Proteolytic and Signaling Role of Protein Ubiquitination in Spermatogenesis.

Giovanna Berruti

Adv Exp Med Biol 2021 ;1288:215-240

Department of Bioscience, University of Milan, Milan, Italy.

Ubiquitination is one of the most diverse forms of protein post-translational modification that changes the function of the landscape of substrate proteins in response to stimuli, without the need for "de novo" protein synthesis. Ubiquitination is involved in almost all aspects of eukaryotic cell biology, from the best-studied role in promoting the removal of faulty or unnecessary proteins by the way of the ubiquitin proteasome system and autophagy-lysosome pathway to the recruitment of proteins in specific non-proteolytic signaling pathways, as emerged by the more recent discoveries about the protein signature with peculiar types of ubiquitin chains. Spermatogenesis, on its own, is a complex cellular developmental process in which mitosis, meiosis, and cell differentiation coexist so to result in the continuous formation of haploid spermatozoa. Read More

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Tissue Oximeter with Selectable Measurement Depth Using Spatially Resolved Near-Infrared Spectroscopy.

Sensors (Basel) 2021 Aug 19;21(16). Epub 2021 Aug 19.

Division of Vascular Surgery, Hamamatsu University School of Medicine, Hamamatsu 431-3192, Japan.

Tissue oxygenation sensing at a few millimeters deep is useful for surgical and postoperative management. However, the measurement sensitivity at each depth and the proper sensor combination have not been clarified. Here, the measurement characteristics of oximetry by spatially resolved near-infrared spectroscopy were analyzed using Monte Carlo simulation and phantom experiment. Read More

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The co-expression of CBX8 and PD-L1 and prognostic value in cervical cancer.

Medicine (Baltimore) 2021 Aug;100(34):e27056

Department of Oncology, The People's Hospital of Kaizhou District, Kaizhou, Chongqing, China.

Abstract: Chromobox homolog 8 (CBX8) plays an important role in the occurrence and development of various tumors, and is closely related to the prognosis of patients with cancer. However, the occurrence, development, and prognostic value of CBX8 in cervical cancer have not been reported yet.In this study, immunohistochemistry was used to detect the expression of CBX8 in cervical cancer tissues and the corresponding normal tissues adjacent to the tumor. Read More

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Contribution of the Commensal Microflora to the Immunological Homeostasis and the Importance of Immune-Related Drug Development for Clinical Applications.

Int J Mol Sci 2021 Aug 18;22(16). Epub 2021 Aug 18.

Experimental and Translational Ophthalmology, Department of Ophthalmology, University Medical Center, 55131 Mainz, Germany.

Not long ago, self-reactive immune activity was considered as pathological trait. A paradigm shift has now led to the recognition of autoimmune processes as part of natural maintenance of molecular homeostasis. The immune system is assigned further roles beneath the defense against pathogenic organisms. Read More

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A Conceptual Design of Smart Management System for Flooding Disaster.

Int J Environ Res Public Health 2021 08 16;18(16). Epub 2021 Aug 16.

Faculty of Logistics, Molde University College-Specialized University in Logistics, 6410 Molde, Norway.

Disasters pose a real threat to the lives and property of citizens; therefore, it is necessary to reduce their impact to the minimum possible. In order to achieve this goal, a framework for enhancing the current disaster management system was proposed, called the smart disaster management system. The smart aspect of this system is due to the application of the principles of information and communication technology, especially the Internet of Things. Read More

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Tracking Development Assistance for Health: A Comparative Study of the 29 Development Assistance Committee Countries, 2011-2019.

Int J Environ Res Public Health 2021 08 12;18(16). Epub 2021 Aug 12.

Department of Global Health Policy, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.

Development assistance for health (DAH) is an important part of financing healthcare in low- and middle-income countries. We estimated the gross disbursement of DAH of the 29 Development Assistance Committee (DAC) member countries of the Organisation for Economic Co-operation and Development (OECD) for 2011-2019; and clarified its flows, including aid type, channel, target region, and target health focus area. Data from the OECD iLibrary were used. Read More

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Fast and Slow Adaptations of Interlimb Coordination Reflex and Learning During Split-Belt Treadmill Walking of a Quadruped Robot.

Front Robot AI 2021 6;8:697612. Epub 2021 Aug 6.

Department of Aeronautics and Astronautics, Graduate School of Engineering, Kyoto University, Kyoto, Japan.

Interlimb coordination plays an important role in adaptive locomotion of humans and animals. This has been investigated using a split-belt treadmill, which imposes different speeds on the two sides of the body. Two types of adaptation have been identified, namely fast and slow adaptations. Read More

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Advances in microglia cellular models: focus on extracellular vesicle production.

Biochem Soc Trans 2021 Aug;49(4):1791-1802

Department of Pharmacy, University of Pisa, Via Bonanno 6, 56126 Pisa, Italy.

Microglia are the major component of the innate immune system in the central nervous system. They promote the maintenance of brain homeostasis as well as support inflammatory processes that are often related to pathological conditions such as neurodegenerative diseases. Depending on the stimulus received, microglia cells dynamically change their phenotype releasing specific soluble factors and largely modify the cargo of their secreted extracellular vesicles (EVs). Read More

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Kinetic assays of DNA polymerase fidelity: A theoretical perspective beyond Michaelis-Menten kinetics.

Phys Rev E 2021 Jul;104(1-1):014408

School of Physical Science, University of Chinese Academy of Sciences, No. 19(A) Yuquan Road, Shijingshan District, Beijing 101400, People's Republic of China.

The high fidelity of DNA polymerase (DNAP) is critical for the faithful replication of DNA. There are several quantitative approaches to measure DNAP fidelity. Directly counting the error frequency in the replication products gives the true fidelity but it turns out very hard to implement in practice. Read More

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Role of microRNAs in etiology of azoospermia and their application as non-invasive biomarkers in diagnosis of azoospermic patients.

J Gynecol Obstet Hum Reprod 2021 Aug 15;50(10):102207. Epub 2021 Aug 15.

Department of Biology, Faculty of Science, Ferdowsi University of Mashhad, Mashhad, Iran; Industrial Biotechnology Research Group, Institute of Biotechnology, Ferdowsi University of Mashhad, Mashhad, Iran.

Azoospermia is a common cause of male infertility without any sperm in the semen and consists of ∼1% of all males and ∼15% of infertile ones. Currently, no accurate non-invasive diagnostic method exists for patients with azoospermia and testis biopsy is mandatory to determine if any spermatozoa exist in the testes. Studies have clarified that the expression of some distinct microRNAs shows alterations in azoospermic patients. Read More

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Bringing Your Idea to the Market: A Primer for Plastic Surgeons.

Plast Reconstr Surg 2021 Aug;148(2):475-481

From the Department of Otology, Neurotology, Texas Health Care PLLC; Division of Plastic Surgery, Michael E. DeBakey Department of Surgery, Baylor College of Medicine; Division of Plastic Surgery, Department of Surgery, Texas Children's Hospital; and Department of Plastic Surgery, University of Texas M. D. Anderson Cancer Center.

Summary: The progress of biotechnology, medical instruments, and applied sciences contributes to a rapidly expanding space for the advancement of the medical field. Surgeons experience first-hand the limitations of current medical devices and thus have unique insight into problems that could be solved with new products. The process of turning an idea into a product capable of success in the marketplace, however, is often unfamiliar to surgeons. Read More

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ROP Risk Management 2021.

Robert S Gold

Curr Opin Ophthalmol 2021 Sep;32(5):494-497

Ophthalmic Mutual Insurance Company; Risk Management Committe; ROP Task Force, San Francisco, California, USA.

Purpose Of Review: It is important for ophthalmologists to keep current with up-to-date recommendations for screening, treating, and follow-up of infants with retinopathy of prematurity (ROP). This paper will review updated ROP Safety Net protocols and Policy Statements to stress that following risk management principles can avoid claims that could arise from poor visual outcomes.

Recent Findings: Ophthalmic Mutual Insurance Company (OMIC) has been proactive in ROP risk management with development of the ROP Safety Net in 2006. Read More

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September 2021

QTL Mapping for Leaf Area of Tea Plants () Based on a High-Quality Genetic Map Constructed by Whole Genome Resequencing.

Front Plant Sci 2021 29;12:705285. Epub 2021 Jul 29.

State Key Laboratory of Tea Plant Biology and Utilization, Anhui Agricultural University, Hefei, China.

High-quality genetic maps play important roles in QTL mapping and molecular marker-assisted breeding. Tea leaves are not only important vegetative organs but are also the organ for harvest with important economic value. However, the key genes and genetic mechanism of regulating leaf area have not been clarified. Read More

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Associations between genetic loci related to lean mass and body composition in type 2 diabetes.

Geriatr Gerontol Int 2021 Aug 14. Epub 2021 Aug 14.

Department of Endocrinology, Metabolism and Diabetes, Kindai University Faculty of Medicine, Osaka, Japan.

Aim: Several genetic loci related to lean mass have been identified in healthy individuals by genome-wide association studies; however, the contribution of these loci to body composition in type 2 diabetes remains to be investigated. Here, we aimed to clarify the genetic determinants of body composition in individuals with type 2 diabetes.

Methods: A total of 176 Japanese outpatients (70 women and 106 men) with type 2 diabetes were studied using a cross-sectional design. Read More

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