22 results match your criteria wilhelmsii koch

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Hydro-alcoholic Extract of C. Koch Reduces the Expression of Cell Death-Associated Genes while Inducing DNA Damage in HeLa Cervical Cancer Cells.

Iran J Med Sci 2020 Sep;45(5):359-367

Cellular and Molecular Research Center, Resistant Tuberculosis Institute, Zahedan University of Medical Sciences, Zahedan, Iran.

Background: C. Koch hydroalcoholic extract (AWHE) is proven to induce cell death. Previous studies suggested that AWHE is an effective inhibitor against the proliferation of prostate cancer cells. Read More

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September 2020

Hydroalcoholic Extract Induces Apoptosis and Alters and Gene Expression in Hela Cervical Cancer Cells.

Rep Biochem Mol Biol 2019 Oct;8(3):318-325

Department of Chemistry, Iran University of Science and Technology; Tehran, Iran.

Background: Inappropriate activation of the proto-oncogene LIN28B and inactivation of the p53 tumor suppressor, have been shown to have a critical role in tumorigenesis. Previous research has shown therapeutic potential for the use of herbal plants as an alternative strategy for cancer treatment. C. Read More

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October 2019

Efficacy and safety of Achillea wilhelmsii C. Koch capsules on symptom severity and quality of life in patients with irritable bowel syndrome: a randomized, placebo-controlled clinical trial.

J Complement Integr Med 2019 Aug 23;16(4). Epub 2019 Aug 23.

Pharmaceutical Sciences Research Center, Faculty of Pharmacy, Kermanshah University of Medical Sciences, Kermanshah, Iran.

Background Irritable bowel syndrome (IBS) is one of the most common digestive diseases. The aim of this clinical trial was to determine the effectiveness of Achillea wilhelmsii C. Koch on the symptom severity and quality of life (QOL) in patients with IBS. Read More

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Therapeutic effects of hydro-alcoholic extract of Achillea wilhelmsii C. Koch on indomethacin-induced gastric ulcer in rats: a proteomic and metabolomic approach.

BMC Complement Altern Med 2019 Aug 7;19(1):205. Epub 2019 Aug 7.

Department of Basic Sciences, Faculty of Paramedical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Background: Gastric ulcer is one of the most prevalent diseases worldwide. In Iranian folk medicine, Achillea wilhelmsii (AW) is used as a treatment for gastric ulcer. Previous reports also mentioned Antiulcerogenic properties for this herbal plant. Read More

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Efficacy and safety of a standardized extract from Achillea wilhelmsii C. Koch in patients with ulcerative colitis: A randomized double blind placebo-controlled clinical trial.

Complement Ther Med 2019 Aug 2;45:262-268. Epub 2019 May 2.

Pharmaceutical Sciences Research Center, Health Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran. Electronic address:

Background: Using Achillea wilhelmsii as a dietary supplement for gastrointestinal disorders is common in Persian traditional medicine. Its anti-inflammatory, anti-spasmodic and antibacterial properties have been proven by different in vitro and in vivo studies, yet it has not been evaluated in a controlled clinical trial.

Aim: This study intended to evaluate the efficacy and safety of A. Read More

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Elemental Characterization of Medicinal Plants and Soils from Hazarganji Chiltan National Park and Nearby Unprotected Areas of Balochistan, Pakistan.

J Oleo Sci 2019 ;68(5):443-461

Institute of Biochemistry, University of Balochistan.

The aim of this work was to evaluate the variability in elemental composition of seven medicinal plants and their respective soils belonging to protected and nearby unprotected sites of the Hazarganji Chiltan National Park. The medical plants under study were Achillea wilhelmsii C. Koch, Peganum harmala Linn, Sophora mollis (Royle) Baker, Perovskia atriplicifolia Benth, Seriphidium quettense (Podlech. Read More

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Inhibition of Phosphodiesterase 5 and Increasing the Level of Cyclic Guanosine 3',5' Monophosphate by Hydroalcoholic C. Koch Extract in Human Breast Cancer Cell Lines MCF-7 and MDA-Mb-468.

Breast Cancer (Auckl) 2017 23;11:1178223417690178. Epub 2017 Feb 23.

Department of Biology, Faculty of Science, University of Sistan and Baluchestan, Zahedan, Iran.

This study aimed to investigate the effect of hydroalcoholic C. Koch extract (HAWE) on phosphodiesterase 5 (PDE5) gene expression and cyclic guanosine 3',5' monophosphate (cGMP) signaling in the MCF-7 and MDA-Mb-468 cell lines. The effective dose (ED50) of HAWE was examined in both cell lines using a 3-(4,5-dimethylhiazol-2-yl)-2,5-diphenyltetrazolium bromide viability test, and the type of cell death was detected by flow cytometry. Read More

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February 2017

Anti-proliferative and apoptosis inducing potential of hydroalcoholic Achillea wilhelmsii C. Koch extract on human breast adenocarcinoma cell lines MCF-7 and MDA-Mb-468.

Pak J Pharm Sci 2016 Nov;29(6 Suppl):2397-2403

Department of Clinical Biochemistry, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran.

Achillea wilhelmsii C. Koch contains a variety of components such as flavonoid. The previous studies showed that flavonoid has anti-cancer properties. Read More

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November 2016

Antibacterial activities of essential oils from Iranian medicinal plants on extended-spectrum β-lactamase-producing Escherichia coli.

Cell Mol Biol (Noisy-le-grand) 2016 Sep 19;62(9):75-82. Epub 2016 Sep 19.

Zabol University of Medical Sciences Zabol Iran

The extended-spectrum beta-lactamase (ESBL) -producing Escherichia coli strains can lead to various infections particularly urinary tract infections. The main objective of this investigation was to evaluate the antibacterial activities of essential oils (EOs) from different Iranian medicinal plants against TEM gene positive ESBL-producing E. coli strains isolated from urine samples of patients with urinary tract infections. Read More

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September 2016

The Chemical Composition of Achillea wilhelmsii C. Koch and Its Desirable Effects on Hyperglycemia, Inflammatory Mediators and Hypercholesterolemia as Risk Factors for Cardiometabolic Disease.

Molecules 2016 Mar 25;21(4):404. Epub 2016 Mar 25.

Department of Natural Drugs, Faculty of Pharmacy, University of Veterinary and Pharmaceutical Sciences, Palackého tř. 1, Brno 61242, Czech Republic.

This study was done to identify the content compounds of Achillea wilhelmsii (A. wilhelmsii) and to evaluate its hypoglycemic and anti-hypercholesterolemic activity and effect on inflammatory mediators. The extracts and fractions of A. Read More

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Chemical composition, antioxidant activity and in vitro antibacterial activity of Achillea wilhelmsii C. Koch essential oil on methicillin-susceptible and methicillin-resistant Staphylococcus aureus spp.

3 Biotech 2015 Feb 5;5(1):39-44. Epub 2014 Feb 5.

, P.O. Box 7, Miki Cho Post Office, 3011-2, Ikenobe, Kagawa-Ken, 761-0799, Japan.

The present study investigated the chemical composition of the essential oil (EO) from aerial parts (flowering stage) of Achillea wilhelmsii C. Koch by GC-MS. In addition, the antioxidant activity of the EO as well as its antimicrobial activity against methicillin-susceptible and methicillin-resistant Staphylococcus aureus (MRSA) strains was tested. Read More

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February 2015

Potential preventive role of Iranian Achillea wilhelmsii C. Koch essential oils in acetaminophen-induced hepatotoxicity.

Bot Stud 2014 Dec 24;55(1):37. Epub 2014 Mar 24.

Department of Biochemistry, Faculty of Sciences, Payame-e-Noor University, Tehran, Iran.

Background: The essential oil of Achillea wilhelmsii C. Koch (100 & 200 mg/kg b.w, i. Read More

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December 2014

Protective effects of Iranian Achillea wilhelmsii essential oil on acetaminophen-induced oxidative stress in rat liver.

Pharm Biol 2015 Feb 22;53(2):220-7. Epub 2014 Sep 22.

Faculty of Medicine, Qom Branch, Islamic Azad University , Qom , Iran .

Context: Achillea wilhelmsii C. Koch (Asteraceae) is widely used in Iranian traditional medicine.

Objective: This in vivo study evaluates the hepatoprotective role of Iranian A. Read More

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February 2015

Acute toxicity and antispasmodic activities of Achillea wilhelmsii C. Koch.

Pak J Pharm Sci 2014 Mar;27(2):309-15

Department of Pharmacy, Abasyn University, Peshawar, KP, Pakistan.

Since Achillea wilhelmsii is used as antispasmodic in traditional medicine, we conducted our current work to investigate its rationale on scientific grounds. Acute toxicity studies of crude methanol extract of Achillea wilhelmsii (Aw. CMeOH) is also performed. Read More

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Chemical composition and anxiolytic evaluation of Achillea Wilhelmsii C. Koch essential oil in rat.

Res Pharm Sci 2013 Oct;8(4):269-75

Medical Biology Research Center, Kermanshah University of Medical Sciences, Kermanshah, I.R. Iran.

Herbal based remedies are used worldwide to treat psychiatric disorders. The aim of this study was to analyse the essential oil composition of Achillea Wilhemsii C. Koch (Asteraceae) and to evaluate its anxiolytic effects in the elevated plus maze (EPM) model of anxiety in rat. Read More

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October 2013

First Report of Orobanche purpurea on Achillea wilhelmsii in Iran.

Plant Dis 2013 May;97(5):694

Department of Agronomy and Plant Breeding, University of Zanjan, Iran.

Achillea wilhelmsii C. Koch (Asteraceae) is a wild herb widely disturbed in Iran and known locally as yarrow. This plant is an important medicinal plant and it has been used for its analgesic, antiphlogistic, antispasmodic, and antibacterial effects in Iranian folk medicine. Read More

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Insecticide activity of essential oils of Mentha longifolia, Pulicaria gnaphalodes and Achillea wilhelmsii against two stored product pests, the flour beetle, Tribolium castaneum, and the cowpea weevil, Callosobruchus maculatus.

J Insect Sci 2012 ;12:73

Department of Plant Protection, Faculty of Agriculture, University of Zabol, Zabol, Iran.

Essential oils extracted from the foliage of Mentha longifolia (L.) (Lamiales: Lamiaceae) and Pulicaria gnaphalodes Ventenat (Asterales: Asteraceae), and flowers of Achillea wilhelmsii C. Koch (Asterales: Asteraceae) were tested in the laboratory for volatile toxicity against two storedproduct insects, the flour beetle, Tribolium castaneum Herbst (Coleoptera: Tenebrionidae) and the cowpea weevil, Callosobruchus maculatus F. Read More

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Investigation of optimal extraction, antioxidant, and antimicrobial activities of Achillea biebersteinii and A. wilhelmsii.

Pharm Biol 2012 Sep;50(9):1168-76

Department of Food Science and Technology, Sabzevar Branch, Islamic Azad Univereity, Sabzevar, Iran.

Objective: Achillea species are endowed with multiple biological activities including antioxidant properties. However, no study has yet investigated the impact of extraction method and pH on the biological activities of these plants. The present study aimed to investigate the antioxidant and antimicrobial effects of methanol extracts from the aerial parts of the species Achillea biebersteinii Afan and Achillea wilhelmsii C. Read More

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September 2012

Cytotoxic and anthelmintic potential of crude saponins isolated from Achillea Wilhelmsii C. Koch and Teucrium Stocksianum boiss.

BMC Complement Altern Med 2011 Nov 3;11:106. Epub 2011 Nov 3.

Department of Pharmacology, Institute of Basic Medical Sciences, Khyber Medical University, Peshawar, KPK, Pakistan.

Background: Saponins isolated from plant sources have a number of traditional and industrial applications. Saponins have pharmacological effects like anti-inflammatory, molluscicidal, antimicrobial, antispasmodic, antidiabetic, anticancer, anticonvulsant, anthelmintic, antitussive and cytotoxic activities. The current work describes the anthelmintic and cytotoxic activities of crude saponins of Achillea Wilhelmsii and Teucrium Stocksianum as these plants are rich with saponins. Read More

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November 2011

The efficacy and safety of herbal medicines used in the treatment of hyperlipidemia; a systematic review.

Curr Pharm Des 2010 ;16(26):2935-47

Endocrinology and Metabolism Research Center, and Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran.

Objective: This review focuses on the efficacy and safety of effective herbal medicines in the management of hyperlipidemia in human.

Methods: PubMed, Scopus, Google Scholar, Web of Science, and IranMedex databases were searched up to 11th May 2010. The search terms were "hyperlipidemia" and ("herbal medicine" or "medicine traditional", "extract plant") without narrowing or limiting search elements. Read More

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Immunomodulatory activity of aqueous extract of Achillea wilhelmsii C. Koch in mice.

Indian J Exp Biol 2009 Aug;47(8):668-71

Department of Pharmacognosy, Research Center of Pharmaceutics, School of Pharmacy, Kerman University of Medical Sciences, Kerman, Iran.

Immunomodulatory activity of aqueous extract of Achillea wilhelmsii (25, 50 and 100 mg/kg body weight for 5 days) was evaluated on body weight, relative organ weight, delayed type of hypersensitivity (DTH) response and haemagglutination titre (HT) in female Swiss albino mice. No significant body weight gain differences were recorded in various groups of animals. Significant increase in relative organ weight of spleen at 100 mg/kg was observed. Read More

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Antihypertensive and antihyperlipidemic effects of Achillea wilhelmsii.

Drugs Exp Clin Res 2000 ;26(3):89-93

Isfahan Cardiovascular Research Center, Isfahan University of Medical Sciences, Iran.

Achillea wilhelmsii C. Koch (Asteraceae) is widely found in different parts of Iran. This plant is full of flavonoids and sesquiterpene lactones, which have been shown to be effective in lowering blood lipids and hypertension. Read More

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December 2000
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