12,136 results match your criteria wiley sons


Perspectives on gene copy number variation and pesticide resistance.

Authors:
David G Heckel

Pest Manag Sci 2021 Sep 4. Epub 2021 Sep 4.

Max Planck Institute for Chemical Ecology, Jena, Germany.

Although the generation of evolutionary diversity by gene duplication has long been known, the implications for pesticide resistance are just now beginning to be appreciated. A few examples will be cited to illustrate the point that there are many variations on the theme that gene duplication does not follow a set pattern. Transposable elements may facilitate the process but the mechanistic details are obscure and unpredictable. Read More

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September 2021

Beyond vegetables: effects of indoor LED light on specialized metabolite biosynthesis in medicinal and aromatic plants, edible flowers, and microgreens.

J Sci Food Agric 2021 Aug 30. Epub 2021 Aug 30.

DISTAL - Department of Agricultural and Food Sciences, Alma Mater Studiorum University of Bologna, Bologna, Italy.

Specialized metabolites from plants are important for human health due to their antioxidant properties. Light is one of the main factors modulating the biosynthesis of specialized metabolites, determining the cascade response activated by photoreceptors and the consequent modulation of expressed genes and biosynthetic pathways. Recent developments in light emitting diode (LED) technology have enabled improvements in artificial light applications for horticulture. Read More

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Comparison of Microemboli Formation Between Irrigated Catheter Tip Architecture Using a Microemboli Monitoring System.

JACC Clin Electrophysiol 2021 Aug 17. Epub 2021 Aug 17.

Translational Interventional Electrophysiology Laboratory, Mayo Clinic, Rochester, Minnesota, USA. Electronic address:

Objectives: This study aimed to compare the efficacy and safety of ablation with high and low power settings using either a flexible tip or straight SF tip irrigated catheter in the left ventricle (LV) using a peripheral microemboli monitoring system.

Background: The microemboli risk of flexible and straight SF tip irrigated catheters in creating ablative lesions in the LV at variable power settings has not been adequately assessed.

Methods: Six pigs underwent catheter ablation in the LV using a flexible tip or straight SF tip catheter with 2 energy settings (30 or 50 W, 30 seconds, irrigation saline 17 mL/min). Read More

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Legumes as basic ingredients in the production of dairy-free cheese alternatives: a review.

J Sci Food Agric 2021 Aug 27. Epub 2021 Aug 27.

Department of Soil, Plant and Food Science (DISSPA), University of Bari Aldo Moro, Bari, Italy.

Research into dairy-free alternative products, whether plant-based or cell-based, is growing fast and the food industry is facing a new challenge of creating innovative, nutritious, accessible, and natural dairy-free cheese alternatives. The market demand for these products is continuing to increase owing to more people choosing to reduce or eliminate meat and dairy products from their diet for health, environmental sustainability, and/or ethical reasons. This review investigates the current status of dairy product alternatives. Read More

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Reciprocal YAP1 loss and INSM1 expression in neuroendocrine prostate cancer.

J Pathol 2021 Aug 24. Epub 2021 Aug 24.

Department of Pathology, Johns Hopkins School of Medicine, Baltimore, MD, USA.

Neuroendocrine prostate cancer (NEPC) is a rare but aggressive histologic variant of prostate cancer that responds poorly to androgen deprivation therapy. Hybrid NEPC-adenocarcinoma (AdCa) tumors are common, often eluding accurate pathologic diagnosis and requiring ancillary markers for classification. We recently performed an outlier-based meta-analysis across a number of independent gene expression microarray datasets to identify novel markers that differentiate NEPC from AdCa, including up-regulation of insulinoma-associated protein 1 (INSM1) and loss of Yes-associated protein 1 (YAP1). Read More

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Brg1 is required to maintain colorectal cancer stem cells.

J Pathol 2021 Jul 19. Epub 2021 Jul 19.

Department of Gastroenterology and Hepatology, Kyoto University Graduate School of Medicine, Kyoto, Japan.

Tumor cells capable of self-renewal and continuous production of progeny cells are called tumor stem cells (TSCs) and are considered to be potential therapeutic targets. However, the mechanisms underlying the survival and function of TSCs are not fully understood. We previously reported that chromatin remodeling regulator Brg1 is essential for intestinal stem cells in mice and Dclk1 is an intestinal TSC marker. Read More

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Long-term mortality in young patients with spontaneous intracerebral haemorrhage: Predictors and causes of death.

Eur Stroke J 2021 Jun 18;6(2):185-193. Epub 2021 Jun 18.

Inserm, CHU Lille, U1172-LilNCog-Lille Neuroscience and Cognition, University of Lille, Lille, France.

Introduction: Intracerebral haemorrhage (ICH) in young adults is rare but has devastating consequences. We investigated long-term mortality rates, causes of death and predictors of long-term mortality in young spontaneous ICH survivors.

Patients And Methods: We included consecutive patients aged 18-55 years from the Prognosis of Intracerebral Haemorrhage cohort (PITCH), a prospective observational cohort of patients admitted to Lille University Hospital (2004-2009), who survived at least 30 days after spontaneous ICH. Read More

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NTRK oncogenic fusions are exclusively associated with the serrated neoplasia pathway in the colorectum and begin to occur in sessile serrated lesions.

J Pathol 2021 Aug 17. Epub 2021 Aug 17.

Department of Pathology, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Republic of Korea.

Neurotrophic tropomyosin receptor kinase (NTRK) gene fusions are emerging tissue-agnostic drug targets in malignancies including colorectal carcinomas (CRCs), but their detailed landscape in the context of various colorectal carcinogenesis pathways remains to be investigated. In this study, pan-tropomyosin receptor kinase (TRK) protein expression was assessed by immunohistochemistry (IHC) in retrospectively collected colorectal epithelial tumor tissues, including 441 CRCs [133 microsatellite instability-high (MSI-high) and 308 microsatellite stable (MSS)] and 595 premalignant colorectal lesions (330 serrated lesions and 265 conventional adenomas). TRK-positive cases were then subjected to next-generation sequencing and/or fluorescence in situ hybridization to confirm NTRK rearrangements. Read More

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Mutation and methylation profiles of ectopic and eutopic endometrial tissues.

J Pathol 2021 Aug 16. Epub 2021 Aug 16.

Department of Gynecology and Obstetrics, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

Adenomyosis and peritoneal endometriosis are common gynecologic lesions; they are characterized by aberrant locations of normal-appearing endometrium in myometrium and peritoneal surface, respectively. Both ectopic lesions are speculated to originate from uterine eutopic endometrium, which is composed of epithelium and stroma, but how these two different tissue types co-evolve in ectopic locations remains unclear. Here, we analyzed exome-wide mutations and global methylation in microdissected epithelium and stroma separately in paired adenomyosis, peritoneal endometriosis, and endometrium to investigate their relationship. Read More

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Insulin-degrading enzyme: an ally against metabolic and neurodegenerative diseases.

J Pathol 2021 Aug 16. Epub 2021 Aug 16.

CEDOC, NOVA Medical School, NMS, Universidade Nova de Lisboa, Lisbon, Portugal.

Insulin-degrading enzyme (IDE) function goes far beyond its known proteolytic role as a regulator of insulin levels. IDE has a wide substrate promiscuity, degrading several proteins such as amyloid-β peptide, glucagon, islet amyloid polypeptide (IAPP), and insulin-like growth factors, which have diverse physiological and pathophysiological functions. Importantly, IDE plays other non-proteolytic functions such as: a chaperone/dead-end chaperone, an E1-ubiquitin activating enzyme, and a proteasome modulator. Read More

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The loss of histone deacetylase 4 in macrophages exacerbates hepatic and adipose tissue inflammation in male but not in female mice with diet-induced non-alcoholic steatohepatitis.

J Pathol 2021 Jul 19. Epub 2021 Jul 19.

Department of Nutritional Sciences, University of Connecticut, Storrs, CT, USA.

Epigenetic regulation in macrophages plays a crucial role in the inflammatory response of cells. We investigated the role of macrophage histone deacetylase 4 (HDAC4) in diet-induced obesity and non-alcoholic steatohepatitis using macrophage-specific Hdac4 knockout mice (Hdac4 ). Hdac4 floxed control (Hdac4 ) and Hdac4 mice were fed a regular chow diet or an obesogenic high-fat/high-sucrose/high-cholesterol (HF/HS/HC) diet for 12 weeks. Read More

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Urinary FABP1 is a biomarker for impaired proximal tubular protein reabsorption and is synergistically enhanced by concurrent liver injury.

J Pathol 2021 Aug 9. Epub 2021 Aug 9.

Department of Cardiovascular Medicine, Gunma University Graduate School of Medicine, Maebashi, Japan.

Urinary fatty acid binding protein 1 (FABP1, also known as liver-type FABP) has been implicated as a biomarker of acute kidney injury (AKI) in humans. However, the precise biological mechanisms underlying its elevation remain elusive. Here, we show that urinary FABP1 primarily reflects impaired protein reabsorption in proximal tubule epithelial cells (PTECs). Read More

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Calcyphosine promotes the proliferation of glioma cells and serves as a potential therapeutic target.

J Pathol 2021 Aug 9. Epub 2021 Aug 9.

Institute of Pathology and Southwest Cancer Center, Southwest Hospital, Third Military Medical University (Army Medical University) and Key Laboratory of Tumor Immunopathology, Ministry of Education of China, Chongqing, PR China.

Calcyphosine (CAPS) was initially identified from the canine thyroid. It also exists in many types of tumor, but its expression and function in glioma remain unknown. Here we explored the clinical significance and the functional mechanisms of CAPS in glioma. Read More

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Effects of flooding cultivation on the composition and quality of taro (Colocasia esculenta cv. Daikichi).

J Sci Food Agric 2021 Aug 6. Epub 2021 Aug 6.

Course of Biological Science & Technology, The United Graduate School of Agricultural Sciences, Kagoshima University, Kagoshima, Japan.

Background: Taro (Colocasia esculenta cv. Daikichi) is believed to be one of the earliest cultivated tuber crops and it is a staple food in many parts of the world. The mother corm and side cormels (daughter and granddaughter tubers) form the major consumed parts; however, the former is rarely preferred. Read More

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Cripto favors chondrocyte hypertrophy via TGF-β SMAD1/5 signaling during development of osteoarthritis.

J Pathol 2021 Aug 6. Epub 2021 Aug 6.

Department of Cell and Chemical Biology, Leiden University Medical Center, Oncode Institute, Leiden, The Netherlands.

Chondrocytes in mice developing osteoarthritis (OA) exhibit an aberrant response to the secreted cytokine transforming growth factor (TGF)-β, consisting in a potentiation of intracellular signaling downstream of the transmembrane type I receptor kinase activin receptor-like kinase (ALK)1 against canonical TGF-β receptor ALK5-mediated signaling. Unfortunately, the underlying mechanisms remain elusive. In order to identify novel druggable targets for OA, we aimed to investigate novel molecules regulating the ALK1/ALK5 balance in OA chondrocytes. Read More

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Weakly supervised learning on unannotated H&E-stained slides predicts BRAF mutation in thyroid cancer with high accuracy.

J Pathol 2021 Aug 4. Epub 2021 Aug 4.

Department of Electrical Engineering, Indian Institute of Technology Bombay, Mumbai, India.

Deep neural networks (DNNs) that predict mutational status from H&E slides of cancers can enable inexpensive and timely precision oncology. Although expert knowledge is reliable for annotating regions informative of malignancy and other known histologic patterns (strong supervision), it is unreliable for identifying regions informative of mutational status. This poses a serious impediment to obtaining higher prognostic accuracy and discovering new knowledge of pathobiology. Read More

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The mechanisms of smell loss after SARS-CoV-2 infection.

Authors:
Richard L Doty

Lancet Neurol 2021 09 30;20(9):693-695. Epub 2021 Jul 30.

Smell and Taste Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address:

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September 2021

Infiltration of NK and plasma cells is associated with a distinct immune subset in non-small cell lung cancer.

J Pathol 2021 Aug 2. Epub 2021 Aug 2.

Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden.

Immune cells of the tumor microenvironment are central but erratic targets for immunotherapy. The aim of this study was to characterize novel patterns of immune cell infiltration in non-small cell lung cancer (NSCLC) in relation to its molecular and clinicopathologic characteristics. Lymphocytes (CD3+, CD4+, CD8+, CD20+, FOXP3+, CD45RO+), macrophages (CD163+), plasma cells (CD138+), NK cells (NKp46+), PD1+, and PD-L1+ were annotated on a tissue microarray including 357 NSCLC cases. Read More

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FOXL2 in adult-type granulosa cell tumour of the ovary: oncogene or tumour suppressor gene?

J Pathol 2021 Aug 2. Epub 2021 Aug 2.

Université de Paris, Paris, France.

A recurrent mutation in FOXL2 (c.402C>G; p.C134W) is present in over 95% of adult-type granulosa cell tumours (AGCTs). Read More

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Clinical ApoA-IV amyloid is associated with fibrillogenic signal sequence.

J Pathol 2021 Jul 31. Epub 2021 Jul 31.

Wolfson Drug Discovery Unit, Centre for Amyloidosis and Acute Phase Proteins, Division of Medicine, University College London, London, UK.

Apolipoprotein A-IV amyloidosis is an uncommon form of the disease normally resulting in renal and cardiac dysfunction. ApoA-IV amyloidosis was identified in 16 patients attending the National Amyloidosis Centre and in eight clinical samples received for histology review. Unexpectedly, proteomics identified the presence of ApoA-IV signal sequence residues (p. Read More

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Fresh pomegranate juices from cultivars and local ecotypes grown in southeastern Italy: comparison of physicochemical properties, antioxidant activity and bioactive compounds.

J Sci Food Agric 2021 Jul 30. Epub 2021 Jul 30.

Department of Soil, Plant and Food Science (DISSPA), University of Bari Aldo Moro, Bari, Italy.

Background: Pomegranate juice has gained attention for its health properties, becoming consequently a highly demanded product. The revival of the pomegranate in Italy, as in other Mediterranean countries, starts with the planting of new intensive orchards characterized by both the new cultivation technique and new varieties. As a result of growing demand and high productivity, pomegranate could become an interesting crop to diversify farm income. Read More

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Fermented goat's milk modulates immune response during iron deficiency anemia recovery.

J Sci Food Agric 2021 Jul 30. Epub 2021 Jul 30.

Department of Physiology, University of Granada, Granada, Spain.

Background: Iron deficiency and iron overload can affect the normal functioning of the innate and adaptive immune responses. Fermented milk products may enhance immune functions, but little is known about the effect of fermented milks on modulation of the immune response during iron deficiency anemia and recovery with normal or high dietary iron intake. Eighty male Wistar rats were randomly assigned to a control group fed a standard diet or to an anemic group fed a diet deficit in iron. Read More

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Acceleration of lipid oxidation in raw stored almond kernels in response to postharvest moisture exposure.

J Sci Food Agric 2021 Jul 30. Epub 2021 Jul 30.

Department of Food Science and Technology, University of California, Davis, Davis, CA, USA.

Background: Almonds are an important crop in California, and increased yields necessitate that dried in-hull almonds are stored in the field for longer periods, increasing the potential for postharvest moisture exposure (e.g., rain, fog). Read More

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Retraction: Rubral modulation of breathing.

Authors:

Exp Physiol 2020 Nov 13;105(11):1971. Epub 2020 Oct 13.

Retraction: [Ghali, M., 2019. Rubral modulation of breathing. Read More

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November 2020

Retraction: Control of hypoglossal pre-inspiratory discharge.

Authors:

Exp Physiol 2020 Nov 13;105(11):1972. Epub 2020 Oct 13.

Retraction: [Ghali, M., 2020. Control of hypoglossal pre-inspiratory discharge. Read More

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November 2020

Retraction: CD248 as a novel therapeutic target in pulmonary arterial hypertension.

Authors:

Clin Transl Med 2021 Jul;11(7):e488

The following article from Clinical and Translational Medicine, "CD248 as a novel therapeutic target in pulmonary arterial hypertension" by Tao Xu, Lei Shao, Aimei Wang, Rui Liang, Yuhan Lin, GuanWang, Yan Zhao, Jing Hu, and Shuangyue Liu, published online on September 17, 2020 in Wiley Online Library (wileyonlinelibrary.com), has been retracted by agreement between the authors, the journal Editor-in-Chief, Xiangdong Wang and John Wiley & Sons, Ltd. The retraction has been agreed due to duplicate use of figures and data in the article. Read More

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A multi-ethnic analysis of immune-related gene expression signatures in patients with ovarian clear cell carcinoma.

J Pathol 2021 Jul 28. Epub 2021 Jul 28.

School of Medicine, College of Medicine, National Taiwan University, Taipei, Taiwan.

Little is known about the immune environment of ovarian clear cell carcinoma (OCCC) and its impact on various ethnic backgrounds. The aim of this OCCC immune-related gene expression signatures (irGES) study was to address the interaction between tumour and immune environment of ethnically-diverse Asian and Caucasian populations and to identify relevant molecular subsets of biological and clinical importance. Our study included 264 women from three different countries (Singapore, Japan, and the UK) and identified four novel immune subtypes (PD1-high, CTLA4-high, antigen-presentation, and pro-angiogenic subtype) with differentially expressed pathways, and gene ontologies using the NanoString nCounter PanCancer Immune Profiling Panel. Read More

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Steady-State Pre-rRNA Analysis to Investigate the Functional Microbiome.

Curr Protoc 2021 Jul;1(7):e209

Department of Environmental and Occupational Health Sciences, University of Washington, Seattle, Washington.

The gut microbiome is recognized as a critical regulator of human diseases. Constituents of the microbiota and their individual activities can affect a broad range of disease states related to autoimmunity, cancer, infection, metabolism, mental health, and toxicant exposure. A substantial number of microbiome species are not culturable, limiting their study in vitro. Read More

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DSCR1 upregulation enhances dural meningeal lymphatic drainage to attenuate amyloid pathology of Alzheimer's disease.

J Pathol 2021 Jul 26. Epub 2021 Jul 26.

Department of Biological Sciences, College of Information and Biotechnology, Ulsan National Institute of Science and Technology, Ulsan, Republic of Korea.

Highly developed meningeal lymphatics remove waste products from the brain. Disruption of meningeal lymphatic vessels in a mouse model of amyloid pathology (5XFAD) accelerates the accumulation of amyloid plaques in the meninges and brain, and causes learning and memory deficits, suggesting that clearance of toxic wastes by lymphatic vessels plays a key role in neurodegenerative diseases. Here, we discovered that DSCR1 (Down syndrome critical region 1, known also as RCAN1, regulator of calcineurin 1) facilitates the drainage of waste products by increasing the coverage of dorsal meningeal lymphatic vessels. Read More

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Deletion of mTOR in liver epithelial cells enhances hepatic metastasis of colon cancer.

J Pathol 2021 Jul 26. Epub 2021 Jul 26.

Department of General, Visceral- and Transplantation Surgery, RWTH University Hospital, Aachen, Germany.

Activation of the mechanistic target of rapamycin (mTOR) pathway is frequently found in cancer, but mTOR inhibitors have thus far failed to demonstrate significant antiproliferative efficacy in the majority of cancer types. Besides cancer cell-intrinsic resistance mechanisms, it is conceivable that mTOR inhibitors impact on non-malignant host cells in a manner that ultimately supports resistance of cancer cells. Against this background, we sought to analyze the functional consequences of mTOR inhibition in hepatocytes for the growth of metastatic colon cancer. Read More

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