21,759 results match your criteria wide markers

Cyclotide host-defense tailored for species and environments in violets from the Canary Islands.

Sci Rep 2021 Jun 14;11(1):12452. Epub 2021 Jun 14.

Department of Pharmaceutical Biosciences, Pharmacognosy, Uppsala University, Biomedical Centre (BMC) 574, 75123, Uppsala, Sweden.

Cyclotides are cyclic peptides produced by plants. Due to their insecticidal properties, they are thought to be involved in host defense. Violets produce complex mixtures of cyclotides, that are characteristic for each species and variable in different environments. Read More

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Prognostic value of inflammatory markers in patients with COVID-19 in Indonesia.

Clin Epidemiol Glob Health 2021 Jul-Sep;11:100803. Epub 2021 Jun 8.

Department of Microbiology, Faculty of Medicine, Pelita Harapan University, Tangerang, Indonesia.

Background & Aims: Coronavirus disease 2019 (COVID-19) has a wide clinical spectrum, ranging from asymptomatic infection to severe diseases with high mortality rate. Early identification of high-risk COVID-19 patients may be beneficial to reduce morbidity and in-hospital mortality. This study aimed to investigate whether baseline levels of inflammatory markers such as C-reactive protein (CRP) and immune-cell-based inflammatory indices, neutrophil to lymphocyte ratio (NLR), derived-NLR (d-NLR), and platelet to lymphocyte ratio (PLR) at hospital admission are associated with adverse disease outcomes in COVID-19 patients. Read More

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Genome-Wide Association Study of Kernel Traits in .

Front Genet 2021 28;12:651785. Epub 2021 May 28.

State Key Laboratory of Crop Gene Exploration and Utilization in Southwest China, Chengdu, China.

is the diploid progenitor of the D subgenome of hexaploid wheat (ivum L.). Here, the phenotypic data of kernel length (KL), kernel width (KW), kernel volume (KV), kernel surface area (KSA), kernel width to length ratio (KWL), and hundred-kernel weight (HKW) for 223 accessions were gathered across three continuous years. Read More

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Contour Map Point Distribution and Surgeon Experience Level Affect Accuracy of Surgical Navigation in a Pilot Study.

Ann Otol Rhinol Laryngol 2021 Jun 13:34894211005982. Epub 2021 Jun 13.

Department of Otorhinolaryngology-Head and Neck Surgery, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, TX, USA.

Background: Reliable use of surgical navigation depends upon the registration process. The gold standard is paired-point registration with bone-anchored fiducials, but contour-map registration is more practical. Surgeons may employ variable contour maps and less experienced team members often perform this critical step. Read More

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Silica and secondary metabolites as chemophenetic markers for characterization of bamboo species in relation to genetic and morphometric analysis.

Mol Biol Rep 2021 Jun 11. Epub 2021 Jun 11.

Environmental Biotechnology and Genomics Division, CSIR-National Environmental Engineering Research Institute, Nehru Marg, Nagpur, 440020, India.

Bamboo is a non-timber forest product and one of the most important grass plants of industrial and domestic use. It is widely distributed in tropical countries including India, China and Southeast Asian countries with wide genetic diversity. The diversity in the available genotypes becomes an important resource for the selection and improvement of the plants for ecological and commercial use. Read More

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Genetic diversity and inter-trait relationship of tropical extra-early maturing quality protein maize inbred lines under low soil nitrogen stress.

PLoS One 2021 11;16(6):e0252506. Epub 2021 Jun 11.

West Africa Centre for Crop Improvement, University of Ghana, Legon, Ghana.

Information on the genetic diversity, population structure, and trait associations of germplasm resources is crucial for predicting hybrid performance. The objective of this study was to dissect the genetic diversity and population structure of extra-early yellow and orange quality protein maize (QPM) inbred lines and identify secondary traits for indirect selection for enhanced grain yield under low-soil nitrogen (LN). One hundred and ten inbred lines were assessed under LN (30 kg ha -1) and assayed for tryptophan content. Read More

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WheatQTLdb: a QTL database for wheat.

Mol Genet Genomics 2021 Jun 11. Epub 2021 Jun 11.

Department of Genetics and Plant Breeding, Chaudhary Charan Singh University, Meerut, Uttar Pradesh, 250004, India.

During the last three decades, QTL analysis in wheat has been conducted for a variety of individual traits, so that thousands of QTL along with the linked markers, their genetic positions and contribution to phenotypic variation (PV) for concerned traits are now known. However, no exhaustive database for wheat QTL is currently available at a single platform. Therefore, the present database was prepared which is an exhaustive information resource for wheat QTL data from the published literature till May, 2020. Read More

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Depletion of Omega-3 Fatty Acids in RBCs and Changes of Inflammation Markers in Patients With Morbid Obesity Undergoing Gastric Bypass.

J Nutr 2021 Jun 10. Epub 2021 Jun 10.

Hackensack University Medical Center, Hackensack, NJ, USA.

Background: Bariatric surgery is considered the most effective treatment for severe obesity. Despite this wide success, bariatric surgery is associated with increased risks of nutritional deficiencies.

Objectives: To examine whether Roux-en-Y-gastric bypass (RYGB) alters essential fatty acid (FA) status and inflammation markers. Read More

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Identification of Resistance Sources and Genome-Wide Association Mapping of Septoria Tritici Blotch Resistance in Spring Bread Wheat Germplasm of ICARDA.

Front Plant Sci 2021 25;12:600176. Epub 2021 May 25.

Biodiversity and Crop Improvement Program, International Center for Agricultural Research in the Dry Areas, Rabat, Morocco.

Septoria tritici blotch (STB) of wheat, caused by the ascomycete (formerly ), is one of the most important foliar diseases of wheat. In Morocco, STB is a devastating disease in temperate wheat-growing regions, and the yield losses can exceed up to 50% under favorable conditions. The aims of this study were to identify sources of resistance to STB in Septoria Association Mapping Panel (SAMP), which is composed of 377 advanced breeding lines (ABLs) from spring bread wheat breeding program of ICARDA, and to identify loci associated with resistance to STB at seedling (SRT) as well as at the adult plant (APS) stages using genome-wide association mapping (GWAM). Read More

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Corona Virus Disease-19 serology, inflammatory markers, hospitalizations, case finding, and aging.

PLoS One 2021 10;16(6):e0252818. Epub 2021 Jun 10.

Research Division, Diazyme Laboratories, Inc., Poway, California, United States of America.

Most deaths from severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection occur in older subjects. We assessed the utility of serum inflammatory markers interleukin-6 (IL-6), C reactive protein (CRP), and ferritin (Roche, Indianapolis, IN), and SARS-CoV-2 immunoglobulin G (IgG), immunoglobulin M (IgM), and neutralizing antibodies (Diazyme, Poway, CA). In controls, non-hospitalized subjects, and hospitalized subjects assessed for SARS-CoV-2 RNA (n = 278), median IgG levels in arbitrary units (AU)/mL were 0. Read More

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Nanoplastics Identification in Complex Environmental Matrices: Strategies for Polystyrene and Polypropylene.

Environ Sci Technol 2021 Jun 10. Epub 2021 Jun 10.

Géosciences, CNRS/Université Rennes 1, UMR 6118, F35000 Rennes, France.

Identification of nanoplastics in complex environmental matrices remains a challenge. Despite the increase in nanoplastics studies, there is a lack of studies dedicated to nanoplastics detection, partially explained by their carbon-based structure, their wide variety of composition, and their low environmental concentrations compared to the natural organic matter. Here, pyrolysis coupled to a GCMS instrumental setup provided a relevant analytical response for polypropylene and polystyrene nanoplastic suspensions. Read More

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Induction of alveolar and bronchiolar phenotypes in human lung organoids.

Physiol Rep 2021 Jun;9(11):e14857

Department of Clinical Science, Faculty of Medicine, University of Bergen, Bergen, Norway.

Patient-derived organoids have revolutionized biomedical research and therapies by "transferring the patient into the Petri dish". In vitro access to human lung organoids representing distal lung tissue, i.e. Read More

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SNP detection and population structure evaluation of Y. L. Chang et Skv. in Hunshandake Sandland, Inner Mongolia, China.

Physiol Mol Biol Plants 2021 May 24;27(5):997-1005. Epub 2021 Apr 24.

Faculty of Resources and Environment, Baotou Teachers' College, Inner Mongolia University of Science and Technology, Baotou, 014030 China.

Single nucleotide polymorphisms (SNPs) are the most abundant and richest form of genomic polymorphism and, hence, are highly favorable markers for genetic map construction and genome-wide association studies. Based on the DNA specific-locus amplified fragment sequencing (SLAF-seq) for large-scale SNP detection, the genetic diversity and population structure of Y. L. Read More

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Genetic dissection of natural variation in oilseed traits of camelina by whole-genome resequencing and QTL mapping.

Plant Genome 2021 Jun 9:e20110. Epub 2021 Jun 9.

Department of Plant Sciences and Plant Pathology, Montana State University, Bozeman, MT, 59717, USA.

Camelina [Camelina sativa (L.) Crantz] is an oilseed crop in the Brassicaceae family that is currently being developed as a source of bioenergy and healthy fatty acids. To facilitate modern breeding efforts through marker-assisted selection and biotechnology, we evaluated genetic variation among a worldwide collection of 222 camelina accessions. Read More

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An updated Axiom buffalo genotyping array map and mapping of cattle quantitative trait loci to the new water buffalo reference genome assembly.

Anim Genet 2021 Jun 9. Epub 2021 Jun 9.

Department of Animal Science, São Paulo State University, Jaboticabal, 14884900, Brazil.

The objectives of this study were to provide the buffalo research community with an updated SNP map for the Axiom Buffalo Genotyping (ABG) array with genomic positions for SNP currently unmapped and to map all cattle QTL from the CattleQTLdb onto the buffalo reference assembly. To update the ABG array map, all SNP probe sequences from the ABG array were re-aligned against the UOA_WB_1 assembly. With the new map, the number of mapped markers increased by approximately 10% and went from 106 778 to 116 708, which reduced the average marker spacing by approximately 2 kb. Read More

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Fitness and mating compatibility of Chrysodeixis includens (W.) (Lepidoptera: Noctuidae) populations collected in different provinces and crops in Argentina.

An Acad Bras Cienc 2021 4;93(2):e20190523. Epub 2021 Jun 4.

Estación Experimental Agroindustrial Obispo Colombres/EEAOC, William Cross 3150, 4101, Las Talitas, Tucumán, Argentina.

Chrysodeixis includens, is an important Plusiinae pest that feeds on soybean, beans, and cotton. This species has a genetic structure determined by molecular markers in populations collected in soybean crops in Brazil and has developed resistance to insecticides. This had led to an increased interest in the genetic diversity of its populations in Argentina. Read More

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Comparative phytochemistry of flavaglines (= rocaglamides), a group of highly bioactive flavolignans from species (Meliaceae).

Harald Greger

Phytochem Rev 2021 Jun 4:1-40. Epub 2021 Jun 4.

Chemodiversity Research Group, Faculty of Life Sciences, University of Vienna, Rennweg 14, 1030 Wien, Austria.

Flavaglines are formed by cycloaddition of a flavonoid nucleus with a cinnamic acid moiety representing a typical chemical character of the genus of the family Meliaceae. Based on biosynthetic considerations 148 derivatives are grouped together into three skeletal types representing 77 cyclopenta[]benzofurans, 61 cyclopenta[]benzopyrans, and 10 benzo[]oxepines. Apart from different hydroxy, methoxy, and methylenedioxy groups of the aromatic rings, important structural variation is created by different substitutions and stereochemistries of the central cyclopentane ring. Read More

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The GEnetic Syntax Score: a genetic risk assessment implementation tool grading the complexity of coronary artery disease-rationale and design of the GESS study.

BMC Cardiovasc Disord 2021 Jun 8;21(1):284. Epub 2021 Jun 8.

Department of Cardiology, AHEPA University Hospital, Aristotle University of Thessaloniki, St. Kiriakidi 1, 54636, Thessaloniki, Greece.

Background: Coronary artery disease (CAD) remains one of the leading causes of mortality worldwide and is associated with multiple inherited and environmental risk factors. This study is designed to identify, design, and develop a panel of genetic markers that combined with clinical and angiographic information, will facilitate the creation of a personalized risk prediction algorithm (GEnetic Syntax Score-GESS). GESS score could be a reliable tool for predicting cardiovascular risk for future adverse events and for guiding therapeutic strategies. Read More

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extract promotes M2 polarization and reduces oligomeric amyloid-β-induced inflammatory reactions in microglial cells.

Neural Regen Res 2022 Jan;17(1):203-209

Department of Ophthalmology, Li Ka Shing Faculty of Medicine; State Key Laboratory of Brain and Cognitive Sciences, The University of Hong Kong, Hong Kong Special Administrative Region, China.

Lycium barbarum (LB) is a traditional Chinese medicine that has been demonstrated to exhibit a wide variety of biological functions, such as antioxidation, neuroprotection, and immune modulation. One of the main mechanisms of Alzheimer's disease is that microglia activated by amyloid beta (Aβ) transform from the resting state to an M1 state and release pro-inflammatory cytokines to the surrounding environment. In the present study, immortalized microglial cells were pretreated with L. Read More

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January 2022

Common variants in Alzheimer's disease and risk stratification by polygenic risk scores.

Nat Commun 2021 06 7;12(1):3417. Epub 2021 Jun 7.

Servei de Neurologia, Hospital Universitari i Politècnic La Fe, Valencia, Spain.

Genetic discoveries of Alzheimer's disease are the drivers of our understanding, and together with polygenetic risk stratification can contribute towards planning of feasible and efficient preventive and curative clinical trials. We first perform a large genetic association study by merging all available case-control datasets and by-proxy study results (discovery n = 409,435 and validation size n = 58,190). Here, we add six variants associated with Alzheimer's disease risk (near APP, CHRNE, PRKD3/NDUFAF7, PLCG2 and two exonic variants in the SHARPIN gene). Read More

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Genome-wide characterization of microsatellite DNA in fishes: survey and analysis of their abundance and frequency in genome-specific regions.

BMC Genomics 2021 Jun 7;22(1):421. Epub 2021 Jun 7.

Sichuan Key Laboratory of Conservation Biology on Endangered Wildlife, College of Life Sciences, Sichuan University, Chengdu, 610065, People's Republic of China.

Background: Microsatellite repeats are ubiquitous in organism genomes and play an important role in the chromatin organization, regulation of gene activity, recombination and DNA replication. Although microsatellite distribution patterns have been studied in most phylogenetic lineages, they are unclear in fish species.

Results: Here, we present the first systematic examination of microsatellite distribution in coding and non-coding regions of 14 fish genomes. Read More

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Uncovering the shared lipidomic markers of subclinical osteoporosis-atherosclerosis comorbidity: The Young Finns Study.

Bone 2021 Jun 5;151:116030. Epub 2021 Jun 5.

Department of Clinical Chemistry, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland; Finnish Cardiovascular Research Centre, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland; Department of Clinical Chemistry, Fimlab Laboratories, Tampere, Finland.

Background: Osteoporosis and atherosclerosis are complex multifactorial diseases sharing common risk factors and pathophysiological mechanisms suggesting that these are comorbidities. Omics studies identifying joint molecular markers associated with these diseases are sparse.

Subjects And Methods: Using liquid chromatography-tandem mass spectrometry, we quantified 437 molecular lipid species from the Young Finns Study cohort (aged 30-45 years and 57% women) and performed lipidome-wide multivariate analysis of variance (MANOVA) with early markers for both diseases. Read More

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Replicating a GWAS: two novel candidate markers for oligospermia in Greek population.

Mol Biol Rep 2021 Jun 7. Epub 2021 Jun 7.

Laboratory of Genetics, Comparative and Evolutionary Biology, Department of Biochemistry and Biotechnology, University of Thessaly, Larisa, Greece.

Genome-wide association studies have paved the way for the discovery of new markers regarding many diseases, including male infertility. A previous study on Caucasians highlighted 172 polymorphisms for their putative association with male infertility and we attempted to replicate these findings on our dataset comprising of Greek male individuals (n = 360). We retrieved 59 out of 172 polymorphisms and tested for all association models on 278 normospermic men and 82 patients with an abnormal seminogram, later separated into oligozoospermic and asthenozoospermic groups. Read More

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Single-marker and haplotype-based genome-wide association studies for the number of teats in two heavy pig breeds.

Anim Genet 2021 Jun 6. Epub 2021 Jun 6.

Department of Agricultural and Food Sciences, Division of Animal Sciences, University of Bologna, Viale Fanin 46, Bologna, 40127, Italy.

The number of teats is a reproductive-related trait of great economic relevance as it affects the mothering ability of the sows and thus the number of properly weaned piglets. Moreover, genetic improvement of this trait is fundamental to parallelly help the selection for increased litter size. We present the results of single-marker and haplotypes-based genome-wide association studies for the number of teats in two large cohorts of heavy pig breeds (Italian Large White and Italian Landrace) including 3990 animals genotyped with the 70K GGP Porcine BeadChip and other 1927 animals genotyped with the Illumina PorcineSNP60 BeadChip. Read More

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Genome-Wide Detection of Copy Number Variations and Their Association With Distinct Phenotypes in the World's Sheep.

Front Genet 2021 20;12:670582. Epub 2021 May 20.

College of Animal Science and Technology, China Agricultural University, Beijing, China.

Copy number variations (CNVs) are a major source of structural variation in mammalian genomes. Here, we characterized the genome-wide CNV in 2059 sheep from 67 populations all over the world using the Ovine Infinium HD (600K) SNP BeadChip. We tested their associations with distinct phenotypic traits by conducting multiple independent genome-wide tests. Read More

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Plasmodium falciparum resistance to ACTs: Emergence, mechanisms, and outlook.

Int J Parasitol Drugs Drug Resist 2021 May 26;16:102-118. Epub 2021 May 26.

Department of Internal Medicine, University of South Florida, Tampa, FL, 33612, USA. Electronic address:

Emergence and spread of resistance in Plasmodium falciparum to the frontline treatment artemisinin-based combination therapies (ACTs) in the epicenter of multidrug resistance of Southeast Asia threaten global malaria control and elimination. Artemisinin (ART) resistance (or tolerance) is defined clinically as delayed parasite clearance after treatment with an ART drug. The resistance phenotype is restricted to the early ring stage and can be measured in vitro using a ring-stage survival assay. Read More

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Unveiling the composition of historical plastics through non-invasive reflection FT-IR spectroscopy in the extended near- and mid-Infrared spectral range.

Anal Chim Acta 2021 Jul 10;1169:338602. Epub 2021 May 10.

CNR-SCITEC, Via Elce di Sotto, 8, Perugia, Italy.

The present research exploits the strengths of external reflection FT-IR spectroscopy to non-invasively study heritage plastic objects through inspection, for the first time, of the wide spectral range including the near- and mid-IR (12500-350 cm). Unlike most of previous works on historical plastic objects, reflection-mode spectra were not corrected for the unfamiliar surface reflection profiles to the more recognizable absorption-like band shapes. This avoided data misinterpretation due to ill-suited Kramers Krönig correction when volume reflection is also present or when highly absorbing IR compounds generate Reststrahlen bands. Read More

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NK-lysin peptides ameliorate viral encephalopathy and retinopathy disease signs and provide partial protection against nodavirus infection in European sea bass.

Antiviral Res 2021 Jun 1;192:105104. Epub 2021 Jun 1.

Immunobiology for Aquaculture Group, Department of Cell Biology and Histology, Faculty of Biology, Regional Campus of International Excellence "Campus Mare Nostrum", University of Murcia, 30100, Murcia, Spain. Electronic address:

Antimicrobial peptides (AMP) comprise a wide range of small molecules with direct antibacterial activity and immunostimulatory role and are proposed as promising substitutes of the antibiotics. Additionally, they also exert a role against other pathogens such as viruses and fungi less evaluated. NK-lysin, a human granulysin orthologue, possess a double function, taking part in the innate immunity as AMP and also as direct effector in the cell-mediated cytotoxic (CMC) response. Read More

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Proximity with limited humanity: How hosting a tent city impacted college students' perceptions of individuals experiencing homelessness.

J Community Psychol 2021 Jun 4. Epub 2021 Jun 4.

School of Psychology Family and Community, Seattle Pacific University, Seattle, Washington, USA.

The current manuscript assessed the impact of a community intervention-hosting a government-sanctioned homeless encampment-on perceptions of individuals experiencing homelessness. College students' perceptions of individuals experiencing homelessness were collected before and after a tent city resided on campus. Perceptions were assessed utilizing a measure of dehumanization that probed the presumed importance of physiological and psychological needs. Read More

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Candidalysin triggers epithelial cellular stresses that induce necrotic death.

Cell Microbiol 2021 Jun 3:e13371. Epub 2021 Jun 3.

Centre for Host-Microbiome Interactions, Faculty of Dentistry, Oral & Craniofacial Sciences, King's College London, London, UK.

Candida albicans is a common opportunistic fungal pathogen that causes a wide range of infections from superficial mucosal to hematogenously disseminated candidiasis. The hyphal form plays an important role in the pathogenic process by invading epithelial cells and causing tissue damage. Notably, the secretion of the hyphal toxin candidalysin is essential for both epithelial cell damage and activation of mucosal immune responses. Read More

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