1,376 results match your criteria wide lumen

Sclerosing polycystic adenosis of the submandibular gland: Two case reports.

World J Clin Cases 2021 Apr;9(12):2930-2936

Department of Stomatology, Tongji Hospital of Tongji Medical College of Huazhong University of Science and Technology, Wuhan 430000, Hubei Province, China.

Background: Sclerosing polycystic adenosis (SPA) is a rare disease of salivary glands, similar to fibrocystic disease of the breast. It occurs over a wide age range and exhibits a slight female preference. Most SPA cases have occurred in the parotid gland. Read More

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A study on the transport and interaction between blood flow and low-density-lipoprotein in near-wall regions of blood vessels.

Comput Methods Biomech Biomed Engin 2021 May 8:1-15. Epub 2021 May 8.

Department of Applied Mechanics, Indian Institute of Technology Madras, Chennai, India.

Differences in the dynamics and transport of blood make certain regions of the arterial network the preferred sites for initiation and formation of arterial diseases like stenosis and aneurysms. Understanding of such arterial diseases is directly linked to critical hemodynamic parameters such as the wall shear stress (WSS). The present work generalises the influence of WSS on the concentration of LDL that was observed in an earlier study. Read More

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Laryngeal cleft: A literature review.

Am J Otolaryngol 2021 Apr 20;42(6):103072. Epub 2021 Apr 20.

Department of Otolaryngology - Head and Neck Surgery, Drexel University College of Medicine, United States of America; Lankenau Institute for Medical Research, United States of America. Electronic address:

Introduction: Laryngeal cleft is a congenital condition in which an opening in the posterior laryngotracheal wall allows food and liquid to pass from the esophageal lumen to the airway and causes aspiration. The severity of a laryngeal cleft is measured using the Benjamin-Inglis system, and can be managed conservatively or with a variety of surgical options With increased awareness, higher suspicion among primary physicians, advanced technology and improved intensive neonatal care services, more babies with laryngeal clefts survive in the modern era. Therefore, the focus has shifted from infant survival to treatment of laryngeal clefts and the challenging, complex medical conditions they create. Read More

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[Roles of Zinc Transporters That Control the Essentiality and Toxicity of Manganese and Cadmium].

Yakugaku Zasshi 2021 ;141(5):695-703

Faculty of Pharmaceutical Sciences, Tokushima Bunri University.

Cellular transport systems for both essential and toxic trace elements remain elusive. In our studies on the transport systems for cadmium (Cd), we found that the cellular uptake of Cd is mediated by the transporter for manganese (Mn). We identified ZIP8 and ZIP14, members of the ZIP zinc (Zn) transporter family, as transporters having high affinities for both Cd and Mn. Read More

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January 2021

A systematic review and meta-analysis on the global prevalence and subtypes distribution of Blastocystis sp. infection in cattle: A zoonotic concern.

Comp Immunol Microbiol Infect Dis 2021 Jun 23;76:101650. Epub 2021 Apr 23.

Gastrointestinal and Liver Diseases Research Center, Guilan University of Medical Sciences, Rasht, Iran. Electronic address:

Blastocystosis is an interesting parasitosis, since the parasitic infection is still seriously neglected and a considerable zoonotic evidence is emerging. Blastocystis sp. infects the intestinal lumen of humans and a wide range of animals, while there is a lack of comprehensive information on Blastocystis epidemiology in cattle worldwide. Read More

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Extrusion-Printing of Multi-Channeled Two-Component Hydrogel Constructs from Gelatinous Peptides and Anhydride-Containing Oligomers.

Biomedicines 2021 Apr 1;9(4). Epub 2021 Apr 1.

Institute of Pharmacy, Pharmaceutical Technology, Faculty of Medicine, University of Leipzig, Eilenburger Straße 15a, 04317 Leipzig, Germany.

The performance of artificial nerve guidance conduits (NGC) in peripheral nerve regeneration can be improved by providing structures with multiple small channels instead of a single wide lumen. 3D-printing is a strategy to access such multi-channeled structures in a defined and reproducible way. This study explores extrusion-based 3D-printing of two-component hydrogels from a single cartridge printhead into multi-channeled structures under aseptic conditions. Read More

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Morphological and molecular characterization of Ceratomyxa xanthopteri n. sp. (Myxosporea: Ceratomyxidae) from the marine ornamental fish Acanthurus xanthopterus Valenciennes 1835 (Acanthuridae) off Vizhinjam coast, Kerala.

Parasitol Res 2021 Apr 29. Epub 2021 Apr 29.

Fish Health Section, Marine Biotechnology Division, Central Marine Fisheries Research Institute, PB No. 1603, North P.O., Ernakulam, Kerala, 682018, India.

A new species of Ceratomyxa infecting the gallbladder of the marine ornamental fish Acanthurus xanthopterus collected from the Vizhinjam coast of Kerala is described. The parasite exhibited a prevalence of 100%. Mature spores recovered from the gallbladder were slightly crescentic with rounded lateral extremities and possessed convex anterior and slightly concave to straight posterior margins. Read More

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A study on risk assessment of effect of hematoxylin dye on cytotoxicity and nephrotoxicity in freshwater fish: Food and water security prospective research.

Saudi J Biol Sci 2021 Apr 20;28(4):2267-2271. Epub 2021 Jan 20.

Department of Zoology, College of Science. King Saud University, Riyadh 11451, Saudi Arabia.

The cytotoxicity in freshwater fishes due to different industrial dyes in industrial effluents is a major worldwide issue. Hematoxylin dye has a wide range of uses in textile industries and laboratories. This study was aimed to evaluate the toxic effects of hematoxylin's sublethal effect in vitro in . Read More

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Functional model of rat thyroid follicles cultured in Matrigel.

Endocr Connect 2021 Apr 1. Epub 2021 Apr 1.

A Boom, Lab Histology, Université Libre de Bruxelles, Bruxelles, 1070, Belgium.

Background: Long term maintenance of functional activity of thyroid cells is an essential requirement for basic in vitro studies on the physiology and pathology of the thyroid. An important prerequisite of thyrocytes' functional activity in vivo and in vitro is their follicle organization.

Aim: This study aimed at developing a method of cultivation of functionally active rat thyroid follicles in Matrigel under three-dimensional conditions. Read More

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The Off-Label Use of a Lumen-Apposing Metal Stent (LAMS) for a Benign Colon Anastomotic Stricture Causing Recurrent Bowel Obstruction in a Patient with Keloids.

Case Rep Gastrointest Med 2021 2;2021:5595518. Epub 2021 Apr 2.

Augusta University, Department of Gastroenterology and Hepatology, 1120 15th Street, Augusta, Georgia, USA.

Anastomotic strictures are a known complication of colorectal surgery. Despite a wide range of medical devices that have been deployed for this complication, outcomes remain challenging. Lumen-apposing metal stents (LAMSs) have recently emerged as a potentially superior therapeutic option. Read More

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Tubularized urethral reconstruction using everted saphenous vein graft in a beagle model.

BMC Urol 2021 Apr 17;21(1):63. Epub 2021 Apr 17.

Department of Urology, The First Affiliated Hospital of Wannan Medical College (Yijishan Hospital of Wannan Medical College), 2 Zheshan West Road, Wuhu, 241000, Anhui Province, China.

Background: A long segment stricture in the anterior urethra is a challenge in urology. We conducted a study to investigate the efficacy of anterior urethral reconstruction using an everted saphenous vein graft (SVG) in a tubular fashion.

Methods: Twelve male beagles were randomly divided into three groups: experimental group (n = 5), control group (n = 5) and normal group (n = 2). Read More

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[Two-stage contralateral combined microvascular and wide-lumen anastomosis inTwo-stage contralateral combined microvascular and wide-lumen anastomosis in a patient with acute ischemic stroke patient with acute ischemic stroke].

Zh Vopr Neirokhir Im N N Burdenko 2021 ;85(2):68-74

Regional Clinical Hospital No. 2, Tyumen, Russia.

Common carotid artery (CCA) thrombosis is a rare cause of ischemic stroke. In available literature, we found no studies devoted to cerebral revascularization for CCA occlusion in acute period of ischemic stroke. Successful treatment of concomitant occlusion of CCA, internal (ICA) and external carotid arteries (ECA) with microvascular anastomoses is very interesting for various specialists. Read More

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[Chronic anastomotic leak after low rectal resection-an unsolved problem?]

Chirurg 2021 Apr 14. Epub 2021 Apr 14.

Allgemein-und Viszeralchirurgie, Theresienkrankenhaus und St. Hedwig-Klinik gGmbH, Bassermannstraße 1, 68165, Mannheim, Deutschland.

There is no generally accepted definition of a chronic anastomotic leak, which often presents as a chronic sinus. The corresponding time interval required from primary anastomotic construction ranges from 2 months to 12 months. Between 2% and 16% of all patients develop this complication after low anterior rectal resection. Read More

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Balloon Endoclamping for Postdissection Infrarenal Aorto-Iliac Aneurysm Repair.

Ann Vasc Surg 2021 Apr 5. Epub 2021 Apr 5.

Lancisi Cardiovascular Center, Vascular Surgery Unit, Ancona, Italy.

Background: Isolated post dissection infrarenal and iliac aneurysm is a rare condition that often requires surgical treatment. Surgical repair should involve the replacement of the aneurysmal segments and a wide fenestration in the residual proximal untreated abdominal aorta. However, in these patients proximal aortic clamping may be challenging. Read More

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rs629301 CELSR2 polymorphism confers a ten-year equivalent risk of critical stenosis assessed by coronary angiography.

Nutr Metab Cardiovasc Dis 2021 05 3;31(5):1542-1547. Epub 2021 Feb 3.

Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties, University of Palermo, Palermo, Italy.

Background And Aims: Novel genetic determinants associated with coronary artery disease (CAD) have been discovered by genome wide association studies. Variants encompassing the CELSR2- PSRC1-SORT1 gene cluster have been associated with CAD. This study is aimed to investigate the rs629301 polymorphism association with the extent of CAD evaluated by coronary angiography (CAG), and to evaluate its associations with an extensive panel of lipid and lipoprotein measurements in a large Italian cohort of 2429 patients. Read More

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Socially Distanced Intercellular Communication: Mechanisms for Extracellular Vesicle Cargo Delivery.

Subcell Biochem 2021 ;97:179-209

University of Cambridge, Metabolic Research Laboratories, Wellcome Trust-Medical Research Council Institute of Metabolic Science, University of Cambridge, Cambridge, UK.

Extracellular vesicles (EVs) are increasingly being recognised as players in intercellular communication within the human body. EVs are nano-sized vesicles that are secreted by virtually all cells, primarily arising from either the plasma membrane or the endocytic system. They contain a wide range of proteins and nucleic acids in their lumen, as well as cell surface proteins on their exterior. Read More

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Mechanistic Drivers of Müllerian Duct Development and Differentiation Into the Oviduct.

Front Cell Dev Biol 2021 8;9:605301. Epub 2021 Mar 8.

MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, United Kingdom.

The conduits of life; the animal oviducts and human fallopian tubes are of paramount importance for reproduction in amniotes. They connect the ovary with the uterus and are essential for fertility. They provide the appropriate environment for gamete maintenance, fertilization and preimplantation embryonic development. Read More

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ER stress in Cardiometabolic Diseases: from Molecular Mechanisms to Therapeutics.

Endocr Rev 2021 Mar 8. Epub 2021 Mar 8.

University of Wyoming College of Health Sciences, Laramie, USA.

The endoplasmic reticulum (ER) hosts linear polypeptides and fosters natural folding of proteins through ER-residing chaperones and enzymes. Failure of the ER to align and compose proper protein architecture leads to accumulation of misfolded/unfolded proteins in the ER lumen, which disturbs ER homeostasis to provoke ER stress. Presence of ER stress initiates the cytoprotective unfolded protein response (UPR) to restore ER homeostasis or instigates a rather maladaptive UPR to promote cell death. Read More

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The ultrastructure of sperm and female sperm storage organs in the water strider Gerris lacustris L. (Heteroptera) and a possible example of genital coevolution.

Arthropod Struct Dev 2021 Mar 6;61:101043. Epub 2021 Mar 6.

Department of Life Sciences, University of Siena, Italy. Electronic address:

The fine structural organization of the male and the female inner reproductive apparatuses of the water-strider Gerris lacustris was studied. The sperm of the species shows a long helicoidal acrosome provided with longitudinal tubules, and a short nucleus. The flagellum is characterized by crescent mitochondrial derivatives and a 9 + 9 + 2 axoneme, as occurs in all Heteroptera. Read More

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Effects of recipient age, heparin release and allogeneic bone marrow-derived stromal cells on vascular graft remodeling.

Acta Biomater 2021 Apr 24;125:172-182. Epub 2021 Feb 24.

Department of Mechanical Engineering, University of Colorado at Boulder, Boulder, CO, United States. Electronic address:

Small-caliber vascular grafts are used in a wide range of clinical conditions. However, there remains a substantial unfulfilled need for readily-available, synthetic vascular grafts with high long-term patency rate. To fulfill the translational goal for bioengineered vascular grafts, important considerations for the pre-clinical evaluation include the graft design, cell incorporation and selection of an animal model. Read More

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Multiseriate cortical sclerenchyma enhance root penetration in compacted soils.

Proc Natl Acad Sci U S A 2021 Feb;118(6)

Department of Plant Science, Pennsylvania State University, University Park, PA 16802;

Mechanical impedance limits soil exploration and resource capture by plant roots. We examine the role of root anatomy in regulating plant adaptation to mechanical impedance and identify a root anatomical phene in maize () and wheat () associated with penetration of hard soil: Multiseriate cortical sclerenchyma (MCS). We characterize this trait and evaluate the utility of MCS for root penetration in compacted soils. Read More

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February 2021

Surgical anatomy of the transcanal infracochlear approach.

Eur Arch Otorhinolaryngol 2021 Feb 3. Epub 2021 Feb 3.

Department of Anatomy, Ankara University School of Medicine, Ankara, Turkey.

Purpose: The objective of this study is to describe the detailed surgical anatomy of the infracochlear approach to prevent complications and to compare the postauricular transcanal microscopic and endoscopic approaches to reach the petrous apex.

Methods: Cadaver heads were dissected using a binocular surgical microscope, endoscopes, and an electric drill. The dimensions of the access field that could be reached and manipulated with surgical instruments and straight drill via postauricular transcanal microscopic and endoscopic approaches were evaluated. Read More

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February 2021

[Tips for Selecting Balloons or Stents for Cerebral Aneurysms: Effective Use of Each Device].

Manabu Shirakawa

No Shinkei Geka 2021 Jan;49(1):111-118

Department of Neurosurgery, Hyogo College of Medicine.

We introduce typical use cases and the appropriate use of balloon catheters and neck bridge stents for coil embolization of cerebral aneurysm. There are two types of balloon catheters: single-lumen and double-lumen catheters. They are also classified into compliant and super-compliant balloons by softness. Read More

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January 2021

A versatile platform for generating engineered extracellular vesicles with defined therapeutic properties.

Mol Ther 2021 May 21;29(5):1729-1743. Epub 2021 Jan 21.

Codiak BioSciences, Cambridge, MA 02140, USA.

Extracellular vesicles (EVs) are an important intercellular communication system facilitating the transfer of macromolecules between cells. Delivery of exogenous cargo tethered to the EV surface or packaged inside the lumen are key strategies for generating therapeutic EVs. We identified two "scaffold" proteins, PTGFRN and BASP1, that are preferentially sorted into EVs and enable high-density surface display and luminal loading of a wide range of molecules, including cytokines, antibody fragments, RNA binding proteins, vaccine antigens, Cas9, and members of the TNF superfamily. Read More

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Cytokine-Mediated Crosstalk between Immune Cells and Epithelial Cells in the Gut.

Cells 2021 Jan 9;10(1). Epub 2021 Jan 9.

Department of Medicine 1, Friedrich-Alexander-University Erlangen-Nuremberg, 91052 Erlangen, Germany.

Cytokines are small proteins that are secreted by a vast majority of cell types in the gut. They not only establish cell-to-cell interactions and facilitate cellular signaling, but also regulate both innate and adaptive immune responses, thereby playing a central role in genetic, inflammatory, and infectious diseases of the gut. Both, immune cells and gut epithelial cells, play important roles in intestinal disease development. Read More

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January 2021

Expanding endoscopic treatment strategies for pancreatic leaks following pancreato-duodenectomy: a single centre experience.

Surg Endosc 2021 Apr 5;35(4):1908-1914. Epub 2021 Jan 5.

Digestive and Interventional Endoscopy Unit, ASST Grande Ospedale Metropolitano Niguarda, Piazza dell'Ospedale Maggiore, 3, 20162, Milan, Italy.

Background And Aim: Clinically relevant pancreatic leaks of jejunal-pancreatic anastomosis after pancreato-duodenectomy (PD) occur in 9-15% of cases. Endoscopic strategies for management of pancreatic fistula, may allow to avoid reoperation and shorten times for fistula closure, but are still understudied and not widely performed. Aim of the present paper is to describe different endoscopic techniques used to treat such conditions. Read More

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A novel method for cannulation of the short limb of aortic stent grafts during endovascular aneurysm repair: Göçer technique.

Turk Gogus Kalp Damar Cerrahisi Derg 2020 Oct 21;28(4):706-707. Epub 2020 Oct 21.

Department of Cardiovascular Surgery, Medical Park Uşak Hospital, Uşak, Turkey.

Cannulation of the shorter limb of an abdominal aortic endograft can be demanding. Confirmation of the accurate cannulation is equally challenging. Interventional cardiologists and cardiovascular surgeons may encounter certain difficulties during this procedure. Read More

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October 2020

Physiological concentrations of short-chain fatty acids induce the formation of neutrophil extracellular traps in vitro.

Int J Immunopathol Pharmacol 2020 Jan-Dec;34:2058738420958949

Laboratorio de Inmunología, Departamento de Fisiología, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara, Jalisco, Mexico.

Neutrophils represent the first line of host cellular defense against various pathogens. The most recently described microbicidal mechanism of these cells is the release of neutrophil extracellular traps (NET). Currently, a wide range of chemical and biological stimuli are known to induce this response; however, the effect of short-chain fatty acids (SCFAs) on the induction of NET is still unknown. Read More

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December 2020

Oleate-induced aggregation of LC3 at the trans-Golgi network is linked to a protein trafficking blockade.

Cell Death Differ 2020 Dec 17. Epub 2020 Dec 17.

Equipe labellisée par la Ligue contre le cancer, Université de Paris, Sorbonne Université, INSERM UMR1138, Centre de Recherche des Cordeliers, Paris, France.

Oleate, the most abundant endogenous and dietary cis-unsaturated fatty acid, has the atypical property to cause the redistribution of microtubule-associated proteins 1A/1B light chain 3B (referred to as LC3) to the trans-Golgi network (TGN), as shown here. A genome-wide screen identified multiple, mostly Golgi transport-related genes specifically involved in the oleate-induced relocation of LC3 to the Golgi apparatus. Follow-up analyses revealed that oleate also caused the retention of secreted proteins in the TGN, as determined in two assays in which the secretion of proteins was synchronized, (i) an assay involving a thermosensitive vesicular stomatitis virus G (VSVG) protein that is retained in the endoplasmic reticulum (ER) until the temperature is lowered, and (ii) an isothermic assay involving the reversible retention of the protein of interest in the ER lumen and that was used both in vitro and in vivo. Read More

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December 2020

33g Hypodermic Needle-Guided Iris Suturing Technique.

J Cataract Refract Surg 2020 Nov 27. Epub 2020 Nov 27.

Philadelphia College of Osteopathic Medicine, Philadelphia, PA 19128.

The purpose of this study is to describe a novel 33g hypodermic needle guided iris suturing technique (33-GIST) for repair of iris defects and its adaptation for use to address a wide range of iris pathology in complex anterior segment reconstruction cases. Our approach uses a 33g hypodermic needle loaded with a 10-0 prolene suture within its lumen which is then used to directly introduce and manipulate the suture within the anterior chamber. Eliminating the need for a needle holder, this technique provides surgeons improved ergonomics and minimizes risk of trauma to adjacent tissues. Read More

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November 2020