3,342 results match your criteria whole-body scans

Kinetic analysis and optimisation of F-rhPSMA-7.3 PET imaging of prostate cancer.

Eur J Nucl Med Mol Imaging 2021 Apr 12. Epub 2021 Apr 12.

Clinical Research Services Turku - CRST Ltd, Turku, Finland.

Purpose: This phase 1 open-label study evaluated the uptake kinetics of a novel theranostic PET radiopharmaceutical, F-rhPSMA-7.3, to optimise its use for imaging of prostate cancer.

Methods: Nine men, three with high-risk localised prostate cancer, three with treatment-naïve hormone-sensitive metastatic disease and three with castration-resistant metastatic disease, underwent dynamic 45-min PET scanning of a target area immediately post-injection of 300 MBq F-rhPSMA-7. Read More

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Genotype-phenotype correlation in pseudoxanthoma elasticum.

Atherosclerosis 2021 Mar 13;324:18-26. Epub 2021 Mar 13.

Department of Vascular Medicine, University Medical Center Utrecht, Utrecht University, the Netherlands. Electronic address:

Background And Aims: Pseudoxanthoma elasticum (PXE) is caused by variants in the ABCC6 gene. It results in calcification in the skin, peripheral arteries and the eyes, but has considerable phenotypic variability. We investigated the association between the ABCC6 genotype and calcification and clinical phenotypes in these different organs. Read More

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Long-Term Follow-Up of Thyroid Incidentalomas Visualized with 18F-Fluorodeoxyglucose Positron Emission Tomography-Impact of Thyroid Scintigraphy in the Diagnostic Work-Up.

Diagnostics (Basel) 2021 Mar 19;11(3). Epub 2021 Mar 19.

Department of Clinical Physiology, Nuclear Medicine and PET, Copenhagen University Hospital, Rigshospitalet, DK-2100 Copenhagen, Denmark.

Our objective was to evaluate the frequency of malignancy in incidental thyroidal uptake on 18F-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT) in a cohort of Danish patients, and furthermore to evaluate the impact of thyroid scinti-graphy in the diagnostic work-up. All whole-body PET/CT reports from 1 January 2010 to 31 December 2013 were retrospectively reviewed and further analyzed if visually increased thyroidal FDG uptake was reported. Patient electronic files were searched for further thyroid evaluation. Read More

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Ultra-low dose whole-body CT for attenuation correction in a dual tracer PET/CT protocol for multiple myeloma.

Phys Med 2021 Mar 31;84:1-9. Epub 2021 Mar 31.

Medical Physics, Clínica Universidad de Navarra, Pamplona, Spain; IdisNA, Instituto de Investigación Sanitaria de Navarra, Pamplona, Spain.

Purpose: To investigate within phantoms the minimum CT dose allowed for accurate attenuation correction of PET data and to quantify the effective dose reduction when a CT for this purpose is incorporated in the clinical setting.

Methods: The NEMA image quality phantom was scanned within a large parallelepiped container. Twenty-one different CT images were acquired to correct attenuation of PET raw data. Read More

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Cell-free DNA concentration and fragment size fraction correlate with FDG PET/CT-derived parameters in NSCLC patients.

Eur J Nucl Med Mol Imaging 2021 Apr 2. Epub 2021 Apr 2.

Thoracic Oncology Unit, Hospital Clínic, Barcelona, Spain.

Purpose: The aim of our study was to investigate the correlation between cfDNA concentration and fragment size fraction with FDG PET/CT- and CT-derived parameters in untreated NSCLC patient.

Methods: Fifty-three patients diagnosed of locally advanced or metastatic NSCLC who had undergone FDG PET/CT, CT and cfDNA analysis prior to any treatment were included in this retrospective study. CfDNA concentration was measured by fluorometry and fragment size fractions were determined by microchip electrophoresis. Read More

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Clinical performance of long axial field of view PET/CT: a head-to-head intra-individual comparison of the Biograph Vision Quadra with the Biograph Vision PET/CT.

Eur J Nucl Med Mol Imaging 2021 Apr 2. Epub 2021 Apr 2.

Department of Nuclear Medicine, Inselspital, Bern University Hospital, University of Bern, Freiburgstr. 18, 3010, Bern, Switzerland.

Purpose: To investigate the performance of the new long axial field-of-view (LAFOV) Biograph Vision Quadra PET/CT and a standard axial field-of-view (SAFOV) Biograph Vision 600 PET/CT (both: Siemens Healthineers) system using an intra-patient comparison.

Methods: Forty-four patients undergoing routine oncological PET/CT were prospectively included and underwent a same-day dual-scanning protocol following a single administration of either F-FDG (n = 20), F-PSMA-1007 (n = 16) or Ga-DOTA-TOC (n = 8). Half the patients first received a clinically routine examination on the SAFOV (FOV 26. Read More

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Multi-task weak supervision enables anatomically-resolved abnormality detection in whole-body FDG-PET/CT.

Nat Commun 2021 03 25;12(1):1880. Epub 2021 Mar 25.

Department of Radiology, Stanford University, Stanford, CA, USA.

Computational decision support systems could provide clinical value in whole-body FDG-PET/CT workflows. However, limited availability of labeled data combined with the large size of PET/CT imaging exams make it challenging to apply existing supervised machine learning systems. Leveraging recent advancements in natural language processing, we describe a weak supervision framework that extracts imperfect, yet highly granular, regional abnormality labels from free-text radiology reports. Read More

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Deterioration of pulmonary function: An early complication in Fibrodysplasia Ossificans Progressiva.

Bone Rep 2021 Jun 25;14:100758. Epub 2021 Feb 25.

Amsterdam UMC, Vrije Universiteit Amsterdam, Department of Internal Medicine section Endocrinology, Amsterdam Movement Sciences, Amsterdam Bone Centre, de Boelelaan 1117, Amsterdam, the Netherlands.

Fibrodysplasia Ossificans Progressiva (FOP) is a genetic disease characterized by the formation of heterotopic ossification (HO) in connective tissues. HO first develops in the thoracic region, before more peripheral sites are affected. Due to HO along the thoracic cage, its movements are restricted and pulmonary function deteriorates. Read More

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Case Report: Asymmetric Bone Marrow Involvement in Patients With Acute Leukemia After Allogeneic Hematopoietic Stem Cell Transplantation.

Front Oncol 2021 4;11:626018. Epub 2021 Mar 4.

Institute of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

After allogeneic hematopoietic stem cell transplantation (allo-HSCT), acute leukemia relapse is common, and asymmetric bone marrow recurrence hasn't been reported. Because the anatomical distribution of acute leukemia clones in the bone marrow after allo-HSCT is presumed to be diffuse, bone marrow aspirations are performed in single site. The first case was a 20-year-old man who was diagnosed with acute myelomonocytic leukemia and received haploidentical allo-HSCT. Read More

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Radiation exposure and establishment of diagnostic reference levels of whole-body low-dose CT for the assessment of multiple myeloma with second- and third-generation dual-source CT.

Acta Radiol 2021 Mar 20:2841851211003287. Epub 2021 Mar 20.

Department of Diagnostic and Interventional Radiology and Neuroradiology, University Hospital Essen, Essen, Germany.

Background: In the assessment of diseases causing skeletal lesions such as multiple myeloma (MM), whole-body low-dose computed tomography (WBLDCT) is a sensitive diagnostic imaging modality, which has the potential to replace the conventional radiographic survey.

Purpose: To optimize radiation protection and examine radiation exposure, and effective and organ doses of WBLDCT using different modern dual-source CT (DSCT) devices, and to establish local diagnostic reference levels (DRL).

Material And Methods: In this retrospective study, 281 WBLDCT scans of 232 patients performed between January 2017 and April 2020 either on a second- (A) or third-generation (B) DSCT device could be included. Read More

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Q-Bot: automatic DICOM metadata monitoring for the next level of quality management in nuclear medicine.

EJNMMI Phys 2021 Mar 18;8(1):28. Epub 2021 Mar 18.

ScanoMed Nuclear Medicine Centers, Nagyerdei krt. 98, Debrecen, H-4032, Hungary.

Background: Regular and precise inspection of the realization of the local nuclear medicine standard operation procedures (SOPs) is very complex and time-consuming, especially when large amount of patient data is obtained from a wide scale of different scan procedures on a daily basis. DICOM metadata comprise a complete set of data related to the patient and the imaging procedure, and consequently all information necessary to evaluate the compliance with the actual SOP.

Methods: Q-Bot, an automatic DICOM metadata monitoring tool which is capable to verify SOP conformities, was tested for 11 months at two nuclear medicine departments. Read More

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Prediction of pathological complete response after neoadjuvant chemotherapy in breast cancer: comparison of diagnostic performances of dedicated breast PET, whole-body PET, and dynamic contrast-enhanced MRI.

Breast Cancer Res Treat 2021 Mar 17. Epub 2021 Mar 17.

Department of Radiology, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita-shi, Osaka, 565-0871, Japan.

Purpose: To compare the diagnostic performance of ring-type dedicated breast PET (dbPET), whole-body PET (WBPET), and DCE-MRI for predicting pathological complete response (pCR) after neoadjuvant chemotherapy (NAC).

Methods: This prospective study included 29 women with histologically proven breast cancer on needle biopsy between July 2016 and July 2019 (age: mean 55 years; range 35-78). Patients underwent WBPET followed by ring-type dbPET and DCE-MRI pre- and post-NAC for preoperative evaluation. Read More

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Comparison of F-FDG PET/CT and Ga-DOTATATE PET/CT in the Targeted Imaging of Culprit Tumors Causing Osteomalacia.

Orthop Surg 2021 Mar 11. Epub 2021 Mar 11.

Department of PET-CT Diagnostic, Tianjin Medical University General Hospital, Tianjin, China.

Objective: To assess and compare the performance of fluorine-18-labeled fluorodeoxyglucose positron emission tomography ( F-FDG-PET/ CT) and gallium-68-labeled tetraazacyclododecanetetraacetic acid-DPhe1-Tyr3-octreotate ( Ga- DOTATATE) PET/CT in the targeted imaging of culprit tumors causing osteomalacia.

Methods: This was a clinical retrospective analysis. We analyzed 13 patients (five men, eight women; mean age, 49 years; range, 19-55 years) with suspicion of tumor-induced osteomalacia (TIO) between March 2017 and October 2019. Read More

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Direct measurement of radiation exposure dose to individual organs during diagnostic computed tomography examination.

Sci Rep 2021 Mar 8;11(1):5435. Epub 2021 Mar 8.

Department of Orthopedics, Institute of Biomedical Sciences, Tokushima University Graduate School, 3-18-15 Kuramoto-cho, Tokushima, Tokushima, 770-8503, Japan.

Ionizing radiation from Computed tomography (CT) examinations and the associated health risks are growing concerns. The purpose of this study was to directly measure individual organ doses during routine clinical CT scanning protocols and to evaluate how these measurements vary with scanning conditions. Optically stimulated luminescence (OSL) dosimeters were surgically implanted into individual organs of fresh non-embalmed whole-body cadavers. Read More

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Evaluation of SNA001, a Novel Recombinant Human Thyroid Stimulating Hormone Injection, in Patients With Differentiated Thyroid Carcinoma.

Front Endocrinol (Lausanne) 2020 17;11:615883. Epub 2021 Feb 17.

Department of Nuclear Medicine, Zhongshan Hospital, Fudan University, Shanghai, China.

SNA001 is a novel recombinant human thyroid stimulating hormone (rhTSH). rhTSH has long been approved in several countries to facilitate monitoring and ablation of thyroid carcinoma without hypothyroidism caused by thyroid hormone withdrawal (THW). To assess the safety, tolerance, pharmacokinetic and pharmacodynamic properties of SNA001, the two-period (SNA001 period and THW period), dose-ascending study in well-differentiated thyroid cancer (DTC) patients was designed. Read More

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February 2021

Analyzing Longitudinal wb-MRI Data and Clinical Course in a Cohort of Former Smoldering Multiple Myeloma Patients: Connections between MRI Findings and Clinical Progression Patterns.

Cancers (Basel) 2021 Feb 25;13(5). Epub 2021 Feb 25.

Diagnostic and Interventional Radiology, University Hospital Heidelberg, Im Neuenheimer Feld 110, 69120 Heidelberg, Germany.

The purpose of this study was to analyze size and growth dynamics of focal lesions (FL) as well as to quantify diffuse infiltration (DI) in untreated smoldering multiple myeloma (SMM) patients and correlate those MRI features with timepoint and cause of progression. We investigated 199 whole-body magnetic resonance imaging (wb-MRI) scans originating from longitudinal imaging of 60 SMM patients and 39 computed tomography (CT) scans for corresponding osteolytic lesions (OL) in 17 patients. All FLs >5 mm were manually segmented to quantify volume and growth dynamics, and DI was scored, rating four compartments separately in T1- and fat-saturated T2-weighted images. Read More

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February 2021

Electromagnetic simulation of RF burn injuries occurring at skin-skin and skin-bore wall contact points in an MRI scanner with a birdcage coil.

Phys Med 2021 Feb 28;82:219-227. Epub 2021 Feb 28.

Division of Biomedical Engineering and Science, Faculty of Health Sciences, Hokkaido University, Sapporo 060-0812, Japan. Electronic address:

Purpose: To simulate radiofrequency (RF) burns that frequently occur at skin-skin and skin-bore wall contact points.

Methods: RF burn injuries (thumb-thigh and elbow-bore wall contacts) that typically occur on the lateral side of the body during 1.5 T magnetic resonance imaging (MRI) scans were simulated using a computational human model. Read More

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February 2021

Bone mass and vertebral fractures in South African children on prolonged oral glucocorticoids for chronic non-malignant illnesses.

Bone Rep 2021 Jun 2;14:100751. Epub 2021 Feb 2.

Department of Paediatrics, Chris Hani Baragwanath Academic Hospital, Johannesburg, South Africa.

Introduction: We hypothesized that the prevalence of vertebral fractures would be low and that bone mineral density (BMD) would be less severely affected in a black South African (SA) population treated with glucocorticoids (GCs) than that reported in mainly white populations.

Methods: All children aged 5-17.9 years with chronic non-malignant illnesses who were on GCs (intravenous or oral) for greater than 3 months duration were evaluated. Read More

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Body Fat Distribution, Glucose Metabolism, and Diabetes Status among Older Adults: The Multiethnic Cohort Adiposity Phenotype Study.

J Epidemiol 2021 Feb 27. Epub 2021 Feb 27.

University of Hawaii Cancer Center.

Aims: As the proportion of visceral (VAT) to subcutaneous adipose tissue (SAT) may contribute to type 2 diabetes (T2D) development, we examined this relation in a cross-sectional design within the Multiethnic Cohort that includes Japanese Americans known to have high VAT. The aim was to understand how ectopic fat accumulation differs by glycemic status across ethnic groups with disparate rates of obesity, T2D, and propensity to accumulate VAT.

Methods: In 2013-16, 1,746 participants aged 69. Read More

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February 2021

Cross-validation study between the HRRT and the PET component of the SIGNA PET/MRI system with focus on neuroimaging.

EJNMMI Phys 2021 Feb 26;8(1):20. Epub 2021 Feb 26.

Department of Physics and Astronomy, University of British Columbia, Vancouver, British Columbia, Canada.

Background: The Siemens high-resolution research tomograph (HRRT - a dedicated brain PET scanner) is to this day one of the highest resolution PET scanners; thus, it can serve as useful benchmark when evaluating performance of newer scanners. Here, we report results from a cross-validation study between the HRRT and the whole-body GE SIGNA PET/MR focusing on brain imaging. Phantom data were acquired to determine recovery coefficients (RCs), % background variability (%BG), and image voxel noise (%). Read More

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February 2021

Incidental Findings on Whole-body Computed Tomography in Major Trauma Patients: Who and What?

Am Surg 2021 Feb 26:3134821998685. Epub 2021 Feb 26.

Department of Trauma and Emergency Surgery, 38014Chang Gung Memorial Hospital, Taoyuan, Taiwan.

Purpose: Whole-body computed tomography (WBCT) scans are frequently used for trauma patients, and sometimes, nontraumatic findings are observed. We aimed to investigate the characteristics of patients with nontraumatic findings on WBCT.

Methods: From 2013 to 2016, adult trauma patients who underwent WBCT were enrolled. Read More

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February 2021

Impact of increasing levels of adaptive statistical iterative reconstruction on image quality in oil-based postmortem CT angiography in coronary arteries.

Int J Legal Med 2021 Feb 24. Epub 2021 Feb 24.

Medical Faculty, Department of Diagnostic and Interventional Radiology, University Dusseldorf, D-40225, Dusseldorf, Germany.

Introduction: Postmortem multi-detector computed tomography (PMCT) has become an important part in forensic imaging. Modern reconstruction techniques such as iterative reconstruction (IR) are frequently used in postmortem CT angiography (PMCTA). The image quality of PMCTA depends on the strength of IR. Read More

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February 2021

Dual-phase 68Ga-PSMA-11 PET/CT may increase the rate of detected lesions in prostate cancer patients.

Urologia 2021 Feb 24:391560321993544. Epub 2021 Feb 24.

Department of Molecular Imaging and Radionuclide Therapy, Bushehr Medical University Hospital, The Persian Gulf Nuclear Medicine Research Center, Bushehr University of Medical Sciences, Bushehr, Iran.

Background: This study was conducted to compare the early static (3-6 min post-injection (p.i.)) and standard whole body (1 h, p. Read More

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February 2021

The impact of neurological disability and sensory loss on mindfulness practice.

Disabil Rehabil 2021 Feb 23:1-9. Epub 2021 Feb 23.

School of Sport Science and Physical Activity, University of Bedfordshire, Luton, UK.

Objectives: Mindfulness-based approaches are increasingly recommended in the management of medical conditions associated with sensory loss and absence, such as Spinal Cord Injury (SCI), Multiple Sclerosis (MS) and Functional Neurological Disorder (FND). Yet the implications of undertaking practices such as body scanning when living with sensory loss have not been considered. This study aimed to explore the impact of sensory loss on the practice and experience of mindfulness in qualified mindfulness teachers with SCI/FND/MS. Read More

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February 2021

Learning-Based Stopping Power Mapping on Dual-Energy CT for Proton Radiation Therapy.

Int J Part Ther 2021 12;7(3):46-60. Epub 2021 Feb 12.

Department of Radiation Oncology and Winship Cancer Institute, Emory University, Atlanta, GA, USA.

Purpose: Dual-energy computed tomography (DECT) has been used to derive relative stopping power (RSP) maps by obtaining the energy dependence of photon interactions. The DECT-derived RSP maps could potentially be compromised by image noise levels and the severity of artifacts when using physics-based mapping techniques. This work presents a noise-robust learning-based method to predict RSP maps from DECT for proton radiation therapy. Read More

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February 2021