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Evaluation of a Home-Based, Nurse Practitioner-led Advanced Illness Care Program.

J Am Med Dir Assoc 2021 Jun 8. Epub 2021 Jun 8.

Innovative Homecare Solutions, UPMC; Department of Physical Medicine & Rehabilitation, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.

Objectives: In the United States, people with serious illness often experience gaps and discontinuity in care. Gaps are frequently exacerbated by limited mobility, need for social support, and challenges managing multiple comorbidities. The Advanced Illness Care (AIC) Program provides nurse practitioner-led, home-based care for people with serious or complex chronic illnesses that specifically targets palliative care needs and coordinates with patients' primary care and specialty health care providers. Read More

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Impact of light quality on freshwater phytoplankton community in outdoor mesocosms.

Environ Sci Pollut Res Int 2021 Jun 11. Epub 2021 Jun 11.

Nanjing Institute of Geography and Limnology, Chinese Academy of Sciences, Nanjing, 210008, China.

In shallow lakes, wind wave turbulence alters underwater spectral composition, but the influence of this phenomenon on phytoplankton community structure is poorly understood. We used 100L mesocosms to investigate the influence of light quality on a natural phytoplankton community collected from Taihu Lake in China. The communities in mesocosms were exposed to sunlight filtered for white, blue, green, and red light, while wave-making pumps simulated wind wave turbulence similar to Taihu Lake. Read More

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Tough Choices: Exploring Medication Decision-Making During Pregnancy and Lactation Among Women With Inflammatory Arthritis.

ACR Open Rheumatol 2021 Jun 11. Epub 2021 Jun 11.

Duke University Medical Center, Durham, North Carolina.

Objective: This study explored how women's beliefs about drug safety and interactions with their health care providers influenced their decisions to continue arthritis medications during pregnancy and lactation.

Methods: We collaborated with ArthritisPower, a patient-powered research network, and CreakyJoints, its partner online community, to develop and disseminate a survey among members with inflammatory arthritis who had at least one pregnancy after diagnosis. Participants' free-text responses were evaluated by using thematic analysis. Read More

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Cancer Incidence Projections in the United States Between 2015 and 2050.

Prev Chronic Dis 2021 Jun 10;18:E59. Epub 2021 Jun 10.

Division of Cancer Prevention and Control, Centers for Disease Control and Prevention, Atlanta, Georgia.

Introduction: The number of adults entering the age groups at greatest risk for being diagnosed with cancer is increasing. Projecting cancer incidence can help the cancer control community plan and evaluate prevention strategies aimed at reducing the growing number of cancer cases.

Methods: We used data from the Surveillance, Epidemiology, and End Results Program and the US Census Bureau to estimate average, annual, age-standardized cancer incidence rates and case counts (for all sites combined and top 22 invasive cancers) in the US for 2015 and to project cancer rates and counts to 2050. Read More

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White and Black Differences in Perceived Access to Health and Community Services and Self-Rated Health in an Age-Friendly Community Assessment.

J Appl Gerontol 2021 Jun 11:7334648211023251. Epub 2021 Jun 11.

Age-Friendly Innovation Center, Columbus, USA.

Objectives: This study sought to identify the race differences in perceived access to health and community services and self-rated health (SRH) among White and Black older adult participants of an age-friendly community assessment.

Methods: Responses ( = 313) to a baseline assessment of Columbus, Ohio, residents aged ≥50 years were analyzed.

Results: Significant differences were found between White and Black older adults regarding SRH, with Black older adults reporting lower SRH. Read More

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Giving birth during the COVID-19 pandemic, perspectives from a sample of the United States birthing persons during the first wave: March-June 2020.

Birth 2021 Jun 11. Epub 2021 Jun 11.

Wellspan, York Hospital, York, PA, USA.

Background: The COVID-19 pandemic forced hospitals in the United States to adjust policy and procedure in order to provide safe care and prevent the spread of disease. At the beginning of the pandemic, media and case reports described pressure for medical interventions, visitor restrictions, separation from newborns, and an increase in patient demand for community birth (home and birth center). The purpose of this study was to describe birth experiences during the COVID-19 pandemic centering the birthing person's perspective. Read More

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Community research collaboration to develop a promotores-based hereditary breast cancer education program for Spanish-speaking Latinas.

Health Educ Res 2021 Jun 11. Epub 2021 Jun 11.

University of California, San Francisco, CA, USA.

Breast cancer (BC) is the most common cancer in Latinas and the leading cause of cancer death. Latinas tend to be diagnosed at later stages, receive poorer quality care and have a higher risk of mortality than non-Latina White (NLW) women. Among women with a genetic predisposition to hereditary BC, genetic counseling can be beneficial. Read More

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The ARIC (Atherosclerosis Risk In Communities) Study: JACC Focus Seminar 3/8.

J Am Coll Cardiol 2021 Jun;77(23):2939-2959

Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.

ARIC (Atherosclerosis Risk In Communities) initiated community-based surveillance in 1987 for myocardial infarction and coronary heart disease (CHD) incidence and mortality and created a prospective cohort of 15,792 Black and White adults ages 45 to 64 years. The primary aims were to improve understanding of the decline in CHD mortality and identify determinants of subclinical atherosclerosis and CHD in Black and White middle-age adults. ARIC has examined areas including health disparities, genomics, heart failure, and prevention, producing more than 2,300 publications. Read More

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Exploring the STEP-uP to practice: A survey of UK Lead Midwives for Education views of the STudent midwife Extended Practice Placement during the first wave of the COVID-19 pandemic.

Midwifery 2021 May 28;101:103048. Epub 2021 May 28.

Division of Nursing, Midwifery and Social Work, The University of Manchester, Jean McFarlane Building, Oxford Road, Manchester, M13 9PL, United Kingdom. Electronic address:

Objective: to assess the effect of implementation of the extended placement option available to midwifery students during the first wave of the COVID-19 pandemic.

Design: Online survey open from 2nd June 2020 to 15th July 2020.

Setting: United Kingdom. Read More

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Racial/Ethnic Group Differences and Sociocultural Factors Associated With Implicit and Explicit Attitudes Toward Undocumented Latino Immigrants.

J Lat Psychol 2021 May 17;9(2):125-139. Epub 2020 Sep 17.

Department of Political Science, The University of New Mexico.

In the context of recent policies aimed at deterring immigration and criminalizing undocumented Latino immigrants, we examined factors predicting implicit and explicit attitudes toward this population. We hypothesized that more positive implicit and explicit attitudes toward undocumented Latino immigrants would be displayed by Latinxs (compared to non-Hispanic Whites) and by individuals having personal connections to undocumented immigrants or a high level of intercultural sensitivity. Latinx ( = 376) and non-Hispanic White ( = 214) college students (70% female, age = 21) participated in this cross-sectional study and completed two Implicit Association Tests and measures of explicit attitudes, personal connections, and intercultural sensitivity. Read More

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Electronic Cigarette Use Is Not Associated with COVID-19 Diagnosis.

J Prim Care Community Health 2021 Jan-Dec;12:21501327211024391

Mayo Clinic, Rochester, MN, USA.

This analysis tested the hypothesis that current e-cigarette use was associated with an increased risk of SARS-CoV-2 infection in patients seeking medical care. E-cigarette and conventional cigarette use were ascertained using a novel electronic health record tool, and COVID-19 diagnosis was ascertained by a validated institutional registry. Logistic regression models were fit to assess whether current e-cigarette use was associated with an increased risk of COVID-19 diagnosis. Read More

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The Effect of Grape Seed Extract Supplementation on Oxidative Stress and Inflammation ─ A Systematic Review and Meta-Analysis of Controlled Trials.

Int J Clin Pract 2021 Jun 9:e14469. Epub 2021 Jun 9.

Department of Clinical Nutrition, School of Nutrition and Food Science, Food Security Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.

Grape seed extract (GSE) seems to have antioxidant and anti-inflammatory properties due to its high polyphenolic content. Nevertheless, the scientific literature in this field is controversial and inconclusive. Therefore, we aimed to conduct a systematic review and meta-analysis of controlled trials to evaluate the effect of supplementation with GSE on biomarkers of oxidative stress and inflammation. Read More

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Effect of Matching Therapists to Patients vs Assignment as Usual on Adult Psychotherapy Outcomes: A Randomized Clinical Trial.

JAMA Psychiatry 2021 Jun 9. Epub 2021 Jun 9.

Outcome Referrals Inc, Framingham, Massachusetts.

Importance: Psychotherapists possess strengths and weaknesses in treating different mental health problems, yet performance information is rarely harnessed in mental health care (MHC). To our knowledge, no prior studies have tested the causal efficacy of prospectively matching patients to therapists with empirically derived strengths in treating patients' specific concerns.

Objective: To test the effect of measurement-based matching vs case assignment as usual (CAU) on psychotherapy outcomes. Read More

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Association of Smartphone Ownership and Internet Use With Markers of Health Literacy and Access: Cross-sectional Survey Study of Perspectives From Project PLACE (Population Level Approaches to Cancer Elimination).

J Med Internet Res 2021 06 9;23(6):e24947. Epub 2021 Jun 9.

Duke Cancer Institute, Durham, NC, United States.

Background: Telehealth is an increasingly important component of health care delivery in response to the COVID-19 pandemic. However, well-documented disparities persist in the use of digital technologies.

Objective: This study aims to describe smartphone and internet use within a diverse sample, to assess the association of smartphone and internet use with markers of health literacy and health access, and to identify the mediating factors in these relationships. Read More

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Formal and informal social participation and elder mistreatment in a national sample of older adults.

J Am Geriatr Soc 2021 Jun 9. Epub 2021 Jun 9.

Division of General Internal Medicine, Department of Medicine, University of California San Francisco, San Francisco, California, USA.

Background/objectives: Older adults' susceptibility to mistreatment may be affected by their participation in social activities, but little is known about relationships between social participation and elder mistreatment.

Design: Cross-sectional analysis.

Setting/participants: National probability sample of older community-dwelling U. Read More

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Human leptospirosis in the municipality of São Paulo, SP, Brazil: distribution and trend according to sociodemographic factors, 2007-2016.

Rev Bras Epidemiol 2021 7;24:e210034. Epub 2021 Jun 7.

Department of Epidemiology, School of Public Health, Universidade de São Paulo - São Paulo (SP), Brazil.

Objectives: This study aimed to describe the incidence and proportional lethality of human leptospirosis in the municipality of São Paulo, between 2007 and 2016, according to sociodemographic factors and characteristics of the disease, and to assess the temporal trends of incidence, according to age group and region of residence.

Methods: Proportional distributions of leptospirosis cases of residents in the municipality were built and regression models with a Binomial Negative response were adjusted.

Results: 2,201 cases of leptospirosis were registered, most of them being males (82%), aged between 20 to 59 years (64. Read More

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Dihydroergotamine infusion for pediatric refractory headache: A retrospective chart review.

Headache 2021 May;61(5):777-789

Neuroscience Programs, Boston Children's Hospital, Boston, MA, USA.

Background: Headaches are a common symptom in children. Children with refractory headaches may be admitted for inpatient treatment with intravenous dihydroergotamine mesylate (DHE). However, very few studies have characterized these patients and their treatment outcomes using validated, self-reported, pain scales. Read More

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Race, Income, and Survival in Stage III Colon Cancer: CALGB 89803 (Alliance).

JNCI Cancer Spectr 2021 Jun 12;5(3):pkab034. Epub 2021 Apr 12.

Yale School of Medicine, New Haven, CT, USA.

Background: Disparities in colon cancer outcomes have been reported across race and socioeconomic status, which may reflect, in part, access to care. We sought to assess the influences of race and median household income (MHI) on outcomes among colon cancer patients with similar access to care.

Methods: We conducted a prospective, observational study of 1206 stage III colon cancer patients enrolled in the CALGB 89803 randomized adjuvant chemotherapy trial. Read More

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Post-COVID symptoms reported at asynchronous virtual review and stratified follow-up after COVID-19 pneumonia.

Clin Med (Lond) 2021 Jun 8. Epub 2021 Jun 8.

Barts Health NHS Trust, London, UK, and hon senior lecturer, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, UK

Background: The COVID-19 pandemic has strained healthcare systems and how best to address post-COVID health needs is uncertain. Here we describe the post-COVID symptoms of 675 patients followed up using a virtual review pathway, stratified by severity of acute COVID infection.

Methods: COVID-19 survivors completed an online/telephone questionnaire of symptoms after 12+ weeks and a chest radiograph. Read More

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Transforming the Care of Patients with Diabetic Kidney Disease.

Clin J Am Soc Nephrol 2021 Jun 8. Epub 2021 Jun 8.

S Quaggin, Feinberg Cardiovascular and Renal Research Institute and the Division of Nephrology & Hypertension, Northwestern University Feinberg School of Medicine, Chicago, United States

Diabetes and its associated complications pose an immediate threat to humankind. Diabetic kidney disease (DKD) is one of the most devastating complications, increasing the risk of death more than 10-fold over that in the general population [1]. Until very recently, the only drugs proven and recommended to slow progression of DKD were angiotensin-converting enzyme (ACE) inhibitors and angiotensin II type 1 receptor blockers (ARBs), which act by inhibiting the renin-angiotensin system (RAS) [2]. Read More

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Cystic fibrosis foundation consensus statements for the care of cystic fibrosis lung transplant recipients.

J Heart Lung Transplant 2021 Apr 22. Epub 2021 Apr 22.

Division of Pulmonary and Critical Care, Washington University School of Medicine, St. Louis, Missouri. Electronic address:

Cystic fibrosis (CF) is the indication for transplantation in approximately 15% of recipients worldwide, and Cystic Fibrosis Lung Transplant Recipients (CFLTRs) have excellent long-term outcomes. Yet, CFLTRs have unique comorbidities that require specialized care. The objective of this document is to provide recommendations to CF and lung transplant clinicians for the management of perioperative and underlying comorbidities of CFLTRs and the impact of transplantation on these comorbidities. Read More

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Community norms of the Muscle Dysmorphic Disorder Inventory (MDDI) among cisgender sexual minority men and women.

BMC Psychiatry 2021 Jun 8;21(1):297. Epub 2021 Jun 8.

The PRIDE Study/PRIDEnet, Stanford University School of Medicine, Stanford, CA, USA.

Background: Representing the pathological extreme pursuit of muscularity, muscle dysmorphia (MD) is characterized by a pervasive belief or fear around insufficient muscularity and an elevated drive for muscularity. Despite evidence of elevated body image-related concerns among sexual minority populations, little is known about the degree of muscle dysmorphia (MD) symptoms among sexual minorities, particularly based on Muscle Dysmorphic Disorder Inventory (MDDI) scores. The objective of this study was to examine the nature and severity of MD symptoms in cisgender sexual minority men and women and provide community norms of the MDDI for these populations. Read More

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Feasibility of 24-h blood pressure telemonitoring in community pharmacies: the TEMPLAR project.

J Hypertens 2021 Jun 4. Epub 2021 Jun 4.

Clinical Research Unit, Italian Institute of Telemedicine, Varese, Italy Department of Cardiology, Sechenov First Moscow State Medical University, Moscow, Russian Federation.

Objectives: Low-quality ambulatory blood pressure monitoring (ABPM) due to recurring artifacts may limit its clinical value. We evaluated the features and impact on BP control and patient management of ABPMs performed in Italian community pharmacies, according to their quality.

Methods: Twenty-four-hour ABPMs were obtained by a clinically validated, automated upper arm device and uploaded on a certified web-based telemedicine platform (www. Read More

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Global Radiotherapy: Current Status and Future Directions-White Paper.

JCO Glob Oncol 2021 Jun;7:827-842

Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.

Recognizing the increase in cancer incidence globally and the need for effective cancer control interventions, several organizations, professional bodies, and international institutions have proposed strategies to improve treatment options and reduce mortality along with minimizing overall incidence. Despite these efforts, an estimated 9.6 million deaths in 2018 was attributed to this noncommunicable disease, making it the second leading cause of death worldwide. Read More

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Time trends and disparities in anxiety among adolescents, 2012-2018.

Soc Psychiatry Psychiatr Epidemiol 2021 Jun 7. Epub 2021 Jun 7.

Department of Community Health Sciences, Boston University, Boston, MA, USA.

Purpose: Prior studies have been inconclusive in documenting whether the prevalence of adolescent anxiety is increasing, given sampling and measurement limitations. This study adds new information on recent time trends in anxiety prevalence, specifically investigating trends among previously unexamined sociodemographic subgroups.

Methods: Weighted data of 37,360 youth respondents (51. Read More

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Onset of substance use: Deviant peer, sex, and sympathetic nervous system predictors.

Dev Psychopathol 2021 Jun 8:1-10. Epub 2021 Jun 8.

Department of Human Development and Family Studies, Auburn University,Auburn,USA.

We evaluated whether the association between deviant peer affiliation and onset of substance use is conditional upon sex and sympathetic nervous system (SNS) reactivity as measured by pre-ejection period (PEP). Community-sampled adolescents (N = 251; M = 15.78 years; 53% female; 66% White, 34% Black) participated in three waves. Read More

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Fear of falling is as important as multiple previous falls in terms of limiting daily activities: a longitudinal study.

BMC Geriatr 2021 Jun 7;21(1):350. Epub 2021 Jun 7.

Johns Hopkins University School of Nursing, MD, Baltimore, USA.

Background: Fear of falling and previous falls are both risk factors that affect daily activities of older adults. However, it remains unclear whether they independently limit daily activities accounting for each other.

Methods: We used the data from Round 1 (Year 1) to Round 5 (Year 5) of the National Health and Aging Trends Study. Read More

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Developing a model of care for substance use in pregnancy and parenting services, Sydney, Australia: Service provider perspectives.

J Subst Abuse Treat 2021 Apr 21;131:108420. Epub 2021 Apr 21.

Sydney Women's Alcohol and Drug Research Group, Level 6, King George V Building, Royal Prince Alfred Hospital, Missenden Road, Camperdown 2050, Sydney, Australia; The University of Sydney, Discipline of Addiction Medicine, Faculty of Medicine and Health, Camperdown, Sydney, Australia; Sydney Local Health District, Sydney Institute for Women Children and their Families, Sydney, Australia.

Introduction: The absence of a clear model of care for services supporting pregnant women and mothers with substance use disorders has impeded opportunities to build an evidence base for the effectiveness of these services. Previous research has typically focused on the needs of pregnant women or mothers, as two distinct groups. This paper explores service providers' perceptions of key components of a model of care, extending from perinatal care to community-based support for up to 17 years post-delivery. Read More

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Patterns of enrollment in a New Orleans women's substance use rehabilitation center.

J Subst Abuse Treat 2021 May 21;131:108490. Epub 2021 May 21.

University of Mississippi Medical Center, Cancer Center, Jackson, MS, United States of America.

Background: Research has told us little about the demographics of individuals entering substance use programs in New Orleans, Louisiana, especially women accessing treatment programs. Considering that New Orleans is a predominantly Black city and both substance use treatment and research have historically left out Black patients, this study evaluates the age, race, insurance status, education level, and substance of choice for patients entering Grace House Rehabilitation Center, an all women nonprofit substance use treatment program in New Orleans, Louisiana.

Methods: Since 2013, Tulane School of Medicine students have held weekly primary care clinics at Grace House. Read More

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Opioid dosing among patients with 3 or more years of continuous prescription opioid use before and after the CDC opioid prescribing guideline.

Int J Drug Policy 2021 Jun 4;97:103308. Epub 2021 Jun 4.

Department of Family and Community Medicine, Saint Louis University School of Medicine, 1008 S. Spring, St. Louis MO. 63110, USA; Advanced HEAlth Data (AHEAD) Research Institute, Saint Louis University School of Medicine, 1008 S. Spring, St. Louis MO. 63110, USA.

Background: Opioid doses declined after the Centers for Disease Control (CDC) opioid prescribing guideline was published. However, it is unknown if dose declines occurred in patients with ≥ 3 years of continuous opioid use.

Methods: Optum® de-identified integrated Electronic Health Record and claims data were used to create an adult sample (n = 400) with continuous opioid use for 18 months before and after the guideline publication. Read More

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