1,772 results match your criteria white bile

Successful Minimally Invasive Management of a Gastroduodenal Artery Pseudoaneurysm Causing Extrinsic Bile Duct Compression.

ACG Case Rep J 2021 Sep 5;8(9):e00663. Epub 2021 Oct 5.

Department of Gastroenterology, Baylor Scott and White Medical Center Temple, Temple, TX.

Gastroduodenal artery (GDA) pseudoaneurysms are rare clinical entities that typically develop in the setting of chronic inflammation of the pancreas, although idiopathic pseudoaneurysms can occur. Although GDA pseudoaneurysms carry the risk of rupture with resultant hemorrhage, they seldom are reported to cause biliary obstruction. We report a unique case of biliary obstruction secondary to extrinsic compression of the bile duct by a GDA pseudoaneurysm successfully managed by nonoperative means. Read More

View Article and Full-Text PDF
September 2021

Transcatheter aortic valve replacement in a patient with premature coronary artery disease and calcific aortic stenosis complicated by heterozygous familial hypercholesterolemia.

J Clin Lipidol 2021 Oct 1. Epub 2021 Oct 1.

Division of Endocrinology, Washington University School of Medicine, 660 S. Euclid, Campus Box 8086, St. Louis, MO, United States. Electronic address:

We describe a case of a 59-year-old man with severe heterozygous familial hypercholesterolemia (FH) and elevated lipoprotein(a) presenting with severe aortic stenosis, treated with transcatheter aortic valve replacement (TAVR). His history also includes premature coronary artery disease requiring coronary artery bypass surgery at age 48 and a stroke at age 55. His pre-treatment lipid values include an LDL-Cholesterol (LDL-C) of 458 mg/dL, total cholesterol of 588 mg/dL, and lipoprotein (a) level of 351 nmol/L. Read More

View Article and Full-Text PDF
October 2021

L. reuteri ZJ617 inhibits inflammatory and autophagy signaling pathways in gut-liver axis in piglet induced by lipopolysaccharide.

J Anim Sci Biotechnol 2021 Oct 13;12(1):110. Epub 2021 Oct 13.

The Key Laboratory of Molecular Animal Nutrition, Ministry of Education, College of Animal Science, Zhejiang University, Hangzhou, 310058, China.

Background: This study investigated the protective effects of L. reuteri ZJ617 on intestinal and liver injury and the underlying mechanisms in modulating inflammatory, autophagy, and apoptosis signaling pathways in a piglet challenged with lipopolysaccharide (LPS).

Methods: Duroc × Landrace × Large White piglets were assigned to 3 groups (n = 6/group): control (CON) and LPS groups received oral phosphate-buffered saline for 2 weeks before intraperitoneal injection (i. Read More

View Article and Full-Text PDF
October 2021

Clinical Impact of Preoperative Relief of Jaundice Following Endoscopic Retrograde Cholangiopancreatography on Determining Optimal Timing of Laparoscopic Cholecystectomy in Patients with Cholangitis.

J Clin Med 2021 Sep 22;10(19). Epub 2021 Sep 22.

Department of Internal Medicine, Liver Research Institute, Seoul National University Hospital, Seoul National University College of Medicine, Seoul 03080, Korea.

Background: About 10% of patients with gallbladder (GB) stones also have concurrent common bile duct (CBD) stones. Laparoscopic cholecystectomy (LC) after removal of CBD stones using endoscopic retrograde cholangiopancreatography (ERCP) is the most widely used method for treating coexisting gallbladder and common bile duct stones. We evaluated the optimal timing of LC after ERCP according to clinical factors, focusing on preoperative relief of jaundice. Read More

View Article and Full-Text PDF
September 2021

Challenging diagnostic work-up of a massive fluid-filled structure in the cranial abdomen of a cat.

Tierarztl Prax Ausg K Kleintiere Heimtiere 2021 Oct 12. Epub 2021 Oct 12.

Small Animal Clinic, University of Veterinary Medicine Hannover, Foundation.

A 9-year-old female, neutered European shorthair cat was presented with acute vomiting, obvious jaundice and painful enlargement of the abdomen. Icteric skin and mucous membranes in addition to severe bilirubinaemia (mainly direct bilirubin) and a large increase in liver enzyme activities were the main findings at the initial examination. Radio- and ultrasonographic evaluation revealed a massive fluid-filled structure caudal to the liver displacing abdominal organs, in particular the stomach. Read More

View Article and Full-Text PDF
October 2021

Biliary-Caval Fistula following Y90 Radioembolization.

Semin Intervent Radiol 2021 Oct 7;38(4):488-491. Epub 2021 Oct 7.

Division of Vascular and Interventional Radiology, Department of Radiology, Medical College of Wisconsin, Milwaukee, Wisconsin.

The safety of radioembolization with yttrium-90 ( Y) is well documented and major complications are rare. Previous studies have demonstrated that biliary complications following Y, including bile duct injury and hepatic abscess formation, occur at an increased rate in patients who have had prior biliary surgery and interventions. This article reviews a case of a patient who developed recurrent cholangitis and sepsis as well as a biliary-caval fistula following radioembolization. Read More

View Article and Full-Text PDF
October 2021

The white test for intraoperative screening of bile leakage: a potential trigger factor for acute pancreatitis after liver resection-a case series.

BMC Surg 2021 Oct 2;21(1):356. Epub 2021 Oct 2.

Department of Digestive Surgery and Liver Transplantation, Hôpital la Timone, 264 rue Saint-Pierre, 13385, Marseille Cedex 05, France.

Background: Acute pancreatitis after liver resection is a rare but serious complication, and few cases have been described in the literature. Extended lymphadenectomy, and long ischemia due to the Pringle maneuver could be responsible of post-liver resection acute pancreatitis, but the exact causes of AP after hepatectomy remain unclear.

Cases Presentation: We report here three cases of AP after hepatectomy and we strongly hypothesize that this is due to the bile leakage white test. Read More

View Article and Full-Text PDF
October 2021

Potential Antihypertensive Mechanisms of the Egg White-Derived Peptide QIGLF in Spontaneously Hypertensive Rats Revealed Using Untargeted Serum Metabolomics.

J Agric Food Chem 2021 Oct 28;69(40):12063-12071. Epub 2021 Sep 28.

College of Food Science and Engineering, Northwest A&F University, Yangling 712100, P. R. China.

The angiotensin-converting enzyme (ACE) inhibitory peptide QIGLF derived from egg white was shown to have significant antihypertensive effects in our previous study, but the intervention mechanisms at the metabolic level are still unclear. The UPLC-QTOF/MS-based untargeted metabolomics approach was used to clarify the potential antihypertensive mechanisms of QIGLF in the serum of spontaneously hypertensive rats (SHRs). Multivariate statistical analysis showed a clear difference in the metabolite profiles between the QIGLF and model groups. Read More

View Article and Full-Text PDF
October 2021

Pearl-white gallstones: A report of a case and a chemical analysis by FTIR and XRD.

Int J Surg Case Rep 2021 Sep 24;87:106449. Epub 2021 Sep 24.

Department of Clinical Medical Sciences, Faculty of Medicine, Yarmouk University, Irbid, Jordan.

Introduction: Gallstones' color is usually yellow, brown, black or more commonly a mixture of two or more of these colors in different proportions, depending on their composition, with yellow being the most commonly encountered color. Pearl-white gallstones are a very rare entity that has not been studied and reported sufficiently.

Case Presentation: Our patient is a 44-year-old lady who was suffering from recurrent attacks of epigastric and right hypochondrial abdominal pain that was aggravated by consumption of fatty meals. Read More

View Article and Full-Text PDF
September 2021

Effects of bile acids on aflatoxin B1 bioaccumulation, detoxification system, and growth performance of Pacific white shrimp.

Food Chem 2021 Sep 20;371:131169. Epub 2021 Sep 20.

The Key Laboratory of Mariculture (Ocean University of China), Ministry of Education, Qingdao, Shandong 266003, China.

The potential of bile acids (BAs) to reduce aflatoxin B (AFB) residues and toxicity in Litopenaeus vannamei was evaluated. Both juveniles and subadults were treated with 0, 0.05, 0. Read More

View Article and Full-Text PDF
September 2021

Longitudinal profiling of plasma and urine metabolites during liver regeneration in living liver donors.

Clin Transplant 2021 Sep 21:e14490. Epub 2021 Sep 21.

Annette C. and Harold C. Simmons Transplant Institute, Baylor University Medical Center, Dallas, Texas, USA.

Background: Knowledge of metabolic processes affected by major hepatectomy (MHx), and the metabolic pathways involved in liver regeneration and recovery of function, is limited and mainly derived from animal models. Assessment of restoration of hepatic function is essential in human living liver donors (LD).

Methods: We used a targeted metabolomic approach to longitudinally quantify changes in plasma and urine biomarkers from healthy LD. Read More

View Article and Full-Text PDF
September 2021

Study of metabolomics in selenium deprived Przewalski's Gazelle ().

Br J Nutr 2021 Sep 13:1-12. Epub 2021 Sep 13.

College of Life Science, Southwest University of Science and Technology, Mianyang, Sichuan621010, People's Republic of China.

To understand why Procapra przewalskii does not show the same white myopathy as sheep in Se-deficient regions and to provide reference for feeding nutrition level of artificial population and selection of wild reintroduction areas in the later period, a Se-deficient model was established. The mineral elements content, physiological and biochemical parameters in blood and serum metabonomics were determined. In the Se-deficient group compared with the control group, the Se content was highly significantly lower (P < 0·01), and the Cu content was significantly higher (P < 0·05). Read More

View Article and Full-Text PDF
September 2021

Eicosapentaenoic and docosahexaenoic acids attenuate hyperglycemia through the microbiome-gut-organs axis in db/db mice.

Microbiome 2021 Sep 10;9(1):185. Epub 2021 Sep 10.

Department of Nutrition, School of Public Health, Department of Clinical Nutrition of Affiliated Second Hospital, Zhejiang University School of Medicine, Hangzhou, 310058, Zhejiang, China.

Background: Eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) have been suggested to prevent the development of metabolic disorders. However, their individual role in treating hyperglycemia and the mechanism of action regarding gut microbiome and metabolome in the context of diabetes remain unclear.

Results: Supplementation of DHA and EPA attenuated hyperglycemia and insulin resistance without changing body weight in db/db mice while the ameliorative effect appeared to be more pronounced for EPA. Read More

View Article and Full-Text PDF
September 2021

Robotic-Assisted Left Hepatectomy: A Video Technique.

Chirurgia (Bucur) 2021 08;116(4):499-500

The robotic liver surgery is gaining momentum and several centers worldwide reported their promising results in terms of shorter recovery, less post-operative pain when compared to the open counterpart. Despite the benefits in terms of better ergonomic, enhanced visualization and microsuturing capabilities in comparison to the laparoscopic surgery, this approach is still confined to high selected centers and the reproducibility of the results published are still questioned. Herein, we report our surgical technique for a robotic-assisted left hepatectomy in a step-by-step fashion. Read More

View Article and Full-Text PDF

Associations of the gut microbiome with hepatic adiposity in the Multiethnic Cohort Adiposity Phenotype Study.

Gut Microbes 2021 Jan-Dec;13(1):1965463

Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, U.S.A.

Nonalcoholic fatty liver disease (NAFLD) is a risk factor for liver cancer and prevalence varies by ethnicity. Along with genetic and lifestyle factors, the gut microbiome (GM) may contribute to NAFLD and its progression to advanced liver disease. Our cross-sectional analysis assessed the association of the GM with hepatic adiposity among African American, Japanese American, White, Latino, and Native Hawaiian participants in the Multiethnic Cohort. Read More

View Article and Full-Text PDF
September 2021

Anti-Obesity and Hypocholesterolemic Actions of Protamine-Derived Peptide RPR (Arg-Pro-Arg) and Protamine in High-Fat Diet-Induced C57BL/6J Mice.

Nutrients 2021 Jul 22;13(8). Epub 2021 Jul 22.

Department of Applied Life Science, Faculty of Applied Biological Sciences, Gifu University, 1-1 Yanagido, Gifu 501-1193, Japan.

Dietary protamine can ameliorate hyperlipidemia; however, the protamine-derived active peptide and its hypolipidemic mechanism of action are unclear. Here, we report the discovery of a novel anti-obesity and hypocholesterolemic peptide, RPR (Arg-Pro-Arg), derived from protamine in mice fed a high-fat diet for 50 days. Serum cholesterol levels were significantly lower in the protamine and RPR groups than in the control group. Read More

View Article and Full-Text PDF

Metabolomic Profiling of Adults with Congenital Heart Disease.

Metabolites 2021 Aug 9;11(8). Epub 2021 Aug 9.

Department of Pediatrics, Johns Hopkins University, Baltimore, MD 21218, USA.

Metabolomic analysis may provide an integrated assessment in genetically and pathologically heterogeneous populations. We used metabolomic analysis to gain mechanistic insight into the small and diverse population of adults with congenital heart disease (ACHD). Consecutive ACHD patients seen at a single institution were enrolled. Read More

View Article and Full-Text PDF

A rare case of hepatocellular carcinoma with bile duct invasion diagnosed by peroral cholangioscopy.

VideoGIE 2021 Aug 26;6(8):354-357. Epub 2021 May 26.

Department of Gastroenterology and Hepatology, Tokyo Medical and Dental University (TMDU), Tokyo, Japan.

Video 1Peroral cholangioscopy showed a 20-mm-diameter, stalked, floating, round mass in the hilar region. The surface of the tumor was covered with white fur, and the tumor tissue was partially exposed in a map-like pattern. The mass was penetrable even with a guidewire, and it bled easily. Read More

View Article and Full-Text PDF

Curdlan intake changes gut microbial composition, short-chain fatty acid production, and bile acid transformation in mice.

Biochem Biophys Rep 2021 Sep 7;27:101095. Epub 2021 Aug 7.

Department of Applied Biological Science, Graduate School of Agriculture, Tokyo University of Agriculture and Technology, Fuchu-shi, Tokyo, 183-8509, Japan.

Indigestible polysaccharides, such as dietary fibers, benefit the host by improving the intestinal environment. Short-chain fatty acids (SCFAs) produced by gut microbial fermentation from dietary fibers exert various physiological effects. The bacterial polysaccharide curdlan benefits the host intestinal environment, although its effect on energy metabolism and SCFA production remains unclear. Read More

View Article and Full-Text PDF
September 2021

Matcha Green Tea Powder does not Prevent Diet-Induced Arteriosclerosis in New Zealand White Rabbits Due to Impaired Reverse Cholesterol Transport.

Mol Nutr Food Res 2021 Aug 14:e2100371. Epub 2021 Aug 14.

Department of Internal Medicine, Medical University of Innsbruck, Innsbruck, Austria.

Introduction: Green tea is associated with decreased risk for cardiovascular disease and stroke. Matcha is a special kind of powdered green tea known for its use in the Japanese tea ceremony. Due to its influence on lipoprotein parameters, it has been postulated to exert antiatherogenic effects. Read More

View Article and Full-Text PDF

Emergency surgery for hemobilia due to hepatic artery pseudoaneurysm rupture complicated by Mirizzi syndrome type II: a case report.

BMC Surg 2021 Aug 5;21(1):318. Epub 2021 Aug 5.

Department of Gastrointestinal Surgery, Shinko Hospital, 1-4-47, Wakinohama-cho, Chuo-ku, Kobe, Hyogo, 6510072, Japan.

Background: Hemobilia refers to bleeding into the biliary tract. Hepatic artery pseudoaneurysm (HAP) rupture is an uncommon cause of hemobilia, and cases of HAP associated with Mirizzi syndrome are extremely rare. Although transarterial embolization is recommended as the first-line treatment for hemobilia, surgery is sometimes required. Read More

View Article and Full-Text PDF

Intestinal hypoxia-inducible factor 2α regulates lactate levels to shape the gut microbiome and alter thermogenesis.

Cell Metab 2021 Oct 29;33(10):1988-2003.e7. Epub 2021 Jul 29.

Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Peking University, and the Key Laboratory of Molecular Cardiovascular Science (Peking University), Ministry of Education, Beijing, China; Center of Basic Medical Research, Institute of Medical Innovation and Research, Third Hospital, Peking University, Beijing, China; Center for Obesity and Metabolic Disease Research, School of Basic Medical Sciences, Peking University, Beijing, China. Electronic address:

Accumulating evidence suggests that the gut microbiota regulates obesity through metabolite-host interactions. However, the mechanisms underlying such interactions have been unclear. Here, we found that intestinal hypoxia-inducible factor 2α (HIF-2α) positively regulates gut lactate by controlling the expression of intestinal Ldha. Read More

View Article and Full-Text PDF
October 2021

Diagnostic role of the 'white test' with lipidic solution in the early intraoperative identification of open bile ducts for the prevention of bile leakage after liver resection: study protocol for a randomised controlled multicentric superiority trial (BiLe-Trial).

BMJ Open 2021 07 29;11(7):e049449. Epub 2021 Jul 29.

Visceral Surgery, Cantonal Hospital Aarau, Aarau, Switzerland

Introduction: Bile leakage is a frequent complication after liver resection associated with the need of interventional drainage, endoscopic retrograde cholangio pancreatography (ERCP) or reoperation. The intraoperative application of the white test could be a promising strategy to reduce the occurrence of bile leakages. Therefore, we propose to conduct the first multicentric randomised controlled trial with rate of postoperative bile leakage as primary endpoint with and without the white test. Read More

View Article and Full-Text PDF

"White bile" as a result of a malignant bile obstruction.

Rev Esp Enferm Dig 2021 Jul 28. Epub 2021 Jul 28.

Medicina Interna, Hospital Comarcal de Baza.

We present the case of an 87-year-old patient who was admitted for obstructive jaundice. ERCP is performed to take a biopsy and place a biliary prosthesis, showing transparent non-mucous bile or "white bile". This finding occurs occasionally in patients with biliary obstructions and carries a worse prognosis. Read More

View Article and Full-Text PDF

The immune response of pIgR and Ig to Flavobacterium columnare in grass carp (Ctenopharyngodon idellus).

Fish Shellfish Immunol 2021 Oct 8;117:320-327. Epub 2021 Jul 8.

Shandong Provincial Key Laboratory of Freshwater Genetics and Breeding, Shandong Freshwater Fisheries Research Institute, Ji'nan, 250013, PR China. Electronic address:

The polymeric immunoglobulin receptor (pIgR) plays an important role in mediating the transcytosis of polymeric immunoglobulins (pIgs) to protect organisms against pathogen invasion. Here, a polyclonal antibody against grass carp (Ctenopharyngodon idellus) recombinant pIgR was developed by immunizing New Zealand white rabbit, and the responses of pIgR, IgM and IgZ were analyzed after bath immunization and intraperitoneal administration with Flavobacterium columnare. The results showed that pIgR transcription level was similar to IgM and IgZ, but pIgR rose much faster and peaked earlier than IgM and IgZ; the pIgR mRNA levels were higher in the skin and spleen for both immunized groups, while IgM and IgZ mRNA expression were higher in skin, gills, and intestines in bath immersion group, or spleen and head kidney in intraperitoneal immunization group. Read More

View Article and Full-Text PDF
October 2021

Indocyanine green (ICG) fluorescent cholangiography during laparoscopic cholecystectomy using RUBINA™ technology: preliminary experience in two pediatric surgery centers.

Surg Endosc 2021 Jul 6. Epub 2021 Jul 6.

Division of Pediatric Surgery, Federico II University of Naples, Via Pansini 5, 80131, Naples, Italy.

Background: Recently, we reported the feasibility of indocyanine green (ICG) near-infrared fluorescence (NIRF) imaging to identify extrahepatic biliary anatomy during laparoscopic cholecystectomy (LC) in pediatric patients. This paper aimed to describe the use of a new technology, RUBINA™, to perform intra-operative ICG fluorescent cholangiography (FC) in pediatric LC.

Methods: During the last year, ICG-FC was performed during LC using the new technology RUBINA™ in two pediatric surgery units. Read More

View Article and Full-Text PDF

Notoginsenoside Ft1 acts as a TGR5 agonist but FXR antagonist to alleviate high fat diet-induced obesity and insulin resistance in mice.

Acta Pharm Sin B 2021 Jun 30;11(6):1541-1554. Epub 2021 Mar 30.

Shanghai Key Laboratory of Complex Prescriptions and MOE Key Laboratory for Standardization of Chinese Medicines, Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.

Obesity and its associated complications are highly related to a current public health crisis around the world. A growing body of evidence has indicated that G-protein coupled bile acid (BA) receptor TGR5 (also known as Gpbar-1) is a potential drug target to treat obesity and associated metabolic disorders. We have identified notoginsenoside Ft1 (Ft1) from as an agonist of TGR5 . Read More

View Article and Full-Text PDF

An unexpected flush of translucent bile in prepapillary stone impaction and the gallbladder .

Vincent Zimmer

Clin Case Rep 2021 Jun 10;9(6):e04310. Epub 2021 Jun 10.

Department of Medicine Marienhausklinik St. Josef Kohlhof Neunkirchen Germany.

- translucent, formerly referred to as "white bile," is devoid of bilirubin and bile acids due to a lacking gallbladder in continuity. - traditionally attributed to malignant obstruction, rarely acute stone impaction may underlie a clear bile aspect. Read More

View Article and Full-Text PDF

Comparison of Liver Condemnation and Bile Microscopy As Tools to Estimate Prevalence and Burden in the Anta Province of Cusco in Peru.

Vector Borne Zoonotic Dis 2021 Sep 14;21(9):707-712. Epub 2021 Jun 14.

Division of Infectious Disease, Department of Internal Medicine, University of Texas Medical Branch, Galveston, Texas, USA.

Fascioliasis is a zoonotic infection linked to significant economic losses in the livestock industry. Infection prevalence and estimated financial burden vary across locations owing to different diagnostic tests used. The accuracy of liver condemnation to estimate the prevalence and costs of fascioliasis has seldom been evaluated. Read More

View Article and Full-Text PDF
September 2021

Achilles Tendon Xanthoma and Cholestanol Revealing Cerebrotendinous Xanthomatosis: A New Case Report.

Case Rep Rheumatol 2021 20;2021:6656584. Epub 2021 May 20.

Rheumatology Department, Military Hospital Mohammed V, Mohammed V University, Rabat, Morocco.

Cerebrotendinous xanthomatosis (CTX) is an autosomal recessive lipid storage disease rarely reported in Africa. Therefore, we report a Moroccan first case report of CTX. A 20-year-old woman was presented in our department for bilateral swelling of the posterior aspect of ankles and the anterior aspect knees with gait disturbances evolving since the age of 7. Read More

View Article and Full-Text PDF