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Single-isocenter stereotactic non-coplanar arc treatment of 200 patients with brain metastases: multileaf collimator size and setup uncertainties.

Strahlenther Onkol 2021 Sep 15. Epub 2021 Sep 15.

Department of Oncology, Radiotherapy Research Unit (52AA), Herlev & Gentofte Hospital, University of Copenhagen, Borgmester Ib Juuls vej 7, 2730, Herlev, Denmark.

Purpose: The purpose of this study was to evaluate our 2 years' experience with single-isocenter, non-coplanar, volumetric modulated arc therapy (VMAT) for brain metastasis (BM) stereotactic radiosurgery (SRS).

Methods: A total of 202 patients treated with the VMAT SRS solution were analyzed retrospectively. Plan quality was assessed for 5 mm (120) and 2. Read More

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September 2021

Arsenic contamination in widely consumed Caribbean sharpnose sharks in southeastern Brazil: Baseline data and concerns regarding fisheries resources.

Mar Pollut Bull 2021 Sep 3;172:112905. Epub 2021 Sep 3.

Laboratório de Avaliação e Promoção da Saúde Ambiental, Instituto Oswaldo Cruz (Fiocruz), 21040-360 Rio de Janeiro, RJ, Brazil. Electronic address:

Although shark meat is consumed worldwide, elevated arsenic (As) concentrations have been increasingly reported. The Caribbean sharpnose shark (Rhizoprionodon porosus) is a widely consumed fishing resource in Brazil, with scarce information on As burdens to date. Herein, commercial-sized juvenile Caribbean sharpnose sharks from Rio de Janeiro (Brazil) were assessed in this regard, presenting significantly higher hepatic As concentrations in males (8. Read More

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September 2021

Construction of an evapotranspiration model and analysis of spatiotemporal variation in Xilin River Basin, China.

PLoS One 2021 10;16(9):e0256981. Epub 2021 Sep 10.

Inner Mongolia Key Laboratory of Remote Sensing and Geographic Information Systems, Inner Mongolia Normal University, Hohhot, China.

Surface evapotranspiration is a water exchange process between the atmosphere, biosphere, and hydrosphere. Accurate evapotranspiration estimations in arid and semi-arid regions are important for monitoring droughts and protecting the ecological environment. The main objective of this study is to build an evapotranspiration estimation model suitable for an effective scientific and objective evaluation of water consumption in the arid and semi-arid regions of the Xilin River Basin based on comprehensive parameters, including meteorological parameters, vegetation coverage, and soil water content. Read More

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September 2021

Heavy metals content in ashes of wood pellets and the health risk assessment related to their presence in the environment.

Sci Rep 2021 Sep 9;11(1):17952. Epub 2021 Sep 9.

School of Science and Technology, Nottingham Trent University, Nottingham, NG11 8NS, UK.

Efforts to reduce air pollution in developing countries may require increased use of biomass fuels. Even biomass fuels are a sustainable alternative to fossil fuels there is limited quantitative information concerning heavy metal content in their ashes. Therefore, this study focuses on the determination of the heavy metal concentrations in wood pellet ash obtained from the combustion of 10 pellet brans from Bosnia and Herzegovina and Italy, the effects of adding the ashes to soils, and the assessment of health risk assessment. Read More

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September 2021

Glycyrrhizic acid alleviates the meconium-induced acute lung injury in neonatal rats by inhibiting oxidative stress through mediating the Keap1/Nrf2/HO-1 signal pathway.

Bioengineered 2021 Dec;12(1):2616-2626

Pediatric Department, Beijing Friendship Hospital, Capital Medical University, Beijing China.

Meconium aspiration syndrome (MAS) is a disease closely related to inflammation and oxidative stress. Glycyrrhizic acid (GA) is a triterpenoid isolated from licorice with multiple bioprotective properties. In the present study, impacts of GA against MAS rats, as well as the potential mechanism, will be investigated. Read More

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December 2021

The multifactorial assessment of the Zn impact on high and low temperature stress towards wheat seedling growth under diverse moisture conditions (optimal and wet) in three soils.

J Hazard Mater 2021 08 14;416:126087. Epub 2021 May 14.

Institute of Soil Science and Plant Cultivation - State Research Institute (IUNG-PIB), Czartoryskich 8, 24-100 Pulawy, Poland. Electronic address:

Anthropogenic activities leading to chemical contamination of soil and global climate change may increase the level of stress for plants. Recent decades studies (mainly two-factors) have reported that the ecotoxicity of soil contaminants could be modified by climate factors. To date, little is known about: the combined climate-chemical stress on plants; the interaction of chemicals with high soil moisture conditions; the impact of soil properties on the combined climate-chemical stress and questions regarding the response of organisms to combined effect of all key factors influencing the ecotoxicity of chemicals under field conditions remain unanswered. Read More

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Positive regulation of TFEB and mitophagy by PGC-1α to alleviate LPS-induced acute lung injury in rats.

Biochem Biophys Res Commun 2021 Aug 24;577:1-5. Epub 2021 Aug 24.

Department of Respiratory, The Second Affiliated Hospital, The Air Force Military Medical University, Xi'an, 710038, ShaanXi, China. Electronic address:

Aim Of The Study: Acute lung injury (ALI) exhibits the features of noncardiogenic pulmonary edema and acute inflammatory process, and it also displays significant morbidity and mortality rates. This work focused on identifying how overexpression of PPARγ coactivator 1α (PGC-1α) positively regulated TFEB and mitophagy for resisting the lipopolysaccharide (LPS)-mediated ALI.

Materials And Methods: The levels of autophagic proteins and inflammatory factors in LPS-induced ALI rats and primary type II alveolar epithelial cells were measured, respectively. Read More

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Monitoring of Cocrystal Dissociation during the Wet Granulation Process in the Presence of Disintegrants by Using Low-Frequency Raman Spectroscopy.

Chem Pharm Bull (Tokyo) 2021 ;69(9):877-885

Department of Molecular Pharmaceutics, Meiji Pharmaceutical University.

The aim of this study was to evaluate the effect of three coformers and five disintegrants in the granulation formulation on the dissociation of cocrystal during the granulation process by monitoring wet granulation with probe-type low-frequency Raman (LF-Raman) spectroscopy. As model cocrystals, paracetamol (APAP)-oxalic acid (OXA), APAP-maleic acid (MLA), and APAP-trimethylglycine (TMG) were used. The monitoring of the granulation recipe containing cocrystals during wet granulation was performed over time with high-performance LF-Raman spectrometry and the dissociation rate was calculated from the results of multivariate analysis of LF-Raman spectra. Read More

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January 2021

Bacterial Vaginosis and Its Association with Incident Trichomonas Vaginalis Infections: A Systematic Review and Meta-Analysis.

Sex Transm Dis 2021 Aug 23. Epub 2021 Aug 23.

From the Department of Medicine, University of North Carolina Institute for Global Health and Infectious Diseases, Chapel Hill, NC The Write Source MSC, LLC, Wilmington, DE School of Public Health, Texas A&M University, College Station, TX Department of Emergency Medicine, Lincoln Medical Center, Bronx, NY Departments of Medicine, Epidemiology and Global Health, University of Washington, Seattle, WA.

Background: Bacterial vaginosis (BV) has been associated with an increased risk for acquisition of HIV and sexually transmitted infections. We evaluated the association between BV and incident Trichomonas vaginalis (TV) infection in women.

Methods: MEDLINE and ClinicalTrials. Read More

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Aposematic signaling and seasonal variation in dorsal pelage in a venomous mammal.

Ecol Evol 2021 Aug 26;11(16):11387-11397. Epub 2021 Jul 26.

Nocturnal Primate Research Group Faculty of Humanities and Social Sciences Oxford Brookes University Oxford UK.

In mammals, colouration patterns are often related to concealment, intraspecific communication, including aposematic signals, and physiological adaptations. Slow lorises ( spp.) are arboreal primates native to Southeast Asia that display stark colour contrast, are highly territorial, regularly enter torpor, and are notably one of only seven mammal taxa that possess venom. Read More

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Mycoremediation of oil contaminant by Pleurotus florida (P.Kumm) in liquid culture.

Fungal Biol 2021 09 26;125(9):667-678. Epub 2021 Apr 26.

Department of Biology, Garmsar Branch, Islamic Azad University, Garmsar, Iran.

This study investigated the potential functions of Pleurotus florida (an edible mushroom) in the biodegradation of gas oil at concentrations of 0 (control), 2.5, 5, and 10% (V: V) for 30 days. The gas oil increased dry weight and protein concentration in all treatments (by an average of 19. Read More

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September 2021

Risk of dietary intake of organochlorine pesticides among the childbearing-age women: A multiple follow-up study in North China.

Ecotoxicol Environ Saf 2021 Aug 16;224:112607. Epub 2021 Aug 16.

School of Environment, Beijing Normal University, Beijing 100875, PR China. Electronic address:

Exposure to organochlorine pesticides (OCPs) can cause adverse health effects in the female population. We investigated the dietary OCP intake of childbearing-age women living in large agricultural areas of Northern China, as well as their associated health risks. Ten childbearing-age women were recruited during 2015-2016. Read More

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Different tree-ring width sensitivities to satellite-based soil moisture from dry, moderate and wet pedunculate oak (Quercus robur L.) stands across a southeastern distribution margin.

Sci Total Environ 2021 Aug 8;800:149536. Epub 2021 Aug 8.

Institute of Lowland Forestry and Environment, University of Novi Sad, Antona Čehova 13d, 21000 Novi Sad, Serbia. Electronic address:

Associations of pedunculate oak (Quercus robur L.) radial growth with satellite-based soil moisture (SM) during the intensive tree growth period over a 30-year time span (1980-2010) were analyzed. This study included tree-ring width (TRW) chronologies from 22 stands located in four southeastern (SE) European countries (Slovenia, Croatia, Serbia and Bulgaria), which were grouped into three wetness groups (WGs): dry (<650 mm), moderate (650-750 mm), and wet (>750 mm), following the annual sum of precipitation. Read More

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Photocatalytic degradation of hydroxychloroquine using ZnO supported on clinoptilolite zeolite.

Water Sci Technol 2021 Aug;84(3):763-776

Department of Chemical Engineering, State University of Maringa, Maringa 87020-900, Parana, Brazil.

The objective of this work was to evaluate the photocatalytic activity of zinc oxide catalysts supported on natural zeolite clinoptilolite for photocatalytic degradation of the drug hydroxychloroquine, used in the treatment of malaria and which has been tested in the treatment of COVID-19. To synthesize 10%ZnOCP and 15%ZnOCP catalysts, the wet impregnation methodology was used. The raw and synthesized catalysts were characterized by XRD, SEM, XRF, BET, DRS, PCZ, FT-IR and PL. Read More

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Speech Recognition in Noise Using Binaural Diotic and Antiphasic Digits-in-Noise in Children: Maturation and Self-Test Validity.

J Am Acad Audiol 2021 May 10;32(5):315-323. Epub 2021 Aug 10.

Department of Speech-Language Pathology and Audiology, University of Pretoria, Pretoria, Gauteng, South Africa.

Background:  Digits-in-noise (DIN) tests have become popular for hearing screening over the past 15 years. Several recent studies have highlighted the potential utility of DIN as a school-aged hearing test. However, age may influence test performance in children due to maturation. Read More

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[The regulatory role of autophagy in rats lung ischemia/reperfusion injury].

Zhongguo Ying Yong Sheng Li Xue Za Zhi 2021 Jul;37(4):385-388

Institute of Ischemia-Reperfusion Injury, Wenzhou Medical University, Wenzhou 325035.

To investigate the role of cell autophagy in lung ischemia/reperfusion injury in rats. Forty SD rats were randomly divided into 5 groups (=8): ①Sham operated group (sham group):just open rat chest for 3.5 h; ②Ischemia/reperfusion group (I/R group):after open chest, clamp pulmonary hilus for 0. Read More

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Collective effect of damage prevention in taenioglossan radular teeth is related to the ecological niche in Paludomidae (Gastropoda: Cerithioidea).

Acta Biomater 2021 Aug 4. Epub 2021 Aug 4.

Functional Morphology and Biomechanics, Zoological Institute, Christian-Albrechts-Universität zu Kiel, Am Botanischen Garten 9, 24118 Kiel, Germany.

The molluscan radula, a thin membrane with embedded rows of teeth, is the structure for food processing and gathering. For proper functioning, radular failures must be either avoided or reduced when interacting with the preferred food, as this might be of high significance for the individual fitness. Thus, the analysis of structural failure in radular teeth could be included in studies on trophic specializations. Read More

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Forces Required for Isolated Malleus Shaft Fractures.

Otol Neurotol 2021 Aug 4. Epub 2021 Aug 4.

Department of Clinical Science, Otorhinolaryngology/Sunderby Research Unit Department of Clinical Science, Otorhinolaryngology Department of Integrative Medical Biology, Laboratory of Muscle Biology, Umeå University, Umeå, Sweden.

Background And Hypothesis: Isolated malleus shaft fractures are rare cases. A commonly reported cause is a finger pulled out from a wet outer ear canal after a shower or bath. The objective was to investigate experimentally the mechanism and forces needed to establish an isolated malleus shaft fracture. Read More

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Assessment of polycyclic aromatic hydrocarbons in seafood collected from coastal aquaculture ponds in Taiwan and human health risk assessment.

J Hazard Mater 2021 Jul 21;421:126708. Epub 2021 Jul 21.

Department of Marine Environmental Engineering, National Kaohsiung University of Science and Technology, Kaohsiung 81157, Taiwan. Electronic address:

The level and distribution of 16 USEPA Polycyclic aromatic hydrocarbon (PAHs) in aquaculture farmed fish (Mugil cephalus and Oreochromis mossambicus) and shellfish (Corbicula fluminea Formosa and Meretrix lusoria) were determined in Taiwan and then assessed cancer and non-cancer risks for those consuming these kinds of seafood. Results indicated that C. fluminea Formosa accumulated the highest average concentration of total PAHs (43. Read More

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A Smart Diaper System Using Bluetooth and Smartphones to Automatically Detect Urination and Volume of Voiding: Prospective Observational Pilot Study in an Acute Care Hospital.

J Med Internet Res 2021 Jul 30;23(7):e29979. Epub 2021 Jul 30.

Department of Internal Medicine, Seoul National University Bundang Hospital, Gyeonggi-do, Republic of Korea.

Background: Caregivers of patients who wear conventional diapers are required to check for voiding every hour because prolonged wearing of wet diapers causes health problems including diaper dermatitis and urinary tract infections. However, frequent checking is labor intensive and disturbs patients' and caregivers' sleep. Furthermore, assessing patients' urine output with diapers in an acute care setting is difficult. Read More

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[2, 3, 5, 4'-tetrahydroxystilbene-2-O-β-d-glucoside alleviates lipopolysaccharide-induced acute lung injury in rats].

Authors:
J Chen H Liu

Nan Fang Yi Ke Da Xue Xue Bao 2021 Jul;41(7):1101-1106

Department of General Practice, First Affiliated Hospital of Guangdong Pharmaceutical University, Guangzhou 510030, China.

Objective: To observe the protective effect of 2, 3, 5, 4'-tetrahydroxystilbene-2-O-β-d-glucoside (TSG) against lipopolysaccharide (LPS)-induced acute lung injury (ALI) in rats and explore the underlying mechanism.

Methods: Thirty-six SD rats were randomized equally into 4 groups: the normal control group, ALI model group, and low- and high-dose TSG groups (treated with 50 and 100 mg/kg TSG via intragastric administration, respectively). In all but the normal control group, the rats were subjected to tail vein injection of LPS to induced ALI. Read More

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Evaluation of essential and non-essential elemental composition of commonly used medicinal plants from district Peshawar, Khyber Pakhtunkhwa, Pakistan.

Environ Sci Pollut Res Int 2021 Jul 24. Epub 2021 Jul 24.

Centralized Resource Laboratory, University of Peshawar, Peshawar, 25120, Pakistan.

This study illustrates a profile of some essential and non-essential elements (Na, K, Mg, Ca, Cu, Zn, Mn, Fe, Pb, Cr, Cd, Co, Al, and Sn) in the aerial parts of six medicinal plants, i.e. Coriandrum sativum L. Read More

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Analysis of the Surface Condition and Changes in Crystallographic Structure of Zirconium Oxide Affected by Mechanical Processing.

Materials (Basel) 2021 Jul 20;14(14). Epub 2021 Jul 20.

Department of Endodontics, Chair of Conservative Dentistry and Endodontics, Medical University of Lodz, 251 Pomorska Str., 92-213 Łódź, Poland.

Zirconium oxide is a material commonly used in dental prosthetics for making cups of permanent prosthetic restorations. In order to properly prepare the surface of zirconium oxide for prosthetic treatment, it must be veneered with ceramics. The quality of cup-veneered ceramics is dependent on many factors, including the surface free energy (SFE) and transformation of zirconium oxide. Read More

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Logistic matrix factorisation and generative adversarial neural network-based method for predicting drug-target interactions.

Mol Divers 2021 Aug 23;25(3):1497-1516. Epub 2021 Jul 23.

Department of Computer Sciences, Faculty of Mathematics and Computer Sciences, University of Science and Technology of Oran, Mohamed Boudiaf USTO-MB, Oran Mnaouer, P.O. Box: 1505, 31000, Oran, Algeria.

Identifying drug-target protein association pairs is a prerequisite and a crucial task in drug discovery and development. Numerous computational models, based on different assumptions and algorithms, have been proposed as an alternative to the laborious, costly, and time-consuming traditional wet-lab methods. Most proposed methods focus on separated drug and target descriptors, calculated, respectively, from chemical structures and protein sequences, and fail to introduce and extract features where the interaction information is embedded. Read More

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Comparative Study on Temperature Response of Hydropower Development in the Dry-Hot Valley.

Geohealth 2021 Jul 1;5(7):e2021GH000438. Epub 2021 Jul 1.

School of Geology and Geomatics Tianjin Chengjian University Tianjin China.

Due to the specific hydrothermal conditions of dry-hot valleys, temperature changes caused by the development of large-scale hydropower projects may be more extreme than they are in other regions. In this study, we analyzed these temperature changes at four hydropower stations in both dry-hot and non-dry-hot valleys. Based on the calculated relative temperatures of the downstream river and the areas surrounding the reservoirs, we employed two indices to quantify the influence of the reservoirs on the temperatures of these two regions: the downstream river temperature change and the reservoir effect change intensity. Read More

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Anti-inflammatory and antibacterial activities of Pyrrosia petiolosa ethyl acetate (PPEAE) against Staphylococcus aureus in mice.

Pak J Pharm Sci 2021 Mar;34(2):493-498

Key Laboratory of Bio-Resource and Eco-Environment of Ministry of Education, College of Life Sciences, Sichuan University, Chengdu, Sichuan, P.R. China.

P. petiolosa as a typical Chinese herbal medicine has been generally utilized as Chinese native medicine formulation for treatment of chronic bronchitis, bronchial asthma and pneumoconiosis. The objective of this study was to evaluate the anti-inflammatory and antibacterial activities of P. Read More

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Magnetic biochar prepared by electromagnetic induction pyrolysis of cellulose: Biochar characterization, mechanism of magnetization and adsorption removal of chromium (VI) from aqueous solution.

Bioresour Technol 2021 Oct 19;337:125429. Epub 2021 Jun 19.

State Key Laboratory of Silicate Materials for Architectures, Wuhan University of Technology, Wuhan 430070, China. Electronic address:

This work introduces a novel methodology for synthesis of magnetic biochar from cellulose using an electromagnetic induction technology. More rough surfaces, sharp corners and edges, and compact regular pore structure with FeO and FeO of magnetic biochar was obtained. Such magnetic biochar possessed higher specific surface area (~236 m/g) and micropore volume (0. Read More

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October 2021

[Water use characteristics of artificial sand-fixing vegetation on the southern edge of Hunshandake Sandy Land, Inner Mongolia, China].

Ying Yong Sheng Tai Xue Bao 2021 Jun;32(6):1980-1988

Institute of Water Conservancy and Civil Engineering, Inner Mongolia Agricultural University, Hohhot 010018, China.

We examined the characteristics of water use in typical tree species of arbor and shrub in Hunshandake Sandy Land, and , in the different seasons, with the aim to provide theoretical basis for the structural optimization of the artificial shelterbelt. Samples of precipitation, soil water, groundwater and stem water of the two vegetation were collected, and their distribution characteristics of δD-δO were analyzed by hydrogen and oxygen stable isotope technology. The contribution rate of these potential water source to the arbor and shrub species were calculated using multi-source linear mixing model. Read More

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Nanoscale Strontium-Substituted Hydroxyapatite Pastes and Gels for Bone Tissue Regeneration.

Nanomaterials (Basel) 2021 Jun 19;11(6). Epub 2021 Jun 19.

School of Clinical Dentistry, The University of Sheffield, 19 Claremont Crescent, Sheffield S10 2TA, UK.

Injectable nanoscale hydroxyapatite (nHA) systems are highly promising biomaterials to address clinical needs in bone tissue regeneration, due to their excellent biocompatibility, bioinspired nature, and ability to be delivered in a minimally invasive manner. Bulk strontium-substituted hydroxyapatite (SrHA) is reported to encourage bone tissue growth by stimulating bone deposition and reducing bone resorption, but there are no detailed reports describing the preparation of a systematic substitution up to 100% at the nanoscale. The aim of this work was therefore to fabricate systematic series (0-100 atomic% Sr) of SrHA pastes and gels using two different rapid-mixing methodological approaches, wet precipitation and sol-gel. Read More

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Effect of Epoxide Content on the Vulcanizate Structure of Silica-Filled Epoxidized Natural Rubber (ENR) Compounds.

Polymers (Basel) 2021 Jun 3;13(11). Epub 2021 Jun 3.

School of Chemical Engineering, Pusan National University, Busan 46241, Korea.

The demand for truck-bus radial (TBR) tires with enhanced fuel efficiency has grown in recent years. Many studies have investigated silica-filled natural rubber (NR) compounds to address these needs. However, silica-filled compounds offer inferior abrasion resistance compared to carbon black-filled compounds. Read More

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