J Cancer Res Clin Oncol 2022 Jun 25. Epub 2022 Jun 25.
Instituto de Química y Fisicoquímica Biológicas (IQUIFIB), Laboratorio de Oncología y Transducción de Señales, Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Junín 956, C1113AAD, Buenos Aires, Argentina.
Purpose: To investigate the effect of TAP7f, a penicillin derivative previously characterized as a potent antitumor agent that promotes ER stress and apoptosis, in combination with thapsigargin, an ER stress inducer, on melanoma cells.
Methods: The synergistic antiproliferative effect of TAP7f in combination with thapsigargin was studied in vitro in murine B16-F0 melanoma cells, and in human A375 and SB2 melanoma cells. In vivo assays were performed with C57BL/6J mice challenged with B16-F0 cells. Read More