752,646 results match your criteria western


Haploidentical vs. sibling, unrelated, or cord blood hematopoietic cell transplantation for acute lymphoblastic leukemia.

Blood Adv 2021 Sep 21. Epub 2021 Sep 21.

University of Virginia, Charlottesville, Virginia, United States.

The role of haploidentical hematopoietic cell transplantation (HCT) using post-transplant cyclophosphamide (PTCy) for acute lymphoblastic leukemia (ALL) is being defined. We performed a retrospective, multivariate analysis comparing outcomes of HCT approaches by donor for adults with ALL in remission. The primary objective was to compare overall survival (OS) between haploidentical HCT using PTCy and HLA-matched sibling donor (MSD), 8/8 HLA-matched unrelated donor (MUD) , 7/8 HLA-matched UD, or umbilical cord blood (UCB) HCT. Read More

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September 2021

Integrated safety analysis of umbralisib, a dual PI3Kδ/CK1ε inhibitor, in relapsed/refractory lymphoid malignancies.

Blood Adv 2021 Sep 21. Epub 2021 Sep 21.

TG Therapeutics, Inc., New York, New York, United States.

Phosphoinositide 3-kinase-delta (PI3Kδ) inhibitors are active in lymphoid malignancies, though associated toxicities can limit their use. Umbralisib is a dual inhibitor of PI3Kδ and casein kinase-1ε (CK1ε). This study analyzed integrated comprehensive toxicity data from 4 open-label, phase 1 and 2 studies that included 371 adult patients (median age, 67 years) with relapsed/refractory non-Hodgkin lymphoma (follicular lymphoma [n = 147]; marginal zone lymphoma [n = 82]; diffuse large B-cell lymphoma/mantle cell lymphoma [n = 74]; chronic lymphocytic leukemia [n = 43]; and other [n = 25]) who were treated with recommended phase 2 dose of umbralisib 800 mg or higher once daily. Read More

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September 2021

Investigating the role of low level reinforcement reflex loops in insect locomotion.

Bioinspir Biomim 2021 Sep 21. Epub 2021 Sep 21.

Mechanical and Aerospace Engineering, West Virginia University, One Waterfront Place, Morgantown, West Virginia, 26506-6201, UNITED STATES.

Insects are highly capable walkers, but many questions remain regarding how the insect nervous system controls locomotion. One particular question is how information is communicated between the ``lower level" ventral nerve cord (VNC) and the ``higher level" head ganglia to facilitate control. In this work, we seek to explore this question by investigating how systems traditionally described as ``positive feedback" may initiate and maintain stepping in the VNC with limited information exchanged between lower and higher level centers. Read More

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September 2021

Modeling small remotely piloted aircraft system to head impact for investigating craniocerebral response.

J Biomech 2021 Sep 10;128:110748. Epub 2021 Sep 10.

Mechanical and Materials Engineering, Faculty of Engineering, Western University, London, Ontario, Canada; School of Biomedical Engineering, Western University, London, Ontario, Canada. Electronic address:

Understanding small remotely piloted aircraft system (sRPAS) to human head impacts is needed to better protect human head during sRPAS ground collision accidents. Recent literature reported cadaveric data on sRPAS to human head impacts, which provided a unique opportunity for developing validated computational models. However, there lacks an understanding of skull stress and brain strain during these impacts. Read More

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September 2021

Role of transient receptor potential channel 6 in the osteogenesis of periodontal ligament cells.

Int Immunopharmacol 2021 Sep 18;100:108134. Epub 2021 Sep 18.

Department of Orthodontics, Shanghai Stomatological Hospital, Fudan University, Shanghai, China; Shanghai Key Laboratory of Craniomaxillofacial Development and Diseases, Fudan University, Shanghai, China. Electronic address:

Transient receptor potential channel 6 (TRPC6) is a receptor-operated Ca channel that plays an important role in Ca influx in the majority of non-excitable cells and influences calcium signalling and cellular responses. Therefore, the purpose of the present study was to gain insight into the role of TRPC6 in the osteogenesis of periodontal ligament cells (PDLCs). By western blot and immunohistochemical staining, the protein level of TRPC6 was found to be increased in a time-dependent manner during osteoblastic differentiation of PDLCs. Read More

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September 2021

Double-edged Swords: Diaryl pyrazoline thiazolidinediones synchronously targeting cancer epigenetics and angiogenesis.

Bioorg Chem 2021 Sep 11;116:105350. Epub 2021 Sep 11.

Department of Pharmaceutical Chemistry, Bharati Vidyapeeth's College of Pharmacy, Navi Mumbai, India. Electronic address:

In the present study, two novel series of compounds incorporating naphthyl and pyridyl linker were synthesized and biological assays revealed 5-((6-(2-(5-(2-chlorophenyl)-3-(4-fluorophenyl)-4,5-dihydro-1H-pyrazol-1-yl)-2-oxoethoxy) naphthalene-2-yl)methylene)thiazolidine-2,4-dione (14b) as the most potent dual inhibitors of vascular endothelial growth factors receptor-2 (VEGFR-2) and histone deacetylase 4 (HDAC4). Compounds 13b, 14b, 17f, and 21f were found to stabilize HDAC4; where, pyridyl linker swords were endowed with higher stabilization effects than naphthyl linker. Also, 13b and 14b showed best inhibitory activity on VEGFR-2 as compared to others. Read More

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September 2021

Increasing of matrix metalloproteinase 3 in bovine endometritis.

Theriogenology 2021 Sep 4;175:83-88. Epub 2021 Sep 4.

Lanzhou Institute of Husbandry and Pharmaceutical Sciences of CAAS, Lanzhou, 730050, PR China; Key Lab of Veterinary Pharmaceutical Development of Ministry of Agriculture, Lanzhou, 730050, PR China.

Matrix metalloproteinase 3 (MMP3), a key member of the MMPs family, is involved in the modulation of endometrial inflammation and innate immunity. However, the role of MMP3 in bovine endometritis remains unknown. To investigate the role of MMP3 in bovine endometritis, endometrial MMP3 expression were determined in uterine biopsies from twenty 40-60 days postpartum dairy cows, which six were healthy cows and fourteen were endometritic cows. Read More

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September 2021

Video-based observation in impact evaluation.

Authors:
Simon Borg

Eval Program Plann 2021 Sep 17;89:102007. Epub 2021 Sep 17.

Department of Language, Literature, Mathematics and Interpretation, Western Norway University of Applied Sciences, Bergen, Norway. Electronic address:

This paper reviews the literature on the use of video-based observation (VBO) with particular attention to monitoring and evaluation (M&E) on development projects. While the use of video both as a research tool and as a strategy for supporting professional development is well-documented across several disciplines, the extent to which VBO has been utilized in M&E contexts is less clearly defined. In order to provide theoretically-grounded recommendations for the development and implementation of one organisation's innovative VBO impact evaluation scheme, this review examines recent evidence of VBO in M&E contexts and draws on VBO literature more generally to identify its advantages and challenges together with advice for enhancing its effectiveness. Read More

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September 2021

Differential pre-pandemic breast milk IgA reactivity against SARS-CoV-2 and circulating human coronaviruses in Ugandan and American mothers.

Int J Infect Dis 2021 Sep 18. Epub 2021 Sep 18.

Department of Medicine, Division of Infectious Diseases, Icahn School of Medicine at Mount Sinai, New York, USA. Electronic address:

Objective: Uganda has registered fewer COVID-19 cases and deaths per capita than Western countries. Lower numbers of cases and deaths might be due to pre-existing cross-immunity induced by circulating common cold human coronaviruses (HCoVs) before the COVID-19 pandemic. To investigate pre-existing mucosal antibodies against COVID-19, we compared IgA reactivity to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and HCoVs in milk of mothers collected in 2018. Read More

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September 2021

Expression, purification, and biochemical characterization of an NAD-dependent homoserine dehydrogenase from the symbiotic Polynucleobacter necessarius subsp. necessarius.

Protein Expr Purif 2021 Sep 18:105977. Epub 2021 Sep 18.

Research Center of Laboratory Medicine, School of Laboratory Medicine, Bengbu Medical College, Bengbu, Anhui, 233030, China.

Homoserine dehydrogenase (HSD), encoded by the hom gene, is a key enzyme in the aspartate pathway, which reversibly catalyzes the conversion of l-aspartate β-semialdehyde to l-homoserine (l-Hse), using either NAD(H) or NADP(H) as a coenzyme. In this work, we presented the first characterization of the HSD from the symbiotic Polynucleobacter necessaries subsp. necessarius (PnHSD) produced in Escherichia coli. Read More

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September 2021

Total Hip Arthroplasty with the Wagner Cone Femoral Stem in Patients with Crowe 4 Developmental Dysplasia of the Hip. A Retrospective Study.

J Arthroplasty 2021 Sep 18. Epub 2021 Sep 18.

Private Ortopedia Hospital, Hip Surgery Department, Cumhuriyet street No:64, Post code: 01130, Seyhan, Adana, Turkey.

Purpose: The aim of this study is to assess treatment of Crowe type IV hip dysplasia with the Wagner Cone femoral stem combined with transverse subtrochanteric shortening osteotomy and augmenting the osteotomy site using the intercalary segment as a strut autograft.

Methods: 127 hips of 91 patients diagnosed with Crowe type IV hip dysplasia and treated with total hip arthroplasty (THA) using the Wagner Cone stem combined with transverse subtrochanteric shortening osteotomy were retrospectively evaluated by clinical and radiographic outcomes as well as complications.

Results: The mean follow-up was 8. Read More

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September 2021

Antimicrobial Susceptibility among Gram-Negative Isolates in Pediatric Patients in Europe from 2013-2018 compared to 2004-2012: Results from the ATLAS Surveillance Study.

Int J Antimicrob Agents 2021 Sep 18:106441. Epub 2021 Sep 18.

Pfizer Inc., 500 Arcola Road, E Dock, Office F-3200, Collegeville, PA 19426, USA.

Aims: Data on antimicrobial resistance (AMR) in the pediatric patient population are scarce. Here, we assess the AMR rates and phenotype distribution of Gram-negative isolates in pediatric patients in Europe from 2004-2012 and 2013-2018.

Methods: Isolates collected were stratified by age groups (<1, 1-5, 6-12, 13-17 years) and regions (North-Western, Eastern, and Southern Europe). Read More

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September 2021

BaZiBuShen alleviates cognitive deficits and regulates Sirt6/NRF2/HO-1 and Sirt6/P53-PGC-1α-TERT signaling pathways in aging mice.

J Ethnopharmacol 2021 Sep 18:114653. Epub 2021 Sep 18.

Diabetes Research Centre, Traditional Chinese Medicine School, Beijing University of Chinese Medicine, Beijing, 100029, China. Electronic address:

Ethnopharmacological Relevance: BaZiBuShen formula (BZBS) is clinically used to counteract mental fatigue and to retard the aging process. Brain aging echoes in major risks of human sufferings and has become one of the main challenges to our societies and the health-care systems.

Aim Of The Study: To investigate the effect and mode of action of BZBS on aging-associated cognitive impairments. Read More

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September 2021

Effects of 2,2',4,4'-tetrabromodiphenyl ether on the development of mouse embryonic stem cells.

Reprod Toxicol 2021 Sep 18. Epub 2021 Sep 18.

State Key Laboratory of Reproductive Medicine, Institute of Toxicology, Nanjing Medical University, Nanjing, 210029, China; Key Laboratory of Modern Toxicology of Ministry of Education, School of Public Health, Nanjing Medical University, Nanjing, 210029, China. Electronic address:

2,2',4,4'-Tetrabromodiphenyl ether (BDE47) poses potential risks to reproduction and development, but the mechanism of its toxicity has not yet been elucidated. To explore the developmental toxicity of BDE47, mouse embryonic stem cells (mESCs), which are ideal models for testing the developmental toxicity of environmental contaminants in vitro, were exposed to BDE47 (0.04 μM, 1 μM, 25 μM, or 100 μM) for 24 h or 48 h in this study. Read More

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September 2021

Heme Oxygenase-1 (HMOX-1) and inhibitor of differentiation proteins (ID1, ID3) are key response mechanisms against iron-overload in pancreatic β-cells.

Mol Cell Endocrinol 2021 Sep 18:111462. Epub 2021 Sep 18.

Sharjah Institute for Medical Research, University of Sharjah, 27272, Sharjah, United Arab Emirates; Department of Basic Medical Sciences, College of Medicine, University of Sharjah, Sharjah, 27272, United Arab Emirates. Electronic address:

Iron overload promotes the generation of reactive oxygen species (ROS). Pancreatic β-cells can counter oxidative stress through multiple anti-oxidant responses. Herein, RNA-sequencing was used to describe the expression profile of iron regulatory genes in human islets with or without diabetes. Read More

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September 2021

Doxorubicin suppresses chondrocyte differentiation by stimulating ROS production.

Eur J Pharm Sci 2021 Sep 18:106013. Epub 2021 Sep 18.

Department of Orthopedics, Affiliated Hospital of Guizhou Medical University, Guiyang City, Guizhou Province, 550004, P. R. China.

Background: Doxorubicin (DOX) is widely used as an effective chemotherapy agent in human cancer. Our study aimed to explore the specific mechanism of DOX in osteoarthritis (OA).

Methods: A mouse OA model was established by destabilizing the medial meniscus (DMM), and the role of DOX was determined by intraperitoneally injecting 5 or 10 mg/kg DOX. Read More

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September 2021

IPR-mediated activation of BK channels contributes to mGluR5-induced protection against spinal cord ischemia-reperfusion injury.

Neurochem Int 2021 Sep 18:105191. Epub 2021 Sep 18.

Department of Neurosurgery, The 904th Hospital of PLA, Medical School of Anhui Medical University, Wuxi, Jiangsu, 214044, China; Department of Neurosurgery, Drum Tower Hospital, Medical School of Nanjing University, Nanjing, Jiangsu, 210000, China. Electronic address:

Spinal cord ischemia-reperfusion injury (SCIRI) can cause dramatic neuron loss and lead to paraplegia in patients. In this research, the role of mGluR5, a member of the metabotropic glutamate receptors (mGluRs) family, was investigated both in vitro and in vivo to explore a possible method to treat this complication. In vitro experiment, after activating mGluR5 via pretreating cells with (RS)-2-Chloro-5-hydroxyphenylglycine (CHPG) and 3-cyano-N-(1,3-diphenyl-1H-pyrazol-5-yl) benzamide (CDPPB), excitotoxicity induced by glutamate (Glu) was attenuated in primary spinal cord neurons, evidenced by higher neuron viability, decreased lactate dehydrogenase (LDH) release and less detected TUNEL-positive cells. Read More

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September 2021

Expression of immunoproteasome subunits in the brains of Toxoplasma gondii-infected mice.

Exp Mol Pathol 2021 Sep 18:104684. Epub 2021 Sep 18.

State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute of Chinese Academy of Agricultural Sciences, Harbin, China. Electronic address:

The immunoproteasomes are specific proteasomes that clear oxidant-damaged proteins under inflammatory conditions in various diseases. Toxoplasma gondii (T. gondii) infects the central nervous system, causing encephalitis. Read More

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September 2021

Mannose-binding lectin promotes blood-brain barrier breakdown and exacerbates axonal damage after traumatic brain injury in mice.

Exp Neurol 2021 Sep 18:113865. Epub 2021 Sep 18.

Department of Neuroscience and Experimental Therapeutics, Institute for Biomedical Research of Barcelona (IIBB), Spanish National Research Council (CSIC), Barcelona, Spain; Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain. Electronic address:

Leukocyte infiltration and blood-brain barrier breakdown contribute to secondary brain damage after traumatic brain injury (TBI). TBI induces neuroimmune responses triggering pathogenic complement activation through different pathways, including the lectin pathway. We investigated mechanisms underlying mannose-binding lectin (MBL)-mediated brain damage focusing on neutrophil infiltration and blood-brain barrier breakdown in a TBI mouse model. Read More

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September 2021

Identification of colon tumor marker NKD1 via integrated bioinformatics analysis and experimental validation.

Cancer Med 2021 Sep 21. Epub 2021 Sep 21.

Department of Oncology, Wujin Hospital Affiliated with Jiangsu University, Jiangsu Province, China.

Background: Colorectal cancer is an important death-related disease in the worldwide. However, specific colon cancer tumor markers currently used for diagnosis and treatment are few. The purpose of this study is to screen the potential colon cancer markers by bioinformatics and verify the results with experiments. Read More

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September 2021

LncRNA CAIF suppresses LPS-induced inflammation and apoptosis of cardiomyocytes through regulating miR-16 demethylation.

Authors:
Yan Wang Yi Zhang

Immun Inflamm Dis 2021 Sep 21. Epub 2021 Sep 21.

Department of Intensive Care Unit, Shaanxi Provincial People's Hospital, Xi'an, China.

Background: The long noncoding RNA, cardiac autophagy inhibitory factor (CAIF), and microRNA (miR)-16 are reported to be involved in lipopolysaccharide (LPS)-induced inflammatory responses and cell apoptosis in many diseases. Herein, we investigated the interaction between CAIF and miR-16 in sepsis-induced chronic heart failure (CHF).

Methods: The expression of CAIF and miR-16 in plasma samples from sepsis-induced CHF patients (n = 60) and healthy controls (n = 60) were measured using quantitative reverse-transcription polymerase chain reaction (qRT-PCR). Read More

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September 2021

Anticancer effects of melatonin via regulating lncRNA JPX-Wnt/β-catenin signalling pathway in human osteosarcoma cells.

J Cell Mol Med 2021 Sep 21. Epub 2021 Sep 21.

Department of Neurosurgery, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, China.

Osteosarcoma (OS) is a type of malignant primary bone cancer, which is highly aggressive and occurs more commonly in children and adolescents. Thus, novel potential drugs and therapeutic methods are urgently needed. In the present study, we aimed to elucidate the effects and mechanism of melatonin on OS cells to provide a potential treatment strategy for OS. Read More

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September 2021

Cholesterol efflux capacity and its association with prevalent metabolic syndrome in a multi-ethnic population (Dallas Heart Study).

PLoS One 2021 21;16(9):e0257574. Epub 2021 Sep 21.

Division of Cardiology, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America.

Metabolic syndrome (MetS) is characterized by adiposity and atherogenic dyslipidemia consisting of elevated triglyceride and decreased high density lipoprotein cholesterol (HDL-C) levels however, cholesterol concentration alone does not reflect HDL functionality. Cholesterol efflux capacity (CEC) captures a key anti-atherosclerotic function of HDL; studies linking CEC to MetS have yielded inconsistent findings and lacked racial/ethnic diversity. The aim of this study was to evaluate the association between CEC and MetS in a large multi-ethnic population utilizing two different CEC assays interrogating overlapping but distinct reverse cholesterol transport pathways. Read More

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September 2021

The impact of green credit on economic growth-The mediating effect of environment on labor supply.

PLoS One 2021 21;16(9):e0257612. Epub 2021 Sep 21.

School of Economics and Management, Shanghai Ocean University, Shanghai, China.

Background: The progress of green credit in China is accelerating, but its development is uneven and insufficient in different regions. And whether the issuance of green credit can effectively promote the improvement of the environment and economy is not well understood.

Objective: Previous research has found that green credit promotes economic growth through improvement of the industrial structure and green technological innovation. Read More

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September 2021

Total mercury concentrations in invasive lionfish (Pterois volitans/miles) from the Atlantic coast of Florida.

PLoS One 2021 21;16(9):e0234534. Epub 2021 Sep 21.

Department of Biology, University of North Florida, Jacksonville, FL, United States of America.

Invasive lionfish (Pterois volitans/miles) pose a serious threat to marine ecosystems throughout the western Atlantic Ocean and Caribbean Sea. The development of a fishery for lionfish has been proposed as a strategy for controlling populations; however, there is concern about consumption of this species by humans due to its high trophic position and potential for bioaccumulation of mercury. We analyzed total mercury (THg) in tissues of lionfish from two locations on the east coast of Florida. Read More

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September 2021

Study on the effect of digital economy on high-quality economic development in China.

PLoS One 2021 21;16(9):e0257365. Epub 2021 Sep 21.

School of Economics and Management, Chongqing University of Posts and Telecommunications, Chongqing, China.

At present, the digital economy, which takes information technology and data as the key elements, is booming and has become an important force in promoting the economic growth of various countries. In order to explore the current dynamic trend of China's digital economy development and the impact of the digital economy on the high-quality economic development, this paper measures the digital economic development index of 30 cities in China from the three dimensions of digital infrastructure, digital industry, and digital integration, uses panel data of 30 cities in China from 2015 to 2019 to construct an econometric model for empirical analysis, and verifies the mediating effect of technological progress between the digital economy and high-quality economic development. The results show that (1) The development level of China's digital economy is increasing year by year, that the growth of digital infrastructure is obvious, and that the development of the digital industry is relatively slow. Read More

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September 2021

Biomarkers of dairy fat intake, incident cardiovascular disease, and all-cause mortality: A cohort study, systematic review, and meta-analysis.

PLoS Med 2021 Sep 21;18(9):e1003763. Epub 2021 Sep 21.

The George Institute for Global Health, Faculty of Medicine, University of New South Wales, Sydney, Australia.

Background: We aimed to investigate the association of serum pentadecanoic acid (15:0), a biomarker of dairy fat intake, with incident cardiovascular disease (CVD) and all-cause mortality in a Swedish cohort study. We also systematically reviewed studies of the association of dairy fat biomarkers (circulating or adipose tissue levels of 15:0, heptadecanoic acid [17:0], and trans-palmitoleic acid [t16:1n-7]) with CVD outcomes or all-cause mortality.

Methods And Findings: We measured 15:0 in serum cholesterol esters at baseline in 4,150 Swedish adults (51% female, median age 60. Read More

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September 2021

Increased Early Mortality in Bilateral Simultaneous TKA Using Conventional Instrumentation Compared with Technology-Assisted Surgery: A Study of 34,908 Procedures from a National Registry.

J Bone Joint Surg Am 2021 Sep 21. Epub 2021 Sep 21.

Australian Orthopaedic Association National Joint Replacement Registry, Adelaide, South Australia, Australia.

Background: Controversy exists regarding the safety of bilateral simultaneous total knee arthroplasty (BSTKA). When conventional instrumentation is used, the increased fat emboli that result from the insertion of intramedullary rods may increase the risk of perioperative complications. We hypothesized that the use of technology-assisted instrumentation (avoiding intramedullary involvement) would be associated with a lower rate of early postoperative death compared with the use of conventional instrumentation. Read More

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September 2021

Shared Language for Shared Work in Population Health.

Ann Fam Med 2021 Sep-Oct;19(5):450-457

Department of Family Medicine and Community Health, University of Minnesota, Minneapolis, Minnesota.

People working on behalf of population health, community health, or public health often experience confusion or ambiguity in the meaning of these and other common terms-the similarities and differences and how they bear on the tasks and division of labor for care delivery and public health. Shared language must be clear enough to help, not hinder people working together as they ultimately come to mutual understanding of roles, responsibilities, and actions in their joint work. Based on an iterative lexicon development process, the authors developed and propose a definitional framework as an aid to navigating among related population and community health terms. Read More

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September 2019

Radiology Education Among Emergency Medicine Residencies: A National Needs Assessment.

West J Emerg Med 2021 Sep 2;22(5):1110-1116. Epub 2021 Sep 2.

University of California, Los Angeles, David Geffen School of Medicine, Department of Emergency Medicine, Los Angeles, California.

Introduction: Radiology training is an important component of emergency medicine (EM) education, but its delivery has been variable. Program directors have reported a lack of radiology skills in incoming interns. A needs assessment is a crucial first step toward improving radiology education among EM residencies. Read More

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September 2021