1,981 results match your criteria well-differentiated papillary


Effects of Social Determinants of Health Care on Pediatric Thyroid Cancer Outcomes in the United States.

Otolaryngol Head Neck Surg 2021 Jul 27:1945998211032901. Epub 2021 Jul 27.

Department of Otolaryngology-Head and Neck Surgery, Stanford University Medical Center, Palo Alto, California, USA.

Objective: To identify social determinants of health care that are associated with poorer pediatric well-differentiated thyroid cancer (WDTC) outcomes and increased stage at presentation.

Study Design: Using the SEER database (Surveillance, Epidemiology, and End Results), we retrospectively gathered data on pediatric WDTC across the United States between 1973 and 2015.

Setting: All patients between 0 and 19 years old with a diagnosis of WDTC were included. Read More

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LONG-TERM FOLLOW-UP OF PATIENTS UNDERGOING ENDOSCOPIC PAPILLECTOMY FOR PAPILLARY NEUROENDOCRINE TUMOR: A CASE SERIES AND LITERATURE REVIEW.

Arq Gastroenterol 2021 Jul 16. Epub 2021 Jul 16.

Hospital 9 de Julho, Serviço de Endoscopia, São Paulo, SP, Brasil.

Background: Duodenal papilla neuroendocrine tumors (DP-NET) are rare. Surgical therapy may be recommended for their treatment. However, they have high rates of morbidity and mortality. Read More

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Total thyroidectomy can still remain the method of choice in some Bethesda III cases.

Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub 2021 Jul 20. Epub 2021 Jul 20.

Institute of Pathology, 1st Faculty of Medicine, Charles University, Prague, Czech Republic.

Background: The latest WHO classification of tumours of endocrine organs defines new units of borderline thyroid tumours (BTT). The aim of our study was to evaluate ultrasonographic and cytological features, mutation profile and surgery treatment in rare thyroid tumours.

Methods: An analysis of 8 BTT out of 487 patients, who underwent thyroid surgery between June 2016 and June 2020. Read More

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First case of huge classic papillary thyroid cancer rupturing spontaneously leading to ischemic necrosis, perforation and inflammation of overlying skin: Case report and review of the literature.

Int J Surg Case Rep 2021 Jun 29;85:106136. Epub 2021 Jun 29.

Department of General Surgery, Hamad General Hospital, Hamad Medical Corporation, Doha, Qatar.

Introduction: Papillary thyroid cancer (PTC) is the commonest form of well-differentiated endocrine carcinoma. It is categorized into indolent and aggressive, where the indolent subtypes (classic, follicular) rarely demonstrate aggressive behavior. We present a classic PTC presenting with a rapidly growing huge anterior neck mass that subsequently spontaneously ruptured subcutaneously resulting in ischemia, necrosis, and perforation of overlying skin leading to inflammation. Read More

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Increased thyroid malignancy in patients with primary hyperparathyroidism.

Endocr Connect 2021 Jul 1. Epub 2021 Jul 1.

L Sheng, Department of Thyroid Surgery, Shandong University Qilu Hospital, Jinan, China.

Background: Multiple studies have reported increased incidence of thyroid cancer in patients with primary hyperparathyroidism (PHPT). However, the underlying risk factors of concomitant thyroid cancer in patients with PHPT remain unknown. The primary aim of this study was to examine the records of patients with PHPT to identify characteristics that correlated with the presence of coexisting thyroid nodules, and which may have an implication for the prediction of thyroid cancer. Read More

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Prophylactic Central Neck Dissection in Well-differentiated Thyroid Cancer.

Acta Clin Croat 2020 Jun;59(Suppl 1):87-95

1Department of Otorhinolaryngology and head and neck surgery, Zagreb University Hospital Centre, Zagreb, Croatia; 2Department of Anaesthesiology, Resuscitation and Intensive Care, Zagreb University Hospital Centre, Zagreb, Croatia; 3Department of Otorhinolaryngology and Maxillofacial Surgery, Faculty of Medicine, J. J. Strossmayer University of Osijek, Osijek, Croatia; 4Department of Dental Medicine, Faculty of Dental Medicine and Health, J. J. Strossmayer University of Osijek, Osijek, Croatia.

Well-differentiated cancers, both papillary and follicular, account for 90% of all diagnosed thyroid cancers. They have an indolent disease course with a 20-year disease-specific survival over 90%. According to current guidelines, the therapy of choice for well-differentiated thyroid carcinoma is total thyroidectomy or lobectomy. Read More

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Diagnostic Value of Galectin-3 in Distinguishing Invasive Encapsulated Carcinoma from Noninvasive Follicular Thyroid Neoplasms with Papillary-Like Nuclear Features (NIFTP).

Cancers (Basel) 2021 Jun 15;13(12). Epub 2021 Jun 15.

Alex and Simona Shnaider Research Laboratory in Molecular Oncology, Lunenfeld-Tanenbaum Research Institute, Sinai Health System, Mount Sinai Hospital, Toronto, ON M5G 1X5, Canada.

: non-invasive follicular thyroid neoplasms with papillary-like nuclear features (NIFTP), which is considered as low-risk cancer, should be distinguished from the malignant invasive encapsulated follicular variant of papillary thyroid carcinoma (EFVPTC). Improved discrimination of NIFTPs from invasive EFVPTCs using a molecular biomarker test could provide useful insights into pre- and post-surgical management of the indeterminate thyroid nodule. Galectin-3 (Gal-3), a β-galactosyl-binding molecule in the lectin group, is involved in different biological functions in well differentiated thyroid carcinomas. Read More

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Well-Differentiated Thyroid Cancer Invading the Trachea in a Pediatric Patient.

AACE Clin Case Rep 2021 May-Jun;7(3):207-210. Epub 2021 Mar 23.

University of Michigan, Department of Otolaryngology-Head and Neck Surgery, Ann Arbor, Michigan.

Objectives: Pediatric thyroid cancer is rare. Most cases are well-differentiated thyroid cancers (WDTCs). However, gross laryngotracheal invasion of WDTCs is unusual. Read More

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Immunohistochemical expression and prognostic significance of VEGF-C in well-differentiated thyroid cancer.

Acta Endocrinol (Buchar) 2020 Oct-Dec;16(4):409-416

University Clinical Center Sarajevo. Bosnia and Herzegovina - Department of Nuclear Medicine and Endocrinology - Sarajevo, Bosnia and Herzegovina.

Context: Neoangiogenesis and lymphangio-genesis are essential for the growth of tumor and progression of malignancy.

Objective: The study examined the significance of VEGF-C expression in comparison to classical prognostic factors in differentiated thyroid carcinoma (DTC), as well as an independent prognostic marker in DTC.

Design: The study included 81 patients with DTC allocated in two groups according to the type of cancer (follicular papillary) and then compared to expression of VEGF-C and clinicopathological features. Read More

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How limited molecular testing can also offer diagnostic and prognostic evaluation of thyroid nodules processed with liquid-based cytology: Role of TERT promoter and BRAF V600E mutation analysis.

Cancer Cytopathol 2021 Jun 2. Epub 2021 Jun 2.

Division of Anatomic Pathology and Histology, Fondazione Policlinico Universitario "Agostino Gemelli"-IRCCS, Rome, Italy.

Background: Mutational analysis contributes to the diagnosis and prognosis of thyroid nodules analyzed with fine-needle aspiration cytology (FNAC). Although several advanced molecular tests based on multiple molecular markers are available for clinical use and have increased their impact on clinical management of patients, they are not widely available. Among them is BRAF V600E, one of the most studied mutations. Read More

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Preoperative ultrasound characteristics in determining the likelihood of cytologically confirmed (Bethesda VI), 1-4 cm papillary thyroid tumours requiring completion thyroidectomy.

Asian J Surg 2021 May 26. Epub 2021 May 26.

Endocrine Surgical Services Unit, Sir Charles Gairdner Hospital, Western Australia, Australia.

Background: Papillary thyroid carcinoma (PTC) is the most commonly diagnosed differentiated thyroid carcinoma. There is controversy about performing upfront lobectomy vs thyroidectomy for smaller well differentiated thyroid carcinoma.

Methods: A retrospective study from 2015 to 2020 was conducted consisting of consecutive patients with a preoperative malignant (Bethesda VI) cytology on fine needle aspirate (FNA) consistent with PTC. Read More

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Should tall cell thyroid cancers be evaluated differently from well-differentiated thyroid cancers?

Ann Ital Chir 2021 ;92:123-130

Objective: In this study, we aimed to investigate the clinical features of Papillary thyroid carcinoma(PTC) Tall cell variant(TCV), long-term outcomes and surgical experience in papillary thyroid carcinoma.

Material-method: 33 patients who were operated in our clinic between August 2012 and March 2018 and diagnosed as TCV in their pathology evaluation were included in the study. The demographic and clinical features of the patients, pathological features of the tumor and long-term results were examined. Read More

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January 2021

Platelet-Derived Growth Factor Receptor-α Subunit Targeting Suppresses Metastasis in Advanced Thyroid Cancer and .

Biomol Ther (Seoul) 2021 May 25. Epub 2021 May 25.

School of Medical Laboratory Science and Biotechnology, College of Medical Science and Technology, Taipei Medical University, Taipei 11031, Taiwan.

Thyroid cancer is the most common endocrine malignancy. Patients with well-differentiated thyroid cancers, such as papillary and follicular cancers, have a favorable prognosis. However, poorly differentiated thyroid cancers, such as medullary, squamous and anaplastic advanced thyroid cancers, are very aggressive and insensitive to radioiodine treatment. Read More

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INSM1 Expression in Breast Neoplasms with Neuroedocrine Features.

Endocr Pathol 2021 May 19. Epub 2021 May 19.

Department of Oncology, Pathology Unit, University of Turin, Via Santena 7, 10126, Turin, Italy.

According to the 2019 WHO classification of breast tumors, neuroendocrine neoplasms (NENs) are classified into well-differentiated NE tumors (NET) and poorly differentiated NE carcinomas (NEC), while other breast cancers (BCs) of special and no special type with neuroendocrine (NE) features are not incorporated in this scheme anymore. We aimed to assess whether INSM1, a novel NE marker, could have a role in breast NEN subtyping. We selected 63 BCs operated from 2003 to 2018, classified as BCs with NE features, with available clinico-pathological data. Read More

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Immunohistochemical staining for IMP3 in patients with duodenal papilla tumors: assessment of the potential for diagnosing endoscopic resectability and predicting prognosis.

BMC Gastroenterol 2021 May 18;21(1):224. Epub 2021 May 18.

Department of Gastroenterology and Hepatology, Nagoya University Graduate School of Medicine, Nagoya, 4668550, Japan.

Background: Endoscopic papillectomy of duodenal papillary tumors (PT) is indicated for adenomas or well-differentiated adenocarcinomas that do not involve the sphincter of Oddi. However, there is currently no reliable pre-operative method to diagnose the infiltration in the sphincter of Oddi.' Insulin-like growth factor 2 mRNA protein 3 (IMP3) staining is reportedly associated with advanced disease stage and clinical outcomes in many carcinomas. Read More

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The role of PI3K signaling pathway and its associated genes in papillary thyroid cancer.

J Egypt Natl Canc Inst 2021 May 17;33(1):11. Epub 2021 May 17.

Biotechnology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.

Background: One of the well-differentiated types of thyroid cancer is papillary thyroid cancer (PTC), often developed by genetic mutations and radiation.

Methods: In this study, the public NCBI-GEO database was systematically searched. The eligible datasets were the targets for biomarker discovery associated with PI3K signaling pathway. Read More

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Pitfalls in Frozen Section: A Case of Incidental Papillary Mesothelioma.

Int J Surg Pathol 2021 May 12:10668969211018259. Epub 2021 May 12.

12286Rutgers-New Jersey Medical School, Newark, NJ, USA.

Well-differentiated papillary mesothelioma is an uncommon benign, although potentially recurrent mesothelial lesion that occurs in the peritoneum of women over a wide age range. We recently encountered an incidental case sent for frozen section at the time of hysterectomy for endometrial carcinoma. Familiarity with this lesion will help prevent overinterpretation as a serous carcinoma. Read More

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HBME1 and CK19 expression in non-invasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) vs other follicular patterned thyroid lesions.

World J Surg Oncol 2021 May 8;19(1):143. Epub 2021 May 8.

Department of Pathology, University of New Mexico School of Medicine, MSC08 4640, 1 University of New Mexico, Albuquerque, NM, 87131, USA.

Background: Thyroid neoplasms with follicular architecture can have overlapping morphologic features and pose diagnostic confusion among pathologists. Various immunohistochemical stains have been investigated as potential diagnostic markers for PTC, among which HBME1 and CK19 have gained popularity. Non-invasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) poses similar diagnostic challenges with interobserver variability and is often misdiagnosed as adenomatoid nodule or follicular adenoma. Read More

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Limited Clinical and Diagnostic Utility of Circulating Tumor DNA Detection in Patients with Early-Stage Well-Differentiated Thyroid Cancer: Comparison with Benign Thyroid Nodules and Healthy Individuals.

Healthcare (Basel) 2021 Apr 1;9(4). Epub 2021 Apr 1.

Hallym University Medical Center, Hallym Institute of Translational Genomics and Bioinformatics, Anyang 14068, Gyeonggi-do, Korea.

Limited data are available on the diagnostic utility of circulating tumor DNA (ctDNA) in early-stage thyroid cancers for , , , and promoter mutations, which are known detectable markers for thyroid cancers. Here, we analyzed the above driver mutations in ctDNA and matched neoplastic tissues from patients with early-stage thyroid cancers in order to investigate diagnostic utility of circulating markers in distinguishing from other mimicking thyroid lesions and healthy individuals. In total, 73 matched neoplastic tissue and plasma samples [thyroid cancers (n = 62), benign thyroid disorders (n = 8), and parathyroid lesions (n = 3)] and 54 plasma samples from healthy individuals (as controls) were analyzed for , , , and promoter mutations using peptide nucleic acid clamp real-time PCR. Read More

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Lateral Neck Dissection for Well-Differentiated Thyroid Carcinoma: Is Prophylactic Level V Neck Dissection Necessary? A Retrospective Cohort Study.

Ear Nose Throat J 2021 Apr 29:1455613211003805. Epub 2021 Apr 29.

Department of Otolaryngology-Head and Neck, Maxillofacial Surgery, Israel.

Objective: The presence of clinically detectable papillary thyroid carcinoma (PTC) metastases in the lateral neck is an indication for neck dissection (ND) and thyroidectomy. Although there is a consensus regarding the importance of therapeutic selective ND of involved levels II to IV in patients with clinically evident locoregional metastatic disease, the prognostic benefit of level V prophylactic ND remains debatable.

Methods: All patients who underwent thyroidectomy with ND for metastatic PTC between 2006 and 2019 were included in a single-institution retrospective study. Read More

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Case Report: A New Entity: Multiple Differentiated Variant of Papillary Thyroid Carcinoma With Advanced Clinical Behavior.

Front Endocrinol (Lausanne) 2021 7;12:654638. Epub 2021 Apr 7.

Thyroid and Parathyroid Surgery Center, West China Hospital, Sichuan University, Chengdu, China.

There are many histological morphological types of papillary thyroid carcinoma (PTC), but the most frequently seen types are conventional. A single PTC commonly has a conventional and/or a variant morphological pattern. PTC with multiple (more than two) well-differentiated morphological patterns are extremely rare. Read More

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Well differentiated carcinoma with a poor prognosis: a retrospective analysis of papillary gastric adenocarcinoma.

Surg Today 2021 Aug 16;51(8):1387-1396. Epub 2021 Apr 16.

Department of Gastric Cancer, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center of Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin's Clinical Research Cancer for Cancer, Tianjin, 300060, China.

Purpose: To explore the clinicopathological features and prognosis of papillary gastric adenocarcinoma (PGC).

Methods: The subjects of this retrospective analysis were 1525 patients with gastric cancer in a single center in China.

Results: The patients with PGC were generally of advanced age and the tumor was located in the upper 1/3 of the stomach. Read More

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Histological and immunohistochemical characteristics and status studied by FISH in six incidentally detected cases of well-differentiated papillary mesothelioma of the peritoneum.

Indian J Pathol Microbiol 2021 Apr-Jun;64(2):277-281

Division of Pathology, Tohoku Medical and Pharmaceutical University, Sendai, Japan.

Well-differentiated papillary mesothelioma (WDPM) is an uncommon mesothelial neoplasm, which is generally regarded as benign or indolent in terms of its clinical behavior. However, details about WDPM have remained relatively unknown. Therefore, in this study, we examined six incidentally detected cases of WDPM of the peritoneum. Read More

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Synchronous intrathyroidal parathyroid carcinoma and thyroid carcinoma: case report and review of the literature.

BMC Endocr Disord 2021 Apr 7;21(1):60. Epub 2021 Apr 7.

General Surgery Unit, Department of Advanced Medical and Surgical Sciences, University of Campania "Luigi Vanvitelli", Piazza Miraglia, 80138, Naples, Italy.

Background: Parathyroid carcinoma is a rare endocrine malignancy, rarer when synchronous with a non medullary well differentiated thyroid carcinoma. Parathyroid carcinoma accounts of 0.005% of all malignant tumors and it is responsible for less than 1% of primary hyperparathyroidism. Read More

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Triple metachronous primary pancreatic and gallbladder cancer associated with pancreaticobiliary maljunction: a case report.

Surg Case Rep 2021 Apr 6;7(1):81. Epub 2021 Apr 6.

Department of Surgery, Hiroshima Memorial Hospital, Honkawa-cho1-4-3, Naka-ku, Hiroshima, 730-0802, Japan.

Background: Metachronous pancreatic and gallbladder cancer is a rare condition and has a dismal prognosis. Herein, we present a patient with triple metachronous primary pancreatic and gallbladder cancer associated with pancreaticobiliary maljunction who achieved long-term survival after undergoing repeat curative surgery.

Case Presentation: A 65-year-old female patient with advanced gallbladder cancer associated with pancreaticobiliary maljunction underwent extended cholecystectomy with extrahepatic bile duct resection. Read More

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Spontaneous urinary bladder perforation: An unusual presentation of well-differentiated papillary peritoneum mesothelioma.

Urologia 2021 Mar 29:3915603211001181. Epub 2021 Mar 29.

Department of Urology, Azienda Ospedaliera Nazionale SS. Antonio e Biagio e Cesare Arrigo, Alessandria, Italy.

Introduction: Well-differentiated papillary mesothelioma (WDPM) is a very rare neoplasm. Most of WDPM are asymptomatic and are often incidentally detected during surgery. This report describes a case of WDPM of the peritoneum unexpectedly diagnosed in a male with a spontaneous intraperitoneal bladder rupture. Read More

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The Effect of BRAF Mutation on Lymph Node Involvement in Papillary Thyroid Cancer.

Turk J Surg 2020 Sep 28;36(3):249-255. Epub 2020 Sep 28.

Ankara University Faculty Of Medicine, Pathology, Ankara, Turkey.

Objectives: Papillary thyroid cancer (PTC) is the most common well-differentiated thyroid cancer. Lymph node (LN) metastasis is frequently seen in PTC. The effect of BRAFV mutation on PTC-associated LN metastasis has not been clearly established. Read More

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September 2020

Time to Surgery and Thyroid Cancer Survival in the United States.

Ann Surg Oncol 2021 Jul 25;28(7):3556-3565. Epub 2021 Mar 25.

Section of Endocrine Surgery, Department of Surgery, Beth Israel Deaconess Medical Center, Boston, MA, USA.

Background: Longer time to surgery worsens survival in multiple malignancies, including lung, colorectal, and breast cancers, but limited data exist for well-differentiated thyroid cancer. We sought to investigate the impact of time to surgery on overall survival in patients with papillary thyroid cancer.

Methods: In a retrospective cohort study of the National Cancer Database, we used Cox proportional hazard models to investigate overall survival as a function of time between diagnosis and surgery for adults with papillary thyroid cancer, adjusting for demographic, patient, and cancer-related variables. Read More

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Palate Squamous Cell Carcinomas:A Ten-Year Single Institute Experience.

Curr Health Sci J 2020 Oct-Dec;46(4):358-370. Epub 2020 Dec 31.

Department of Oral and Maxillofacial Surgery, University of Medicine and Pharmacy of Craiova, Romania.

The literature date estimated that about 5% of all oral cavity cancers are hard palate cancers while soft palate cancers account for about 5-12% of oropharyngeal cancers. Although rare, usually these tumors had a more aggressively behavior than other oral cancer sites. That is why our study aimed to investigate comparatively the epidemiological, clinical and histopathological peculiarities of the two palatal sites of oral squamous cell carcinomas. Read More

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December 2020