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The Effect of Ranibizumab Loading Treatment on Vision-Related Quality of Life in Diabetic Macular Edema.

Clin Pract 2021 Sep 14;11(3):659-670. Epub 2021 Sep 14.

Faculty of Medicine, Usak University, 64000 Usak, Turkey.

Aims: To investigate the changes in vision-related quality of life after a loading dose of three consecutive intravitreal ranibizumab (IVR) injections in patients with unilateral diabetic macular edema (DME).

Materials And Methods: Fifty-two eyes of 52 patients who received IVR injections in only one eye with DME were included in our study. The following characteristics of the patients were recorded: gender, education status, marital status, work status, presence of chronic disease. Read More

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September 2021

Genetically Encoded Sensor Cells for the Screening of Glucocorticoid Receptor (GR) Effectors in Herbal Extracts.

Biosensors (Basel) 2021 Sep 16;11(9). Epub 2021 Sep 16.

Department of Biomedical Engineering, Dongguk University, Seoul 04620, Korea.

Although in vitro sensors provide facile low-cost ways to screen for biologically active targets, their results may not accurately represent the molecular interactions in biological systems. Cell-based sensors have emerged as promising platforms to screen targets in biologically relevant environments. However, there are few examples where cell-based sensors have been practically applied for drug screening. Read More

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September 2021

A membraneless self-powered photoelectrochemical biosensor based on BiS/BiPO heterojunction photoanode coupling with redox cycling signal amplification strategy.

Biosens Bioelectron 2021 Sep 20;195:113651. Epub 2021 Sep 20.

College of Chemistry and Chemical Engineering, Xinyang Key Laboratory of Functional Nanomaterials for Bioanalysis, Xinyang Normal University, Xinyang 464000, China. Electronic address:

The photoelectrochemical (PEC) self-powered system has attracted great attention in disease detection. The determination of a simple and efficient approach for disease-related biomarkers is highly interesting and appealing. Herein, an ingenious visible light-induced membraneless self-powered PEC biosensing platform was constructed, integrating a signal amplification strategy for ultrasensitive split-type PEC bioanalysis. Read More

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September 2021

The alkaloid cryptolepine as a source of polyadenylate targeting therapeutic agent: Induction of self-assembly in the polyadenylate moiety.

Arch Biochem Biophys 2021 Sep 22:109042. Epub 2021 Sep 22.

Physical Chemistry Section, Department of Chemistry, Jadavpur University, 188, Raja S. C. Mallick Road, Kolkata, 700032, India. Electronic address:

RNAs have become a well-known target for chemotherapeutic agents in the recent years. The tails of most eukaryotic m-RNA are characterized by the presence of a long polyadenylate sequence which plays an important role in its growth and maturation. This lays emphasis on development of molecular probes that target the polyadenylate sequence. Read More

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September 2021

Regulation of prophage induction and lysogenization by phage communication systems.

Curr Biol 2021 Sep 22. Epub 2021 Sep 22.

CEFE, CNRS, Univ Montpellier, EPHE, IRD, Univ Paul Valéry Montpellier 3, Montpellier, France. Electronic address:

Many viruses cause both lytic infections, where they release viral particles, and dormant infections, where they await future opportunities to reactivate. The benefits of each transmission mode depend on the density of susceptible hosts in the environment. Some viruses infecting bacteria use molecular signaling to respond plastically to changes in host availability. Read More

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September 2021

Characterization of Neodymium Speciation in the Presence of Fulvic Acid by Ion Exchange Technique and Single Particle ICP-MS.

Bull Environ Contam Toxicol 2021 Sep 25. Epub 2021 Sep 25.

School of Environmental Science and Engineering, Guangdong Provincial Key Laboratory of Environmental Pollution Control and Remediation Technology, Sun Yat-Sen University, Guangzhou, China.

It has been well known that the free ion concentration of metals plays a vital role in metal bioavailability. However, measurement of this fraction is still not easy over years of development. Nowadays, rare earth elements (REEs) are drawing more attentions as an emerging contaminant due to their wide applications in our daily life. Read More

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September 2021

Computed tomography of the airways and lungs in congenital heart disease.

Pediatr Radiol 2021 Sep 25. Epub 2021 Sep 25.

Department of Radiology, Children's Hospital of Philadelphia, 3401 Civic Center Blvd., Philadelphia, PA, 19104, USA.

The presence of airway and lung disease in children with congenital heart disease is commonly observed with both cardiac CT angiography and routine chest CT. In this review we discuss abnormalities encountered on CT imaging of the chest beyond the heart and central vasculature, focusing on the airways, lung parenchyma and peripheral vasculature. Preoperative and postoperative findings are reviewed as well. Read More

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September 2021

ACE2 function in pancreatic islet: Implications for relationship between SARS-CoV-2 and diabetes.

Acta Physiol (Oxf) 2021 Sep 24:e13733. Epub 2021 Sep 24.

College of Health and Life Sciences, Hamad Bin Khalifa University (HBKU), Qatar Foundation, Education City, Doha, Qatar.

The molecular link between SARS-CoV-2 infection and susceptibility is not well understood. Nonetheless, a bi-directional relationship between SARS-CoV-2 and diabetes has been proposed. The angiotensin converting enzyme 2 (ACE2) is considered as the primary protein facilitating SARS-CoV and SARS-CoV-2 attachment and entry into the host cells. Read More

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September 2021

Pre-transplant donor-specific HLA antibodies and risk for poor first year renal transplant outcomes - Results from the Swiss Transplant Cohort Study.

Transpl Int 2021 Sep 24. Epub 2021 Sep 24.

Clinic for Transplantation Immunology and Nephrology, University Hospital Basel, Basel, Switzerland.

The aim of this study was to analyze first year renal outcomes in a nationwide prospective multicenter cohort comprising 2215 renal transplants, with a special emphasis on the presence of pre-transplant donor-specific HLA antibodies (DSA). All transplants had a complete virtual crossmatch and DSA were detected in 19% (411/2215). The investigated composite endpoint was a poor first year outcome defined as (i) allograft failure or (ii) death or (iii) poor allograft function (eGFR ≤25 ml/min/1. Read More

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September 2021

Vulvar vitiligo and lichen sclerosus in children: A clinical challenge.

Pediatr Dermatol 2021 Sep 24. Epub 2021 Sep 24.

Division of Dermatology - IRCSS Azienda Ospedaliero Universitaria di Bologna, Division of Dermatology, Department of Experimental, Diagnostic and Specialty Medicine, University of Bologna, Bologna, Italy.

Vulvar vitiligo (VV) and vulvar lichen sclerosus (VLS), both feature skin and mucosal hypo-/depigmentation. The aim of this study was to describe the clinical and dermoscopic features of VV and VLS in the pediatric population, providing diagnostic clues, and to define their association. We performed a systematic literature review of the clinical and dermoscopic features of pediatric VV and VLS. Read More

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September 2021

Intraoperative Indocyanine Green Angiography of Parathyroid Glands and the Prevention of Post-Thyroidectomy Hypocalcemia.

World J Surg 2021 Sep 24. Epub 2021 Sep 24.

Unidad de Cirugía Endocrina. Hospital Universitari de Bellvitge, Universidad de Barcelona (UB), C/ Feixa Llarga s/n, 08907, Barcelona, Spain.

Background: We compared the reliability of indocyanine green (ICG) angiography and intraoperative PTH levels for predicting early post-thyroidectomy hypocalcemia.

Methods: Prospective study of 94 patients (71% women, mean age 53.7 years) undergoing total thyroidectomy. Read More

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September 2021

Permanent Cerebrospinal Fluid Diversion in Adults With Posterior Fossa Tumors: Incidence and Predictors.

Neurosurgery 2021 Sep 24. Epub 2021 Sep 24.

Department of Neurosurgery, School of Medicine, Emory University, Atlanta, Georgia, USA.

Background: Posterior fossa tumors (PFTs) can cause hydrocephalus. Hydrocephalus can persist despite resection of PFTs in a subset of patients requiring permanent cerebrospinal fluid (CSF) diversion. Characteristics of this patient subset are not well defined. Read More

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September 2021

Aposematism facilitates the diversification of parental care strategies in poison frogs.

Sci Rep 2021 Sep 24;11(1):19047. Epub 2021 Sep 24.

Department of Biological Sciences, St. John's University, Jamaica-Queens, NY, USA.

Many organisms have evolved adaptations to increase the odds of survival of their offspring. Parental care has evolved several times in animals including ectotherms. In amphibians, ~ 10% of species exhibit parental care. Read More

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September 2021

ARe we there yet? Understanding androgen receptor signaling in breast cancer.

NPJ Breast Cancer 2020 Sep 25;6(1):47. Epub 2020 Sep 25.

Department of Radiation Oncology, University of Michigan, Ann Arbor, MI, USA.

The role of androgen receptor (AR) activation and expression is well understood in prostate cancer. In breast cancer, expression and activation of AR is increasingly recognized for its role in cancer development and its importance in promoting cell growth in the presence or absence of estrogen. As both prostate and breast cancers often share a reliance on nuclear hormone signaling, there is increasing appreciation of the overlap between activated cellular pathways in these cancers in response to androgen signaling. Read More

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September 2020

Recent advances in nemaline myopathy.

Neuromuscul Disord 2021 Jul 24. Epub 2021 Jul 24.

The Folkhälsan Institute of Genetics, Folkhälsan Research Center, Helsinki, Finland; Department of Medical Genetics, Medicum, University of Helsinki, Finland.

The nemaline myopathies constitute a large proportion of the congenital or structural myopathies. Common to all patients is muscle weakness and the presence in the muscle biopsy of nemaline rods. The causative genes are at least twelve, encoding structural or regulatory proteins of the thin filament, and the clinical picture as well as the histological appearance on muscle biopsy vary widely. Read More

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Nanocellulose-mediated transparent high strength conductive hydrogel based on in-situ formed polypyrrole nanofibrils as a multimodal sensor.

Carbohydr Polym 2021 Dec 24;273:118600. Epub 2021 Aug 24.

Key Lab of Science and Technology of Eco-textile, Ministry of Education, College of Chemistry, Chemical Engineering and Biotechnology, Innovation Center for Textile Science and Technology, Donghua University, Shanghai 201620, People's Republic of China; Innovation Center for Textile Science and Technology of DHU, Donghua University, Shanghai 201620, People's Republic of China. Electronic address:

A simple method was provided to prepare a transparent, highly conductive, mechanically reinforced, stretchable, and compressible hydrogel. In this system, pyrrole (Py) monomers were gently polymerized and uniformly deposited on the surface of cellulose nanofiber (CNF) via the improved in-situ polymerization. In the opaque [email protected] suspension, acrylamide monomers (AM) were dissolved and radical-polymerized to construct the [email protected] hydrogel with the in-situ formation of PPy nanofibrils in the presence of excess ammonium persulfate (APS). Read More

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December 2021

Pd-catalyzed cross-coupling of arabinogalactan propargyl ethers with 5-bromosalicylic acid.

Carbohydr Polym 2021 Dec 17;273:118561. Epub 2021 Aug 17.

A. E. Favorsky Irkutsk Institute of Chemistry, Siberian Branch of the Russian Academy of Sciences, 1 Favorsky Str., 664033 Irkutsk, Russian Federation. Electronic address:

New salicylate derivatives of arabinogalactan have been synthesized in up to 90% yield by cross-coupling of propargyl ethers of arabinogalactan with 5-bromosalicylic acid salts. The reaction proceeds in the presence of the catalytic system Pd(PPh)/PPh with CuBr (CuI), and piperidine or 1,8-diazabicyclo-[5.4. Read More

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December 2021

Malignant Gonadal Germ Cell Tumors (Other Than Pure Germinoma) in Patients With Disorders of Sex Development: A Report of 21 Cases Based Largely on the Collection of Dr Robert E. Scully, Illustrating a High Frequency of Yolk Sac Tumor With Prominent Hepatoid and Glandular Features.

Am J Surg Pathol 2021 Sep 23. Epub 2021 Sep 23.

Department of Pathology & Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN James Homer Wright Pathology Laboratories, Massachusetts General Hospital, Harvard Medical School, Boston, MA.

We describe 21 nonpure germinomatous gonadal germ cell tumors (9 with a germinoma component), all but 1 associated with gonadoblastoma, in patients with disorders of sex development who ranged from 7 to 36 years old (average, 20 y). Twenty patients were clinically described as phenotypic females with ambiguous genitalia/virilization and primary amenorrhea. The most common documented peripheral karyotype was 46,XY (10/12; 83%). Read More

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September 2021

Utility of D2-40, Cytokeratin 5/6, and High-Molecular-weight Cytokeratin (Clone 34βE12) in Distinguishing Intraductal Spread of Urothelial Carcinoma From Prostatic Stromal Invasion.

Am J Surg Pathol 2021 Sep 23. Epub 2021 Sep 23.

Departments of Pathology and Laboratory Medicine Urology Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, FL.

Intraductal spread of urothelial carcinoma (UC) is not an uncommon finding in bladder cancer that requires appropriate clinical management. The presence of prostatic stromal invasion in non-muscle-invasive bladder cancer upstages the disease, necessitating cisplatin-based neoadjuvant chemotherapy and subsequent cystroprostatectomy. However, the identification of prostatic stromal invasion can be challenging, especially in biopsy and transurethral resection specimens. Read More

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September 2021

Symptom and clinical recovery outcomes for pediatric concussion following early physical activity.

J Neurosurg Pediatr 2021 Sep 24:1-8. Epub 2021 Sep 24.

3Sports Medicine Center, Children's Hospital Colorado, Aurora.

Objective: Recent research supports initiating physical activity as soon as 24 to 48 hours after concussion to reduce persistent postconcussive symptoms. However, this practice has not been widely adopted. The objective of this study was to evaluate the association of early physical activity with patient-reported and functional outcomes for pediatric patients following a concussion. Read More

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September 2021

Effectiveness of dual-detergent strategy using Triton X-100 in membrane protein purification.

Biochem Biophys Res Commun 2021 Sep 20;578:122-128. Epub 2021 Sep 20.

Crystallography and Molecular Biology Division, Saha Institute of Nuclear Physics, Homi Bhabha National Institute, 1/AF Bidhannagar, Kolkata, 700 064, India. Electronic address:

Membrane solubilization by detergents is a critical step for successful membrane protein purification. Alkyl maltoside detergents such as DDM and DM are very expensive and are commonly used to produce most of the high-quality proteins in stable and functional form. Recently, dual-detergent strategy using inexpensive detergents for membrane solubilization step has been shown to be highly effective in purifying different classes of membrane proteins in a cost-effective manner. Read More

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September 2021

Tracing the toxic ions of an endodontic tricalcium silicate-based sealer in local tissues and body organs.

J Trace Elem Med Biol 2021 Sep 13;68:126856. Epub 2021 Sep 13.

Departmento de Dentística, Endodontia e Materiais Odontológicos, Faculdade de Odontologia de Bauru, FOB/USP, Bauru, Brazil.

Background: This study aimed to track the toxic ions released by MTA Fillapex, BioRoot RCS, and an experimental tricalcium silicate-based sealer (CEO) into local and distant tissues as well as to investigate their potential adverse effects. In addition, the chemical constituents of the sealers were also evaluated. The main components of the dry powders, pastes, and mixed sealers were characterized. Read More

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September 2021

Discovering pesticides and their TPs in Luxembourg waters using open cheminformatics approaches.

Environ Int 2021 Sep 21;158:106885. Epub 2021 Sep 21.

Luxembourg Centre for Systems Biomedicine (LCSB), University of Luxembourg, 6 Avenue du Swing, Luxembourg. Electronic address:

The diversity of hundreds of thousands of potential organic pollutants and the lack of (publicly available) information about many of them is a huge challenge for environmental sciences, engineering, and regulation. Suspect screening based on high-resolution liquid chromatography-mass spectrometry (LC-HRMS) has enormous potential to help characterize the presence of these chemicals in our environment, enabling the detection of known and newly emerging pollutants, as well as their potential transformation products (TPs). Here, suspect list creation (focusing on pesticides relevant for Luxembourg, incorporating data sources in 4 languages) was coupled to an automated retrieval of related TPs from PubChem based on high confidence suspect hits, to screen for pesticides and their TPs in Luxembourgish river samples. Read More

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September 2021

Obstructive sleep apnea in surgical patients and its relationship with difficult intubation: two years of experience from a single center.

Braz J Anesthesiol 2021 Sep 21. Epub 2021 Sep 21.

Demiroglu Bilim University Florence Nightingale Hospital School of Nursing, Istanbul, Turkey.

Background And Objectives: In this study, we aimed to determine the risk of obstructive sleep apnea (OSA) in patients undergoing elective surgery and its relationship with difficult intubation (DI).

Methods: This prospective, descriptive cross-sectional study was conducted between December 2018 and February 2020 in the anesthesiology and reanimation service of a training and research hospital. The study included patients who were ASA I-II, 18 years of age and older who underwent elective surgery under general anesthesia. Read More

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September 2021

Simultaneous analyses of urinary eicosanoids and related mediators identified tetranor-prostaglandin E metabolite as a novel biomarker of diabetic nephropathy.

J Lipid Res 2021 Sep 21:100120. Epub 2021 Sep 21.

Department of Clinical Laboratory, University of Tokyo Hospital, Tokyo, Japan; Department of Clinical Laboratory Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.

Diabetic nephropathy is a major complication of diabetes mellitus, and thus novel biomarkers are desired to evaluate the presence and progression of diabetic nephropathy. In this study, we sought to identify possible metabolites related to diabetic nephropathy among urinary eicosanoids and related mediators. Using liquid chromatogram-tandem mass spectrometry, we optimized the lipid extraction from urine using the Monospin C18 as a solid-phase extraction cartridge, and measured the urinary lipid mediators in 111 subjects with type 2 diabetes mellitus as well as 33 heathy subjects. Read More

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September 2021

Prevalence of depressive disorders and treatment in China: a cross-sectional epidemiological study.

Lancet Psychiatry 2021 Sep 21. Epub 2021 Sep 21.

Mental Health Centre, West China Hospital, Sichuan University, Chengdu, China.

Background: In China, depressive disorders have been estimated to be the second leading cause of years lived with disability. However, nationally representative epidemiological data for depressive disorders, in particular use of mental health services by adults with these disorders, are unavailable in China. The present study, part of the China Mental Health Survey, 2012-15, aims to describe the socioeconomic characteristics and the use of mental health services in people with depressive disorders in China. Read More

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September 2021

No increased circular inference in adults with high levels of autistic traits or autism.

PLoS Comput Biol 2021 Sep 24;17(9):e1009006. Epub 2021 Sep 24.

Institute for Adaptive and Neural Computation, School of Informatics, University of Edinburgh, Edinburgh, United Kingdom.

Autism spectrum disorders have been proposed to arise from impairments in the probabilistic integration of prior knowledge with sensory inputs. Circular inference is one such possible impairment, in which excitation-to-inhibition imbalances in the cerebral cortex cause the reverberation and amplification of prior beliefs and sensory information. Recent empirical work has associated circular inference with the clinical dimensions of schizophrenia. Read More

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September 2021

Prevalence and associated factors of needle stick and sharps injuries among healthcare workers in northwestern Ethiopia.

PLoS One 2021 24;16(9):e0252039. Epub 2021 Sep 24.

Department of Epidemiology and Biostatistics, School of Public Health, College of Medicine and Health Sciences, Wollo University, Dessie, Ethiopia.

Background: Needle stick and sharp injuries (NSSIs) are a common problem among healthcare workers (HCWs). Although the factors related to NSSIs for HCWs are well documented by several studies in Ethiopia, no evidence has been reported about the magnitude of and factors related to NSSIs in hospitals in northwestern Ethiopia.

Methods: An institution-based cross-sectional study was carried out from January to March 2019 among 318 HCWs in three randomly-selected hospitals of the eight hospitals found in South Gondar Zone. Read More

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September 2021

Psychiatric Comorbidity in Bariatric Surgery: A Retrospective Study in a General Hospital.

Psychiatr Danub 2021 Sep;33(Suppl 9):75-79

Department of Psychiatry, University of Perugia, Piazzale Lucio Severi, 1, 06132, S. Andrea delle Fratte, Perugia, Italy.

Background: Candidates for bariatric surgery undergo a multidisciplinary evaluation in the pre-operative phase, including a psychiatric visit aimed at the screening for psychiatric comorbidities, including feeding and eating disorders (FEDs), which are shortcomings to the intervention or predictors of worse prognosis. The presence of FEDs, such as Binge Eating Disorder (BED) and Bulimia Nervosa (BN), is associated with higher rates of other psychiatric disorders. Furthermore, there is evidence of the association between obesity and Depressive Disorders, as well as B and C Cluster Personality Disorders. Read More

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September 2021

Agreement Analysis on Angle Characteristics with Automated Gonioscopy.

J Glaucoma 2021 Sep 23. Epub 2021 Sep 23.

Department of Ophthalmology, Hospital de Santa Maria, CHULN, Portugal Visual Sciences Study Center, Faculty of Medicine, University of Lisbon, Lisbon, Portugal IRCCS Ospedale Policlinico San Martino, Genoa, Italy DINOGMI, Clinica Oculistica, University of Genoa, Italy Department of Ophthalmology, Shimane University Faculty of Medicine, Izumo, Japan Glaucoma Unit, Hera Hospital, Vienna, Austria Department of Ophthalmology, Medical University of Graz, Graz, Austria.

Prcis: Automated gonioscopy is a recent method of recording angle pictures. Our study shows that agreement between observers is moderate in most categories used in clinical practice, underlying its clinical usefulness but also room for improvement.

Introduction: Iridocorneal angle (ICA) imaging methods have been recently developed to record gonioscopic images. Read More

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September 2021