50,405 results match your criteria well migration

Siderite/PMS conditioning-pressurized vertical electro-osmotic dewatering process for activated sludge volume reduction: Evolution of protein secondary structure and typical amino acid in EPS.

Water Res 2021 Jun 10;201:117352. Epub 2021 Jun 10.

College of Science, Beijing Forestry University, Beijing 100083, China.

In this study, the siderite/PMS conditioning-pressurized vertical electro-osmotic dewatering (PEOD) process was used to reduce the volume of activated sludge (AS). The changes in water content, cell, extracellular polymeric substances (EPS) distribution, protein secondary structures and typical amino acids in EPS fractions of AS along siderite/PMS conditioning-PEOD process were investigated. Results showed that the final water content (WC) of dewatered AS was 58. Read More

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Clinicopathological significance of the EMT-related proteins and their interrelationships in prostate cancer. An immunohistochemical study.

PLoS One 2021 22;16(6):e0253112. Epub 2021 Jun 22.

Department of Clinical Pathomorphology, Faculty of Medicine, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Torun, Toruń, Poland.

The chronic inflammation influences a microenvironment, where as a result of losing control over tissue homeostatic mechanisms, the carcinogenesis process may be induced. Inflammatory response cells can secrete a number of factors that support both initiation and progression of cancer and also they may consequently induct an epithelial-mesenchymal transition (EMT), the process responsible for development of distant metastasis. Macrophage migration inhibitory factor (MIF) acts as a pro-inflammatory cytokine that is considered as a link between chronic inflammation and tumor development. Read More

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A Domain-guided Noise-optimization-based Inversion Method for Facial Image Manipulation.

IEEE Trans Image Process 2021 Jun 22;PP. Epub 2021 Jun 22.

A style-based architecture (StyleGAN2) yields outstanding results in data-driven unconditional generative image modeling. This work proposes a Domain-guided Noise-optimization-based Inversion (DNI) method to perform facial image manipulation. It works based on an inverse code that includes: a) a novel domain-guided encoder called Image2latent to project the image to StyleGAN2 latent space, which can reconstruct an input image with high-quality and maintain its semantic meaning well; b) a noise optimization mechanism in which a set of noise vectors are used to capture the high-frequency details such as image edges, further improving image reconstruction quality; and c) a mask for seamless image fusion and local style migration. Read More

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H, C, and N backbone resonance assignments of the SET/TAF-1β/I2PP2A oncoprotein (residues 23-225).

Biomol NMR Assign 2021 Jun 22. Epub 2021 Jun 22.

Department of Biochemistry and Molecular Biology, Medical University of South Carolina, Hollings Cancer Center, 86 Jonathan Lucas Street, Charleston, SC, 29425, USA.

SET (TAF-1β/I2PP2A) is a ubiquitously expressed, multifunctional protein that plays a role in regulating diverse cellular processes, including cell cycle progression, migration, apoptosis, transcription, and DNA repair. SET expression is ubiquitous across all cell types. However, it is overexpressed or post-translationally modified in several solid tumors and blood cancers, where expression levels are correlated with worsening clinical outcomes. Read More

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Latino-to-Latino: Promotores' Beliefs on Engaging Latino Participants in Autism Research.

J Racial Ethn Health Disparities 2021 Jun 22. Epub 2021 Jun 22.

Department of Pediatrics, Cincinnati Children's Hospital Medical Center/University of Cincinnati College of Medicine, 3333 Burnet Ave. MLC 2008, Cincinnati, OH, 45229, USA.

Background: In Latino(a) communities, promotores de salud (i.e., community health workers; promotores) are becoming critical participants in prevention, health promotion, and the delivery of health care. Read More

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Preparation of 5-Fluorouracil loaded chitosan microtube via in situ precipitation for glaucoma drainage device application: in vitro and in vivo investigation.

J Biomater Sci Polym Ed 2021 Jun 22:1-11. Epub 2021 Jun 22.

School of Ophthalmology & Optometry, Eye Hospital, Wenzhou Medical University, Wenzhou, China.

The main reason for the failure of glaucoma drainage devices is the chronic inflammatory reaction caused by the poor biocompatibility of biomaterials, which leads to the migration and proliferation of scleral fibroblasts surrounding the devices thus forming the encapsulation that will block the aqueous humor drainage channel. In order to inhibit the reaction of scleral fibroblasts after glaucoma drainage device implantation, this study designed and fabricated a 5-fluorouracil (5-FU) loaded chitosan microtube (CMT) for glaucoma aqueous humor drainage. The CMTs were made by template based adsorption-precipitation method using chitosan with excellent biocompatibility as raw material due to its characteristic of pH dependent solubility. Read More

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Insulin-like growth factor-I and wound healing, a potential answer to non-healing wounds: A systematic review of the literature and future perspectives.

Biomed Rep 2021 Aug 8;15(2):66. Epub 2021 Jun 8.

Second Department of Propaedeutic Surgery, Laiko General Hospital, Athens 11527, Greece.

The induction of wound healing by insulin-like growth factor-I (IGF-I) has been demonstrated in several animal studies; however, there are disproportionately fewer studies assessing its value in humans. The aim of the present review is to provide a comprehensive summary of all the available evidence pertaining to the effects of IGF-I administration on the process of wound anaplasias, both in human tissues and in cells . A systematic search of Medline, Scopus and Google Scholar was performed for relevant studies published until May 2020. Read More

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RNA-binding protein IMP3 is a novel regulator of MEK1/ERK signaling pathway in the progression of colorectal Cancer through the stabilization of MEKK1 mRNA.

J Exp Clin Cancer Res 2021 Jun 21;40(1):200. Epub 2021 Jun 21.

Department of Pathology, Fudan University Shanghai Cancer Center, Shanghai, 200032, China.

Background: MEK1/ERK signaling pathway plays an important role in most tumor progression, including colorectal cancer (CRC), however, MEK1-targeting therapy has little effective in treating CRC patients, indicating there may be a complex mechanism to activate MEK1/ERK signaling pathway except RAS activated mechanism.

Methods: To investigate the clinical significance of IMP3, we analyzed its expression levels in publicly available dataset and samples from Fudan University Shanghai Cancer Center. The effects of IMP3 on proliferation, migration, and invasion were determined by in vitro and in vivo experiments. Read More

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Feasibility of and barriers to thalassemia screening in migrant populations: a cross-sectional study of Myanmar and Cambodian migrants in Thailand.

BMC Public Health 2021 Jun 21;21(1):1177. Epub 2021 Jun 21.

Thalassemia Center, Faculty of Medicine Siriraj Hospital, Mahidol University, 2 Wanglang Road, Bangkoknoi, Bangkok, 10700, Thailand.

Background: Thalassemia, an inherited hemoglobin disorder, has become a global public health problem due to population migration. Evidence-based strategies for thalassemia prevention in migrants are lacking. We characterized barriers to thalassemia screening and the burden of thalassemia in migrant workers in Thailand. Read More

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Posttranslational Modifications of the Cytoskeleton.

Cytoskeleton (Hoboken) 2021 Jun 21. Epub 2021 Jun 21.

Department of Biomedical Sciences, University of Pennsylvania, School of Veterinary Medicine, Philadelphia, PA.

The cytoskeleton plays important roles in many essential processes at the cellular and organismal levels, including cell migration and motility, cell division, and the establishment and maintenance of cell and tissue architecture. In order to facilitate these varied functions, the main cytoskeletal components - microtubules, actin filaments, and intermediate filaments - must form highly diverse intracellular arrays in different subcellular areas and cell types. The question of how this diversity is conferred has been the focus of research for decades. Read More

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Profiling heterogenous sizes of circulating tumor microemboli to track therapeutic resistance and prognosis in advanced gastric cancer.

Hum Cell 2021 Jun 21. Epub 2021 Jun 21.

Department of Gastrointestinal Oncology, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Peking University Cancer Hospital and Institute, Fucheng Road 52, Haidian District, Beijing, 100142, China.

Circulating tumor microemboli (CTM) aggregated by ≥ 2 circulating tumor cells (CTCs) are more migratory than single CTCs. Aside from the plasticity in their molecular characteristics, which have been considered tumor migration, CTM also possesses high size heterogeneity. This study, therefore, systematically investigated the heterogeneous sizes of CTM and their involvement in therapeutic resistance in 114 patients with advanced gastric cancer (GC) using a pre-established surface molecule-independent subtraction enrichment (SE)-iFISH strategy. Read More

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Integrated Bioinformatic Analysis Revealed the Regulation of Angiogenesis by Tumor Cells in Hepatocellular Carcinoma.

Biosci Rep 2021 Jun 21. Epub 2021 Jun 21.

Huashan Hospital Fudan University Department of Infectious Diseases, Shanghai, China.

Hepatocellular carcinoma (HCC) is one of the leading causes of cancer mortality, metastasis accounts for most of the cases. Angiogenesis plays an important role in cancer metastasis, but how tumor cells affect the function of endothelial cells by dictating their miRNA expression remains largely unknown.Differentially expressed miRNAs (DEMs) were identified through dataset downloaded from the Gene Expression Omnibus (GEO) database and analyzed by GEO2R. Read More

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Impact of Bupivacaine on malignant proliferation, apoptosis and autophagy of human colorectal cancer SW480 cells through regulating NF-κB signaling path.

Bioengineered 2021 Dec;12(1):2723-2733

Department of Anesthesiology, Guizhou Provincial People's Hospital, Guiyang City, Guizhou Province, China.

To probe into the impact of Bupivacaine on colorectal cancer (CRC) proliferation, apoptosis, and autophagy through regulating the NF-κB signaling pathway. Our work treated CRC cells with Bupivacaine, detected cell vitality through MTT assay, apoptosis through flow cytometry, cell migration through wound healing assay, NF-κB activity through immunofluorescence, inflammatory factor level, including TNF-α, IL-1β as well as IL-6 through ESLIA, apoptosis factor mRNA expression, including Bcl-2, Bax and caspase-3q through qRT-PCR, and protein expression linking with NF-κB signaling pathway as well as autophagy-related proteins via western blot. In in vivo experiments, we explored the impact of Bupivacaine on tumor volume, tumor and NF-κB expression. Read More

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December 2021

Downregulation of circITCH promotes osteosarcoma development and resistance to doxorubicin via the miR-524/RASSF6 axis.

J Gene Med 2021 Jun 20:e3373. Epub 2021 Jun 20.

Department of Orthopedics, Zhengzhou University First Affiliated Hospital, China.

Background: Osteosarcoma (OS) is a malignant bone cancer, in which circular RNAs (circRNAs) acting as important modulators. Here, we aimed to explore the functional role of circRNA itchy E3 ubiquitin protein ligase (circITCH) in the development and doxorubicin (DXR) resistance of OS and the possible mechanistic pathway.

Methods: Quantitative real-time PCR or western blot assays were exploited to analyze the expression of circITCH, miR-524 and Ras association domain family member 6 (RASSF6). Read More

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Different Effects of Endothelial Extracellular Vesicles and LPS-Induced Endothelial Extracellular Vesicles on Vascular Smooth Muscle Cells: Role of Curcumin and Its Derivatives.

Front Cardiovasc Med 2021 31;8:649352. Epub 2021 May 31.

Key Laboratory for Quality Evaluation of Bulk Herbs of Hunan Province, Hunan University of Chinese Medicine, Changsha, China.

During the progression of atherosclerosis (AS), the vascular endothelial and smooth muscle cells are reciprocally regulated by extracellular vesicles (EVs). EVs have different effects on pathological and physiological processes due to the different cargoes contained in EVs. To study the effects of endothelial cells-derived EVs on normal and inflammatory conditions. Read More

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The effect of dexmedetomidine on biological behavior of osteosarcoma cells through miR-1307 expression.

Am J Transl Res 2021 15;13(5):4876-4883. Epub 2021 May 15.

Department of Spinal Column Surgery, Zhoushan Guhechuan Hospital Zhoushan 316000, Zhejiang, China.

Objectives: This study analyzed the effect of dexmedetomidine (DEX) on biological behavior of osteosarcoma cells through expression of miR-1307.

Methods: We performed routine culture of human osteosarcoma cells MG-63 and randomly divided into control group, low-dose DEX group (25 ng/ml), medium-dose DEX group (50 ng/ml) and high-dose DEX group (100 ng/ml). Subsequently, we detected the cell proliferation (by CCK8 method), cell apoptosis (flow cytometry), mir-1307 expression (qRT-PCR), cell invasion (Transwell), and cell migration (scratch test) respectively. Read More

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ApoM is an important potential protective factor in the pathogenesis of primary liver cancer.

J Cancer 2021 4;12(15):4661-4671. Epub 2021 Jun 4.

Anhui Province Key Laboratory of Biological Macro-molecules Research, Wannan Medical College, Wuhu 241002, China.

In recent years, abnormal liver lipid metabolism has emerged as one of the important pathogenesis pathways of primary liver cancer. It is highly important to identify the mechanisms to explore potential prevention and treatment targets. Apolipoprotein M is specifically expressed in the liver and participates in liver lipid metabolism, but the evidence that ApoM affects primary liver cancer is insufficient. Read More

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Flavonoid GL-V9 suppresses invasion and migration of human colorectal cancer cells by inhibiting PI3K/Akt and MMP-2/9 signaling.

J Cancer 2021 1;12(15):4542-4551. Epub 2021 Jun 1.

Department of Gastroenterology, Key Laboratory of Clinical Cancer Pharmacology and Toxicology Research of Zhejiang Province, Affiliated Hangzhou First People's Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310006, P.R.China.

Tumor distant metastasis is the primary cause of death in colorectal cancer (CRC) patients. GL-V9 is a newly synthesized flavonoid derivative with several beneficial biological functions including anti-tumor and anti-inflammation. However, the anti-metastatic effect of GL-V9 and related mechanisms in CRC remains unknown. Read More

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A review of estimating population exposure to sea-level rise and the relevance for migration.

Environ Res Lett 2020 Dec 27;15(12):123005. Epub 2020 Nov 27.

Corresponding author: University College London (UCL), United Kingdom.

This review analyses global or near-global estimates of population exposure to sea-level rise (SLR) and related hazards, followed by critically examining subsequent estimates of population migration due to this exposure. Our review identified 33 publications that provide global or near-global estimates of population exposure to SLR and associated hazards. They fall into three main categories of exposure, based on definitions in the publications: (i) the population impacted by specified levels of SLR; (ii) the number of people living in floodplains that are subject to coastal flood events with a specific return period; and (iii) the population living in low-elevation coastal zones. Read More

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December 2020

Relationship of intracellular proteolysis with CAP1 and cofilin1 in non-small-cell lung cancer.

J Biosci 2021 ;46

Tomsk National Research Medical Center of the Russian Academy of Sciences, Tomsk, Russian Federation 634050.

The main cause of death in non-small-cell lung cancer (NSCLC) is tumor progression, in which metastasis and invasion play an important role. The metastatic cascade is marked by a change in morphological, biological, biochemical and functional characteristics, including the acquisition of cellular mobility. The migration activity of tumor cells determines the work of actin-binding proteins that cause their functional partners CAP1 and cofilin. Read More

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January 2021

Circ_0072088 promotes progression of hepatocellular carcinoma by activating JAK2/STAT3 signaling pathway via miR-375.

IUBMB Life 2021 Jun 20. Epub 2021 Jun 20.

Department of General Surgery, Guangdong Second Provincial General Hospital, Guangzhou, Guangdong, China.

Background: Circular RNAs feature prominently in cancer development. Nonetheless, the role of circ_0072088 in hepatocellular carcinoma (HCC) remains unclear.

Methods: GEO databases (GSE97332, GSE108724, GSE36915, and GSE33006) were used to screen out the differentially expressed circRNAs, miRNAs, and mRNA in HCC. Read More

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Exon-1 skipping and intron-1 retaining by alternative splicing of the c-KIT gene encodes a novel splice variant in the skin of Merino sheep (Ovis aries).

Mol Biol Rep 2021 Jun 20. Epub 2021 Jun 20.

School of Biosciences and Veterinary Medicine, University of Camerino, Via Gentile III da Varano, 62032, Camerino, Italy.

c-KIT, a type III receptor protein tyrosine kinase, plays an essential role in melanocyte development, migration, and survival. Mutations within the c-KIT gene are previously shown to cause the white coat color phenotypes in pigs, mice, goats, and humans. However, up so far, the splicing isoform(s), genomic architecture of c-KIT have not been characterized well in merino sheep. Read More

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SP1 transcriptionally activates NLRP6 inflammasome and induces immune evasion and radioresistance in glioma cells.

Int Immunopharmacol 2021 Jun 17;98:107858. Epub 2021 Jun 17.

Clinical Research Center for Neurological Disease, People's Hospital of Honghuagang District of Zunyi, Zunyi 563000, Guizhou, PR China.

Glioma accounts for approximately 80% of all malignant brain tumors. This study aimed to investigate the interaction between specificity protein 1 (SP1) and NLR family pyrin domain containing 6 (NLRP6) and their roles in the activity of glioma cells. Differentially expressed genes in glioma were identified using transcriptome analysis tools, and a protein-protein-interaction network was performed based on the DEGs. Read More

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The potential of mechanistic information organised within the AOP framework to increase regulatory uptake of the developmental neurotoxicity (DNT) in vitro battery of assays.

Reprod Toxicol 2021 Jun 17. Epub 2021 Jun 17.

European Commission Joint Research Centre (JRC), Ispra, Italy. Electronic address:

A major challenge in regulatory developmental neurotoxicity (DNT) assessment is lack of toxicological information for many compounds. Therefore, the Test Guidelines programme of the Organisation for Economic Cooperation and Development (OECD) took the initiative to coordinate an international collaboration between diverse stakeholders to consider integration of alternative approaches towards improving the current chemical DNT testing. During the past few years, a series of workshops was organized during which a consensus was reached that incorporation of a DNT testing battery that relies on in vitro assays anchored to key neurodevelopmental processes should be developed. Read More

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The use of cardiac computed tomography angiography in the assessment of percutaneous left atrial appendage closure - Review and experts recommendations endorsed by the Société française d'imagerie cardiaque et vasculaire diagnostique et interventionnelle.

Diagn Interv Imaging 2021 Jun 16. Epub 2021 Jun 16.

Unité Inserm U955, Équipe 18, Université Paris Est, Hôpital Henri-Mondor, AP-HP, 94010 Créteil, France; Department of Radiology, Hôpital Henri-Mondor, AP-HP, 94010 Créteil, France.

Atrial fibrillation is the most common cause of arrhythmia which is responsible for over 15% of ischemic strokes, most of these being secondary to migration of a left atrial appendage (LAA) thrombus. In patient with contraindication to anticoagulant therapy, percutaneous closure system placement may be indicated. Cardiac computed tomography (CT) angiography plays a central role in the initial assessment as well as in the follow-up. Read More

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Tinea capitis asymptomatic carriers: What is the evidence behind treatment?

J Eur Acad Dermatol Venereol 2021 Jun 19. Epub 2021 Jun 19.

Dept. of Dermatology, Zealand University Hospital, Roskilde, Denmark.

Tinea capitis is a fungal infection mostly affecting children. Epidemiology is changing over time due to migration and it has been estimated that up to 40 % of children from certain developing countries are affected. The mechanism of transmission is still unclear although asymptomatic carriage seems to have an influence in establishing persistent reservoirs that can cause or fuel epidemics. Read More

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Contributions of PD-L1 reverse signaling to dendritic cell trafficking.

FEBS J 2021 Jun 19. Epub 2021 Jun 19.

Department of Medicine, Division of Gastroenterology and Hepatology, University of Colorado School of Medicine Aurora, CO, USA.

Programmed Death-1 (PD-1)/Programmed Death-Ligand 1 (PD-L1) interactions are critical for dampening the immune response to both self and foreign antigens. The signaling of PD-L1 via its cytoplasmic domain, rather than through its interactions with PD-1 via the extracellular domain, has been termed PD-L1 reverse signaling. While this signaling is beneficial for cancer progression, little is understood about the consequences of PD-L1 reverse signaling in immune cells that express PD-L1 at steady state or in response to infection. Read More

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Seasonal spatial dynamics of butterfly migration.

Ecol Lett 2021 Jun 18. Epub 2021 Jun 18.

School of Biological Sciences, The University of Queensland, Saint Lucia, Qld, Australia.

Understanding the seasonal movements of migratory species underpins ecological studies. Several hundred butterfly species show migratory behaviour, yet the spatial pattern of these migrations is poorly understood. We developed climatic niche models for 405 migratory butterfly species globally to estimate patterns of seasonal movement and the distribution of seasonal habitat suitability. Read More

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Inherited duplications of PPP2R3B predispose to nevi and melanoma via a C21orf91-driven proliferative phenotype.

Genet Med 2021 Jun 18. Epub 2021 Jun 18.

Department of Twin Research and Genetic Epidemiology, King's College London, South Wing Block D, London, UK.

Purpose: Much of the heredity of melanoma remains unexplained. We sought predisposing germline copy-number variants using a rare disease approach.

Methods: Whole-genome copy-number findings in patients with melanoma predisposition syndrome congenital melanocytic nevus were extrapolated to a sporadic melanoma cohort. Read More

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Long noncoding RNA AFAP1-AS1 promotes tumor progression and invasion by regulating the miR-2110/Sp1 axis in triple-negative breast cancer.

Cell Death Dis 2021 Jun 18;12(7):627. Epub 2021 Jun 18.

Department of Breast Surgery, Peking Union Medical College Hospital, Peking Union Medical College &Chinese Academy of Medical Sciences (CAMS), Beijing, China.

Long noncoding ribonucleic acids (LncRNAs) have been found to be involved in the proliferation, apoptosis, invasion, migration, and other pathological processes of triple-negative breast cancer (TNBC). Expression of the lncRNA actin filament-associated protein 1 antisense RNA1 (AFAP1-AS1) has been found to be significantly higher in TNBC than in other subtypes or in normal tissue samples, but the specific mechanism by which AFAP1-AS1 affects the occurrence and development of TNBC is yet to be revealed. In this study, we used Cell Counting Kit-8 (CCK-8), colony formation, wound healing migration, Transwell invasion, and nude mouse xenograft assays to confirm the role of AFAP1-AS1 in the proliferation, migration of TNBC cells in vitro and in vivo. Read More

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