264,392 results match your criteria well large

Basic concepts of radiation emergency medicine.

J Radiol Prot 2021 Sep 15. Epub 2021 Sep 15.

Health Division, IRSN, Fontenay-aux-Roses, 92260, FRANCE.

Nuclear and radiological accidents are not frequent but may lead to major consequences in the population. For the health systems, the need to handle a large number of victims will probably remain as an exception. However, a high number of affected victims can be expected in some terrorist scenarios. Read More

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September 2021

ER exit sites in Drosophila display abundant ER-Golgi vesicles and pearled tubes but no megacarriers.

Cell Rep 2021 Sep;36(11):109707

School of Life Sciences, Tsinghua University, Beijing, China; Tsinghua-Peking Center for Life Sciences, Beijing, China. Electronic address:

Secretory cargos are collected at endoplasmic reticulum (ER) exit sites (ERES) before transport to the Golgi apparatus. Decades of research have provided many details of the molecular events underlying ER-Golgi exchanges. Essential questions, however, remain about the organization of the ER-Golgi interface in cells and the type of membrane structures mediating traffic from ERES. Read More

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September 2021

Artificial intelligence in nutrition research: perspectives on current and future applications.

Appl Physiol Nutr Metab 2021 Sep 15. Epub 2021 Sep 15.

Université Laval, INAF, Pavillon des services, 2440 Hochelaga, Québec, Quebec, Canada, G1V 0A6;

Artificial intelligence (AI) is a rapidly evolving area that offers unparalleled opportunities of progress and applications in many healthcare fields. In this review, we provide an overview of the main and latest applications of AI in nutrition research and identify gaps to address to potentialize this emerging field. AI algorithms may help better understand and predict the complex and non-linear interactions between nutrition-related data and health outcomes, particularly when large amounts of data need to be structured and integrated, such as in metabolomics. Read More

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September 2021

ReactionDataExtractor: A Tool for Automated Extraction of Information from Chemical Reaction Schemes.

J Chem Inf Model 2021 Sep 15. Epub 2021 Sep 15.

Cavendish Laboratory, Department of Physics, University of Cambridge, J. J. Thomson Avenue, Cambridge CB3 0HE, U.K.

Chemical reaction schemes are commonly used for visual encapsulation of chemical information. Figures of reaction schemes contain chemical transformations, the chemical species involved, as well as reaction conditions. From a data-mining point of view, they constitute rich sources, densely packed with knowledge. Read More

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September 2021

Defining and Treating High-grade B-cell lymphoma, NOS.

Blood 2021 Sep 15. Epub 2021 Sep 15.

Rutgers Cancer Institute of New Jersey, New Brunswick, New Jersey, United States.

High-grade B-cell lymphoma, not otherwise specified (HGBL, NOS) is a recently introduced diagnostic category for aggressive B-cell lymphomas. It includes tumors with Burkitt-like or blastoid morphology that do not have double-hit cytogenetics and that cannot be classified as other well-defined lymphoma subtypes. HBCL, NOS are rare and heterogeneous; most have germinal center B-cell phenotype, and up to 45% carry a single-hit MYC rearrangement, but otherwise they have no unifying immunophenotypic or cytogenetic characteristics. Read More

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September 2021

Seroprevalence of SARS-CoV-2 antibodies among homeless people living rough, in shelters and squats: A large population-based study in France.

PLoS One 2021 15;16(9):e0255498. Epub 2021 Sep 15.

CEReSS: Health Service Research and Quality of Life Center, Aix Marseille University, Marseille, France.

Background: Overcrowded housing, as well as inadequate sanitary conditions, contribute to making homeless people particularly vulnerable to the SARS-CoV-2 infection. We aimed to assess the seroprevalence of the SARS-CoV-2 infection among people experiencing homelessness on a large city-wide scale in Marseille, France, taking into account different types of accommodation.

Methods: A consortium of outreach teams in 48 different locations including streets, slums, squats, emergency or transitional shelters and drop-in centres participated in the inclusion process. Read More

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September 2021

Spectral beam combining gratings: high diffraction efficiency at a large deviation angle achieved around conical Littrow mounting.

Kairu Wei Lifeng Li

Opt Lett 2021 Sep;46(18):4626-4629

We theoretically make plausible and numerically verify that when a high-efficiency, polarization-independent grating, designed to work at or near Littrow mounting, is used in conical Littrow mounting, its high efficiency and polarization independence can be very well maintained at a large off-principal-plane deviation angle. This finding provides a new degree of freedom to the design of high-efficiency, more compact spectral beam combining grating systems. Read More

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September 2021

Genomic epidemiology and strain taxonomy of .

J Clin Microbiol 2021 Sep 15:JCM0158121. Epub 2021 Sep 15.

Institut Pasteur, Biodiversity and Epidemiology of Bacterial Pathogens.

is highly transmissible and can cause large diphtheria outbreaks where vaccination coverage is insufficient. Sporadic cases or small clusters are observed in high-vaccination settings. The phylogeography and short timescale evolution of are not well understood, in part due to a lack of harmonized analytical approaches of genomic surveillance and strain tracking. Read More

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September 2021

Temperature-Dependent Conformational Evolution of SARS CoV-2 RNA Genome Using Network Analysis.

J Phys Chem B 2021 Sep 15. Epub 2021 Sep 15.

Biophysical and Computational Chemistry Laboratory, Department of Chemistry, National Institute of Technology Karnataka, Mangalore, Karnataka 575025, India.

Understanding the dynamics of the SARS CoV-2 RNA genome and its dependence on temperature is necessary to fight the current COVID-19 crisis. Computationally, the handling of large data is a major challenge in the elucidation of the structures of RNA. This work presents network analysis as an important tool to see the conformational evolution and the most dominant structures of the RNA genome at six different temperatures. Read More

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September 2021

Early Warning Diagnostics for Emerging Infectious Diseases in Developing into Late-Stage Pandemics.

Acc Chem Res 2021 Sep 15. Epub 2021 Sep 15.

Department of Population Health Sciences, Weill Cornell Medicine, New York, New York 10065, United States.

ConspectusThe spread of infectious diseases due to travel and trade can be seen throughout history, whether from early settlers or traveling businessmen. Increased globalization has allowed infectious diseases to quickly spread to different parts of the world and cause widespread infection. Posthoc analysis of more recent outbreaks-SARS, MERS, swine flu, and COVID-19-has demonstrated that the causative viruses were circulating through populations for days or weeks before they were first detected, allowing disease to spread before quarantines, contact tracing, and travel restrictions could be implemented. Read More

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September 2021

The Assessment of Functional Movement in Children and Adolescents: A Systematic Review and Meta-Analysis.

Sports Med 2021 Sep 15. Epub 2021 Sep 15.

School of Public Health, Physiotherapy and Sports Science, University College Dublin, Dublin, Ireland.

Background: The Functional Movement Screen™ (FMS™) is an assessment of human movement that may signal potential deficits that could predispose an otherwise healthy person to injury risk. FMS™ scores are well reported in both athletic and adult samples. However, to date, there has been no comprehensive systematic review and meta-analysis of FMS™ data among school-aged children and adolescents. Read More

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September 2021

Risk factors for invasive aspergillosis in ICU patients with COVID-19: current insights and new key elements.

Ann Intensive Care 2021 Sep 15;11(1):136. Epub 2021 Sep 15.

Department of Surgical Sciences, University of Turin, 10126, Turin, Italy.

Invasive pulmonary aspergillosis (IPA) has always been a challenging diagnosis and risk factors an important guide to investigate specific population, especially in Intensive Care Unit. Traditionally recognized risk factors for IPA have been haematological diseases or condition associated with severe immunosuppression, lately completed by chronic conditions (such as obstructive pulmonary disease, liver cirrhosis, chronic kidney disease and diabetes), influenza infection and Intensive Care Unit (ICU) admission. Recently, a new association with SARS-CoV2 infection, named COVID-19-associated pulmonary aspergillosis (CAPA), has been reported worldwide, even if its basic epidemiological characteristics have not been completely established yet. Read More

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September 2021

Fcc hcp competition in colloidal hard-sphere nucleation: on their relative stability, interfacial free energy and nucleation rate.

Phys Chem Chem Phys 2021 Sep 15;23(35):19611-19626. Epub 2021 Sep 15.

Maxwell Centre, Cavendish Laboratory, Department of Physics, University of Cambridge, J J Thomson Avenue, Cambridge CB3 0HE, UK.

Hard-sphere crystallization has been widely investigated over the last six decades by means of colloidal suspensions and numerical methods. However, some aspects of its nucleation behaviour are still under debate. Here, we provide a detailed computational characterisation of the polymorphic nucleation competition between the face-centered cubic (fcc) and the hexagonal-close packed (hcp) hard-sphere crystal phases. Read More

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September 2021

Direct PCR assays without DNA extraction for rapid detection of hemoglobin Constant Spring and Pakse' genes: application for carrier screening and prenatal diagnosis.

Scand J Clin Lab Invest 2021 Sep 15:1-7. Epub 2021 Sep 15.

Centre for Research and Development of Medical Diagnostic Laboratories, Faculty of Associated Medical Sciences, Khon Kaen University, Khon Kaen, Thailand.

Hemoglobin Constant Spring (Hb CS) and Hb Pakse' (PS) are the common non-deletional α-thalassemia found in Thailand. These two variants can cause severe thalassemia syndromes, especially in fetus and neonate. Molecular diagnosis is the only confirmatory method because Hb CS and Hb PS are usually missed by routine screening and Hb analysis. Read More

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September 2021

Arthroscopic Versus Mini-open Rotator Cuff Repair: A Randomized Trial and Meta-analysis.

Am J Sports Med 2021 Sep 15:3635465211038233. Epub 2021 Sep 15.

Department of Surgery, University of Western Ontario, London, Ontario, Canada; Roth McFarlane Hand and Upper Limb Centre, St. Joseph's Health Care, London, Ontario, Canada.

Background: Patients with complete rotator cuff tears who fail a course of nonoperative therapy can benefit from surgical repair.

Purpose: This randomized trial compared mini-open (MO) versus all-arthroscopic (AA) rotator cuff repair.

Study Design: Randomized controlled trial; Level of evidence, 1. Read More

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September 2021

[Botox preceding ventral hernia repair: it's not about esthetics].

Ned Tijdschr Geneeskd 2021 Aug 19;165. Epub 2021 Aug 19.

Amsterdam UMC, locatie AMC, Amsterdam: Afd. Chirurgie.

Ventral hernia is a common complication after laparotomy. The aim during ventral hernia repair is to close the abdomen through medialization of the rectus muscles. Particularly in patients with large ventral hernia, chronically retracted lateral muscles may preclude muscle medialization and therewith closure of the abdomen. Read More

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Tree phyllospheres are a habitat for diverse populations of CO-oxidising bacteria.

Environ Microbiol 2021 Sep 15. Epub 2021 Sep 15.

School of Life Sciences, University of Warwick, Coventry, CV4 7AL, UK.

Carbon monoxide (CO) is both a ubiquitous atmospheric trace gas and an air pollutant. While aerobic CO-degrading microorganisms in soils and oceans are estimated to remove ~370 Tg of CO per year, the presence of CO-degrading microorganisms in above-ground habitats, such as the phyllosphere, and their potential role in CO cycling remains unknown. CO-degradation by leaf washes of two common British trees, Ilex aquifolium and Crataegus monogyna, demonstrated CO uptake in all samples investigated. Read More

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September 2021

Theoretical study of the Cl(P) + SiH reaction: global potential energy surface and product pair-correlated distributions. Comparison with experiment.

Phys Chem Chem Phys 2021 Sep 15. Epub 2021 Sep 15.

Área de Química Física and Instituto de Computación Científica Avanzada, Universidad de Extremadura, 06071 Badajoz, Spain.

For the theoretical study of the title reaction, an analytical full-dimensional potential energy surface named PES-2021 was developed for the first time, by fitting high-level explicitly-correlated data. This reaction presented high exothermicity, (298 K) = -11.6 kcal mol, reproducing the experimental evidence; it is a barrierless reaction and no intermediate complexes were found. Read More

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September 2021

In-situ catalytic upgrading of bio-oil from rapid pyrolysis of biomass over hollow HZSM-5 with mesoporous shell.

Bioresour Technol 2021 Sep 2;341:125874. Epub 2021 Sep 2.

Graduate School of Science and Technology, Hirosaki University, 1-Bunkyocho, Hirosaki 036-8560, Japan; Energy Conversion Engineering Laboratory, Institute of Regional Innovation, Hirosaki University, 2-1-3, Matsubara, Aomori 030-0813, Japan. Electronic address:

To solve the issue of narrow micropores in traditional protonic type Zeolite Socony Mobil-5 (HZSM-5) catalysts in the restricting of large-molecular reactants/products diffusion, hollow HZSM-5 with a mesoporous shell was prepared using a hydrothermal method combined with a tetrapropylammonium hydroxide (TPAOH) treatment process. Applying for in-situ catalyst upgrading of bio-oil from rapid pyrolysis of biomass, the obtained most efficient catalyst of Hollow(30)-TP resulted in aromatic hydrocarbon yields in the range of 78.49-78. Read More

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September 2021

A critical review of the environmental impacts of manufactured nano-objects on earthworm species.

Environ Pollut 2021 Aug 31;290:118041. Epub 2021 Aug 31.

Beijing Key Laboratory of Farmland Soil Pollution Prevention and Remediation and College of Resources and Environmental Sciences, China Agricultural University, Beijing, 100193, PR China. Electronic address:

The presence of manufactured nano-objects (MNOs) in various consumer or their (future large-scale) use as nanoagrochemical have increased with the rapid development of nanotechnology and therefore, concerns associated with its possible ecotoxicological effects are also arising. MNOs are releasing along the product life cycle, consequently accumulating in soils and other environmental matrices, and potentially leading to adverse effects on soil biota and their associated processes. Earthworms, of the group of Oligochaetes, are an ecologically significant group of organisms and play an important role in soil remediation, as well as acting as a potential vector for trophic transfer of MNOs through the food chain. Read More

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Novel Z-scheme Binary Zinc Tungsten Oxide/Nickel Ferrite Nanohybrids for Photocatalytic Reduction of Chromium (Cr (VI)), Photoelectrochemical Water Splitting and Degradation of Toxic Organic Pollutants.

J Hazard Mater 2021 Aug 28;423(Pt A):127044. Epub 2021 Aug 28.

School of Advanced Sciences, KLE Technological University, Hubballi, Karnataka 580031, India. Electronic address:

A simple hydrothermal approach was demonstrated for synthesizing a coupled NiFeO-ZnWO nanocomposite, wherein one-dimensional ZnWO nanorods were inserted into two-dimensional NiFeO nanoplates. Herein, we evaluated the photocatalytic removal of Cr(VI), and degradation of tetracycline (TC) and methylene blue (MB) by the nanocomposite, as well as its ability to split water. The ZnWO nanorods enriched the synergistic interactions, upgraded the solar light fascination proficiency, and demonstrated outstanding detachment and migration of the photogenerated charges, as confirmed by a transient photocurrent study and electrochemical impedance spectroscopy measurements. Read More

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Factors associated with fluoxetine and norfluoxetine plasma concentrations and clinical response in Mexican patients with mental disorders.

Pharmacol Res Perspect 2021 Oct;9(5):e00864

Department of Pharmacy, Faculty of Chemical Sciences, Autonomous University of San Luis Potosí, San Luis Potosí, México.

Over the last few years, fluoxetine has been one of the most prescribed medications for the treatment of diverse psychiatric conditions in Mexico. Fluoxetine therapeutic effect is consequence of the joint action of the parent drug and its active metabolite, norfluoxetine. However, the clinical efficacy of fluoxetine, can be affected due to diverse factors, such as drug-drug interactions and the large interindividual variability in the pharmacokinetics of this drug. Read More

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October 2021

A consumer-driven recycling theory for the impact of large herbivores on terrestrial ecosystem stoichiometry.

Tanguy Daufresne

Ecol Lett 2021 Sep 14. Epub 2021 Sep 14.

Unite Eco&Sols, INRAE, (French Institute for Agriculture and Environmental Research), Montpellier, France.

Biological control of nutrient cycles is well documented in aquatic ecosystems, where consumer-driven recycling by herbivores can significantly impact ecosystem stoichiometry. In contrast, little is known in terrestrial ecosystems, where there is evidence that herbivores can also impact ecosystem stoichiometry. I studied a stoichiometric model of the soil-plant-herbivore system. Read More

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September 2021

Ultralow Thermal Conductivity, Multiband Electronic Structure and High Thermoelectric Figure of Merit in TlCuSe.

Adv Mater 2021 Sep 14:e2104908. Epub 2021 Sep 14.

Department of Chemistry, Northwestern University, Evanston, IL, 60208, USA.

The entanglement of lattice thermal conductivity, electrical conductivity, and Seebeck coefficient complicates the process of optimizing thermoelectric performance in most thermoelectric materials. Semiconductors with ultralow lattice thermal conductivities and high power factors at the same time are scarce but fundamentally interesting and practically important for energy conversion. Herein, an intrinsic p-type semiconductor TlCuSe that has an intrinsically ultralow thermal conductivity (0. Read More

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September 2021

The Role of Coronary Artery Calcium Testing for Value-Based Clinical Trials in Primary Prevention.

Curr Atheroscler Rep 2021 Sep 15;23(11):73. Epub 2021 Sep 15.

Division of Cardiovascular Medicine, Brigham and Women's Hospital, Boston, MA, USA.

Purpose Of Review: Review the role of coronary artery calcium (CAC) testing in designing future clinical trials in primary prevention.

Recent Findings: While there are numerous new agents that have been found to lower cardiovascular event rates in clinical trials, these studies have required a large sample size, in part due to low event rates as well as improved baseline treatments. More precise risk assessment could allow for better identification of individuals who stand to derive the most benefit from various therapies. Read More

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September 2021

Electrokinetics of polymeric fluids in narrow rectangular confinements.

Soft Matter 2021 Sep 15. Epub 2021 Sep 15.

Discipline of Mechanical Engineering, Indian Institute of Technology Gandhinagar, Gujarat-382355, India.

The flow of polymeric liquids in narrow confinements with a rectangular cross section, in the presence of electrical double layers is analyzed here. Our analysis is motivated by the fact that many of the previous studies on the flow of complex fluids tend to focus on highly idealized parallel plate channels, which are markedly different from the rectangular ducts, used in many experiments and devices. We consider the combined electroosmotic and pressure driven flows as well as the streaming potential resulting from a mechanically driven flow. Read More

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September 2021

Digital printing of selective and reversible ion optodes on fabrics: toward smart clothes for epidermal chemical sensing.

Analyst 2021 Sep 15. Epub 2021 Sep 15.

Department of Chemistry, Virginia Commonwealth University, 1001 W. Main St., Richmond, VA 23283, USA.

While wearable chemical sensors often rely on electrochemical techniques, optical chemical sensors coupled with a smartphone or a miniaturized camera represent an attractive approach to the monitoring of sweat composition. In this paper, we modify real sports fabrics such as polyester-spandex fabrics with rational combinations of sensing chemicals including a pH indicator, an ion exchanger, and an ionophore one-step inkjet printing. Highly selective and fully reversible pH optodes as well as Na- and K-selective optodes are obtained only when the most hydrophobic sensing chemicals are used (, sodium ionophore VIII sodium ionophore VI). Read More

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September 2021

Factors controlling surface ozone in the Seoul Metropolitan Area during the KORUS-AQ campaign.

Elementa (Wash D C) 2020 ;8(46)

Research Center for Atmospheric Environment, Hankuk University of Foreign Sturdies, Yongin, KR.

To understand the characteristics of air quality in the Seoul Metropolitan Area, intensive measurements were conducted under the Korea-United States Air Quality (KORUS-AQ) campaign. Trace gases such as O, NO, NO, SO, CO, and volatile organic compounds (VOCs), photochemical byproducts such as HO and HCHO, aerosol species, and meteorological variables including planetary boundary layer height were simultaneously measured at Olympic Park in Seoul. During the measurement period, high O episodes that exceeded the 90 ppbv hourly maximum occurred on 14 days under four distinct synoptic meteorological conditions. Read More

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January 2020

A Huge Carotid Space Schwannoma Arising from The Cervical Sympathetic Chain - A Case Report.

Ann Maxillofac Surg 2021 Jan-Jun;11(1):144-147. Epub 2021 Jul 24.

Department of Plastic Surgery, Faculty of Medicine, Suez Canal University, Ismailia, Egypt.

The Rationale: Although 25%-45% of schwannomas are originating from the neck, carotid space schwannomas are extremely rare.

Patient Concerns: We report a rare case of huge-sized schwannoma in a 20-year-old student who presented with a symptomless large carotid space mass.

Diagnosis: Cervical magnetic resonance imaging (MRI) with contrast revealed a huge, well-defined mass measuring 13. Read More

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Identification of novel inhibitory metabolites and impact verification on growth and protein synthesis in mammalian cells.

Metab Eng Commun 2021 Dec 6;13:e00182. Epub 2021 Sep 6.

Department of Chemical Engineering, University of Massachusetts Lowell, Lowell, MA, 01854, USA.

Mammalian cells consume large amount of nutrients during growth and production. However, endogenous metabolic inefficiencies often prevent cells to fully utilize nutrients to support growth and protein production. Instead, significant fraction of fed nutrients is diverted into extracellular accumulation of waste by-products and metabolites, further inhibiting proliferation and protein synthesis. Read More

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December 2021