37 results match your criteria well above-standard

An Updated Systematic Review of Quantitative Studies Assessing Anxiety, Depression, Fear of Cancer Recurrence or Psychological Distress in Testicular Cancer Survivors.

Cancer Manag Res 2021 11;13:3803-3816. Epub 2021 May 11.

NHMRC Clinical Trials Centre, The University of Sydney, Camperdown, New South Wales, Australia.

Purpose: A diagnosis of testicular cancer (TC) at a relatively young age can have a dramatic impact on the psychological well-being of those affected. The aim of this review was to synthesize recent evidence to provide an updated account of the prevalence, severity and correlates of anxiety, depression, fear of cancer recurrence (FCR) and distress in TC survivors.

Patients And Methods: A systematic literature review was conducted from September 2017 until June 2020 using electronic databases including Embase, MEDLINE, PsycINFO, Scopus and Web of Science. Read More

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Right ventricular dysfunction in critically ill COVID-19 ARDS.

Int J Cardiol 2021 03 23;327:251-258. Epub 2020 Nov 23.

Department of Cardiology, Royal Brompton Hospital, Sydney Street, London, UK; Department of Adult Critical Care, Royal Brompton Hospital, Sydney Street, London, UK. Electronic address:

Aims: Comprehensive echocardiography assessment of right ventricular (RV) impairment has not been reported in critically ill patients with COVID-19. We detail the specific phenotype and clinical associations of RV impairment in COVID-19 acute respiratory distress syndrome (ARDS).

Methods: Transthoracic echocardiography (TTE) measures of RV function were collected in critically unwell patients for associations with clinical, ventilatory and laboratory data. Read More

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Recent Advances in the Management of Acute Lymphoblastic Leukaemia.

Curr Treat Options Oncol 2020 02 20;21(3):23. Epub 2020 Feb 20.

Bristol Haematology and Oncology Centre, University Hospitals Bristol NHS Trust, Bristol, UK.

Opinion Statement: The last few years have seen unprecedented advances in treatment options for patients diagnosed with acute lymphoblastic leukaemia (ALL) in adulthood. New targeted drug therapies have been shown in randomised trials to offer significant survival improvements above standard-of-care (SoC) for relapsed disease, whilst being relatively well tolerated. Chimeric antigen receptor T cell therapy (CAR-T) has offered spectacular promise amongst the young adult population, with the possibility of cure for refractory disease. Read More

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February 2020

Treatment Patterns and Health Resource Use Among Patients with Metastatic Gastroenteropancreatic Neuroendocrine Tumors Treated at a Tertiary Referral Center.

Oncologist 2020 04 30;25(4):e644-e650. Epub 2020 Jan 30.

Dana Faber Cancer Institute, Boston, Massachusetts, USA.

Background: Although an increasing number of treatments have become available for patients with advanced gastroenteropancreatic neuroendocrine tumors (GEP-NETs), there remains little consensus on treatment sequence and its impact on health care resource use (HRU). We sought to describe treatment patterns and HRU, in a cohort of patients with metastatic GEP-NETs treated at a tertiary referral center in the U.S. Read More

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Cost-effectiveness of Imaging Protocols for Suspected Appendicitis.

Pediatrics 2020 02 21;145(2). Epub 2020 Jan 21.

Departments of Pediatrics and.

Background: Inaccurate diagnosis of appendicitis leads to increased costs and morbidity. Ultrasound costs less than computed tomography (CT) or MRI but has lower sensitivity and may not visualize the appendix.

Methods: We conducted a cost-effectiveness analysis using a decision-analytic model of 10 imaging strategies for suspected appendicitis in a hypothetical cohort of patients: no imaging with discharge or surgery; CT only; MRI only; or staged approach with CT or MRI after 1) negative ultrasound result or ultrasound without appendix visualization, 2) ultrasound without appendix visualization, or 3) ultrasound without appendix visualization but with secondary signs of inflammation. Read More

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February 2020

Pharmacists among Members of the Czech-Moravian Capuchin Province.

Karel Nesměrák

Ceska Slov Farm 2019 ;68(6):243-262

Based on a profound examination and evaluation of archival materials, the paper reconstructs the lives of eighteen pharmacists - members of the Czech-Moravian Capuchin Province from the 17th to the 19th century, of which sixteen served as monastic pharmacists. In addition to the identified biographical data (based on archival materials), the Latin summary reports on the life of a particular capuchin on the occasion of his death (the so-called elogia) from the Capuchin Provincial Chronicle (Annales capucinorum) are edited, together with their commented Czech translation. The discovered data allow a deeper insight into the pharmaceutical history of the Czech-Moravian Capuchin Province, where three monastic pharmacies were operated in Brno, Prague in Hradčany and Olomouc, and also a monastic pharmaceutical study was established. Read More

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January 2020

Bilastine: a lifetime companion for the treatment of allergies.

Curr Med Res Opin 2020 03 13;36(3):445-454. Epub 2019 Nov 13.

Paediatric Department, University of Szeged, Szeged, Hungary.

Bilastine is a potent and highly selective H-antihistamine approved for the treatment of allergic rhinoconjunctivitis and urticaria. This article summarizes available data on the use of bilastine in the treatment of allergic disorders in different age groups, including younger and older adults, and school-age children and adolescents. A PubMed literature search ("bilastine") was conducted on 25 February 2019. Read More

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How to Increase Post-Thaw Semen Quality in Poor Freezing Stallions: Preliminary Results of the Promising Role of Seminal Plasma Added after Thawing.

Animals (Basel) 2019 Jul 3;9(7). Epub 2019 Jul 3.

Department of Veterinary Sciences, Faculty of Agrobiology, Food and Natural Resources, Czech University of Life Sciences Prague, Kamýcká 129, 165 00 Praha 6-Suchdol, Czech Republic.

The aim of this study was to evaluate the effect of the addition of two types of seminal plasma (SP) after thawing on the functional characteristics of frozen-thawed (F-T) spermatozoa of poor freezing stallions during prolonged incubation periods. Seminal plasma from stallions with 35-40% (standard seminal plasma, (S-SP)) and 60-70% (above standard seminal plasma, (A-SP)) progressively motile spermatozoa after thawing was used. The motility, kinematic parameters (Computer Assisted Sperm Analysis), distribution of spermatozoa into subpopulations, integrity (carboxyfluorescein diacetate/propidium iodide staining), and functionality (hypo-osmotic swelling (HOS) test) of the spermatozoa plasma membrane were evaluated after thawing (T0) and after 30 min (T30) of incubation at 37 °C. Read More

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Living donor liver transplant from an HIV-positive mother to her HIV-negative child: opening up new therapeutic options.

AIDS 2018 10;32(16):F13-F19

Centre for HIV & STIs, National Institute for Communicable Diseases, Johannesburg.

Objective: Transplant a liver from an HIV-positive mother to her HIV-negative child to save the child's life.

Design: A unique case of living donor liver transplantation from an HIV-positive mother to her HIV-negative child in South Africa. Two aspects of this case are ground-breaking. Read More

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October 2018

Blood Pressure Response during Cardiopulmonary Exercise Testing in Heart Failure.

Med Sci Sports Exerc 2018 07;50(7):1345-1349

Duke University Medical Center, Durham, NC.

Introduction: The prognostic value of peak V˙O2 and V˙E/V˙CO2 slope measured during cardiopulmonary exercise (CPX) testing has been well established in patients with advanced heart failure, but blood pressure response to exercise is less well characterized.

Methods: We retrospectively studied 151 outpatients who underwent CPX testing as part of an advanced heart failure evaluation. The outcome of interest was failure of medical management, defined by death, cardiac transplantation, or left ventricular assist device placement. Read More

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A mouse model of vitamin D insufficiency: is there a relationship between 25(OH) vitamin D levels and obesity?

Nutr Metab (Lond) 2017 11;14:26. Epub 2017 Mar 11.

Division of Geriatrics and Palliative Medicine, Department of Medicine, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo and Research Service, Veterans Affairs Western New York Healthcare System, Buffalo, NY USA.

Background: Vitamin D insufficiency (serum 25-OH vitamin D > 10 ng/ml and < 30 ng/ml) is prevalent in the obese (body mass index (BMI) > 30 kg/m), yet relationships between the two are poorly understood. Objectives of this study include identification of the impact of obesity on reducing serum 25-OH vitamin D concentration, particularly in response to altered vitamin D supplementation, and to elucidate the longitudinal impact of serum 25-OH vitamin D on body mass index.

Methods: Twenty four-week-old lean and obese male C57BL/6 J mice were fed low, standard, or high levels of cholecalciferol supplementation and followed for 24 weeks. Read More

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Using urine as a biomarker in human exposure risk associated with arsenic and other heavy metals contaminating drinking groundwater in intensively agricultural areas of Thailand.

Environ Geochem Health 2018 Feb 7;40(1):323-348. Epub 2017 Feb 7.

Thai Fogarty ITREOH Center, Chulalongkorn University, Bangkok, 10330, Thailand.

Urine used as a biomarker was collected and compared between two groups of participants: (1) a groundwater-drinking group and (2) a non-groundwater-drinking group in intensively agricultural areas in Ubon Ratchathani province, Thailand. The statistical relationship with the metal concentration in shallow groundwater wells was established with urine data. According to the groundwater data, the health risk assessment results for four metals appeared to be higher for participants who drank groundwater than for the other group. Read More

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February 2018

Brownfields to green fields: Realising wider benefits from practical contaminant phytomanagement strategies.

J Environ Manage 2016 Dec 5;184(Pt 1):67-77. Epub 2016 Apr 5.

Centre for Environmental Sciences (CMK), Hasselt University, 3590 Diepenbeek, Belgium.

Gentle remediation options (GROs) are risk management strategies or technologies involving plant (phyto-), fungi (myco-), and/or bacteria-based methods that result in a net gain (or at least no gross reduction) in soil function as well as effective risk management. GRO strategies can be customised along contaminant linkages, and can generate a range of wider economic, environmental and societal benefits in contaminated land management (and in brownfields management more widely). The application of GROs as practical on-site remedial solutions is still limited however, particularly in Europe and at trace element (typically metal and metalloid) contaminated sites. Read More

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December 2016

Development of early mathematical skills with a tablet intervention: a randomized control trial in Malawi.

Front Psychol 2015 23;6:485. Epub 2015 Apr 23.

School of Psychology, University of Nottingham Nottingham, UK.

Evaluation of educational interventions is necessary prior to wide-scale rollout. Yet very few rigorous studies have been conducted on the effectiveness of tablet-based interventions, especially in the early years and in developing countries. This study reports a randomized control trial to evaluate the effectiveness of a tablet intervention for supporting the development of early mathematical skills in primary school children in Malawi. Read More

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Management of osteoporosis in rheumatoid arthritis patients.

Expert Opin Pharmacother 2015 Mar 27;16(4):559-71. Epub 2015 Jan 27.

VU University Medical Center, Department of Rheumatology , De Boelelaan 1117, 1081 HV, Amsterdam , The Netherlands

Introduction: In rheumatoid arthritis (RA) patients, the risk of both vertebral and non-vertebral fractures is roughly doubled, which is for an important part caused by inflammation-mediated amplification of bone loss and by immobilization. New treatments have become available in the last two decades to treat both RA and osteoporosis.

Areas Covered: Epidemiology and assessment of osteoporosis and fracture risk (including the influence of RA disease activity and bone-influencing medications such as glucocorticoids), the importance of vertebral fracture assessment in addition to bone density measurement in patients with RA, the use of disease-modifying antirheumatic drugs and their effects on generalized bone loss, and current and possible future anti-osteoporotic pharmacotherapeutic options are discussed with special focus on RA. Read More

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Stress, health and well-being: the mediating role of employee and organizational commitment.

Int J Environ Res Public Health 2013 Oct 11;10(10):4907-24. Epub 2013 Oct 11.

Department of Psychology and Behavioral Sciences, Aarhus University, DK-8000 Aarhus C, Denmark.

This study investigates the mediating impact of organizational commitment on the relationship between organizational stressors and employee health and well-being. Data were collected from 401 operator level employees working in business process outsourcing organizations (BPOs) based in New Delhi, India. In this research several dimensions from ASSET, which is an organizational stress screening tool, were used to measure employee perceptions of stressors, their commitment to the organization, their perception of the organization's commitment to them, and their health and well-being. Read More

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October 2013

Abnormal task modulation of oscillatory neural activity in schizophrenia.

Front Psychol 2013 27;4:540. Epub 2013 Aug 27.

Center for Schizophrenia Research, Nathan Kline Institute for Psychiatric Research Orangeburg, NY, USA.

Schizophrenia patients have deficits in cognitive function that are a core feature of the disorder. AX-CPT is commonly used to study cognition in schizophrenia, and patients have characteristic pattern of behavioral and ERP response. In AX-CPT subjects respond when a flashed cue "A" is followed by a target "X," ignoring other letter combinations. Read More

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Exposure to urban air pollution and bone health in clinically healthy six-year-old children.

Arh Hig Rada Toksikol 2013 ;64(1):23-34

The Center for Structural and Functional Neurosciences, The University of Montana, Missoula, MT 59812, USA.

Air pollution induces systemic inflammation, as well as respiratory, myocardial and brain inflammation in children. Peak bone mass is influenced by environmental factors. We tested the hypothesis that six-year-olds with lifetime exposures to urban air pollution will have alterations in inflammatory markers and bone mineral density (BMD) as opposed to low-polluted city residents when matched for BMI, breast feeding history, skin phototype, age, sex and socioeconomic status. Read More

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Sinogram affirmed iterative reconstruction in head CT: improvement of objective and subjective image quality with concomitant radiation dose reduction.

Eur J Radiol 2013 Sep 12;82(9):1431-5. Epub 2013 Apr 12.

Department of Diagnostic und Interventional Neuroradiology, Hoppe-Seyler-Straße 3, 72076 Tübingen, Germany.

Purpose: Iterative reconstruction has recently been revisited as a promising concept for substantial CT dose reduction. The purpose of this study was to assess the potential benefit of sinogram affirmed iterative reconstruction (SAFIRE) in head CT by comparing objective and subjective image quality at reduced tube current with standard dose filtered back projection (FBP).

Materials And Methods: Non-contrast reduced dose head CT (255 mAs, CTDIvol 47. Read More

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September 2013

Surfactant protein-D is more useful than Krebs von den Lungen 6 as a marker for the early diagnosis of interstitial pneumonitis during pegylated interferon treatment for chronic hepatitis C.

Hepatogastroenterology 2012 Oct;59(119):2260-3

Department of Gastroenterology and Hepatology, Saiseikai Niigata Daini Hospital, Niigata, Japan.

Background/aims: To examine the usefulness of serum Krebs von den Lungen 6 (KL-6) and surfactant protein-D (SP-D) as markers of interstitial pneumonitis. Many antiviral therapies have become available for chronic hepatitis C, including pegylated interferon (PEGIFN) plus ribavirin. Since interstitial pneumonitis is a serious adverse drug reaction during interferon therapy, interferon treatment requires caution in respiratory disease patients. Read More

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October 2012

Can renal nutrition education improve adherence to a low-protein diet in patients with stages 3 to 5 chronic kidney disease?

J Ren Nutr 2013 May 27;23(3):164-71. Epub 2012 Nov 27.

Postgraduate Program in Food, Nutrition, and Health, Nutrition Institute, Rio de Janeiro State University, Rio de Janeiro, Brazil.

Objective: Low adherence is frequently observed in patients with chronic kidney disease (CKD) who are following a low-protein diet. We have evaluated whether a specific nutrition education program motivates patients with CKD who do not yet receive dialysis to reduce their protein intake and whether such a program improves adherence to a low-protein diet over and above standard dietary counseling.

Design And Methods: This was a randomized controlled clinical trial conducted at the CKD outpatient clinic at Pedro Ernesto University Hospital, Rio de Janeiro, Brazil. Read More

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Efficacy of a brief acute neurobehavioural intervention following traumatic brain injury: a preliminary investigation.

Brain Inj 2011 23;25(7-8):680-90. Epub 2011 May 23.

Department of Physical Medicine and Rehabilitation,Virginia Commonwealth University, Richmond, VA 23298-0542, USA.

Primary Objective: To evaluate the effectiveness of a brief acute neurobehavioural intervention, the First Steps Acute Neurobehavioural and Cognitive Intervention (FANCI), with persons who have traumatic brain injury (TBI).

Research Design: Prospective, controlled, repeated measures design.

Methods And Procedures: Seventy-two patients in acute TBI rehabilitation participated either as FANCI subjects or as control participants who watched videos to control for time and attention. Read More

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September 2011

Quantifying the added value of BNP in suspected heart failure in general practice: an individual patient data meta-analysis.

Heart 2011 Jun 8;97(12):959-63. Epub 2011 Apr 8.

Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, GA, Utrecht, The Netherlands.

Background: Diagnosing early stages of heart failure with mild symptoms is difficult. B-type natriuretic peptide (BNP) has promising biochemical test characteristics, but its diagnostic yield on top of readily available diagnostic knowledge has not been sufficiently quantified in early stages of heart failure.

Objectives: To quantify the added diagnostic value of BNP for the diagnosis of heart failure in a population relevant to GPs and validate the findings in an independent primary care patient population. Read More

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Histopathologic findings of HPV and p16 positive HNSCC.

Laryngoscope 2010 Sep;120(9):1788-94

Division of Head and Neck Surgery, Department of Surgery, David Geffen School of Medicine at UCLA, Los Angeles, California 90095, USA.

Objective: Human papilloma virus (HPV) and p16INKa (p16) positivity in head and neck squamous cell carcinomas (HNSCCs) is currently thought to be an encouraging prognostic indicator. However, the histopathologic changes responsible for this behavior are poorly understood. It is our objective to elucidate these histopathologic characteristics to help define the clinical utility of these markers. Read More

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September 2010

Happiness and neurological diseases.

Expert Rev Neurother 2009 Apr;9(4):445-59

MS Center, Sheba Medical Center, Tel Hashomer and the Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, 52612, Israel.

Happiness is an emotional state reflecting positive feelings and satisfaction with life, which, as an outcome in disease states or as an end point in clinical trials, is a neglected concept in most therapeutic areas. In neurological disease, happiness is important as it can be diminished either as a direct result of damage to neuronal tissue or as a reaction to a poor prognosis. The monitoring and maintenance of happiness and wellbeing have historically been considered to be peripheral to medicine. Read More

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Ab initio study of interaction-induced NMR shielding constants in mixed rare gas dimers.

J Chem Phys 2007 Feb;126(7):074303

Institute of Organic Chemistry, Polish Academy of Sciences, Kasprzaka 44, 01224 Warsaw, Poland.

The interaction-induced contribution to the NMR shielding constants in homonuclear A2 and heteronuclear AB (A,B=He,Ne,Ar) dimers is obtained ab initio by employing a coupled cluster singles and doubles with perturbative treatment of triples wave function model and extended correlation-consistent basis sets. The second virial coefficients entering the expansion of the property with the density are then computed in a fully quantum mechanical approach, for temperatures ranging from the limit of dissociation of the dimer to well above standard conditions. The results can be used to describe the density and temperature dependence of the shielding constants in binary mixtures of helium, neon, and argon. Read More

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February 2007

Preclinical trial of L-arginine monotherapy alone or with N-acetylcysteine in septic shock.

Crit Care Med 2006 Nov;34(11):2719-28

Critical Care Medicine Department, Clinical Center, National Institutes of Health, Bethesda, MD, USA.

Objective: L-arginine supplementation in sepsis is controversial. Septic shock has been alternatively viewed as an L-arginine-deficient state or as a syndrome caused by excess nitric oxide, an end-product of L-arginine metabolism.

Design: Randomized, placebo-controlled, and double-blinded (investigators, veterinarians, and pharmacists). Read More

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November 2006

The effect of meal composition on specific dynamic action in burmese pythons (Python molurus).

Physiol Biochem Zool 2005 Mar-Apr;78(2):182-92. Epub 2005 Feb 25.

Department of Ecology and Evolutionary Biology, University of California, Irvine, 92697-2525, USA.

We quantified the specific dynamic action (SDA) resulting from the ingestion of various meal types in Burmese pythons (Python molurus) at 30 degrees C. Each snake was fed a series of experimental meals consisting of amino acid mixtures, simple proteins, simple or complex carbohydrates, or lipids as well as meals of whole animal tissue (chicken breast, beef suet, and mouse). Rates of oxygen consumption were measured for approximately 4 d after feeding, and the increment above standard metabolic rate was determined and compared to energy content of the meals. Read More

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Atmospheric input of elements to forest ecosystems: a method of estimation using artificial foliage placed above rain collectors.

Environ Pollut 2000 Nov;110(2):345-56

Department of Plant Ecology, Institute of Ecology, Polish Academy of Sciences, Dziekanów Leśny near Warsaw, 05-092 Łomianki, Poland.

Usefulness of a method of artificial foliage was tested for estimation of total ionic inputs from the atmosphere to forest ecosystems, as well as of processes relevant to ionic fluxes through tree canopies: uptake, leaching, passive flow. The studies were performed in Norway spruce and European beech stands in Karkonosze Mountains (Poland), in 1995-97. Artificial leaves of increasing leaf area index: 0, 2, 6 and 12 m(2) m(-2 )were placed above standard rain collectors. Read More

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November 2000

Communicating air quality information: experimental evaluation of alternative formats.

Risk Anal 2003 Feb;23(1):91-103

Bureau of Risk Analysis, Division of Science, Research and Technology, New Jersey Department of Environmental Protection, Po Box 409, Trenton, NJ 08625-0409, USA.

A long-running effort in environmental communication is daily publication of a report on local air pollution in many American newspapers based on the Pollutant Standards Index (PSI). A 1998 proposal by the U.S. Read More

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February 2003