87,252 results match your criteria weight regulation


LncRNA ZFAS1 plays a role in regulating the inflammatory responses in sepsis-induced acute lung injury via mediating miR-193a-3p.

Authors:
Yan Jiang Wei Zhang

Infect Genet Evol 2021 Apr 10:104860. Epub 2021 Apr 10.

Department of Critical Care Medicine, Yantaishan Hospital, Yantai 264001, China. Electronic address:

Objective: To explore the role of lncRNA ZFAS1-mediated miR-193a-3p in the regulation of inflammatory responses in rats with sepsis-induced acute lung injury (ALI).

Methods: Sepsis-induced ALI models were constructed by LPS induction and then injected with ZFAS1 overexpression plasmid. Thereafter, lung injury score and the W/D weight ratio were calculated. Read More

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The brominated flame retardants TBECH and DPTE alter prostate growth, histology and gene expression patterns in the mouse.

Reprod Toxicol 2021 Apr 10. Epub 2021 Apr 10.

Biology, The Life Science Center, School of Science and Technology, Örebro University, SE-701 82, Örebro, Sweden. Electronic address:

The brominated flame retardants (BFRs), 1,2-dibromo-4-(1,2 dibromoethyl)cyclohexane (TBECH) and 2,3-dibromopropyl-2,4,6-tribromophenyl ether (DPTE) bind to the androgen receptor (AR). In vitro bioassays have shown that TBECH is a potent androgen agonist while DPTE is a potent AR antagonist. Both TBECH and DPTE alter gene expression associated with AR regulation. Read More

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Nicotine and energy balance: A review examining the effect of nicotine on hormonal appetite regulation and energy expenditure.

Appetite 2021 Apr 10:105260. Epub 2021 Apr 10.

School of Nutrition, Ryerson University, Toronto, Ontario, Canada. Electronic address:

Nicotine has been shown to decrease appetite, food intake (FI) and body weight, but the mechanisms are unclear. The purpose of this review was to examine research on the effects of nicotine on energy balance by exploring physiological mechanisms and hormone regulation related to FI, subjective appetite and energy expenditure (EE). We searched PubMed and MEDLINE, and included articles investigating the effects of nicotine on central appetite regulation, FI, leptin, peptide-YY (PYY), ghrelin, glucagon-like peptide-1 (GLP-1), adiponectin, cholecystokinin (CCK), orexin, and EE. Read More

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Cinacalcet as a surrogate therapy for diabetic cardiomyopathy in rats through AMPK-mediated promotion of mitochondrial and autophagic function.

Toxicol Appl Pharmacol 2021 Apr 10:115533. Epub 2021 Apr 10.

Physiology Department, Faculty of Medicine for Girls, Al-Azhar University, Cairo, Egypt.

Decreased activity of AMP-activated protein kinase (AMPK) is implicated in the pathogenesis of diabetic cardiomyopathy (DCM). Recent evidence suggests a crosstalk between cinacalcet and AMPK activation. This study investigated the effects of cinacalcet on cardiac remodeling and dysfunction in type 2 diabetic rats (T2DM). Read More

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Dietary Restraint Related to Body Weight Maintenance and Neural Processing in Value-Coding Areas in Adolescents.

J Nutr 2021 Apr 13. Epub 2021 Apr 13.

The Center for Integrative Science of Human Behavior (CiSHuB), The University of Tokyo, Tokyo, Japan.

Background: There is an alarming increase in the obesity prevalence among children in an environment of increasing availability of preprocessed high-calorie foods. However, some people maintain a healthy weight even in such obesogenic environments. This difference in body weight management could be attributed to individual differences in dietary restraint; however, its underlying neurocognitive mechanisms in adolescents remain unclear. Read More

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Binge eating attitudes in community adolescent sample and relationships with interview-assessed attachment representations in girls: a multi-center study from North Italy.

Eat Weight Disord 2021 Apr 12. Epub 2021 Apr 12.

Department of Psychology, University of Milano-Bicocca, Piazza dell'Ateneo Nuovo, 1, Milan, Italy.

Purpose: To compare community girls at risk and not at risk for binge eating (BE) in attachment representations through a narrative interview and to test the predictive role of attachment pattern(s) on the risk of binge eating among community girls.

Methods: From 772 community adolescents of both sexes (33% boys) screened through the Binge Eating Scale (BES), 112 girls between 14 and 18 years, 56 placed in a group at risk for binge eating (BEG), and 56 matched peers, not at risk (NBEG), were assessed in attachment representations through the Friends and Family Interview (FFI).

Results: (1) Compared to NBEG, girls in the BEG showed more insecure-preoccupied classifications and scores, together with lower narrative coherence, mother's representation as a secure base/safe haven, reflective functioning, adaptive response, and more anger toward mother. Read More

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Astragaloside IV alleviates liver injury in type 2 diabetes due to promotion of AMPK/mTOR‑mediated autophagy.

Mol Med Rep 2021 Jun 13;23(6). Epub 2021 Apr 13.

Key Laboratory of Anti‑Inflammatory and Immunopharmacology, Ministry of Education, Department of Pharmacology, Basic Medicine College, Anhui Medical University, Hefei, Anhui 230032, P.R. China.

Diabetic liver injury is a serious complication of type 2 diabetes mellitus (T2DM), which is often irreversible in the later stage, and affects the quality of life. Autophagy serves an important role in the occurrence and development of diabetic liver injury. For example, it can improve insulin resistance (IR), dyslipidaemia, oxidative stress and inflammation. Read More

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Loss of CREB coactivator CRTC1 in SF1 cells leads to hyperphagia and obesity by high-fat diet but not normal chow diet.

Endocrinology 2021 Apr 13. Epub 2021 Apr 13.

Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University, Gokasho, Uji city, Kyoto, Japan.

Cyclic adenosine monophosphate responsive element-binding protein-1 (CREB1)-regulated transcription coactivator-1 (CRTC1) is a cytoplasmic coactivator that translocates to the nucleus in response to cyclic adenosine monophosphate. Whole-body knockdown of Crtc1 causes obesity, resulting in increased food intake and reduced energy expenditure. CRTC1 is highly expressed in the brain; therefore, it might play an important role in energy metabolism via the neuronal pathway. Read More

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Reciprocal regulation of RIG-I and XRCC4 connects DNA repair with RIG-I immune signaling.

Nat Commun 2021 04 12;12(1):2187. Epub 2021 Apr 12.

Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, MN, USA.

The RNA-sensing pathway contributes to type I interferon (IFN) production induced by DNA damaging agents. However, the potential involvement of RNA sensors in DNA repair is unknown. Here, we found that retinoic acid-inducible gene I (RIG-I), a key cytosolic RNA sensor that recognizes RNA virus and initiates the MAVS-IRF3-type I IFN signaling cascade, is recruited to double-stranded breaks (DSBs) and suppresses non-homologous end joining (NHEJ). Read More

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Regulation data for the horizontal jump of children and adolescents.

Eur J Transl Myol 2021 Apr 13. Epub 2021 Apr 13.

Universidad Católica del Maule, Talca.

The Horizontal Jump (HJ) is a daily tool that could be used to categorize the level of muscle fitness performance of the lower limbs. The goal was to compare the muscle fitness with those of international studies and to propose percentiles to assess the HJ performance of children and adolescents. A cross-sectional study was conducted. Read More

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Farrerol ameliorate adjuvant-induced ankle injury via alteration of PPAR-γ signal pathway.

J Food Biochem 2021 Apr 12:e13585. Epub 2021 Apr 12.

Department of Hand Surgery, Honghui Hospital, Xi'an Jiaotong University College of Medicine, Xi'an, Shaanxi, 710054, China.

This study evaluated the anti-inflammatory activity against lipopolysaccharide (LPS)-mediated mouse macrophages (in vitro) and assessed the protective effect of farrerol on arthritis caused by complete freund adjuvant (CFA) in rats. For the evaluation of the pharmacological effect of farrerol on the activity of nitric oxide (NO) and cyclooxygenase, pro-inflammatory cytokines including interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), and interleukin-1β, RAW 264.7 cells were used. Read More

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The Collective Effect of MIP-3α and FL Promotes Dendritic Cell Function Within the Immune Microenvironment of Murine Liver Cancer.

Front Oncol 2021 26;11:646527. Epub 2021 Mar 26.

Graduate School, Shanxi Medical University, Taiyuan, China.

Hepatocellular carcinoma is a highly malignant and lethal tumor. In addition to surgery, immunotherapy is currently a more effective treatment for hepatocellular carcinoma. The tumor immune microenvironment (TIME) largely determines the efficacy of cancer immunotherapy. Read More

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The Spectral Irradiance, Growth, Photosynthetic Characteristics, Antioxidant System, and Nutritional Status of Green Onion ( L.) Grown Under Different Photo-Selective Nets.

Front Plant Sci 2021 25;12:650471. Epub 2021 Mar 25.

College of Horticulture Science and Engineering, Shandong Agricultural University, Tai'an, China.

The active regulation of the plant growth environment is a common method for optimizing plant yield and quality. In horticulture today, light quality control is carried out using photo-selective nets or membranes to improve the yield and quality of cultivated plants. In the present study, with natural light as the control (CK), we tested different photo-selective nets (white, WN; blue, BN; green, GN; yellow, YN; and red, RN) with 30% shade for characteristics of growth, development, quality, yield, photosynthesis, and chlorophyll fluorescence, considering the antioxidant system, as well as the influence of element absorption and transformation of green onion ( L. Read More

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Exploring unknown per- and polyfluoroalkyl substances in the German environment - The total oxidizable precursor assay as helpful tool in research and regulation.

Sci Total Environ 2021 Mar 29;782:146825. Epub 2021 Mar 29.

German Environment Agency (Umweltbundesamt), 06813 Dessau-Rosslau, Germany.

Limnetic, marine and soil samples of the German environmental specimen bank (ESB) were analyzed for per- and polyfluoroalkyl substances (PFAS) using target analysis and a modified total oxidizable precursor (TOP) assay (direct TOP assay (dTOP)) that works without prior extraction. Target analysis determined ∑PFAS concentrations in bream livers of 8.7-282 μg kg wet weight (ww) in 2019, with highest contaminations in the Rhine and lower Elbe. Read More

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Microbial ACBP/DBI-like genes are rare in the human gut microbiome and show no links with obesity.

Appl Environ Microbiol 2021 Apr 9. Epub 2021 Apr 9.

Department CIBIO, University of Trento, Italy

Acyl coenzyme A (CoA) binding protein (ACBP), also called diazepam-binding inhibitor (DBI) is a phylogenetically conserved protein that is expressed by all eukaryotic species as well as by some bacteria. Since elevated ACBP/DBI levels play a major role in the inhibition of autophagy, increase in appetite and lipoanabolism that accompany obesity, we wondered whether ACBP/DBI produced by the human microbiome might affect host weight. We found that the genomes of bacterial commensals rarely contain ACBP/DBI homologues, which are rather encoded by genomes of some pathogenic or environmental taxa that were not prevalent in human feces. Read More

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Examining the impact of weight bias on the association between exercise identity and maladaptive exercise behaviors.

Eat Behav 2021 Mar 29;41:101503. Epub 2021 Mar 29.

Department of Psychology, University of South Florida, Tampa, USA.

Objective: Though exercise behaviors are typically viewed as health-promoting, certain forms of exercise (i.e., excessive exercise, unhealthy muscle-building behaviors) are considered maladaptive and are associated with negative physical and psychological outcomes. Read More

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Maternal transfer of antibodies specific for avian influenza viruses in captive whooper swans (Cygnus cygnus).

Comp Immunol Microbiol Infect Dis 2021 Apr 2;76:101644. Epub 2021 Apr 2.

Anhui Province Key Laboratory of Animal Nutritional Regulation and Health, Anhui Science and Technology University, Fengyang, Anhui, China; College of Animal Science, Anhui Science and Technology University, Fengyang, China. Electronic address:

The transfer of maternal antibodies to offspring can effectively protect against avian influenza virus (AIV) infection during early life in chickens and can prevent AIV spread by decreasing the overall percentage of the avian population susceptible to this pathogen. Herein, we evaluated maternal antibody transfer dynamics in whooper swans (Cygnus cygnus), which represent an important AIV host species. In total, 57 eggs from 19 nests were collected to study the relationship between egg yolk AIV-specific antibody concentrations and factors including egg size, laying order, maternal serum AIV antibody titer, and maternal body condition. Read More

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IgG modulation in male mice with reproductive failure after prenatal inflammation.

Reproduction 2021 Apr 1. Epub 2021 Apr 1.

L Zakharova, biochemistry of ontogenesis, Koltzov Institute of Development Biology RAS, Moskva, Russian Federation.

Sexual performance in adult male rats is highly sensitive to prenatal stress which can affect the functionality of the reproductive system and various brain structures involved in modulating sexual behavior. The immunomodulatory effect of mouse IgG on reproductive maturity in male offspring after LPS exposure in vivo and in vitro was studied. Prenatal IgG injection (20 µg / mouse) had a positive impact on the puberty of male mice whose mothers were exposed to LPS (100 µg / kg) on the 12th day of pregnancy. Read More

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Paraventricular Calcitonin Receptor Expressing Neurons Modulate Energy Homeostasis in Male Mice.

Endocrinology 2021 Apr 9. Epub 2021 Apr 9.

Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI.

The paraventricular nucleus of the hypothalamus (PVH) is a heterogeneous collection of neurons that play important roles in modulating feeding and energy expenditure. Abnormal development or ablation of the PVH results in hyperphagic obesity and defects in energy expenditure whereas selective activation of defined PVH neuronal populations can suppress feeding and may promote energy expenditure. Here, we characterize the contribution of calcitonin receptor-expressing PVH neurons (CalcR PVH) to energy balance control. Read More

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Dimeric mimetic of BDNF loop 4 promotes survival of serum-deprived cell through TrkB-dependent apoptosis suppression.

Sci Rep 2021 Apr 8;11(1):7781. Epub 2021 Apr 8.

Federal State Budgetary Institution "Research Zakusov Institute of Pharmacology", 125315, Baltiyskaya str. 8, Moscow, Russia.

Brain-derived neurotrophic factor (BDNF) is involved in the regulation of neuronal cell growth, differentiation, neuroprotection and synaptic plasticity. Although aberrant BDNF/TrkB signaling is implicated in several neurological, neurodegenerative and psychiatric disorders, neurotrophin-based therapy is challenging and is limited by improper pharmacokinetic properties of BDNF. Dimeric dipeptide compound GSB-106 (bis-(N-monosuccinyl-L-seryl-L-lysine) hexamethylenediamide) has earlier been designed to mimic the TrkB-interaction 4 loop of BDNF. Read More

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Evaluation of cytokines expression in the phytoflavonoids treated epileptic rats: An in vivo study.

Pak J Pharm Sci 2020 Sep;33(5(Supplementary)):2371-2377

Faculty of Pharmacy, The University of Lahore, Lahore, Pakistan/Faculty of Pharmacy, University of Central Punjab, Lahore, Pakistan.

Seizure are basic characteristic of epilepsy; these initiate due to irregular, excessive and synchronous electrical discharges. We aimed to determine the antiepileptic potential of phyto-flavonoids on the evaluation of the mRNA expression of TNF-α, IL-6, IL-1 Beta, IL-10, IL-1Ra, IL 4 and NF-κB. We induced chronic epilepsy in rats by administering sub-convulsive dose of pentylenetetrazole (25 mg/kg/day for 28 days). Read More

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September 2020

Perinatal exposure to di-(2-ethylhexyl) phthalate induces hepatic lipid accumulation mediated by diacylglycerol acyltransferase 1.

Hum Exp Toxicol 2021 Apr 9:9603271211003314. Epub 2021 Apr 9.

Institute of Biomedical Science, Catholic Kwandong University International St Mary's Hospital, Incheon, Republic of Korea.

Introduction: Di-(2-ethylhexyl) phthalate (DEHP) is a commonly used plasticizer in consumer products and medical devices. It is also suspected to exacerbate the development of fatty liver. However, the mechanisms underlying excessive lipid synthesis and its deposition in the liver are yet to be identified. Read More

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Sex Differences in miRNA Expression and Cardiometabolic Risk Factors in Hispanic Adolescents With Obesity.

J Pediatr 2021 Apr 5. Epub 2021 Apr 5.

Department of Pediatrics, Baylor College of Medicine, Children's Hospital of San Antonio, San Antonio, Texas.

Objective: To evaluate sex differences in microRNA (miRNA) expression, anthropometric measures and cardiometabolic risk factors in Hispanic adolescents with obesity.

Study Design: Cross-sectional study of 68 (60% male) Hispanic adolescents with obesity, aged 13-17 years, recruited from a pediatric weight management clinic. We used small RNA sequencing to identify differentially expressed circulating miRNAs. Read More

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Oral intake of Lactobacillus plantarum L-14 extract alleviates TLR2- and AMPK-mediated obesity-associated disorders in high-fat-diet-induced obese C57BL/6J mice.

Cell Prolif 2021 Apr 8:e13039. Epub 2021 Apr 8.

Cellular Reprogramming and Embryo Biotechnology Laboratory, Dental Research Institute, Seoul National University School of Dentistry, Seoul, Korea.

Objectives: Whether periodic oral intake of postbiotics positively affects weight regulation and prevents obesity-associated diseases in vivo is unclear. This study evaluated the action mechanism of Lactobacillus plantarum L-14 (KTCT13497BP) extract and the effects of its periodic oral intake in a high-fat-diet (HFD) mouse model.

Materials And Methods: Mouse pre-adipocyte 3T3-L1 cells and human bone marrow mesenchymal stem cells (hBM-MSC) were treated with L-14 extract every 2 days during adipogenic differentiation, and the mechanism underlying anti-adipogenic effects was analysed at cellular and molecular levels. Read More

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Genetically determined SCFA concentration modifies the association of dietary fiber intake with changes in bone mineral density during weight loss: The Preventing Overweight Using Novel Dietary Strategies (POUNDS LOST) trial.

Am J Clin Nutr 2021 Apr 7. Epub 2021 Apr 7.

Department of Epidemiology, School of Public Health and Tropical Medicine, Tulane University, New Orleans, LA, USA.

Background: SCFAs are involved in regulation of body weight and bone health.

Objectives: We aimed to examine whether genetic variations related to butyrate modified the relation between dietary fiber intake and changes in bone mineral density (BMD) in response to weight-loss dietary interventions.

Methods: In the 2-y Preventing Overweight Using Novel Dietary Strategies trial, 424 participants with BMD measured by DXA scan were randomly assigned to 1 of 4 diets varying in macronutrient intakes. Read More

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Food cue images and subjective appetitive responses in obese children.

Nutr Health 2021 Apr 7:2601060211003985. Epub 2021 Apr 7.

Department of Paediatric Medicine, 204733Sri Ramachandra Institute of Higher Education and Research (DU), Chennai, India.

Background: Food decision-making is based on various intrinsic and extrinsic factors of an individual. Food preferences and food cue sensitivity influence energy intake, which in turn affects body weight.

Aim: The present study assessed the subjective appetite of obese children in response to food cue images. Read More

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Dietary cinnamaldehyde nanoemulsion boosts growth and transcriptomes of antioxidant and immune related genes to fight Streptococcus agalactiae infection in Nile tilapia (Oreochromis niloticus).

Fish Shellfish Immunol 2021 Apr 4. Epub 2021 Apr 4.

Department of Nutrition and Clinical Nutrition, Faculty of Veterinary Medicine, Zagazig University, Zagazig, 44519, Egypt. Electronic address:

The present study was conducted to investigate the effects of dietary cinnamaldehyde nanoemulsion (CNE) on growth, digestive activity, antioxidant and immune responses and resistance against Streptococcus agalactiae (S. agalactiae) in Nile tilapia. Four experimental diets were formulated containing CNE at levels of 0, 100, 200 and 300 mg/kg diet for 12 weeks. Read More

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Ascorbate and glutathione independently alleviate arsenate toxicity in brinjal but both require endogenous nitric oxide.

Physiol Plant 2021 Apr 7. Epub 2021 Apr 7.

Botany and Microbiology Department, College of Science, King Saud University, P.O. Box 2455, Riyadh, Saudi Arabia.

In this study, we have explored the possible role of ascorbic acid (ASC) and glutathione (GSH) in alleviating arsenate (As ) toxicity in brinjal roots. Moreover, we have also focused our attention on the possible involvement of endogenous nitric oxide (NO) in accomplishing this task. Arsenate treatment negatively impacts the length and fresh weight of roots and shoots as well as the dry weight and fitness of roots, and this was accompanied by greater As accumulation in roots and shoots of brinjal. Read More

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The RabGAP TBC-11 controls Argonaute localization for proper microRNA function in C. elegans.

PLoS Genet 2021 Apr 7;17(4):e1009511. Epub 2021 Apr 7.

CHU de Québec-Université Laval Research Center (Oncology division), Québec, Canada.

Once loaded onto Argonaute proteins, microRNAs form a silencing complex called miRISC that targets mostly the 3'UTR of mRNAs to silence their translation. How microRNAs are transported to and from their target mRNA remains poorly characterized. While some reports linked intracellular trafficking to microRNA activity, it is still unclear how these pathways coordinate for proper microRNA-mediated gene silencing and turnover. Read More

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Efficacy of Liangxue Guyuan decoction on radiation-induced intestinal injury in rats via the toll-like receptor 4/myeloid differentiation primary response 88/ nuclear factor-kappa B pathway.

J Tradit Chin Med 2021 04;41(2):254-261

Department of Traditional Chinese Medicine, Chinese People's Liberation Army General Hospital, Beijing 100853, China.

Objective: To evaluate the efficacy of Liangxue Guyuan decoction ( LGD) on radiation-induced intestinal injury in rats, and the possible underlying mechanism of action.

Methods: A total of 255 male Sprague-Dawley rats were used. 15 rats were assigned to the control group and the remaining 240 rats were exposed to a 60Co source at a dose of 11 Gy. Read More

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