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Aspirin Responsiveness at a Dose of 80 mg and Its Impact on Birth Weight when Used in Twin Pregnancies: The GAP Pilot Randomized Trial.

Am J Perinatol 2021 Apr 21. Epub 2021 Apr 21.

Centre de recherche du Centre Hospitalier, Universiatire de Québec-Université Laval, Axe Santé Reproduction Mère et Enfant, Québec, Canada.

Objective:  Daily aspirin, started in the first trimester of pregnancy, is commonly used for the prevention of preeclampsia and fetal growth restriction in multiple gestation. However, the optimal dose remains controversial and the evidence for the use of aspirin in multiple pregnancies is scarce. We aimed to estimate the impact of 80 mg of aspirin in twin pregnancies. Read More

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Unexpected Term Neonatal Intensive Care Unit Admissions and a Potential Role for Centralized Remote Fetal Monitoring.

Am J Perinatol 2021 Apr 21. Epub 2021 Apr 21.

Section of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, Women's Service Line, Ochsner Health, New Orleans, Louisiana.

Objective:  Centralized remote fetal monitoring (CRFM) has been proposed as a method to improve the performance of intrapartum fetal heart rate (FHR) monitoring and perinatal outcomes. The purpose of this study is to determine whether CRFM was associated with a reduction in unexpected term neonatal intensive care unit (NICU) admissions.

Study Design:  A pre-post design was used to examine the effectiveness of CRFM which was implemented in stages across five hospitals. Read More

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European Guidelines for Obesity Management in Adults with a Very Low-Calorie Ketogenic Diet: A Systematic Review and Meta-Analysis.

Obes Facts 2021 Apr 21:1-24. Epub 2021 Apr 21.

Dipartimento di Medicina, Università degli Studi di Padova, Padova, Italy.

Background: The very low-calorie ketogenic diet (VLCKD) has been recently proposed as an appealing nutritional strategy for obesity management. The VLCKD is characterized by a low carbohydrate content (<50 g/day), 1-1.5 g of protein/kg of ideal body weight, 15-30 g of fat/day, and a daily intake of about 500-800 calories. Read More

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From Obesity to Chronic Kidney Disease: How Can Adipose Tissue Affect Renal Function?

Nephron 2021 Apr 21:1-5. Epub 2021 Apr 21.

Departamento de Ciencias Básicas de la Salud, Área de Bioquímica y Biología Molecular, Facultad de Ciencias de la Salud, Universidad Rey Juan Carlos, Madrid, Spain.

Obesity is directly associated with an increased risk of developing CKD, regardless of other comorbid conditions. Although the molecular mechanisms that link both diseases are not well established, the role of adipose tissue (AT) is becoming increasingly important in obesity-associated kidney damage. In the context of obesity, lipotoxicity and the alteration of AT secretion profile promote inflammation, oxidative stress, and fibrosis in the kidney, which ultimately leads to impaired renal function. Read More

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EMG based classification for pick and place task.

Biomed Phys Eng Express 2021 Apr 21. Epub 2021 Apr 21.

Dept. of Electronics Engineering, Aligarh Muslim University, ZH College of Engineering & Technology, Aligarh, UP, 202002, INDIA.

The hand amputee is deprived of number of activities of daily living. To help the hand amputee, it is important to learn the pattern of muscles activity. There are several elements of tasks, which involve forearm along with the wrist and hand. Read More

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Ovarian morphometrical evaluation to assess reproductive activity suppression in heavy weight finishing gilts immunized against gonadotropin-releasing hormone.

Res Vet Sci 2021 Apr 14;136:519-526. Epub 2021 Apr 14.

Department of Morphology, Institute of Biological Sciences, Federal University of Minas Gerais, Av. Antônio Carlos, 6627, 31.270-901 Belo Horizonte, MG, Brazil. Electronic address:

It is known that immunizing gilts against gonadotropin-releasing hormone (GnRH) is an efficient castration method that increases their growth performance. However, it is still unknown the ovarian histophysiology outcomes after this procedure. Therefore, the aim of this study was to investigate in detail, using morphological and morphometrical methods, changes in the ovarian structure that result in the suppression of ovarian activity, as well as to gain knowledge on the ovarian structure to assist in ovarian histopathological diagnoses. Read More

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Ingestion of contaminated kelps by the herbivore Tetrapygus niger: Negative effects on food intake, growth, fertility, and early development.

Mar Pollut Bull 2021 Apr 18;167:112365. Epub 2021 Apr 18.

Departamento de Ecología y Biodiversidad, Facultad de Ciencias de la Vida, Universidad Andres Bello, Santiago, Chile; Centro de Investigación Marina Quintay (CIMARQ), Facultad de Ciencias de la Vida, Universidad Andres Bello, Quintay, Chile; Center of Applied Ecology and Sustainability (CAPES), Santiago, Chile; Instituto Milenio en Socio-Ecología Costera (SECOS), Santiago, Chile. Electronic address:

Macrocystis pyrifera reaches distant areas after detachment, accumulate heavy metals, and serve as trophic subsidy. In this context, effects on both adults and larvae of Tetrapygus niger fed with polluted kelps were determined by assessing growth, fertility, and early larval development. Results revealed that sea urchins fed with polluted kelps from highly impacted zone (HIZ) showed a lower growth (3. Read More

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Obesity management in primary care: systematic review exploring the influence of therapeutic alliance.

Fam Pract 2021 Apr 21. Epub 2021 Apr 21.

Vice President Research and Innovation office, University of Alberta, Edmonton, Canada.

Purpose: To identify the influence of the therapeutic alliance on the effectiveness of obesity interventions delivered in primary care.

Method: Systematic review of randomized controlled trials of primary care interventions for adult patients living with obesity. Comprehensive search strategy using the terms 'obesity', 'primary care' and 'intervention' of seven databases from 1 January 1998 to March 2018. Read More

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Bodyweight change and cognitive performance in the older population.

PLoS One 2021 21;16(4):e0249651. Epub 2021 Apr 21.

Munich Center for the Economics of Aging (MEA), Max Planck Institute for Social Law and Social Policy, Munich, Germany.

Preservation of cognitive function is one of the major concerns in contemporary ageing societies. At the same time, overweight and obesity, which have been identified as risk factors for poor health development, have been increasing in many countries all over the world. This study examines the relationship between bodyweight change and cognitive decline in old age and it aims to determine whether and how changes in body mass index (BMI) affect the development of cognitive functioning in old age. Read More

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Obesity, insulin resistance and their interaction on liver enzymes.

PLoS One 2021 21;16(4):e0249299. Epub 2021 Apr 21.

Department of Health Management, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.

Introduction: To investigate weight status, insulin resistance assessed by HOMA-IR, and their interaction on liver function in non-diabetic Chinese adults.

Methods And Results: A total of 7066 subjects were included, and divided into normal weight (n = 3447), overweight (n = 2801), and obese (n = 818) groups. Data including weight, height, waist circumference, fasting blood glucose, fasting insulin, total cholesterol, triglycerides, y-glutamyl transferase (GGT), aspartate aminotransferase (AST), and alanine aminotransferase (ALT) were acquired. Read More

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Obesity under full fresh fruit and vegetable access conditions.

PLoS One 2021 21;16(4):e0249333. Epub 2021 Apr 21.

Analysis Unit, Servicio Nacional de Capacitación y Empleo, Ministerio del Trabajo, Santiago, Chile.

There is no agreement regarding the role of fresh fruit and vegetables' affordability, accessibility and availability, or access in general, on obesity rates. In this article we investigated whether access to fresh fruit and vegetables is related to better biometric indicators such as weight and body mass index. Using mediation and matching methods and assuming that farmers and traditional market sellers have easy access to fruit and vegetables, we found that having better access is not associated to a reduction in weight or body mass index. Read More

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Evaluation of nutritional and medicinal potential of defatted seed kernel.

Prep Biochem Biotechnol 2021 Apr 21:1-6. Epub 2021 Apr 21.

Chemical Engineering Department, Institute of Chemical Technology, Matunga, India.

This work deals with the evaluation of nutritional and medicinal potential of a defatted kernel of s seed. Defatted sapindus seed kernel is a rich source of proteins (33.4 ± 2. Read More

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Cloning, Expression, Characterization, and Tissue Distribution of Cystatin C from Silver Carp ().

J Agric Food Chem 2021 Apr 21. Epub 2021 Apr 21.

Department of Microbiology, Faculty of Agriculture and Forestry, University of Helsinki, Helsinki 00014, Finland.

Cystatins are proteins, which inhibit cysteine proteases, such as papain. In this study, the 336-bp gene (family II, Hm) of silver carp () was cloned and expressed in BL21 (DE3). Hm encodes the mature peptide of cystatin C (HmCystatin C), with 111 amino acids. Read More

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Peptides and Antibiotic Therapy: Advances in Design and Delivery.

Acc Chem Res 2021 Apr 21. Epub 2021 Apr 21.

Division of Pulmonary, Allergy and Immunology, Cystic Fibrosis, and Sleep, Department of Pediatrics and Center for Cystic Fibrosis and Airway Diseases Research, Children's Healthcare of Atlanta, Emory University School of Medicine, 1510 Clifton Road NE, Suite 3009, Atlanta, Georgia 30322, United States.

ConspectusAntibiotic resistance (AMR) is an increasing public health crisis worldwide. This threatens our ability to adequately care for patients with infections due to multi-drug-resistant (MDR) pathogens. As such, there is an urgent need to develop new classes of antimicrobials that are not based on currently utilized antibiotic scaffolds. Read More

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Insights into the mechanism of shortened developmental duration and accelerated weight gain associated with Wolbachia infection in Hylyphantes graminicola.

Integr Zool 2021 Apr 21. Epub 2021 Apr 21.

State Key Laboratory of Biocatalysis and Enzyme Engineering, School of Life Sciences, Hubei University, Wuhan, 430062, China.

Wolbachia infection is known to affect host reproduction and development. To date, however, the underlying mechanism related to the effects of Wolbachia on host development has not yet been reported. Here, we compared the developmental duration and body weight in different instars of Wolbachia-positive (W ) and Wolbachia-negative (W ) spiders (Hylyphantes graminicola) and detected the relative expression levels of six insulin-related genes and three ecdysone-related genes using reverse transcription qPCR (RT-qPCR). Read More

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Determination of the route of excretion of robenacoxib (Onsior™) in cats and dogs: A pilot study.

J Vet Pharmacol Ther 2021 Apr 21. Epub 2021 Apr 21.

Elanco Animal Health Inc., Basel, Switzerland.

The objective of the studies was to determine the route of excretion, faecal or urinary, of the nonsteroidal anti-inflammatory drug (NSAID) robenacoxib (Onsior™) in cats and dogs. The studies employed a two-part crossover design in 4 beagle dogs (2 female and 2 male, age 36-41 months and body weight 9.0-10. Read More

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The relationship between the risk of eating disorder and meal patterns in University students.

Eat Weight Disord 2021 Apr 21. Epub 2021 Apr 21.

Department of Nutrition and Dietetics, Faculty of Health Sciences, Gazi University, Çankaya, Ankara, Turkey.

Purpose: This study was carried out to evaluate the relation between meal patterns and the risk of eating disorders in university students.

Methods: The study was conducted on a total of 331 volunteer students with a mean age of 22.08 ± 1. Read More

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Trends in Serum Vitamin D Levels within 12 Months after One Anastomosis Gastric Bypass (OAGB).

Obes Surg 2021 Apr 21. Epub 2021 Apr 21.

Department of Clinical Nutrition and Dietetics, Faculty of Nutrition and Food Technology, National Nutrition and Food Technology Research Institute, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Purpose: To assess serum vitamin D trend from baseline to 12 months after one anastomosis gastric bypass (OAGB).

Materials And Methods: In this observational cohort analysis of longitudinal data, we assessed the trend of serum vitamin D, and its associations with anthropometric, and biochemical measurements in 98 patients undergoing OAGB in a bariatric surgery center. All participants were on >800 IU/day vitamin D supplementation. Read More

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Analgesic Activity of Jin Ling Zi Powder () and Its Single Herbs: A Serum Metabonomics Study.

Chin J Integr Med 2021 Apr 21. Epub 2021 Apr 21.

Institute of Radiation Medicine, Academy of Military Medical Sciences, Beijing, 100850, China.

Objective: To compare the analgesic effect of Jin Ling Zi Powder (, JLZ) and its two single herbs.

Methods: The hot plate method was used to induce pain. Totally 36 mice were randomly divided into 6 groups by a complete random design, including control, model, aspirin (ASP, 0. Read More

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An endophytic Schizophyllum commune Fr. exhibits in-vitro and in-vivo antidiabetic activity in streptozotocin induced diabetic rats.

AMB Express 2021 Apr 21;11(1):58. Epub 2021 Apr 21.

Department of Microbiology, Guru Nanak Dev University, Amritsar, Punjab, 143005, India.

The present study aimed at isolation of endophytic basidiomycetous fungi and evaluation of their in-vitro and in-vivo antidiabetic potential. Preliminary screening for in-vitro activity was carried out using α-glucosidase inhibition assay. An endophytic isolate Sch1 (isolated from Aloe vera), identified to be Schizophyllum commune Fr. Read More

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The function of adipsin and C9 protein in the complement system in HIV-associated preeclampsia.

Arch Gynecol Obstet 2021 Apr 21. Epub 2021 Apr 21.

Women's Health and HIV Research Group, Department of Obstetrics and Gynecology, Nelson R. Mandela School of Medicine, University of KwaZulu-Natal, Durban, South Africa.

Objective: In preeclampsia, there are excessive complement components expressed due to increased complement activation; therefore, this study investigated the concentration of adipsin and C9 in HIV-associated preeclampsia.

Method: The study population (n = 76) was stratified by pregnancy type (normotensive pregnant and preeclampsia) and by HIV status. Serum was assayed for the concentration of adipsin and C9 using a Bioplex immunoassay procedure. Read More

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Age and time trends of dairy intake among children and adolescents of the DONALD study.

Eur J Nutr 2021 Apr 21. Epub 2021 Apr 21.

Department of Nutritional and Food Sciences, Nutritional Epidemiology, University of Bonn, DONALD Study Dortmund, Heinstück 11, 44225, Dortmund, Germany.

Purpose: To describe age and time trends in dietary intake of Total Dairy (TD) (g/1000 kcal Total Energy Intake) and types of dairy (weight percent of total dairy intake, w%TD) represented as Low Fat Dairy (LFD), High Sugar Dairy (HSD), Fermented Dairy (FD) and Liquid Dairy (LD) among children and adolescents in Germany.

Methods: Overall, 10,333 3-day dietary records kept between 1985 and 2019 by 1275 DONALD participants (3.5-18. Read More

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Antibiotic Resistance Crisis: An Update on Antagonistic Interactions between Probiotics and Methicillin-Resistant Staphylococcus aureus (MRSA).

Curr Microbiol 2021 Apr 21. Epub 2021 Apr 21.

Molecular Biology Unit, Dairy Microbiology Division, ICAR-National Dairy Research Institute, Karnal-132001, Haryana, India.

Antimicrobial resistance (AMR) havoc is a global multifaceted crisis endowing a significant challenge for the successful eradication of devastating pathogens. Methicillin-Resistant Staphylococcus aureus (MRSA) is an enduring superbug involved in causing devastating infections. Although MRSA is a frequent colonizer of human skin, wound, and anterior nares, the intestinal colonization of MRSA has greatly increased the risk of inducing MRSA-associated colitis besides creating a conducive environment for horizontal transfer of resistant genes to commensal microbes. Read More

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No correlation between symmetry-based performance measures and patient-related outcome prior to and after total knee arthroplasty.

Knee Surg Sports Traumatol Arthrosc 2021 Apr 21. Epub 2021 Apr 21.

Department of Orthopedics and Traumatology, Centre of Joint Replacement West Brandenburg, Brandenburg Medical School Theodor Fontane, Hochstraße 29, 14770, Brandenburg, Germany.

Purpose: Standardized outcome measures are crucial for the evaluation of different treatment and rehabilitation regimes in patients after total knee arthroplasty (TKA). Performance-based measures are necessary to capture different aspects of physical function. High reliability and agreement of five performance-based measures were hypothesized to differentiate between measurement error and change in test performance. Read More

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Optimal vial sizes for infliximab injection: a simulation study of Japanese demographic data.

Int J Pharm Pract 2021 Apr 21. Epub 2021 Apr 21.

Education and Research Center for Clinical Pharmacy, Kyoto Pharmaceutical University, Kyoto, Japan.

Objectives: Drug wastage costs in the medical field must be reduced, particularly for expensive biological drugs. In Japan, the Ministry of Health, Labour and Welfare (MHLW) has developed specific criteria for the divided use of injectable vials and vial sharing of anticancer injection drugs to reduce drug wastage. This study investigates the optimal vial size for infliximab infusion to reduce drug wastage in Japan. Read More

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Association of Multigenerational Family History of Depression With Lifetime Depressive and Other Psychiatric Disorders in Children: Results from the Adolescent Brain Cognitive Development (ABCD) Study.

JAMA Psychiatry 2021 Apr 21. Epub 2021 Apr 21.

Department of Psychiatry, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, New York.

Importance: Three-generation family studies of depression have established added risk of psychopathology for offspring with 2 previous generations affected with depression compared with 1 or none. Because of their rigorous methodology, there are few of these studies, and existing studies are limited by sample sizes. Consequently, the 3-generation family risk paradigm established in family studies can be a critical neuropsychiatric tool if similar transmission patterns are reliably demonstrated with the family history method. Read More

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Nutritional Implications of Baby-Led Weaning and Baby Food Pouches as Novel Methods of Infant Feeding: Protocol for an Observational Study.

JMIR Res Protoc 2021 Apr 21;10(4):e29048. Epub 2021 Apr 21.

Department of Human Nutrition, University of Otago, Dunedin, New Zealand.

Background: The complementary feeding period is a time of unparalleled dietary change for every human, during which the diet changes from one that is 100% milk to one that resembles the usual diet of the wider family in less than a year. Despite this major dietary shift, we know relatively little about food and nutrient intake in infants worldwide and virtually nothing about the impact of baby food "pouches" and "baby-led weaning" (BLW), which are infant feeding approaches that are becoming increasingly popular. Pouches are squeezable containers with a plastic spout that have great appeal for parents, as evidenced by their extraordinary market share worldwide. Read More

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Maternal exposure to low doses of bisphenol A affects learning and memory in male rat offspring with abnormal -methyl-d-aspartate receptors in the hippocampus.

Toxicol Ind Health 2021 Apr 21:748233720984624. Epub 2021 Apr 21.

Medical Experiment Center, 107652Shaanxi University of Chinese Medicine, Xianyang, Shaanxi, China.

Bisphenol A (BPA), a component of polycarbonate and epoxy resins, has been reported to induce learning and memory deficits. However, the mechanisms have not been fully elucidated. Growing evidence has suggested that -methyl-d-aspartate receptors (NMDARs) are involved in cognitive impairments. Read More

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Dietary fat and low fiber in purified diets differently impact the gut-liver axis to promote obesity-linked metabolic impairments.

Am J Physiol Gastrointest Liver Physiol 2021 Apr 21. Epub 2021 Apr 21.

Université Laval.

Purified high-fat diets are commonly used to promote obesity and metabolic disturbances in animal models. However, most studies also use unpurified chow (low in fat, high in fiber content) as a "healthy" diet which can impact gut health. Here, we investigated the impact of feeding chow or purified diets varying in fat content on metabolic and intestinal functions in relation with temporal changes in gut microbiota composition. Read More

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Is level of anxiety associated with overweight and obesity risk in university students? The NUTSAU study.

Nutr Hosp 2021 Apr 21. Epub 2021 Apr 21.

Leila Sicupira Carneiro de Souza Leão. Department of Nutrition and Public Health. Universidade Federal do Estado do Rio de Janeiro (UNIRIO).

Introduction: effective ways of overcoming overweight may depend, in part, on the ability to identify mood disorders (anxiety is most prevalent) and their association with overeating and weight gain. The use of anthropometric indicators for such purposes can inform individual strategies for intervention before obesity sets in.

Objective: to verify the association between anxiety and anthropometric indicators in university students. Read More

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