5,912 results match your criteria weeks testis

SIRT 3 was involved in seed oil protection testis from oxidative stress: and analyses.

Pharm Biol 2021 Dec;59(1):1314-1325

Key Laboratory of Fertility Preservation and Maintenance of Ministry of Education in Ningxia Medical University, Yinchuan, China.

Context: L. (Solanaceae) seed oil (LBSO) exerts LBSO exerts protective effects in the testis and via upregulating SIRT3.

Objective: This study evaluates the effects and mechanism of LBSO in the d-galactose (d-gal)-induced ageing testis. Read More

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December 2021

Untargeted LC-MS-based metabonomic analysis of the effect of photoperiod on the testes of broiler roosters.

J Anim Physiol Anim Nutr (Berl) 2021 Sep 26. Epub 2021 Sep 26.

Joint Laboratory of Modern Agricultural Technology International Cooperation, Ministry of Education, Jilin Agricultural University, Changchun, China.

Photoperiod is an important factor that stimulates the reproductive performance of broiler breeder roosters. However, the mechanism by which photoperiod affects the reproductive performance of broiler breeder roosters has not been fully studied. To study the effects of different photoperiods on the reproductive performance of broiler breeder roosters, 120 Arbor Acres broiler breeder roosters aged 20 weeks were randomly assigned to three groups (n = 40), and the three groups were treated with different photoperiod regimes: control (CTR; 12. Read More

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September 2021

(Dracaenaceae) Increases Sexual Hormones and Sperm Parameters, Lowers Oxidative Stress, and Ameliorates Testicular Architecture in Rats with 3 Weeks of Experimental Varicocele.

Evid Based Complement Alternat Med 2021 14;2021:1378112. Epub 2021 Sep 14.

Research Unit of Animal Physiology and Phytopharmacology, Faculty of Science, University of Dschang, P.O. BOX. 67, Dschang, Cameroon.

Varicocele is a disease characterized by an abnormal dilation of the pampiniform plexus that drains the testis. The main objective of this work was to evaluate the curative effects of aqueous and ethanolic extracts of on some reproductive and antioxidant markers in rats with experimental varicocele. Following varicocele induction, rats (5 per group) were randomly partitioned into untreated varicocele, vitamin E-treated (150 mg/kg), aqueous extract-treated (500 mg/kg), and ethanolic extract-treated (100 mg/kg) animals. Read More

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September 2021

Ginkgo biloba extract (EGb 761) mitigates methotrexate-induced testicular insult in rats: Targeting oxidative stress, energy deficit and spermatogenesis.

Biomed Pharmacother 2021 Sep 21;143:112201. Epub 2021 Sep 21.

Department of Biochemistry, Faculty of Pharmacy and Biotechnology, German University in Cairo, Cairo, Egypt.

Methotrexate (MTX) is commonly used as a therapeutic agent in the treatment of malignancies and autoimmune disorders. Risk of subsequent infertility following MTX administration has been reported as a significant side effect due to testicular toxicity. The aim of the study was to evaluate the modulatory effects of Ginkgo biloba (standardized extract, EGb 761) on MTX-induced testicular oxidative stress, energy deficits and spermatogenic status in rats. Read More

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September 2021

Anti-Müllerian hormone, testosterone, and insulin-like peptide 3 as biomarkers of Sertoli and Leydig cell function during deslorelin-induced testicular downregulation in the dog.

Theriogenology 2021 Aug 15;175:100-110. Epub 2021 Aug 15.

Department of Obstetrics and Food Animal Medicine Clinic, University of Veterinary Medicine Budapest, Hungary; ATRC Aurigon Ltd., Dunakeszi, Hungary.

The role of anti-Müllerian hormone (AMH) and insulin-like peptide 3 (INSL3) in male infertility is not fully understood. We used the downregulated testis as a model of gonadotropin-dependent infertility. Serum testosterone and AMH concentrations were studied in five adult male Beagles implanted (day 0) with 4. Read More

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Ameliorative effect of hesperidin on streptozotocin-diabetes mellitus-induced testicular DNA damage and sperm quality degradation in Sprague-Dawley rats.

J Food Biochem 2021 Sep 16:e13938. Epub 2021 Sep 16.

Division of Biochemistry, Faculty of Veterinary, Atatürk University, Erzurum, Turkey.

This study aimed to investigate the effect of hesperidin on reproductive damage caused by diabetes mellitus. A total of 24 adult male rats were divided into four groups: control group, hesperidin group, diabetes mellitus group, and diabetes mellitus + hesperidin group. The study was conducted for 4 weeks. Read More

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September 2021

Effects of endurance training on the expression of host proteins involved in SARS-CoV-2 cell entry in C57BL/6J mouse.

Physiol Rep 2021 09;9(17):e15014

Graduate School of Health and Sport Science, Nippon Sport Science University, Tokyo, Japan.

The coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is threatening people's lives and impacting their health. It is still unclear whether people engaged in physical activity are at an increased risk of SARS-CoV-2 infection and severe forms of COVID-19. In order to provide data to help answer this question, we, therefore, investigated the effects of endurance training on the levels of host proteins involved in SARS-CoV-2 infection in mice. Read More

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September 2021

Experimental data-sets on sex reversal and histopathological assessment of potential endocrine disrupting effects of graphene oxide on Japanese medaka () larvae at the onset of maturity.

Data Brief 2021 Oct 27;38:107330. Epub 2021 Aug 27.

RCMI Center for Environmental Health, Jackson State University, Jackson, MS 39217, USA.

The datasets of this article present the experimental parameters resulting from the assessment of sex reversal (SR) as a biomarker of endocrine disrupting effect of graphene oxide (GO), together with the histopathological assessment of ovary, testis, liver and kidneys of medaka larvae. These data sets support the published article "Sex-reversal and histopathological assessment of potential endocrine-disrupting effect of graphene oxide on Japanese medaka () larvae." The experiments were conducted on one day-post hatch (dph) Japanese medaka fries (orange-red variety) exposed to different concentrations of GO (2. Read More

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October 2021

Cornuside Alleviates Diabetes Mellitus-Induced Testicular Damage by Modulating the Gut Microbiota.

Evid Based Complement Alternat Med 2021 30;2021:5301942. Epub 2021 Aug 30.

Department of Basic Medical Science, Jiangsu Vocational College of Medicine, Yancheng 224005, Jiangsu, China.

Background: Male reproductive damage, as a common complication of diabetes mellitus (DM), is getting more attention lately. We aimed to explore the protective effects and mechanism of cornuside (Cor) modulating gut microbiota to alleviate diabetes mellitus- (DM-) induced testicular damage.

Methods: KK-Ay mice with reproductive damage were randomly divided into the model and Cor treatment groups, and the C57BL/6J mice were used as the normal group. Read More

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Cryoprotective Effect of Pentoxifylline on Spermatogonial Stem Cell During Transplantation into Azoospermic Torsion Mouse Model.

Reprod Sci 2021 Sep 7. Epub 2021 Sep 7.

Department of Anatomy, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.

Preserving the spermatogonial stem cells (SSCs) in long periods of time during the treatment of male infertility using stem cell banking systems and transplantation is an important issue. Therefore, this study was conducted to develop an optimal cryopreservation protocol for SSCs using 10 mM pentoxifylline (PTX) as an antioxidant in basal freezing medium. Testicular torsion-a mouse model for long-term infertility-was used to transplant fresh SSCs (n = 6), fresh SSCs treated with PTX (n = 6), cryopreserved SSCs with basal freezing medium (n = 6), and cryopreserved SSCs treated with PTX (n = 6). Read More

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September 2021

Effects of a Recombinant Gonadotropin-Releasing Hormone Vaccine on Reproductive Function in Adult Male ICR Mice.

Vaccines (Basel) 2021 Jul 21;9(8). Epub 2021 Jul 21.

International Program in Animal Vaccine Technology, International College, National Pingtung University of Science and Technology, Pingtung 91201, Taiwan.

Gonadotropin-releasing hormone (GnRH) regulates the reproductive endocrine system in mammals. The GnRH immunocontraception vaccine can aid animal population control and management. We evaluated a recombinant GnRH fusion protein with the adjuvant MONTANIDE ISA 206 VG as a GnRH vaccine in adult male ICR mice by evaluating anti-GnRH antibodies; concentrations of follicle-stimulating hormone (FSH), luteinizing hormone (LH), and testosterone; testis size and histomorphology; and semen quality. Read More

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IgG4-Related Disease With Testicular Involvement: A Case Report and Review of Literature.

Front Immunol 2021 10;12:717902. Epub 2021 Aug 10.

Department of Rheumatology and Immunology, Zhuzhou Hospital Affiliated to Xiangya Medical College, Central South University, Zhuzhou, China.

Immunoglobulin G4-related disease (IgG4-RD) is an autoimmune inflammatory disease characterized by infiltration of IgG4+ plasma cells that can simulate a tumor manifesting as a tumor-like mass. This disease involves the pancreas, biliary tract, kidneys, salivary glands, lymph nodes, aorta, and retroperitoneum amongst other organs. However, testicular involvement is a rare entity in this disease. Read More

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The I510V mutation in KLHL10 in a patient with oligoasthenoteratozoospermia.

J Reprod Dev 2021 Aug 26. Epub 2021 Aug 26.

Department of Cell Biology, School of Basic Medical Sciences, Southern Medical University, Guangzhou 510515, P. R. China.

Oligoasthenoteratozoospermia is a human infertility syndrome caused by defects in spermatogenesis, spermiogenesis, and sperm maturation, and its etiology remains unclear. Kelch-like 10 (KLHL10) is a component of ubiquitin ligase E3 10 (KLHL10) and plays an important role in male fertility. Deletion or mutation of the Klhl10 gene in Drosophila or mice results in defects in spermatogenesis or sperm maturation. Read More

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Randomized phase II trial of a first-in-human cancer cell lysate vaccine in patients with thoracic malignancies.

Transl Lung Cancer Res 2021 Jul;10(7):3079-3092

Thoracic Epigenetics Section, Thoracic Surgery Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA.

Background: Although most malignancies express cancer-testis antigens (CTA), immune responses to these proteins are limited in thoracic oncology patients. This trial was undertaken to examine if a cancer cell lysate vaccine could induce immunity to CTA, and to ascertain if metronomic cyclophosphamide and celecoxib enhances vaccine-induced immune responses.

Methods: Eleven patients with primary thoracic malignancies and 10 patients with extrathoracic neoplasms metastatic to the chest rendered NED by conventional therapies were randomized to receive H1299 lung cancer cell lysates (10 mg protein/vaccine) with Iscomatrix™ adjuvant via deep intradermal injection q 4 weeks ×6 with or without daily oral metronomic cyclophosphamide/celecoxib. Read More

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Biodistribution of adeno-associated virus type 2 carrying multi-characteristic opsin in dogs following intravitreal injection.

J Cell Mol Med 2021 Sep 21;25(18):8676-8686. Epub 2021 Aug 21.

Nanoscope Technologies LLC, Arlington, Texas, USA.

Gene therapy of retinal diseases using recombinant adeno-associated virus (rAAV) vector-based delivery has shown clinical success, and clinical trials based on rAAV-based optogenetic therapies are currently in progress. Recently, we have developed multi-characteristic opsin (MCO), which has been shown to effectively re-photosensitize photoreceptor-degenerated retina in mice leading to vision restoration at ambient light environment. Here, we report the biodistribution of the rAAV2 carried MCO (vMCO-I) in live samples and post-mortem organs following intraocular delivery in wild-type dogs. Read More

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September 2021

ZSWIM7 is associated with human female meiosis and familial primary ovarian insufficiency.

J Clin Endocrinol Metab 2021 Aug 17. Epub 2021 Aug 17.

Institute for Women's Health, University College London, London, United Kingdom.

Background: Primary ovarian insufficiency (POI) affects 1% of women and is associated with significant medical consequences. A genetic cause for POI can be found in up to 30% of women, elucidating key roles for these genes in human ovary development.

Objective: We aimed to identify the genetic mechanism underlying early-onset POI in two sisters from a consanguineous pedigree. Read More

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Runjing extract promotes spermatogenesis in rats with ornidazole-induced oligoasthenoteratozoospermia through extracellular signal-regulated kinase signalling, and regulating vimentin expression.

J Tradit Chin Med 2021 Aug;41(4):581-587

Department of Andrology,The Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing 210029, China.

Objective: To investigate the efficacy of Runjing (RJ) extract on oligoasthenoteratozoospermia (OAT) induced by ornidazole (ORN) in rats, and to study the underlying mechanism.

Methods: Twenty-four adult male Sprague-Dawley rats were treated with normal saline (control), ORN (OAT model), ORN + 4.725 g·kg-1·d-1 RJ extract (low-dose) and ORN+ 18. Read More

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Microarray profiling of LncRNA expression in the testis of pubertal mice following morning and evening exposure to 1800 MHz radiofrequency fields.

Chronobiol Int 2021 Aug 8:1-16. Epub 2021 Aug 8.

School of Radiation Medicine and Protection, Soochow University, Suzhou, China.

In this paper, the chronotoxicity of radiofrequency fields (RF) in the pubertal testis development and the involved molecular pathways were investigated by exposing four-week-old mice to RF (1800 MHz, SAR, 0.50 W/kg) in the morning and evening of each day for three weeks. Then, pathological changes and functional indices within the testis were determined. Read More

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Ellagic acid improved diabetes mellitus-induced testicular damage and sperm abnormalities by activation of Nrf2.

Saudi J Biol Sci 2021 Aug 20;28(8):4300-4310. Epub 2021 Apr 20.

Department of Food Science and Nutrition, College of Food and Agricultural Sciences, King Saud University, Riyadh, Saudi Arabia.

Diabetes mellitus induces testicular damage, increases sperm abnormalities, and impairs reproductive dysfunction due to induction of endocrine disturbance and testicular oxidative stress. This study evaluated the reproductive protective effect of ellagic acid (EA) against testicular damage and abnormalities in sperm parameters in Streptozotocin (STZ)-induced diabetic rats (T1DM) and examined some possible mechanisms of protection. Adult male rats were segregated into 5 groups (n = 12 rat/each) as control, control + EA (50 mg/kg/day), T1DM, T1DM + EA, and T1DM + EA + brusatol (an Nrf-2 inhibitor) (2 mg/twice/week). Read More

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Elevated plasma levels of the appetite-stimulator ACBP/DBI in fasting and obese subjects.

Cell Stress 2021 Jul 28;5(7):89-98. Epub 2021 Jun 28.

Centre de Recherche des Cordeliers, Equipe labellisée par la Ligue contre le cancer, Inserm U1138, Université de Paris, Sorbonne Université, Paris, France.

Eukaryotic cells release the phylogenetically ancient protein acyl coenzyme A binding protein (ACBP, which in humans is encoded by the gene DBI, diazepam binding inhibitor) upon nutrient deprivation. Accordingly, mice that are starved for one to two days and humans that undergo voluntary fasting for one to three weeks manifest an increase in the plasma concentration of ACBP/DBI. Paradoxically, ACBP/DBI levels also increase in obese mice and humans. Read More

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Rno_circRNA_016194 might be involved in the testicular injury induced by long-term formaldehyde exposure via rno-miR-449a-5p mediated Atg4b activation.

Food Chem Toxicol 2021 Sep 12;155:112409. Epub 2021 Jul 12.

Department of Pathology, Medical School, Xi'an Jiaotong University, Xi'an, 710061, China; Institute of Genetics and Developmental Biology, Medical School, Xi'an Jiaotong University, Xi'an, 710061, China. Electronic address:

Although circular RNAs (circRNAs) can function as microRNAs (miRNAs) sponges to participate in spermatogenesis, little is known about the functions of circRNAs in testis exposed to formaldehyde. In this study, twenty-four male SD rats (6-8 weeks) were randomly assigned to four groups, including a control group, 0.5, 2. Read More

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September 2021

Dosing-time dependent testicular toxicity of everolimus in mice.

Eur J Pharm Sci 2021 Oct 7;165:105926. Epub 2021 Jul 7.

Department of Pharmacology, Faculty of Pharmacy, Istanbul University, Beyazit-Istanbul, Turkey. Electronic address:

The circadian timing system controls many biological functions in mammals including drug metabolism and detoxification, cell cycle events, and thus may affect pharmacokinetics, target organ toxicity and efficacy of medicines. Selective mTOR (mammalian target of rapamycin) inhibitor everolimus is an immunosuppressant and anticancer drug that is effective against several cancers. The aim of this study was to investigate dosing-time dependent testicular toxicity of subacute everolimus administration in mice. Read More

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October 2021

Protective Effects of Fisetin in the Mice Induced by Long-Term Scrotal Hyperthermia.

Reprod Sci 2021 Jul 6. Epub 2021 Jul 6.

Department of Biology and Anatomical Sciences, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Exposure to heat in the male reproductive system can lead to transient periods of partial or complete infertility. The current study aimed to examine the beneficial effects of  Fisetin against spermatogenic disorders in mice affected by long-term scrotal hyperthermia. For this purpose, hyperthermia was induced daily by exposure to the temperature of 43 °C for 20 min for 5 weeks. Read More

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Effect of extract on reproductive damages in streptozotocin induced diabetic male rats.

J Diabetes Metab Disord 2021 Jun 22;20(1):77-85. Epub 2021 Jan 22.

Neuroscience Research Center, Qom University of Medical Sciences, Pardis Campus, Ghadir Blvd, Qom, Iran.

Purpose: Infertility is one of the systemic problems in diabetic men. The purpose of the present study is investigation of the effects of the () hydro-alcoholic extract on the reproductive system damages in diabetic male rats.

Methods: Twenty four male rats were randomly assigned into 4 groups ( = 6); i. Read More

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Ameliorative Potential of Hydroethanolic Leaf Extract of on d-Galactose-Induced Testicular Injury.

Molecules 2021 Jun 5;26(11). Epub 2021 Jun 5.

Department of Biochemistry, Faculty of Natural and Agricultural Science, Mafikeng Campus, North West University, Mmabatho 2735, South Africa.

Background: There is an increasing need for botanicals to be used as an alternative and complementary medicine in the management of male infertility. Male infertility has been a major health/social challenge to people all over the world. This study, therefore, investigated the ameliorative potential of hydroethanolic leaf extract of (HELEPN) against d-galactose-induced testicular injury. Read More

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Simultaneous quantification of imidacloprid and its metabolites in tissues of mice upon chronic low-dose administration of imidacloprid.

J Chromatogr A 2021 Aug 15;1652:462350. Epub 2021 Jun 15.

Laboratory of Toxicology, Department of Environmental Veterinary Sciences, Faculty of Veterinary Medicine, Hokkaido University, Japan.

This study aimed to (i) develop a sensitive method for simultaneous detection and quantification of imidacloprid (IMI) and seven of its metabolites in tissue specimens, and to (ii) determine the biodistribution of the IMI compounds in tissues of C57BL/6J male mice; after exposure to 0.6 mg/kg bw/day of IMI (10% of no observable adverse effect level of IMI) through a powdered diet for 24 weeks. We successfully developed a method which was accurate (recoveries were ≥ 70% for most compounds), sensitive (LODs ≤ 0. Read More

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Disruption of anchoring junctions in the testes of experimental varicocele rats.

Exp Ther Med 2021 Aug 16;22(2):887. Epub 2021 Jun 16.

Department of Human Anatomy, Histology and Embryology, School of Basic Medical Sciences, Fujian Medical University, Fuzhou, Fujian 350122, P.R. China.

Varicocele is a common disease of the male reproductive system and is the main cause of male infertility; however, the pathological mechanisms of varicocele remain unclear. The anchoring junctions (AJs) in the testies are located between Sertoli cells, or between Sertoli cells and germ cells. Intact and functional AJs are crucial for spermatogenesis. Read More

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Deficiency of Type I Platelet-Activating Factor-Acetylhydrolase Catalytic Subunits Causes an Increase in Body Weight.

Biol Pharm Bull 2021 ;44(7):920-925

Faculty of Pharma-sciences, Teikyo University.

Type I platelet-activating factor-acetylhydrolase (PAF-AH) forms a complex consisting of two catalytic subunits (α1 and/or α2) with a regulatory subunit (β). Although this protein was discovered as an enzyme that degrades an acetyl ester linked at the sn-2 position of platelet-activating factor (PAF), its physiological function remains unknown. In this study, to examine whether knockout mice lacking the catalytic subunits of this enzyme showed a different phenotype from that of wild-type mice, we measured and compared the body weights of knockout mice and control mice. Read More

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January 2021

Ameliorative effect of morin on dutasteride-tamsulosin-induced testicular oxidative stress in rat.

J Complement Integr Med 2020 Dec 23;18(2):327-337. Epub 2020 Dec 23.

Department of Biochemistry, Faculty of Basic Medical Sciences, University of Medical SciencesOndo, Ondo State,Nigeria.

Objectives: Dutasteride-Tamsulosin (DUT-TAM), a drug of choice for the treatment of prostate enlargement (Benign Prostatic Hyperplasia, BPH) has been implicated in testicular toxicity. This study investigated the protective effect of morin, a plant-derived flavonoid on DUT-TAM-induced testicular toxicity in Wistar rat.

Methods: Twenty-four male Wistar rats (110-140 g) were randomly divided into four treatment groups (n=6). Read More

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December 2020

Vinclozolin-induced mouse penile malformation and "small testis" via miR132, miR195a together with the Hippo signaling pathway.

Toxicology 2021 Aug 26;460:152842. Epub 2021 Jun 26.

Key Laboratory of Study and Discovery of Small Targeted Molecules of Hunan Province, Medical School, Hunan Normal University, Changsha, 410013, PR China. Electronic address:

Vinclozolin (VCZ) is a fungicide with antiandrogen activity. Exposure to VCZ in maternal uterus may cause uterine, ovarian and testicular damage, hypospadias and prostate abnormality in the offspring. Hippo pathway, which is highly conservative and may be activated by miR132 and miR195a, can control organ size and tissue regeneration, and participate in injury and deformity. Read More

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