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Cardiac Afferent Signaling Partially Underlies Premature Ventricular Contraction-Induced Cardiomyopathy.

Heart Rhythm 2021 Apr 9. Epub 2021 Apr 9.

UCLA Cardiac Arrhythmia Center, UCLA Neurocardiology Research Program of Excellence, University of California, Los Angeles CA. Electronic address:

Background: The mechanisms underlying premature ventricular contraction (PVC)-induced cardiomyopathy remain unknown. Transient receptor potential vanilloid 1 (TRPV1) afferent fibers are implicated in the reflex processing of cardiac stress.

Objective: We aimed to determine whether cardiac TRPV1 afferent signaling promote PVC-induced cardiomyopathy. Read More

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Avelumab vs docetaxel in patients with platinum-treated advanced non-small-cell lung cancer: 2-year follow-up from the JAVELIN Lung 200 phase 3 trial.

J Thorac Oncol 2021 Apr 9. Epub 2021 Apr 9.

Aix Marseille University, CNRS, INSERM, CRCM, Marseille, France†; Gustave Roussy Cancer Campus, Villejuif, France. Electronic address:

Introduction: In the JAVELIN Lung 200 trial, avelumab (anti-PD-L1 antibody) did not significantly prolong overall survival (OS) vs docetaxel in patients with platinum-treated PD-L1+ NSCLC. We report >2-year follow-up data.

Methods: Patients with stage IIIB/IV or recurrent NSCLC with disease progression following platinum-doublet chemotherapy were randomized 1:1 to avelumab 10 mg/kg every 2 weeks or docetaxel 75 mg/m every 3 weeks. Read More

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Pembrolizumab in Patients With Metastatic Breast Cancer With High Tumor Mutational Burden: Results From the Targeted Agent and Profiling Utilization Registry (TAPUR) Study.

J Clin Oncol 2021 Apr 12:JCO2002923. Epub 2021 Apr 12.

American Society of Clinical Oncology, Alexandria, VA.

Purpose: The TAPUR Study is a phase II basket trial that aims to identify signals of antitumor activity of commercially available targeted agents in patients with advanced cancers harboring genomic alterations known to be drug targets. Results in a cohort of patients with metastatic breast cancer (mBC) with high tumor mutational burden (HTMB) treated with pembrolizumab are reported.

Methods: Patients with advanced mBC received standard doses of either 2 mg/kg or 200 mg infusions of pembrolizumab every 3 weeks. Read More

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Neoadjuvant Cytoreductive Treatment with BRAF/MEK Inhibition of prior Unresectable Regionally Advanced Melanoma to Allow Complete Surgical Resection, REDUCTOR: A Prospective, Single Arm, Open-label Phase II Trial.

Ann Surg 2021 Apr 9. Epub 2021 Apr 9.

Department of Surgical Oncology, Netherlands Cancer Institute, Amsterdam, the Netherlands Department of Medical Oncology, Netherlands Cancer Institute, Amsterdam, the Netherlands Department of Head and Neck Surgery and Oncology, Netherlands Cancer Institute, Amsterdam, the Netherlands Department of Nuclear Medicine, Netherlands Cancer Institute, Amsterdam, the Netherlands Department of Pathology, Netherlands Cancer Institute, Amsterdam, the Netherlands Department of Radiology, Netherlands Cancer Institute, Amsterdam, the Netherlands Department of Biometrics, Netherlands Cancer Institute, Amsterdam, the Netherlands Department of Biometrics, Princes Máxima Centrum, Utrecht, the Netherlands Department of Biomedical Data Sciences, Leiden University Medical Center, Leiden, the Netherlands.

Objective: To evaluate the potency of short-term neoadjuvant cytoreductive therapy with dabrafenib plus trametinib (BRAF and MEK inhibitor) to allow for radical surgical resection in patients with unresectable locally advanced melanoma.

Summary Background Data: Approximately 5% of stage III melanoma patients presents with unresectable locally advanced disease, making standard of care with resection followed by adjuvant systemic therapy impossible. Although neoadjuvant targeted therapy has shown promising results in resectable stage III melanoma, its potency to enable surgical resection in patients with primarily unresectable locally advanced stage III melanoma is still unclear. Read More

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Overcoming barriers to maintain hemodialysis adequacy among hemodialysis patient in hospital: a best practice implementation project.

JBI Evid Implement 2021 Apr 9. Epub 2021 Apr 9.

Department of Nursing, Pingtung Christian Hospital Department of Nursing, Meiho University Department of Internal Medicine, Pingtung Christian Hospital, Pingtung Institute of Clinical Nursing, College of Nursing, National Yang Ming Chiao Tung University Taiwan Evidence Based Practice Centre: A Joanna Briggs Centre of Excellence, Taipei, Taiwan.

Objective: The aim of this evidence implementation project was to identify the barriers and omissions affecting adequacy of hemodialysis and to develop implementable strategies to maintain hemodialysis adequacy among hemodialysis patients with end-stage renal disease.

Introduction: Assessing adequacy of hemodialysis and improving quality of life are important issues for patients with end-stage renal disease. However, they are often inadequately addressed, and evidence-based practices are not always followed. Read More

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A new approach to predicting shoulder dystocia: Fetal clavicle length.

Authors:
Elif Terzi

Turk J Med Sci 2021 Apr 12. Epub 2021 Apr 12.

Objective: This study aimed to evaluate the relationship between second- and third-trimester clavicle length and birth weight and shoulder dystocia.

Methods: This prospective observational study included 181 patients who presented to the Private Etlik Lokman Hekim Hospital for routine pregnancy visits between March 2019 and March 2020. In addition to routine pregnancy examinations, the patients also underwent ultrasonography twice at weeks 20-23 and 33-36 to determine the length of the fetal clavicle. Read More

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Neoadjuvant pembrolizumab with chemotherapy for the treatment of stage IIB-IIIB resectable lung squamous cell carcinoma.

J Thorac Dis 2021 Mar;13(3):1760-1768

Department of Thoracic Surgery, Cancer Hospital of University of Chinese Academy of Sciences (Zhejiang Cancer Hospital), Hangzhou, China.

Background: Researches on programmed cell death (PD-1) as neoadjuvant immunotherapy for resectable non-small cell lung cancer is underway, which brings hope for individuals with the disease. However, a study dedicated to lung squamous cell carcinoma (LUSC) specifically has yet to be conducted. Now, data from our pilot prospective research neoadjuvant study provide new insights in the field of neoadjuvant regimen for LUSC. Read More

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Stiffness of aortic arch and carotid arteries increases in -knockout mice with high-fat diet: evidence from echocardiography.

Am J Transl Res 2021 15;13(3):1352-1364. Epub 2021 Mar 15.

Department of Medicine, University of Illinois at Chicago Chicago, IL 60612, USA.

Arterial stiffness is an effective predictor of atherosclerosis. Measurement of pulse-wave velocity (PWV) is a gold-standard approach to study arterial stiffness. This study aims to examine arterial stiffness and heart functions via echocardiography at an early stage of atherosclerosis. Read More

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Long Multi-Stage Training for a Motor-Impaired User in a BCI Competition.

Front Hum Neurosci 2021 25;15:647908. Epub 2021 Mar 25.

Université Côte d'Azur, Inria, France.

In a Mental Imagery Brain-Computer Interface the user has to perform a specific mental task that generates electroencephalography (EEG) components, which can be translated in commands to control a BCI system. The development of a high-performance MI-BCI requires a long training, lasting several weeks or months, in order to improve the ability of the user to manage his/her mental tasks. This works aims to present the design of a MI-BCI combining mental imaginary and cognitive tasks for a severely motor impaired user, involved in the BCI race of the Cybathlon event, a competition of people with severe motor disability. Read More

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[Impact of prematurity on the optic nerve].

J Fr Ophtalmol 2021 Apr 8. Epub 2021 Apr 8.

CHU de Nantes, Nantes, France.

Introduction: Thanks to the progress made in the past few years in pediatric intensive care as well as the increased survival of preterm infants, the consequences of premature birth are increasingly well documented. With regard to ophthalmologic complications, retinopathy of prematurity is well described, but the optic nerve may also be affected. The goal of this study is to compare the optic nerves of preterm infants as a function of their gestational period with a control group of the same age. Read More

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Late onset periprosthetic joint infection of the knee caused by Streptococcus anginosus. Case presentation and literature review.

J Infect Dev Ctries 2021 Mar 31;15(3):436-441. Epub 2021 Mar 31.

Department of Chemistry and Pharmacy, University of Sassari, Sassari, Italy.

Periprosthetic joint infection (PJI) is one of the most dramatic complications of joint arthroplasty. Although streptococcal bone and joint infections are less common than staphylococcal cases, their role as causative agents of bone and joint remains significant accounting for at least 10% of PJIs. Streptococcus anginosus group (SAG) bacteria are usually found in the normal flora of the urogenital tract, intestinal tract and oropharynx and could cause pyogenic infections to affect brain, lungs and liver. Read More

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CopenFast trial: Faster-acting insulin Fiasp versus insulin NovoRapid in the treatment of women with type 1 or type 2 diabetes during pregnancy and lactation - a randomised controlled trial.

BMJ Open 2021 Apr 9;11(4):e045650. Epub 2021 Apr 9.

Center for Pregnant Women with Diabetes, Rigshospitalet, Copenhagen, Denmark.

Introduction: Faster-acting insulin aspart (Fiasp) is approved for use in pregnancy and lactation, but no clinical study has evaluated its effects during this life stage in women with pre-existing diabetes. The aim of the CopenFast trial is to evaluate the effect of Fiasp compared with insulin aspart (NovoRapid) on maternal glycaemic control during pregnancy, delivery and lactation and on fetal growth and infant health.

Methods And Analysis: An open-label randomised controlled trial of pregnant women with type 1 or type 2 diabetes including women on multiple daily injection (MDI) therapy or insulin pump therapy. Read More

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Exercise Medicine in the Management of Pancreatic Cancer: A Systematic Review.

Pancreas 2021 Mar;50(3):280-292

Abstract: The aim of this study was to examine the health-related effects of exercise in patients with pancreatic cancer (PanCa) through a systematic review of current evidence. Studies were obtained through searching PubMed, Web of Science, PsycINFO, Embase, CINAHL Plus, and Cochrane Library databases with additional hand searches. All intervention-based studies were included if it involved (1) adult patients with PanCa, (2) exercise training, and (3) findings in quality of life, cancer-related fatigue, psychological distress, and physical function. Read More

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Effects of aging on proteasomal-ubiquitin system, oxidative stress balance and calcium homeostasis in middle-aged female rat colon.

Physiol Int 2021 Apr 8. Epub 2021 Apr 8.

1Department of Physiology, Anatomy and Neuroscience, Faculty of Science and Informatics, University of Szeged, Szeged, Hungary.

Aging is a multifactorial process, which is considered as a decline over time. It is increasingly clear that there is a gender difference in aging and in the prevalence of age-related diseases as well. We aimed to examine the effects of the aging process in the colonic tissue of female Wistar rats aged 10 weeks (young) and 13 months (middle-aged) at an early stage, according to three main symptoms associated with aging: a decrease in the efficacy of the proteasome and muscle function and an increase in oxidative stress. Read More

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Effects of Myo-inositol Hexaphosphate (SNF472) on Bone Mineral Density in Patients Receiving Hemodialysis: An Analysis of the Randomized, Placebo-Controlled CaLIPSO Study.

Clin J Am Soc Nephrol 2021 Apr 7. Epub 2021 Apr 7.

Department of Medicine, Stanford University, Palo Alto, California.

Background And Objectives: In the CaLIPSO study, intravenous administration of SNF472 (300 or 600 mg) during hemodialysis significantly attenuated progression of coronary artery and aortic valve calcification. SNF472 selectively inhibits formation of hydroxyapatite, the final step in cardiovascular calcification. Because bone mineral is predominantly hydroxyapatite, we assessed changes in bone mineral density in CaLIPSO. Read More

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[Failed back surgery syndrome: the role of central sensitization and treatment approaches].

Zh Nevrol Psikhiatr Im S S Korsakova 2021 ;121(3):64-69

Clinic of the Medical University, Kazan, Russia.

Objective: To study a role of central sensitization (CS) in patients with Failed Back Surgery Syndrome (FBSS) after decompression of the lumbar and/or sacral roots.

Material And Methods: The study included three groups of patients: 1) early FBSS (e-FBSS, =23), pain after surgery decreased, but continued to significantly bother the patient, or recurred in the first 6 months after surgery; 2) middle FBSS (m-FBSS, =42), pain after surgery completely stopped, but recurred within 6-12 months; 3) late FBSS (l-FBSS, =31), if pain relapse occurred more than 12 months later. Neurological status assessment, study of muscle trigger zones (MTZ), postoperative scar trigger zones (TZS), pain assessment according to the Visual Analogue Scale (VAS), CS assessment according to the Russian version of the Central Sensitization Inventory (CSI) were performed. Read More

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Single-cell transcriptomics of human embryos identifies multiple sympathoblast lineages with potential implications for neuroblastoma origin.

Nat Genet 2021 Apr 8. Epub 2021 Apr 8.

Department of Physiology and Pharmacology, Karolinska Institutet, Solna, Sweden.

Characterization of the progression of cellular states during human embryogenesis can provide insights into the origin of pediatric diseases. We examined the transcriptional states of neural crest- and mesoderm-derived lineages differentiating into adrenal glands, kidneys, endothelium and hematopoietic tissue between post-conception weeks 6 and 14 of human development. Our results reveal transitions connecting the intermediate mesoderm and progenitors of organ primordia, the hematopoietic system and endothelial subtypes. Read More

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Exercise Medicine in the Management of Pancreatic Cancer: A Systematic Review.

Pancreas 2021 Apr 7. Epub 2021 Apr 7.

From the Exercise Medicine Research Institute School of Medical and Health Sciences, Edith Cowan University, Joondalup School of Human Movement and Nutrition Sciences, University of Queensland, Brisbane Department of Radiation Oncology, Sir Charles Gairdner Hospital Department of Radiation Oncology, GenesisCare, Perth, Australia.

Abstract: The aim of this study was to examine the health-related effects of exercise in patients with pancreatic cancer (PanCa) through a systematic review of current evidence. Studies were obtained through searching PubMed, Web of Science, PsycINFO, Embase, CINAHL Plus, and Cochrane Library databases with additional hand searches. All intervention-based studies were included if it involved (1) adult patients with PanCa, (2) exercise training, and (3) findings in quality of life, cancer-related fatigue, psychological distress, and physical function. Read More

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Plasma KIM-1 is associated with recurrence risk after nephrectomy for localized renal cell carcinoma: A trial of the ECOG-ACRIN Research Group (E2805).

Clin Cancer Res 2021 Apr 8. Epub 2021 Apr 8.

Division of Hematology-Oncology, Beth Israel Deaconess Medical Center

Purpose: No circulating biomarkers are currently available to identify patients at highest risk of recurrence after nephrectomy for renal cell carcinoma (RCC). Kidney injury molecule-1 (KIM-1) is overexpressed in RCC and its ectodomain circulates in plasma. We investigated whether plasma KIM-1 is a prognostic biomarker in patients with localized RCC after nephrectomy. Read More

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Low feasibility of in vitro matured oocytes originating from cumulus complexes found during ovarian tissue preparation at the moment of gender confirmation surgery and during testosterone treatment for fertility preservation in transgender men.

Fertil Steril 2021 Apr 5. Epub 2021 Apr 5.

Department for Reproductive Medicine, Ghent University Hospital, Ghent, Belgium. Electronic address:

Objective: To study the feasibility of in vitro maturation of ovarian tissue oocytes for fertility preservation in transgender men on testosterone treatment.

Design: Cross-sectional study SETTING: University hospital PATIENT(S): Eighty-three transgender men enrolled from November 2015 to January 2019 INTERVENTION(S): In vitro maturation of cumulus-oocyte complexes (COCs) harvested at the time of gender confirmation surgery, and fertilization through intracytoplasmic sperm injection.

Main Outcome Measure(s): In vitro maturation, fertilization, and blastulation rates; comparison of morphokinetics with vitrified-warmed oocytes; and analysis of the genetic profiles of embryos. Read More

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Tolerability and antitumor activity of cemiplimab, a human monoclonal anti-PD-1, as monotherapy in patients with pretreated non-small cell lung cancer (NSCLC): Data from the Phase 1 NSCLC expansion cohort.

Lung Cancer 2021 Mar 4;155:151-155. Epub 2021 Mar 4.

Regeneron Pharmaceuticals, Inc., Tarrytown, NY, USA.

Objectives: Blockade of programmed cell death-1 (PD-1) and its ligand (PD-L1) has transformed the treatment of NSCLC. In a first-in-human, Phase 1, dose escalation and cohort expansion study, cemiplimab, a monoclonal antibody directed against PD-1, was evaluated for the treatment of patients with advanced solid tumors (NCT02383212). Here, we report results in patients with advanced NSCLC from the dose expansion cohort. Read More

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The impact on obstetric outcomes following complete amputation of the cervix uteri in fertility preservation surgery for cervical neoplasm.

Eur J Obstet Gynecol Reprod Biol 2021 Mar 26;260:171-176. Epub 2021 Mar 26.

Institute of Cancer and Genomic Sciences, University of Birmingham, Vincent Drive, Birmingham, B15 2TT, United Kingdom; Pan-Birmingham Gynaecological Cancer Centre, City Hospital, Dudley Road, Birmingham, B18 7QH, United Kingdom. Electronic address:

Objectives: Radical trachelectomy is offered to women with early-stage cervical neoplasia who desire fertility. The presence of isthmic glands within histological specimens suggests complete cervical amputation and as such, we examined if the presence of these glands in surgical specimens adversely affects obstetric outcomes.

Study Design: The study cohort comprises 43 consecutive cases of early-stage cervical neoplasia. Read More

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The impact of Tai Chi and mind-body breathing in COPD: Insights from a qualitative sub-study of a randomized controlled trial.

PLoS One 2021 8;16(4):e0249263. Epub 2021 Apr 8.

Division of General Medicine, Department of Medicine, Beth Israel Deaconess Medical Center, Brookline, MA, United States of America.

Purpose: Chronic obstructive pulmonary disease (COPD) is associated with multiple psychosocial and behavioral factors. Prior research suggests that mind-body interventions may support the development and maintenance of healthy behaviors and improve health-related quality-of-life in such patients. We sought to qualitatively explore cognitive, psychosocial, and behavioral changes in patients with COPD who participated in two different mind-body interventions compared to an education control. Read More

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Transcranial Ultrasound Stimulation Suppresses Neuroinflammation in a Chronic Mouse Model of Parkinson's Disease.

IEEE Trans Biomed Eng 2021 Apr 8;PP. Epub 2021 Apr 8.

Objective: Neuroinflammation contributes to the development and progression of Parkinson's disease (PD). The aim of this study was to examine whether ultrasound (US) stimulation of the subthalamic nucleus (STN) could suppress the neuroinflammation in a chronic PD mouse model induced by 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP).

Methods: Chronic PD mouse model was built by injection of 20mg/kg MPTP and 250 mg/kg probenecid at 3. Read More

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Oral intake of Lactobacillus plantarum L-14 extract alleviates TLR2- and AMPK-mediated obesity-associated disorders in high-fat-diet-induced obese C57BL/6J mice.

Cell Prolif 2021 Apr 8:e13039. Epub 2021 Apr 8.

Cellular Reprogramming and Embryo Biotechnology Laboratory, Dental Research Institute, Seoul National University School of Dentistry, Seoul, Korea.

Objectives: Whether periodic oral intake of postbiotics positively affects weight regulation and prevents obesity-associated diseases in vivo is unclear. This study evaluated the action mechanism of Lactobacillus plantarum L-14 (KTCT13497BP) extract and the effects of its periodic oral intake in a high-fat-diet (HFD) mouse model.

Materials And Methods: Mouse pre-adipocyte 3T3-L1 cells and human bone marrow mesenchymal stem cells (hBM-MSC) were treated with L-14 extract every 2 days during adipogenic differentiation, and the mechanism underlying anti-adipogenic effects was analysed at cellular and molecular levels. Read More

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Incessant Atrial Tachycardia Following Combination Chemotherapy with Cetuximab, Cisplatin and 5-Fluorouracil for Hypopharyngeal Cancer.

Cardiovasc Toxicol 2021 Apr 8. Epub 2021 Apr 8.

Department of Cardiology, Gifu Seiryu Hospital, 3-25 Kawabe, Gifu, 501-1151, Japan.

A 72-year-old man with stage IV hypopharyngeal cancer, who had been treated for three months with combination chemotherapy, was referred to our cardiology department for evaluation of transient palpitation. Combination therapy with cetuximab, cisplatin, and 5-fluorouracil per cycle had been administered intravenously for five cycles every three weeks for three months. After the admission due to slight palpitation and severe hypomagnesemia (Mg = 0. Read More

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The effectiveness of high-intensity laser therapy in the treatment of post-stroke patients with hemiplegic shoulder pain: a prospective randomized controlled study.

Lasers Med Sci 2021 Apr 8. Epub 2021 Apr 8.

Department of Physical Medicine and Rehabilitation, Health Sciences University, Gaziler Physical Medicine and Rehabilitation Education and Research Hospital, Ankara, Turkey.

To evaluate clinical and ultrasonographic efficacy of high-intensity laser therapy (HILT) in patients with hemiplegic shoulder pain (HSP) accompanied by partial thickness rotator cuff tear (PTRCT). The study was designed as a prospective, randomized, controlled trial. Patients with HSP accompanied by PTRCT (n = 44) were randomly assigned to HILT and control groups. Read More

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Mycobacterial periprosthetic joint infection after primary total knee arthroplasty.

Int Orthop 2021 Apr 8. Epub 2021 Apr 8.

Department of Orthopaedic Surgery, Yonsei University College of Medicine, Seoul, Republic of Korea.

Purpose: Mycobacterial periprosthetic joint infection (PJI) is very rare and is generally associated with an immunosuppressive environment. Few large-scale studies of this unusual PJI have been conducted. The current study was performed to assess the clinical features and outcomes following two-stage re-implantation for mycobacterial PJI after primary total knee arthroplasty (TKA). Read More

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A randomized trial to evaluate the impact of exercise-based cardiac rehabilitation for the prevention of chemotherapy-induced cardiotoxicity in patients with breast cancer: ONCORE study protocol.

BMC Cardiovasc Disord 2021 Apr 7;21(1):165. Epub 2021 Apr 7.

Cardiology Department, Centro de Investigación Biomédica en Red de Enfermedades Cardiovasculares (CIBERCV), University Clinical Hospital of Santiago de Compostela (SERGAS), A Choupana s/n, 15706, Santiago de Compostela, A Coruña, Spain.

Background: Anthracyclines and monoclonal antibodies against human epidermal growth factor receptor-2 (HER2) are frequently used to treat breast cancer but they are associated with risk of developing cardiotoxicity. Implementation of cardioprotective strategies as part of breast cancer treatment are needed. To date, a limited number of studies have examined the effectiveness of cardiac rehabilitation programs or exercise programs in the prevention of cardiotoxicity through an integral assessment of cardiac function. Read More

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Breathing-based leg exercises during hemodialysis improve quality of life: A randomized controlled trial.

Clin Rehabil 2021 Apr 8:2692155211000738. Epub 2021 Apr 8.

Department of Nursing, National Taipei University of Nursing and Health Sciences, Taipei City, Taiwan.

Objective: To evaluate the effect of a 12-week breathing-based leg exercises program on quality of life under stabilizing heart rate variability and reducing fatigue in regular hemodialysis patients.

Design: Randomized controlled trial.

Setting: A 94-bed hemodialysis department at a medical center in northern Taiwan. Read More

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