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Effects of Proprioceptive Neuromuscular Facilitation Stretching Combined with Aerobic Training on Pulmonary Function in COPD Patients: A Randomized Controlled Trial.

Int J Chron Obstruct Pulmon Dis 2021 13;16:969-977. Epub 2021 Apr 13.

Department of Respiratory and Critical Medicine, Respiratory Disease Key Laboratory of Qingdao, Qingdao Municipal Hospital, Qingdao University, Qingdao, People's Republic of China.

Background: The proprioceptive neuromuscular facilitation (PNF) stretching could improve the contractile capacity of respiratory muscles, but the effect on pulmonary function, when it is combined with aerobic training, remains unknown.

Objective: To evaluate the effect of PNF combined with aerobic training on respiratory symptoms, pulmonary function and neck/shoulder mobility in patients with COPD.

Design: Randomized controlled trial. Read More

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Delayed development of aphasia related to degeneration of the arcuate fasciculus in the dominant hemisphere nine years after the onset in a patient with intracerebral hemorrhage: a case report.

BMC Neurol 2021 Apr 20;21(1):166. Epub 2021 Apr 20.

Department of Physical Medicine and Rehabilitation, College of Medicine, Yeungnam University, 317-1, Daemyungdong, Namku, Daegu, 705-717, Republic of Korea.

Background: We report on a patient with an intracerebral hemorrhage (ICH), who showed delayed development of aphasia, which was demonstrated via follow up diffusion tensor tractography (DTT) to be related to neural degeneration of the arcuate fasciculus (AF).

Case Presentation: A 51-year-old, right-handed male presented with right hemiparesis, which occurred at the onset of a spontaneous ICH in the left corona radiata and basal ganglia. Brain magnetic resonance images showed a hematoma in the left subcortical area at one month after onset and hemosiderin deposits in the left subcortical area at nine years after onset. Read More

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A patient with a homozygous diacylglycerol kinase epsilon (DGKE) gene mutation with atypical haemolytic uraemic syndrome and low C3 responded well to eculizumab: a case report.

BMC Nephrol 2021 Apr 20;22(1):140. Epub 2021 Apr 20.

Department Paediatric Nephrology, King Abdullah Specialists Children Hospital, Riyadh, Saudi Arabia.

Background: Atypical haemolytic uraemic syndrome (aHUS) is a rare systemic syndrome characterized by non-immune haemolytic anaemia, thrombocytopenia, and kidney injury. In most cases, alternative complement pathway dysregulation is the identifying cause. Recently, other genetic causes have been identified, including a mutation in the diacylglycerol kinase epsilon (DGKE) gene, which theoretically affect the coagulation pathway and does not affect the complement pathway. Read More

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Delayed bowel perforation after instilling over warmed peritoneal dialysate.

BMC Nephrol 2021 Apr 20;22(1):139. Epub 2021 Apr 20.

Department of Nephrology, Shanghai Changhai Hospital, 168 Changhai Road, Shanghai, 200433, P.R. China.

Background: Peritoneal dialysis (PD) is a safe and home-based treatment for end-stage renal disease (ESRD) patients. The direct thermal damage of abdominal organs is very rare.

Case Presentation: We report a peritoneal dialysis patient presented abdominal pain and feculent effluent 3 weeks after he instilled hot dialysis solution. Read More

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Disparities in Trial of Labor among Women with Twin Gestations in the United States.

Am J Perinatol 2021 Apr 20. Epub 2021 Apr 20.

Department of Obstetrics and Gynecology, Division of Maternal-Fetal Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois.

Objective:  The aim of the study is to examine clinical and demographic factors associated with trial of labor (TOL) among women with twin gestations eligible for a vaginal delivery.

Study Design:  This was a population-based cohort study of women giving birth to twin gestations in the United States (2012-2014). Inclusion criteria for the analysis included live births greater than 23 weeks' gestation and a cephalic presenting twin. Read More

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Thyroid immune-related adverse events following immune checkpoint inhibitor treatment.

J Clin Endocrinol Metab 2021 Apr 20. Epub 2021 Apr 20.

Faculty of Medicine and Health, The University of Sydney, Sydney, Australia.

Background: Thyroid dysfunction occurs commonly following immune checkpoint inhibition. The etiology of thyroid immune-related adverse events (irAEs) remains unclear and clinical presentation can be variable. This study sought to define thyroid irAEs following immune checkpoint inhibitor (ICI) treatment and describe their clinical and biochemical associations. Read More

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The PanSurg-PREDICT Study: Endocrine Surgery During the COVID-19 Pandemic.

World J Surg 2021 Apr 20. Epub 2021 Apr 20.

Department of Endocrine Surgery, Hammersmith Hospital, 72 Du Cane Rd, London, W12 0HS, UK.

Background: In the midst of the COVID-19 pandemic, patients have continued to present with endocrine (surgical) pathology in an environment depleted of resources. This study investigated how the pandemic affected endocrine surgery practice.

Methods: PanSurg-PREDICT is an international, multicentre, prospective, observational cohort study of emergency and elective surgical patients in secondary/tertiary care during the pandemic. Read More

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Cerebral aspergillose.

Tidsskr Nor Laegeforen 2021 Apr 7;141(6). Epub 2021 Apr 7.

Background: The diagnosis of intracerebral fungal abscesses may be difficult due to the paucity of laboratory tests and similar radiological appearance to other lesions.

Case Presentation: We present an immunocompromised woman in her forties who was admitted with a diagnosis of bacterial meningitis. MRI examination showed findings suggestive of fungal abscesses, and a subsequent lumbar puncture showed PCR positive for non-fumigatus Aspergillus. Read More

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A pregnant woman with acute abdomen.

Tidsskr Nor Laegeforen 2021 Apr 19;141(6). Epub 2021 Apr 19.

Background: Acute abdomen in pregnancy is challenging. The presentation of symptoms and available diagnostic tools are directed and complicated by the pregnancy. A rare cause of acute abdomen in pregnancy requiring immediate intervention is presented. Read More

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Long-term survival achieved by repeated administration of ramucirumab after drug holidays due to proteinuria in recurrent gastric cancer.

Surg Case Rep 2021 Apr 20;7(1):97. Epub 2021 Apr 20.

Department of Surgery, National Defense Medical College, 3-2 Namiki, Tokorozawa, Saitama, 359-8513, Japan.

Background: The prognosis of recurrent and unresectable gastric cancer remains poor despite the development of multidisciplinary treatments. Ramucirumab (RAM) has been proven effective against unresectable or recurrent gastric cancer. However, its administration is often discontinued because of adverse events, including hypertension and proteinuria. Read More

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Neonatal listeriosis presentation and outcome: a prospective study of 189 cases.

Clin Infect Dis 2021 Apr 20. Epub 2021 Apr 20.

Institut Pasteur, Biology of Infection Unit, Paris, France.

Context: Listeriosis is caused by the foodborne pathogen Listeria monocytogenes. It can present as a maternal-neonatal infection. We implemented the nationwide prospective cohort MONALISA and analyzed the features of neonatal listeriosis. Read More

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Velamentous cord insertion ruptured during labour leading to acute fetal blood loss.

BMJ Case Rep 2021 Apr 19;14(4). Epub 2021 Apr 19.

Integrated Women's Health, St Luke's International Hospital, Tokyo, Japan.

Umbilical cord rupture (UCR) in utero is a very rare and critical emergency that can cause fetal death within minutes. A 38-year-old nulliparous woman was admitted at 39 weeks in labour. Sudden watery vaginal discharge and bleeding with a rapid drop in the fetal heart rate to 60 beats/min necessitated an emergency caesarean section. Read More

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Pregnancy Associated Granulomatous Mastitis: Clinical Characteristics, Management, and Outcome.

Breastfeed Med 2021 Apr 19. Epub 2021 Apr 19.

Department of Breast, Chengdu Women's and Children's Central Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China.

We have already known that idiopathic granulomatous mastitis (IGM) is a rare benign chronic inflammatory disorder that can clinically mimic breast carcinoma, especially affects parous women of childbearing age, but there is little literature to report about pregnancy associated granulomatous mastitis (PAGM). The aim of our study is to report and describe the clinical signs, managements, clinical course, and clinical outcomes after treatment of PAGM in our hospital. We retrospectively analyzed 15 pregnant patients who were diagnosed as PAGM in our hospital collected from December 2018 to December 2020 by reviewing medical records and questionnaire survey, including the patients' characteristics, clinical presentations, microbiological workups, tissue pathology, treatment modalities, outcomes, and follow-up data. Read More

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Myelopathy associated with SARS-COV-2 infection. A systematic review.

Neurol Res 2021 Apr 17:1-9. Epub 2021 Apr 17.

Medical School, University of Cyprus, Nicosia, Cyprus.

COVID-19 (CoranaVirus disease 2019) is an ongoing infectious disease caused by the RNA SARS-CoV-2 virus (Severe Acute Respiratory Syndrome CoronaVirus-2). More than one-third of COVID-19 patients report neurological symptoms and cases of neurological diseases are increasingly accumulating. The aim of this systematic review was to characterize all - to date - reported cases with COVID-19 related myelopathy. Read More

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Encephalitis due to miliary tuberculosis in a patient with human immunodeficiency virus: A case report.

J Clin Tuberc Other Mycobact Dis 2021 May 19;23:100230. Epub 2021 Mar 19.

Duta Wacana Christian University School of Medicine, Yogyakarta, Indonesia.

Background: Miliary tuberculosis (TB) is a form of extrapulmonary tuberculosis due to hematogenous dissemination and occurs more frequently in immunocompromised patients. Clinical manifestations are non-specific and varied with the related organ, including central nervous system involvement. We report the first case of encephalitis associated with miliary TB in human immunodeficiency virus (HIV)-the infected patient. Read More

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Acute esophageal necrosis complicated by refractory stricture formation.

JGH Open 2021 Apr 1;5(4):528-530. Epub 2021 Mar 1.

Department of Gastroenterology and Hepatology University of California Fresno California USA.

Acute esophageal necrosis (AEN) is a rare presentation of severe esophageal injury. The optimal long-term management of complications related to AEN, particularly stricture formation, are not well defined. We report a case of AEN in a patient who presented with diabetic ketoacidosis (DKA) and had dysphagia due to refractory stricture formation after mucosal healing occurred. Read More

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Case Report: Transarterial Chemoembolization in Combination With Tislelizumab Downstages Unresectable Hepatocellular Carcinoma Followed by Radical Salvage Resection.

Front Oncol 2021 29;11:667555. Epub 2021 Mar 29.

Department of General Surgery, Shanghai Organ Transplantation Medical Center, Shanghai General Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.

Introduction: Transarterial chemoembolization (TACE) is inefficient at converting unresectable hepatocellular carcinoma (uHCC) to resectable. Treatment with immune checkpoint inhibitors (ICIs) is an emerging strategy for uHCC. Combined therapy of TACE with ICIs is considered to improve the therapeutic effect. Read More

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Acute severe autoimmune hepatitis with anti-rods and rings autoantibodies; literature first evidence.

Gastroenterol Hepatol Bed Bench 2021 ;14(1):89-94

Clinical Investigation Laboratory, ASST Bergamo Est, Seriate, Bergamo, Italy.

Autoimmune hepatitis (AIH) was defined as a progressive, chronic inflammatory autoimmune liver disease (ALD). The diagnosis of AIH requires the presence of characteristic clinical and laboratory features, and the exclusion of other clinical conditions that cause chronic hepatitis and cirrhosis. AIH can have an acute onset that mimics an acute viral or toxic hepatitis or an acute severe (fulminant, ASF) presentation that satisfies criteria for acute liver. Read More

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January 2021

Classic Kaposi sarcoma in a patient of Miao ethnicity followed up for 7 years: a case report.

J Med Case Rep 2021 Apr 19;15(1):179. Epub 2021 Apr 19.

Department of Dermatology, The Affiliated Hospital, Guizhou Medical University, Beijing Road 4, Yunyan District, Guiyang, China.

Background: Classic Kaposi sarcoma (CKS) is a vascular sarcoma associated with human herpesvirus 8 (HHV-8), which is known to be more common in Mediterranean elderly men and is characterized by indolent clinical behavior. Xinjiang province in China is considered an endemic region for Kaposi's sarcoma-associated herpesvirus (KSHV), with higher incidence among adults of Kazak and Uyghur ethnicities. Cases of CKS are rarely reported in inland China. Read More

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Severe pneumonia caused by Parvimonas micra: a case report.

BMC Infect Dis 2021 Apr 17;21(1):364. Epub 2021 Apr 17.

Department of Intense Care Unit, Shenzhen Longhua Central Hospital, Guanlan Boulevard, Shenzhen, 187, China.

Background: Parvimonas micra (P. micra) is a gram-positive anaerobic coccus that is detected widely on the skin, in the oral mucosa and in the gastrointestinal tract. In certain circumstances, P. Read More

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Cytomegalovirus events in high-risk allogeneic hematopoietic-cell transplantation patients who received letermovir prophylaxis.

Transpl Infect Dis 2021 Apr 18:e13619. Epub 2021 Apr 18.

Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.

Letermovir is approved for the prevention of cytomegalovirus (CMV) reactivation and clinical disease in patients undergoing allogeneic hematopoietic-cell transplantation (HCT). However, there is uncertainty about letermovir's ability to prevent clinical events during the period of prophylaxis as well as after the discontinuation of prophylaxis in the post-transplant setting. We performed a retrospective cohort study in CMV-seropositive allogeneic HCT recipients at high risk of CMV events who received letermovir for primary prophylaxis from November 2017 through December 2019. Read More

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The effect of COVID-19 pandemic restrictions on neovascular AMD patients treated with treat-and-extend protocol.

Int Ophthalmol 2021 Apr 17. Epub 2021 Apr 17.

Department of Ophthalmology, Marmara University School of Medicine, Fevzi Çakmak Mah, Muhsin Yazıcıoğlu Cd, No: 10, Marmara Üniversitesi Pendik Eğitim ve Araştırma Hastanesi, Kat: 3, Oftalmoloji Servisi, Pendik, 34899, Istanbul, Turkey.

Purpose: To investigate the adherence rate of neovascular age-related macular degeneration (nAMD) patients in treat-and-extend (TAE) protocol to their anti-vascular endothelial growth factor (anti-VEGF) intravitreal injection (IVI) appointments and to evaluate the functional and anatomical outcomes of the patients who attended and did not attend their IVI appointments during the coronavirus disease 2019 (COVID-19) restriction period (RP).

Methods: The patients with nAMD having IVI appointments between March 16 and June 1, 2020 (RP in Turkey) were included in this retrospective study. For adherence analysis, the patients who attended (Group 1, n = 44) and who did not attend (Group 2, n = 60) their IVI appointment visits during the RP (V) were evaluated according to their last visit before the RP (V). Read More

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[Acute perforated appendicitis with pre-surgical diagnosis and bilateral inguinal hernia in preterm infants].

Rev Chil Pediatr 2020 Dec 21;91(6):936-940. Epub 2020 Oct 21.

Clínica Las Condes, Santiago, Chile.

Introduction: Acute neonatal appendicitis is a rare pathology, with few reports in the last 30 years. Since its clinical presentation and imaging studies are non-specific, most cases are diagnosed during a surgical pro cedure.

Objective: To describe a neonatal case of acute perforated appendicitis associated with later appearance of inguinal hernia, with pre-surgical diagnosis and treated through laparoscopy. Read More

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December 2020

[Prevalence of Arterial Hypertension in a neonatal intensive care unit].

Rev Chil Pediatr 2020 Dec 8;91(6):891-898. Epub 2020 Oct 8.

Hospital General de Niños Pedro de Elizalde, Ciudad Autónoma de Buenos Aires, Argentina.

Introduction: The prevalence of neonatal hypertension in neonatal intensive care units (NICU) ranges between 3 and 9%. However, there is no current data on Latin America.

Objective: To estimate the prevalence of neonatal hypertension and to assess its association with causes previously related to this condi tion. Read More

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December 2020

Multimodal Analysis of the Tissue Response to a Bone-Anchored Hearing Implant: Presentation of a Two-Year Case Report of a Patient With Recurrent Pain, Inflammation, and Infection, Including a Systematic Literature Review.

Front Cell Infect Microbiol 2021 30;11:640899. Epub 2021 Mar 30.

Department of Biomaterials, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.

Osseointegration is a well-established concept used in applications including the percutaneous Bone-Anchored Hearing System (BAHS) and auricular rehabilitation. To date, few retrieved implants have been described. A systematic review including cases where percutaneous bone-anchored implants inserted in the temporal bone were retrieved and analyzed was performed. Read More

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Subpalpebral Antibiotic Lavage as Safe, Emergent, and Cost-Effective Management of Acute Infectious Keratitis Related to Contact Lens Overwear: Case Report and Literature Review.

Cornea 2021 Apr 14. Epub 2021 Apr 14.

Faculty of Medicine, University of New South Wales, Sydney, Australia; Royal North Shore Hospital, Sydney, Australia; and Department of Ophthalmology, Prince of Wales Hospital, Sydney, Australia.

Purpose: The aim of this study is to describe the technique of subpalpebral antibiotic lavage (SAL), which is a highly therapeutic, efficient, and cost-effective method for managing severe bacterial keratitis.

Methods: This case report describes a 26-year-old woman with severe bacterial keratitis in the right eye due to contact lens overwear, with progressive corneal thinning, a hypopyon, impending perforation, and marked visual loss to perception of light despite treatment with intensive topical antibiotics. This was managed with SAL that involves the insertion of a cannula transcutaneously into the upper conjunctival fornix to provide continuous antibiotic irrigation of the ocular surface. Read More

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New-onset focal seizure as a presenting feature of HIV infection: a case report and mini review to the challenge in resource-limited settings.

AIDS Res Ther 2021 Apr 15;18(1):12. Epub 2021 Apr 15.

Hayat Medical College, Addis Ababa, Ethiopia.

Background: The frequency of new-onset HIV-associated seizure in the HIV-infected patient is estimated to be between 2 and 11%. Identifying the underlying etiology of new-onset seizure will have a vital impact on the mortality and morbidity of patients living with HIV infection.

Case Presentation: We report a 34-year old newly diagnosed HIV+ male patient presented with abnormal body movement (ABM) involving his right hemibody associated with loss of consciousness lasting few minutes of two weeks duration. Read More

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Evaluation of Implementation of Early-Onset Sepsis Calculator in Newborns in Israel.

J Pediatr 2021 Apr 12. Epub 2021 Apr 12.

Department of Neonatology and Pediatrics; Haifa, Israel; Technion, Israel Institute of Technology; Haifa, Israel.

Objective: To evaluate the recommendations based on the early-onset sepsis (EOS) calculator in the first two years of its implementation in Israel.

Study Design: Prospective two-year surveillance of a cohort of infants born at gestational age (GA) ≥34 weeks in Bnai Zion Medical Center, who were evaluated using the EOS calculator because of peripartum risk factors.

Results: 1146 newborns with peripartum risk factors were evaluated using the EOS calculator. Read More

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Clinical Presentation, Management, and Outcomes of Patients With Brain Abscess due to Species.

Open Forum Infect Dis 2021 Apr 7;8(4):ofab067. Epub 2021 Apr 7.

Section of Infectious Diseases, Baylor College of Medicine, Houston, Texas, USA.

Background: Nocardial brain abscesses are rare, and published literature describing brain abscesses due to species is limited to individual case reports or small series. We report one of the largest contemporary retrospective studies describing risk factors, diagnostic evaluation, management, and outcomes of nocardial brain abscess.

Methods: Retrospective review of all adults with brain abscess due to culture-confirmed species at our institution between January 1, 2009, and June 30, 2020. Read More

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The Mystery of Episodic Recurrent Jaundice in a Young Male: Cholestasis With a Normal Gamma-Glutamyl Transferase.

Cureus 2021 Mar 11;13(3):e13834. Epub 2021 Mar 11.

Digestive Diseases and Nutrition, University of Oklahoma Health Sciences Center, Oklahoma City, USA.

Benign recurrent intrahepatic cholestasis (BRIC) is a very rare autosomal recessive genetic disorder which presents with recurrent jaundice. We report the case of a young male with a history of methamphetamine use who presented with recurrent episodes of right upper quadrant abdominal pain, vomiting, dark urine, and pale stools. These symptoms always resolved within four weeks of presentation. Read More

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