237,846 results match your criteria weeks compared


Perinatal Outcomes in Twin Pregnancies Complicated by Gestational Diabetes.

Am J Obstet Gynecol MFM 2021 May 12:100396. Epub 2021 May 12.

Department of Obstetrics, Gynecology, and Reproductive Sciences, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania; Magee-Womens Research Institute, Pittsburgh, Pennsylvania. Electronic address:

Background: Gestational diabetes in singleton pregnancies increases the risk of large for gestational age infants, hypertensive disorders of pregnancy, and neonatal morbidity.[1,2,3,4] Compared to singleton gestations, twin gestations are at increased risk for fetal growth abnormalities, hypertensive disorders and neonatal morbidity.[5] Whether gestational diabetes further increases the risk of these outcomes is unclear. Read More

View Article and Full-Text PDF

Metabolites from mid-trimester plasma of pregnant patients at high-risk for preterm birth.

Am J Obstet Gynecol MFM 2021 May 12:100393. Epub 2021 May 12.

Institute for Environmental Health Solutions, Gillings School of Global Public Health, University of North Carolina-Chapel Hill, Chapel Hill, NC; Department of Environmental Sciences and Engineering, Gillings School of Global Public Health, University of North Carolina-Chapel Hill, Chapel Hill, NC.

Background: There is an increased awareness regarding the association between exposure to environmental contaminants and adverse pregnancy outcomes including preterm birth. Whether an individual's metabolic profile can be utilized during pregnancy to differentiate the subset of patients who are ultimately destined to deliver preterm remains uncertain but could have significant clinical implications.

Objective: We sought to objectively quantify metabolomic profiles of patients at high risk for preterm birth by evaluating mid-trimester maternal plasma, and to measure whether endogenous metabolites and exogenous environmental substances differ among those who ultimately deliver preterm compared to those who deliver at term. Read More

View Article and Full-Text PDF

Use of the angiogenic biomarker profile to risk stratify patients with fetal growth restriction.

Am J Obstet Gynecol MFM 2021 May 12:100394. Epub 2021 May 12.

Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, University of Chicago, Chicago, IL, United States. Electronic address:

Background: Novel angiogenic biomarker profiles have demonstrated emerging evidence for predicting preeclampsia onset, severity, and adverse outcomes. Limited data exists in screening patients with fetal growth restriction for preeclampsia development using angiogenic biomarkers.

Objective: The objective of this study was to risk stratify patients with fetal growth restriction using a soluble fms-like tyrosine kinase-1 (sFlt1) to placental growth factor (PlGF) ratio. Read More

View Article and Full-Text PDF

Prevention of non-alcoholic steatohepatitis by long-term exercise via the induction of phenotypic changes in Kupffer cells of hyperphagic obese mice.

Physiol Rep 2021 May;9(9):e14859

Faculty of Medicine, University of Tsukuba, Tsukuba-shi, Ibaraki, Japan.

Exercise ameliorates nonalcoholic fatty liver disease (NAFLD) by inducing phenotypic changes in Kupffer cells (KCs). p62/Sqstm1-knockout (p62-KO) mice develop NAFLD alongside hyperphagia-induced obesity. We evaluated (1) the effects of long-term exercise on the foreign-body phagocytic capacity of KCs, their surface marker expression, and the production of steroid hormones in p62-KO mice; and (2) whether long-term exercise prevented the development of non-alcoholic steatohepatitis (NASH) in p62-KO mice fed a high-fat diet (HFD). Read More

View Article and Full-Text PDF

Strength training in addition to neuromuscular exercise and education in individuals with knee osteoarthritis the effects on pain and sensitization.

Eur J Pain 2021 May 15. Epub 2021 May 15.

The Research Unit PROgrez, Department of Physiotherapy and Occupational Therapy, Naestved-Slagelse-Ringsted Hospitals, Region Zealand, Slagelse, Denmark.

Background: There is a lack of evidence of the relative effects of different exercise modes on pain sensitization and pain intensity in individuals with knee osteoarthritis (KOA).

Methods: Ninety individuals with radiographic and symptomatic KOA, ineligible for knee replacement surgery, were randomized to 12 weeks of twice-weekly strength training in addition to neuromuscular exercise and education (ST+NEMEX-EDU) or neuromuscular exercise and education alone (NEMEX-EDU). Outcomes were bilateral, lower-leg, cuff pressure pain- and tolerance thresholds (PPT, PTT), temporal summation (TS), conditioned pain modulation (CPM), self-reported knee pain intensity, and number of painful body sites. Read More

View Article and Full-Text PDF

Population Pharmacokinetic Analysis of Bedaquiline-Clarithromycin for Dose Selection Against Pulmonary Nontuberculous Mycobacteria Based on a Phase 1, Randomized, Pharmacokinetic Study.

J Clin Pharmacol 2021 May 15. Epub 2021 May 15.

Johnson and Johnson Services, Inc, New Brunswick, NJ, USA.

Based on in vitro profile of bedaquiline against mycobacterial species, it is being investigated for clinical efficacy against pulmonary nontuberculous mycobacteria (PNTM). Being a cytochrome P450 (CYP) 3A substrate, pharmacokinetic interactions of bedaquiline are anticipated with clarithromycin (a CYP3A inhibitor), which is routinely used in PNTM treatment. This Phase 1, randomized, crossover study assessed the impact of steady-state clarithromycin (500 mg every 12 hours; 14 days) on the pharmacokinetics of bedaquiline and its metabolite (M2) after single-dose bedaquiline (100 mg; n  =  16). Read More

View Article and Full-Text PDF

Direct Comparison of Risankizumab and Fumaric Acid Esters in Systemic-Therapy-Naive Patients With Moderate to Severe Plaque Psoriasis: A Randomized Controlled Trial.

Br J Dermatol 2021 May 15. Epub 2021 May 15.

Dermatologikum, Hamburg, Germany.

Background: Fumaric acid esters (FAEs; Fumaderm ) are the most frequently prescribed first-line systemic treatment for moderate-to-severe plaque psoriasis in Germany. Risankizumab (Skyrizi ) is a humanized IgG1 monoclonal antibody that specifically binds to the p19 subunit of interleukin-23.

Objective: This study compared risankizumab treatment with FAEs in psoriasis patients. Read More

View Article and Full-Text PDF

Pelvic capacity in pregnant women, identified using magnetic resonance imaging.

Acta Obstet Gynecol Scand 2021 May 15. Epub 2021 May 15.

Department of Obstetrics and Gynecology, Aarhus University Hospital, Aarhus, Denmark.

Introduction: Maternal pelvic capacity plays a major role during childbirth because the passage of the fetus through the bony birth canal enables vaginal birth. Maternal birthing position may influence pelvic capacity because upright positions optimize capacity, possibly due to free movement of the pelvic joints. Herein, pelvic capacity was assessed by comparing changes in pelvic dimensions across pregnancy and during three birthing positions. Read More

View Article and Full-Text PDF

Trematodes coupled with neonicotinoids: effects on blood cell profiles of a model amphibian.

Parasitol Res 2021 May 15. Epub 2021 May 15.

Ecotoxicology and Wildlife Health Division, Wildlife and Landscape Science Directorate, Science and Technology Branch, National Wildlife Research Centre, Environment and Climate Change Canada, 1125 Colonel By Drive, Ottawa, Ontario, K1A 0H3, Canada.

Habitat loss, climate change, environmental contaminants, and parasites and pathogens are among the main factors thought to act singly or together in causing amphibian declines. We tested for combined effects of neonicotinoid pesticides and parasites (versus parasites-only) on mortality, growth, and white blood cell profiles of a model amphibian: the northern leopard frog (Rana pipiens). We first exposed infectious stages of frog trematodes (cercariae of Echinostoma spp. Read More

View Article and Full-Text PDF

Co-treatment of vitamin D supplementation with enriched environment improves synaptic plasticity and spatial learning and memory in aged rats.

Psychopharmacology (Berl) 2021 May 15. Epub 2021 May 15.

Neuroscience Research Center, Neuropharmacology Institute, Kerman University of Medical Sciences, Kerman, Iran.

Rationale And Objective: Environmental enrichment (EE) has been shown in old rats to improve learning and memory. Vitamin D (VitD) has also been shown to modulate age-related, cognitive dysfunction. As both EE and VitD could work to improve cognition via enhancement of neurotrophic factors, their effects might occlude one another. Read More

View Article and Full-Text PDF

Effect of orlistat on live birth rate in overweight or obese women undergoing IVF-ET: A randomized clinical trial.

J Clin Endocrinol Metab 2021 May 15. Epub 2021 May 15.

Center for Reproductive Medicine, Cheeloo College of Medicine, Shandong University; The Key Laboratory of Reproductive Endocrinology of Ministry of Education; National Research Center for Assisted Reproductive Technology and Reproductive Genetics, Jinan, China.

Context: Obesity management prior to infertility treatment remains a challenge. To date, results from randomized clinical trials involving weight loss by lifestyle interventions have shown no evidence of improved live birth rate.

Objective: To determine whether pharmacologic weight-loss intervention before in vitro fertilization and embryo transfer (IVF-ET) can improve live birth rate among overweight or obese women. Read More

View Article and Full-Text PDF

Fatigue Perpetuating Factors as Mediators of Change in a Cognitive Behavioral Intervention for Targeted Therapy-Related Fatigue in Chronic Myeloid Leukemia: A Pilot Study.

Ann Behav Med 2021 May 15. Epub 2021 May 15.

Department of Health Outcomes and Behavior, Moffitt Cancer Center, Tampa, FL, USA.

Background: Cognitive behavioral therapy for targeted-therapy related fatigue (CBT-TTF) has demonstrated preliminary efficacy in reducing fatigue in patients treated with tyrosine kinase inhibitors (TKIs) for chronic myeloid leukemia (CML).

Purpose: The aim of the current analyses was to explore whether fatigue perpetuating factors (disturbed sleep/wake cycle, dysregulated activity patterns, maladaptive cognitions about fatigue and cancer, insufficient processing of cancer and treatment, inadequate social support and interactions, heightened fear of cancer progression) changed over time in patients receiving CBT-TTF, and whether the effect of CBT-TTF on fatigue was mediated by these factors.

Methods: Secondary data analyses were conducted from a pilot randomized controlled trial. Read More

View Article and Full-Text PDF

Shedding light into the black box of infant multiple-breath washout.

Pediatr Pulmonol 2021 May 15. Epub 2021 May 15.

Pediatric Respiratory Medicine, Inselspital, University Children's Hospital of Bern, University of Bern, Switzerland.

Background: Multiple-breath inert gas washout (MBW) is a sensitive technique to assess lung volumes and ventilation inhomogeneity in infancy. Poor agreement amongst commercially available setups and a lack of transparency in the underlying algorithms for the computation of infant MBW outcomes currently limit the widespread application of MBW as a surveillance tool in early lung disease.

Methods: We determined all computational steps in signal processing and the calculation of MBW outcomes in the current infant WBreath/Exhalyzer D setup (Exhalyzer D device, Eco Medics AG; WBreath software version 3. Read More

View Article and Full-Text PDF

Flexor tendon repair using a reinforced tubular, medicated electrospun construct.

J Orthop Res 2021 May 15. Epub 2021 May 15.

Ghent University Faculty of Veterinary Medicine, Surgery and Anaesthesiology of Domestic Animals, Merelbeke, BE.

A reinforced tubular, medicated electrospun construct was developed for deep flexor tendon repair. This construct combines mechanical strength with the release of anti-inflammatory and anti-adhesion drugs. In this study, the reinforced construct was evaluated using a rabbit model. Read More

View Article and Full-Text PDF

Ischemia reperfusion injury induces pyroptosis and mediates injury in steatotic liver thorough Caspase 1 activation.

Apoptosis 2021 May 14. Epub 2021 May 14.

Department of Pediatrics, Emory University School of Medicine, 1760 Haygood Drive, Atlanta, GA, 30322, USA.

A steatotic liver is increasingly vulnerable to ischemia reperfusion injury (IRI), and the underlying mechanisms are incompletely defined. Caspases are endo-proteases, which provide critical regulatory connections between cell death and inflammation. Caspase 1 is driven by inflammasomes which are key signaling platforms, that detect sterile stressors (DAMPs), releasing the highly pro-inflammatory cytokine interleukin IL-8 and IL-1β. Read More

View Article and Full-Text PDF

Comparison of gene expression and biotransformation activity of HepaRG cells under static and dynamic culture conditions.

Sci Rep 2021 May 14;11(1):10327. Epub 2021 May 14.

Wageningen Food Safety Research, P.O. Box 230, 6700 AE, Wageningen, The Netherlands.

Flow conditions have been shown to be important in improving longevity and functionality of primary hepatocytes, but the impact of flow on HepaRG cells is largely unknown. We studied the expression of genes encoding CYP enzymes and transporter proteins and CYP1 and CYP3A4 activity during 8 weeks of culture in HepaRG cells cultured under static conditions (conventional 24-/96-well plate culture with common bicarbonate/CO buffering) and under flow conditions in an organ-on-chip (OOC) device. Since the OOC-device is a closed system, bicarbonate/CO buffering was not possible, requiring application of another buffering agent, such as HEPES. Read More

View Article and Full-Text PDF

Adverse Pregnancy Outcomes Among HIV-positive Women in the Era of Universal Antiretroviral Therapy Remain Elevated Compared With HIV-negative Women.

Pediatr Infect Dis J 2021 May 7. Epub 2021 May 7.

From the Elizabeth Glaser Pediatric AIDS Foundation, Maseru, Lesotho Department of Biostatistics and Bioinformatics, George Washington University Milken Institute School of Public Health, Washington, District of Columbia Elizabeth Glaser Pediatric AIDS Foundation, Washington, District of Columbia Ministry of Health, Maseru, Lesotho Department of Epidemiology, George Washington University Milken Institute School of Public Health, Washington, District of Columbia Department of global public health and primary care, Center for International Health, University of Bergen, Bergen, Norway.

Background: Without treatment, HIV infection in pregnant women is associated with adverse pregnancy outcomes. We compared adverse pregnancy outcomes among HIV-positive women on antiretroviral therapy (ART) and HIV-negative women who enrolled for antenatal care in selected health facilities in Maseru district, Lesotho.

Methods: We enrolled a cohort of HIV-positive and HIV-negative women at their first antenatal visit and followed them through delivery. Read More

View Article and Full-Text PDF

Fremanezumab for the Preventive Treatment of Migraine: Subgroup Analysis by Number of Prior Preventive Treatments with Inadequate Response.

Cephalalgia 2021 May 14:3331024211008401. Epub 2021 May 14.

Headache Unit, Neurology Department, Vall d'Hebron University Hospital, Barcelona, Spain.

Objective: To evaluate the efficacy of monthly or quarterly fremanezumab in patients with chronic migraine or episodic migraine and documented inadequate response to 2, 3, or 4 classes of prior migraine preventive medications.

Methods: This is an exploratory analysis of a randomized, double-blind, placebo-controlled, phase 3b trial for patients with chronic migraine or episodic migraine and inadequate response to 2 to 4 prior migraine preventive medication classes randomized (1:1:1) to fremanezumab (quarterly or monthly) or placebo. In this exploratory analysis, changes from baseline in the monthly average number of migraine days during 12 weeks of double-blind treatment and adverse events were evaluated for predefined subgroups of patients by number of prior preventive medication classes with inadequate response. Read More

View Article and Full-Text PDF

Use of Vasopressors in Extremely Preterm Infants in First Week of Life.

Am J Perinatol 2021 May 14. Epub 2021 May 14.

Department of Pediatrics, University of Tennessee Health Science Center, Memphis, Tennessee.

Objective:  A significant variability exists for diagnosis and treatment of hypotension in extremely preterm infants. Benefits of the use of vasopressors remain unclear. We wanted to identify the risk factors associated with use of vasopressors in the first week of life and their impact on outcomes of extremely preterm infants. Read More

View Article and Full-Text PDF

Life-Threatening Bleeding in Children: A Prospective Observational Study.

Crit Care Med 2021 May 12. Epub 2021 May 12.

Division of Emergency Medicine, Department of Pediatrics, The Ohio State University College of Medicine, Nationwide Children's Hospital, Columbus, OH. Department of Pathology & Laboratory Medicine, Emory University School of Medicine, Children's Healthcare of Atlanta, Atlanta, GA. Department of Epidemiology, University of Pittsburgh Graduate School of Public Health, Pittsburgh, PA. Division of Pediatric Critical Care Medicine, Department of Pediatrics, University of Oklahoma College of Medicine, The Children's Hospital at University of Oklahoma Health Sciences Center, Oklahoma City, OK. Department of Anesthesia and Critical Care, ARCO Rome, Bambino Gesù Children's Hospital, Rome, Italy. Division of Pediatric Emergency Medicine, University of Toronto, Hospital for Sick Children, Toronto, ON, Canada. Division of Pediatric Emergency Medicine, Weill Cornell Medicine, New York Presbyterian Hospital, New York, NY. Department of Anesthesiology and Critical Care Medicine, Department of Pediatrics, The University of Pennsylvania Perelman School of Medicine, Children's Hospital of Philadelphia, Philadelphia, PA. Division of Pediatric Surgery, Department of Surgery, University of Pittsburgh School of Medicine, Children's Hospital of Pittsburgh, Pittsburgh, PA. Department of Anesthesiology, Critical Care and Pain Medicine, Harvard Medical School, Boston Children's Hospital, Boston, MA. Department of Pediatrics, Critical Care Section, Medical College of Wisconsin, Children's Wisconsin, Milwaukee, WI. Division of Pediatric Emergency Medicine, Department of Pediatrics, University of Utah School of Medicine, Primary Children's Medical Center, Salt Lake City, UT. Division of Emergency Medicine, Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati Children's Hospital Medical Center, Cincinnati, OH. Orange Park Medical Center, Orange Park, Florida. Division of Pediatric Surgery, Akron Children's Hospital, Akron, OH. Division of Critical Care Medicine, Department of Pediatrics, The Ohio State University College of Medicine, Nationwide Children's Hospital, Columbus, OH. Division of Neonatology, Department of Pediatrics, University of California San Francisco Pritzker School of Medicine, University of California San Francisco Medical Center Parnassus, San Francisco, CA. Division of Pediatric Critical Care Medicine, Department of Child Health, University of Arizona College of Medicine, Phoenix Children's Hospital, Phoenix, AZ. Department of Surgery, Indiana University School of Medicine, Riley Hospital for Children, Indianapolis, IN. Department of Emergency Medicine, University of Michigan, C.S. Mott Children's Hospital, Ann Arbor, MI. Department of Pediatrics, Dartmouth Hitchcock Medical Center, Children's Hospital at Dartmouth, Lebanon, NH. Division of Pediatric Hematology and Oncology, Department of Pediatrics, University of Minnesota Medical School, Department of Pediatric Critical Care Medicine, University of Minnesota Masonic Children's Hospital, Minneapolis, MN. Department of Pediatric Surgery, Vanderbilt University College of Medicine, Monroe Carell Jr Children's Hospital Nashville, TN. Keck School of Medicine of University of Southern California, Children's Hospital Los Angeles, Los Angeles, CA. Department of Pediatric Surgery, Baylor College of Medicine, Texas Children's Hospital, Houston, TX. Department of Surgery, Texas A&M University College of Medicine, McLane Children's Hospital, Temple TX. Division of Pediatric Surgery, Alpert Medical School of Brown University, Hasbro Children's Hospital, Providence, RI. Southlake Pediatrics, Birmingham, AL. Department of Pediatrics, University of Alabama School of Medicine, Children's of Alabama, Birmingham, AL. Division of Critical Care, Department of Pediatrics, Washington University in St. Louis School of Medicine, St. Louis Children's Hospital, St. Louis, MO.

Objectives: The purpose of our study was to describe children with life-threatening bleeding.

Design: We conducted a prospective observational study of children with life-threatening bleeding events.

Setting: Twenty-four childrens hospitals in the United States, Canada, and Italy participated. Read More

View Article and Full-Text PDF

Safety of lateral access to the concave side for adult spinal deformity.

J Neurosurg Spine 2021 May 14:1-5. Epub 2021 May 14.

1Department of Neurosurgery, Barrow Neurological Institute, St. Joseph's Hospital and Medical Center, Phoenix, Arizona; and.

Objective: Minimally invasive surgery (MIS) techniques, particularly lateral lumbar interbody fusion (LLIF), have become increasingly popular for adult spinal deformity (ASD) correction. Much discussion has been had regarding theoretical and clinical advantages to addressing coronal curvature from the convex versus concave side of the curve. In this study, the authors aimed to broadly evaluate the clinical outcomes of addressing ASD with circumferential MIS (cMIS) techniques while accessing the lumbar coronal curvature from the concave side. Read More

View Article and Full-Text PDF

Delta oscillation underlies the interictal spike changes after repeated transcranial direct current stimulation in a rat model of chronic seizures.

Brain Stimul 2021 May 11. Epub 2021 May 11.

Department of Pharmacology, College of Medicine, National Cheng Kung University, Tainan 70101, Taiwan; Institute of Basic Medical Sciences, College of Medicine, National Cheng Kung University, Tainan 70101, Taiwan. Electronic address:

Background: Transcranial direct current stimulation (tDCS) provides a noninvasive polarity-specific constant current to treat epilepsy, through a mechanism possibly involving excitability modulation and neural oscillation.

Objective: To determine whether EEG oscillations underlie the interictal spike changes after tDCS in rats with chronic spontaneous seizures.

Methods: Rats with kainic acid-induced spontaneous seizures were subjected to cathodal tDCS or sham stimulation for 5 consecutive days. Read More

View Article and Full-Text PDF

Intrahepatic cholestasis induced by α-naphthylisothiocyanate can cause gut-liver axis disorders.

Environ Toxicol Pharmacol 2021 May 11:103672. Epub 2021 May 11.

School of Pharmaceutical Sciences, Guangzhou University of Chinese Medicine, Guangzhou, 510006, China. Electronic address:

Clinical studies have shown that Intrahepatic cholestasis is closely related to intestinal injury. The gut-liver axis theory suggests that the intestine and liver are closely related, and that bile acids are important mediators linking the intestine and liver. We compared two cholestasis models: a single injection model that received a single intravenous ANIT injection (75 mg/kg), and a multiple injection model that received an injection of ANIT (50 mg/kg) every other day for 2 weeks. Read More

View Article and Full-Text PDF

Postoperative pain control after arthroscopic rotator cuff repair: Arthroscopy-guided continuous suprascapular nerve block versus ultrasound-guided continuous inter-scalene block.

Arthroscopy 2021 May 11. Epub 2021 May 11.

Department of Orthopaedic Surgery, Asan Medical Center, College of Medicine, University of Ulsan, Seoul, Korea. Electronic address:

Purpose: We aimed to compare the clinical efficacy and safety of arthroscopy-guided continuous suprascapular nerve block (AS-SSNB) and ultrasound-guided continuous interscalene block (US-ISB) in postoperative analgesia in patients undergoing arthroscopic rotator cuff repair (ARCR).

Methods: A prospective study was performed between March and November 2020. In total, 76 patients were enrolled and divided into two groups: in 38 patients of group 1 (AS-SSNB), an indwelling catheter was introduced via the Neviaser portal under arthroscopic view before closing the portal at the end of the surgery; and in 38 patients of group 2 (US-ISB), an indwelling catheter was inserted directing towards the interscalene brachial plexus prior to the surgery under ultrasound-guidance. Read More

View Article and Full-Text PDF

The role of salt-inducible kinases on the modulation of renal and intestinal Na,K-ATPase activity during short- and long-term high-salt intake.

Eur J Pharmacol 2021 May 11:174153. Epub 2021 May 11.

Unit of Pharmacology and Therapeutics, Department of Biomedicine, Faculty of Medicine, University of Porto, 4200 Porto, Portugal; MedInUp - Center for Drug Discovery and Innovative Medicines, University of Porto, 4200 Porto, Portugal; Division of Research and Development, BIAL-Portela & C(a), S.A, 4745-457 Coronado (S. Mamede & S. Romão), Portugal. Electronic address:

Type 1 salt-inducible kinases (SIK1) has been shown to act as a mediator during the cellular adaptation to variations in intracellular sodium in a variety of cell types. Type 2 SIK (SIK2) modulates various biological functions and acts as a signal transmitter in various pathways. To evaluate the role of both SIK isoforms in renal and intestinal Na,K-ATPase (NKA) activity, we made use of constitutive sik1 (SIK1-KO), sik2 (SIK2-KO), double sik1sik2 (double SIK1*2-KO) knockout and wild-type (WT) mice challenged to a standard (0. Read More

View Article and Full-Text PDF

The articular cartilage preservative effects of genistein in an experimental model of knees osteoarthritis.

Appl Physiol Nutr Metab 2021 May 14. Epub 2021 May 14.

Ninth People's Hospital of Chongqing, Chongquing, China;

The study aimed to investigate the preservative effects of genistein on articular cartilage in an experimental model of knee osteoarthritis in rats. Thirty male Wistar rats were assigned to three equal groups: the sham group (SG), osteoarthritis control group (OAG), and genistein-treated osteoarthritis group (GTG). Intra-articular injections of monosodium iodoacetate were used for osteoarthritis induction. Read More

View Article and Full-Text PDF

Impact of the COVID-19 Pandemic on Child and Adolescent Psychiatric Emergencies.

J Clin Psychiatry 2021 Apr 6;82(3). Epub 2021 Apr 6.

Child Neurology and Psychiatry Unit, Systems Medicine Department, Tor Vergata University, Via Montpellier 1, 00133 Rome, Italy.

Objective: By forcing closure of schools, curtailing outpatient services, and imposing strict social distancing, the COVID-19 pandemic has abruptly affected the daily life of millions worldwide, with still unclear consequences for mental health. This study aimed to evaluate if and how child and adolescent psychiatric visits to hospital emergency departments (EDs) changed during the pandemic lockdown, which started in Italy on February 24, 2020.

Methods: We examined all ED visits by patients under 18 years of age in the 7 weeks prior to February 24, 2020, and in the subsequent 8 weeks of COVID-19 lockdown at two urban university hospitals, in Turin and Rome, Italy. Read More

View Article and Full-Text PDF

Long-term Pre-Clinical Evaluation of an Injectable Chitosan Nanocellulose Hydrogel with Encapsulated Adipose-Derived Stem Cells in an Ovine Model for IVD Regeneration.

J Tissue Eng Regen Med 2021 May 14. Epub 2021 May 14.

University of Leipzig, Translational Centre for Regenerative Medicine, Leipzig, Germany.

The potential therapeutic benefit of adipose-derived stem cells (ASCs) encapsulated in an injectable hydrogel for stimulating intervertebral disc (IVD) regeneration has been assessed by a number of translational and preclinical studies. However, previous work has been primarily limited to small animal models and short-term outcomes of only a few weeks. Long-term studies in representative large animal models are crucial for translation into clinical success, especially for permanent stabilization of major defects such as disc herniation. Read More

View Article and Full-Text PDF

Breaking potentially bad news of cancer workup to well-informed patients by telephone versus in-person: A randomised controlled trial on psychosocial consequences.

Eur J Cancer Care (Engl) 2021 May 14:e13435. Epub 2021 May 14.

The Research Unit for General Practice and Section of General Practice, Department of Public Health, University of Copenhagen, Copenhagen K, Denmark.

Background: The use of telephone in delivering cancer care increases, but not in cancer workup. Current protocols for breaking bad news assume a single in-person meeting. Cancer workup involves multiple opportunities for patient information. Read More

View Article and Full-Text PDF

Family-centered music therapy-Empowering premature infants and their primary caregivers through music: Results of a pilot study.

PLoS One 2021 14;16(5):e0250071. Epub 2021 May 14.

Department of Neonatology, University Children's Hospital, Heidelberg, Germany.

Background: In Neonatal Intensive Care Units (NICUs) premature infants are exposed to various acoustic, environmental and emotional stressors which have a negative impact on their development and the mental health of their parents. Family-centred music therapy bears the potential to positively influence these stressors. The few existing studies indicate that interactive live-improvised music therapy interventions both reduce parental stress factors and support preterm infants' development. Read More

View Article and Full-Text PDF