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[Predictors of the Utilization and Waiting Period Before Starting an Oncological Rehabilitation after Breast Cancer].

Rehabilitation (Stuttg) 2021 Apr 15;60(2):86-94. Epub 2021 Apr 15.

Forschungs- und Lehreinheit Medizinische Soziologie, Med. Hochschule Hannover.

Purpose: This study explores the sociodemographic, medical and work-related factors leading to a participation in an in-house rehabilitation measure after primary treatment for breast cancer.

Methods: The prospective multi-center study is based on a written survey with employed breast cancer patients who were recruited at 11 breast cancer centers in Lower Saxony, Germany. Predictors of participation were examined by logistic regression, predictors of the time period before starting the rehabilitation by linear regression. Read More

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Oral CBD-rich cannabis induces clinical but not endoscopic response in patients with Crohn's disease, a randomized controlled trial.

J Crohns Colitis 2021 Apr 15. Epub 2021 Apr 15.

Institute of Gastroenterology and Hepatology, Meir Medical Center,KfarSaba,Israel.

Aims: Despite reports that medical cannabis improves symptoms in Crohn's disease (CD), controlled studies evaluating disease response are lacking. This study assessed the effect of cannabidiol (CBD)-rich cannabis oil for induction of remission in CD.

Methods: In a double-blind, randomized, placebo-controlled single center trial, patients received orally eithercannabis oil containing160/40mg/ml cannabidiol/ tetrahydrocannabinol (CBD/THC) or placebo for eight weeks. Read More

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Cevimeline-induced anti-inflammatory effect through upregulations of mucins in the ocular surface of a dry eye mouse model.

Biomed Pharmacother 2021 Apr 12;139:111571. Epub 2021 Apr 12.

T2B infrastructure Center for Ocular Disease, Inje University Busan Paik Hospital, Busan 47392, Republic of Korea; Department of Ophthalmology, Inje University College of Medicine, Inje University Busan Paik Hospital, Busan 47392, Republic of Korea. Electronic address:

This study aimed to investigate the effects of various concentrations of cevimelines (CVMs) and compare them with commercial drugs in a murine model of dry eye. The experimental mouse model used male and female NOD.B10. Read More

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Neonatal outcomes and risk of neonatal sepsis in an expectantly managed cohort of late preterm prelabor rupture of membranes.

Eur J Obstet Gynecol Reprod Biol 2021 Apr 1;261:1-6. Epub 2021 Apr 1.

Obstetrics and Gynecology, University of Milano-Bicocca, FMBBM Monza, Carate Hospital, Lecco Hospital, Italy.

Objective: Expectant management in patients with prelabor preterm rupture of membranes between between 34 and 36 weeks (late preterm pPROM or LpPROM) has been shown to decrease the burden of prematurity, when compared to immediate delivery. As the severity of prematurity depends on gestational age (GA) at PROM, and PROM to delivery interval, we first investigated how such variables affect neonatal outcomes (NO). Second, we assessed the risk of neonatal sepsis. Read More

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Evaluation of Implementation of Early-Onset Sepsis Calculator in Newborns in Israel.

J Pediatr 2021 Apr 12. Epub 2021 Apr 12.

Department of Neonatology and Pediatrics; Haifa, Israel; Technion, Israel Institute of Technology; Haifa, Israel.

Objective: To evaluate the recommendations based on the early-onset sepsis (EOS) calculator in the first two years of its implementation in Israel.

Study Design: Prospective two-year surveillance of a cohort of infants born at gestational age (GA) ≥34 weeks in Bnai Zion Medical Center, who were evaluated using the EOS calculator because of peripartum risk factors.

Results: 1146 newborns with peripartum risk factors were evaluated using the EOS calculator. Read More

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Cerebral Oxygenation and Perfusion When Positioning Preterm Infants: Clinical Implications.

J Pediatr 2021 Apr 12. Epub 2021 Apr 12.

Westmead Hospital, Westmead, New South Wales; University of Sydney, Sydney, New South Wales.

Objectives: To evaluate cerebral oxygenation (cTOI) and cerebral perfusion in preterm infants in supine versus prone positions.

Study Design: Sixty preterm infants, born before 32 weeks gestation, were enrolled; 30 had bronchopulmonary dysplasia (BPD, defined as the need for respiratory support and/or supplemental oxygen at 36 weeks post menstrual age). Cerebral perfusion, cTOI and polysomnography was measured in both the supine and prone position with the initial position being randomized. Read More

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Impact of 13-valent pneumococcal conjugate vaccine on laboratory-confirmed pneumococcal meningitis and purulent meningitis among children ˂5 years in Cameroon, 2011-2018.

PLoS One 2021 15;16(4):e0250010. Epub 2021 Apr 15.

Pfizer Vaccines Medical Development & Medical/Scientific Affairs, New York, New York, United States of America.

Background: The 13-valent pneumococcal conjugate vaccine (PCV13) entered Cameroon's childhood national immunization programme (NIP) in July 2011 under a 3-dose schedule (6, 10, 14 weeks of age) without any catch-up. We described the impact of PCV13 onserotype distribution among pneumococcal meningitis cases over time.

Methods: We used laboratory-based sentinel surveillance data to identify meningitis cases among 2- to 59-month-old children with clinically-suspected bacterial meningitis (CSBM) admitted to hospitals in Yaoundé (August 2011-December 2018). Read More

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Clinical risk factors for preeclampsia in twin pregnancies.

PLoS One 2021 15;16(4):e0249555. Epub 2021 Apr 15.

Department of Obstetrics and Gynecology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.

Background: Preeclampsia is a common obstetric complication. The rate of preeclampsia is increased in twin pregnancies. The aim of this study was to assess the clinical risk factors for developing preeclampsia in twin pregnancies. Read More

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Ultrasound-guided paravertebral perineural glucocorticoid injection for signs of refractory cervical pain associated with foraminal intervertebral disk protrusion in four dogs.

J Am Vet Med Assoc 2021 May;258(9):999-1006

Case Description: 4 dogs, 7.5 to 10 years of age, were presented for evaluation of signs of chronic cervical pain and forelimb lameness secondary to cervical foraminal intervertebral disk protrusion (IVDP). All dogs were refractory to ≥ 2 weeks of conservative management including strict rest and pain management with anti-inflammatory drugs, methocarbamol, and gabapentin. Read More

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Influence of Aerobic Exercise Volume on Postconcussion Symptoms.

Am J Sports Med 2021 Apr 15:3635465211005761. Epub 2021 Apr 15.

Cerebrovascular Research Laboratory, Spaulding Rehabilitation Hospital, Boston, Massachusetts, USA.

Background: Aerobic exercise has emerged as a useful treatment to improve outcomes among individuals who experience a concussion. However, compliance with exercise recommendations and the effect of exercise volume on symptom recovery require further investigation.

Purpose: To examine (1) if an 8-week aerobic exercise prescription, provided within 2 weeks of concussion, affects symptom severity or exercise volume; (2) whether prescription adherence, rather than randomized group assignment, reflects the actual effect of aerobic exercise in postconcussion recovery; and (3) the optimal volume of exercise associated with symptom resolution after 1 month of study. Read More

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The alliance-outcome association in the treatment of adolescent depression.

Psychotherapy (Chic) 2021 Mar;58(1):95-108

Department of Applied Health Research.

A growing body of research has consistently demonstrated a relationship between alliance and treatment outcomes in youth psychotherapy. However, previous research often suffered methodological issues that prevented detailed investigation of temporal relationships between alliance and symptomatology. The current study explored the directions of effect between alliance and outcome by examining the associations between early alliance and subsequent outcome while controlling for patients' baseline severity and prior symptom change. Read More

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Tibial Macrostructure and Microarchitecture Adaptations in Women During 44 Weeks of Arduous Military Training.

J Bone Miner Res 2021 Apr 15. Epub 2021 Apr 15.

Army Health and Performance Research, Army Headquarters, Andover, UK.

Bone adapts to unaccustomed, high-impact loading but loses mechanosensitivity quickly. Short periods of military training (≤12 weeks) increase the density and size of the tibia in women. The effect of longer periods of military training, where the incidence of stress fracture is high, on tibial macrostructure and microarchitecture in women is unknown. Read More

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Efficacy and Safety of Propranolol vs Atenolol in Infants With Problematic Infantile Hemangiomas: A Randomized Clinical Trial.

JAMA Otolaryngol Head Neck Surg 2021 Apr 15. Epub 2021 Apr 15.

Department of Pediatric Surgery, Chengdu Women and Children's Central Hospital, Chengdu, China.

Importance: Propranolol has become the first-line therapy for problematic infantile hemangiomas (IHs) that require systemic therapy. However, different adverse events have been reported during propranolol treatment. The positive efficacy and safety of atenolol raise the question of whether it could be used as a promising therapy for IH. Read More

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Persistent and Widespread Pain Among Blacks Six Weeks after MVC: Emergency Department-based Cohort Study.

West J Emerg Med 2020 Dec 16;22(2):139-147. Epub 2020 Dec 16.

University of North Carolina - Chapel Hill, Department of Anesthesiology and Emergency Medicine, Chapel Hill, North Carolina.

Introduction: Blacks in the United States experience greater persistent pain than non-Hispanic Whites across a range of medical conditions, but to our knowledge no longitudinal studies have examined the risk factors or incidence of persistent pain among Blacks experiencing common traumatic stress exposures such as after a motor vehicle collision (MVC). We evaluated the incidence and predictors of moderate to severe axial musculoskeletal pain (MSAP) and widespread pain six weeks after a MVC in a large cohort of Black adults presenting to the emergency department (ED) for care.

Methods: This prospective, multi-center, cohort study enrolled Black adults who presented to one of 13 EDs across the US within 24 hours of a MVC and were discharged home after their evaluation. Read More

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December 2020

Isolation of in turkey flocks with skeletal abnormalities: a retrospective study.

Avian Pathol 2021 Apr 15:1-22. Epub 2021 Apr 15.

Mycoplasma Unit, Istituto Zooprofilattico Sperimentale delle Venezie, SCT1, via San Giacomo 5 - 37135, Verona (VR) Italy.

is a pathogen affecting the turkey industry which is commonly associated with decreased hatchability and leg abnormalities in the young progeny. This was in the spotlight more in the past than today since its prevalence has been decreasing over time. Reports of in turkeys showing reduced growth performances, leg problems and skeletal abnormalities are scarce although there is no report whether this pathogen has been completely eradicated in commercial turkeys. Read More

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COVID-19 neuropathology at Columbia University Irving Medical Center/New York Presbyterian Hospital.

Brain 2021 Apr 15. Epub 2021 Apr 15.

Department of Pathology and Cell Biology, Division of Neuropathology, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, and the New York Presbyterian Hospital, New York, NY, 10032, USA.

Many patients with SARS-CoV-2 infection develop neurological signs and symptoms, though, to date, little evidence exists that primary infection of the brain is a significant contributing factor. We present the clinical, neuropathological, and molecular findings of 41 consecutive patients with SARS-CoV-2 infections who died and underwent autopsy in our medical center. The mean age was 74 years (38-97 years), 27 patients (66%) were male and 34 (83%) were of Hispanic/Latinx ethnicity. Read More

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[Effectiveness of extended Carlson approach in treatment of lateral femoral condylar Hoffa fractures].

Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi 2021 Apr;35(4):439-444

Department of Orthopedic Trauma & Ankle Surgery, Fujian Trauma Medical Center, First Affiliated Hospital of Fujian Medical University, Fuzhou Fujian, 350004, P.R.China.

Objective: To investigate the effectiveness of the extended Carlson approach in the treatment of lateral femoral condylar Hoffa fractures.

Methods: The clinical data of 17 patients with lateral femoral condyle Hoffa fractures between September 2012 and January 2019 were retrospectively analyzed. There were 10 males and 7 females, with a mean age of 43 years (range, 32-68 years). Read More

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[Comparison of effectiveness between plate and screw internal fixation in treatment of posterior malleolus fractures through posterolateral approach].

Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi 2021 Apr;35(4):431-438

Guizhou Medical University, Guizhou Guiyang, 550004, P.R.China.

Objective: To compare the effectiveness of posterior malleolus fractures treated by plate and screw internal fixation through posterolateral approach.

Methods: The clinical data of 95 patients with posterior malleolus fractures who were admitted between January 2016 and December 2019 and met the selection criteria were retrospectively analysed. They were divided into plate group (44 cases, treated with posterolateral plate internal fixation) and screw group (51 cases, treated with posterolateral screw internal fixation) according to different treatment methods. Read More

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Quality of nutritional care provided to patients who develop hospital acquired malnutrition: A study across five Australian public hospitals.

J Hum Nutr Diet 2021 Apr 15. Epub 2021 Apr 15.

Nutrition & Dietetics, Logan Hospital, Meadowbrook, QLD, Australia.

Background: Little is known about the nutritional care provided to patients who develop hospital acquired malnutrition (HAM). The present study aimed to describe the quality of nutritional care provided to patients who developed HAM and determine whether this differed by length of stay (LOS).

Methods: A retrospective medical records audit was conducted on adults with LOS > 14 days across five Australian public hospitals from July 2015 to January 2019 who were clinically assessed to have HAM. Read More

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Cerebrovascular Neuroprotection after Acute Concussion in Adolescents.

Ann Neurol 2021 Apr 14. Epub 2021 Apr 14.

Department of Physical Medicine and Rehabilitation, Harvard Medical School, Boston, MA.

Objective: To assess acute cerebrovascular function in concussed adolescents (14-21 years of age), whether it related to resting cerebral hemodynamics, and whether it recovered chronically.

Methods: Cerebral vasoreactivity and autoregulation, based on middle cerebral artery blood flow velocity, were assessed in 28 concussed participants (≤14 days of injury) and 29 matched controls. The participants in the concussion group returned for an 8-week follow-up assessment. Read More

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Paired exercise has superior effects on psychosocial health compared to individual exercise in female cancer patients.

Support Care Cancer 2021 Apr 15. Epub 2021 Apr 15.

Population Sciences in the Pacific Program, University of Hawaii Cancer Center, Honolulu, HI, USA.

Purpose: Exercise improves the quality of life (QOL) in cancer patients recovering from treatment. Since group exercise fosters cohesion, we sought to determine if paired exercise would have similar, positive effects. An experiential study design was used to compare the effect of exercise (12 weeks) on psychosocial health in paired versus individually trained cancer patients. Read More

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Intermittent two-drug antiretroviral therapies maintain long-term viral suppression in real life in highly experienced HIV-infected patients.

J Antimicrob Chemother 2021 Apr 14. Epub 2021 Apr 14.

Sorbonne University, Infectious Diseases Department, Pitié-Salpêtrière Hospital, AP-HP, Pierre Louis Epidemiology and Public Health Institute (iPLESP), INSERM 1136, Paris, France.

Objectives: To assess in real life whether two-drug regimens (2-DRs) given 4-5 days a week in virally suppressed patients can maintain viral suppression over 48 and 96 weeks.

Methods: This observational single-centre study enrolled all patients who initiated an intermittent 2-DR between 01/01/2016 and 30/06/2019. The primary outcome was the rate of virological failure (VF), defined as confirmed plasma viral load (pVL) ≥50 copies/mL or single pVL ≥50 copies/mL followed by ART change at week 48 (W48) and W96. Read More

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Changes in the lipidome in type 1 diabetes following low carbohydrate diet: Post-hoc analysis of a randomized crossover trial.

Endocrinol Diabetes Metab 2021 Apr 4;4(2):e00213. Epub 2021 Jan 4.

Steno Diabetes Center Copenhagen Gentofte Denmark.

Aims: Lipid metabolism might be compromised in type 1 diabetes, and the understanding of lipid physiology is critically important. This study aimed to compare the change in plasma lipid concentrations during carbohydrate dietary changes in individuals with type 1 diabetes and identify links to early-stage dyslipidaemia. We hypothesized that (1) the lipidomic profiles after ingesting low or high carbohydrate diet for 12 weeks would be different; and (2) specific annotated lipid species could have significant associations with metabolic outcomes. Read More

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Effect of 12-week continuous positive airway pressure therapy on glucose levels assessed by continuous glucose monitoring in people with type 2 diabetes and obstructive sleep apnoea; a randomized controlled trial.

Endocrinol Diabetes Metab 2021 Apr 8;4(2):e00148. Epub 2020 Aug 8.

Steno Diabetes Center Sjælland Holbæk Denmark.

Aim: Obstructive sleep apnoea (OSA) is frequent in type 2 diabetes (T2D). The aim was to investigate the effect of a 12-week treatment with continuous positive airway pressure (CPAP) on glycaemic control assessed by continuous glucose monitoring (CGM), HbA1c and fasting blood glucose in patients with T2D and newly detected OSA.

Methods: In a randomized controlled multicentre study, 72 participants with T2D and moderate to severe OSA (78% male, age 62 ± 7, AHI 35 ± 15) were recruited from outpatient clinics in three Danish hospitals and were randomized to CPAP intervention or control. Read More

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Clinical Presentation, Management, and Outcomes of Patients With Brain Abscess due to Species.

Open Forum Infect Dis 2021 Apr 7;8(4):ofab067. Epub 2021 Apr 7.

Section of Infectious Diseases, Baylor College of Medicine, Houston, Texas, USA.

Background: Nocardial brain abscesses are rare, and published literature describing brain abscesses due to species is limited to individual case reports or small series. We report one of the largest contemporary retrospective studies describing risk factors, diagnostic evaluation, management, and outcomes of nocardial brain abscess.

Methods: Retrospective review of all adults with brain abscess due to culture-confirmed species at our institution between January 1, 2009, and June 30, 2020. Read More

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Surgical Repair of Distal Biceps Femoris Avulsion Injuries in Professional Athletes.

Orthop J Sports Med 2021 Mar 26;9(3):2325967121999643. Epub 2021 Mar 26.

Department of Orthopaedic Surgery, The Princess Grace Hospital, London, United Kingdom.

Background: Understanding the optimal management of distal biceps femoris avulsion injuries is critical for restoring preinjury function, restoring hamstring muscle strength, increasing range of motion, and minimizing risk of complications and recurrence. Due to the rarity of these injuries, prognosis and outcomes within the literature are limited to case reports and small case series.

Purpose: To assess the effect of surgical repair for acute distal avulsion injuries of the biceps femoris tendon on (1) return to preinjury level of sporting function and (2) time to return to preinjury level of sporting function, patient satisfaction, and complications. Read More

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Effect of Species Probiotics on Growth Performance of Dual-Purpose Chicken.

Vet Med (Auckl) 2021 6;12:75-83. Epub 2021 Apr 6.

Department of Veterinary Parasitology, Wolaita Sodo University, School of Veterinary Medicine, Wolaita Sodo, Ethiopia.

Introduction: In-feed probiotics are becoming attractive alternatives to antibiotics in the poultry industry due to the ever-growing strict prohibitions on antibiotic growth promoters (AGP) in animal production.

Methods: The study was conducted to investigate the effects of and on the growth performance of 120 day-olds randomly selected Sasso dual-purpose chicken. They were divided into four groups with two replicates per group and 15 chicks per replicate. Read More

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Examination of a blood-brain barrier targeting β-galactosidase-monoclonal antibody fusion protein in a murine model of GM1-gangliosidosis.

Mol Genet Metab Rep 2021 Jun 25;27:100748. Epub 2021 Mar 25.

Gene Therapy Center, Department of Pediatrics, University of Minnesota, Minneapolis, MN, USA.

GM1-gangliosidosis is a lysosomal disease resulting from a deficiency in the hydrolase β-galactosidase (β-gal) and subsequent accumulation of gangliosides, primarily in neuronal tissue, leading to progressive neurological deterioration and eventually early death. Lysosomal diseases with neurological involvement have limited non-invasive therapies due to the inability of lysosomal enzymes to cross the blood-brain barrier (BBB). A novel fusion enzyme, labeled mTfR-GLB1, was designed to act as a ferry across the BBB by fusing β-gal to the mouse monoclonal antibody against the mouse transferrin receptor and tested in a murine model of GM1-gangliosidosis (β-gal). Read More

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The LN Flap for Nasal Defect Reconstruction: An 84-case Experience with a Novel Technique.

Plast Reconstr Surg Glob Open 2021 Apr 8;9(4):e3526. Epub 2021 Apr 8.

Division of Plastic & Reconstructive Surgery, Université de Montréal, Montreal, QC, Canada.

Background: The nose is a common site for cutaneous malignancy and post-ablative reconstruction. To our knowledge, a myocutaneous island flap based on the levator labii superioris alaeque nasi (LLSAN) and nasalis muscles, with vascularity from the lateral nasal and angular arteries, has not been described for reconstruction of the lower lateral nose.

Methods: A retrospective chart review of patients who underwent LLSAN-nasalis island flap reconstruction between 2015 and 2019 was performed. Read More

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Effect of simultaneous application of arthrocentesis and occlusal splint versus splint in management of non-reducing TMJ disc displacement.

J Dent Sci 2021 Mar 14;16(2):732-737. Epub 2020 Sep 14.

Substitutive Dental Science Department, College of Dentistry, Taibah University, Saudi Arabia.

Background/purpose: This study aimed to compare the effect of four approaches in the treatment of TMJ disc displacement without reduction (DDwoR).

Materials And Methods: Thirty-two patients (40 joints) with mean age 28.025 ± 7. Read More

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