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Flexion contracture can be relieved by concurrent notchplasty in medial open wedge high tibial osteotomy.

Orthop Traumatol Surg Res 2021 Jul 24:103020. Epub 2021 Jul 24.

Department of Orthopedic Surgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea.

Background: Given that medial open wedge high tibial osteotomy (OWHTO) not only delays the progression of osteoarthritis but also alleviates the resulting pain, surgical outcomes would be improved if limited ROM can also be managed. In this regard, the effect of concurrent notchplasty on flexion contracture has not been evaluated.

Hypothesis: (1) Concurrent notchplasty in OWHTO would relieve flexion contracture regardless of the severity of osteoarthritis and this effect would be maintained over time, and (2) concurrent notchplasty would not cause any added complications compared to the same procedure without notchplasty. Read More

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The Induction Mechanism of the Flavonoid-Responsive Regulator FrrA.

FEBS J 2021 Jul 27. Epub 2021 Jul 27.

Institute for Biochemistry, Dept. Molecular Structural Biology, University of Greifswald, Greifswald, Germany.

Bradyrhizobium diazoefficiens, a bacterial symbiont of soybean and other leguminous plants, enters a nodulation-promoting genetic programme in the presence of host-produced flavonoids and related signalling compounds. Here, we describe the crystal structure of an isoflavonoid-responsive regulator (FrrA) from Bradyrhizobium, as well as co-crystal structures with inducing and non-inducing ligands (genistein and naringenin, respectively). The structures reveal a TetR-like fold whose DNA-binding domain is capable of adopting a range of orientations. Read More

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A framework for localizing global climate solutions and their carbon reduction potential.

Proc Natl Acad Sci U S A 2021 Aug;118(31)

Global Change Program, Georgia Institute of Technology, Atlanta, GA 30332.

Localized carbon reduction strategies are especially critical in states and regions that lack top-down climate leadership. This paper illustrates the use of coupled systems in assessments of subnational climate solutions with a case study of Georgia, a state located in the southeastern United States that does not have statewide climate goals or plans. The paper illustrates how robust place-specific plans for climate action could be derived from foundational global and national work and by embedding that research into the context of socio-ecological-technological systems. Read More

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Postoperative Pulmonary Function After Complex Segmentectomy.

Ann Surg Oncol 2021 Jul 22. Epub 2021 Jul 22.

Department of Surgical Oncology, Research Institute for Radiation Biology and Medicine, Hiroshima University, Minami-ku, Hiroshima, Japan.

Background: Segmentectomy has been increasingly used for lung cancer treatment, however there are very limited data evaluating the postoperative pulmonary function of patients treated with complex segmentectomy. We evaluated the postoperative pulmonary function of patients who underwent complex segmentectomy compared with simple segmentectomy, wedge resection, and lobectomy.

Methods: We retrospectively analyzed data from 580 patients who underwent surgical resection. Read More

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Process, content, and experiences of delivering the Carer Support Needs Assessment Tool Intervention (CSNAT-I) in the Danish specialised palliative care setting.

Support Care Cancer 2021 Jul 23. Epub 2021 Jul 23.

Palliative Care Research Unit, Department of Geriatrics and Palliative Medicine GP, Bispebjerg and Frederiksberg Hospitals, University of Copenhagen, Bispebjerg Bakke 23, 2400, Copenhagen, NV, Denmark.

Purpose: The Carer Support Needs Assessment Tool Intervention (CSNAT-I) has shown positive effects in the Danish specialised palliative care (SPC) setting. Here, we explore the process, content, and experiences of delivering the CSNAT-I.

Methods: Data were collected during a stepped wedge cluster randomised controlled trial investigating the impact of the CSNAT-I in the Danish SPC setting in 2018-2019. Read More

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J Am Soc Echocardiogr 2021 Jul 23. Epub 2021 Jul 23.

Department of Medicine and Surgery, University Milano-Bicocca, Milano, Italy; Department of cardiac, neural and metabolic sciences, Istituto Auxologico Italiano, IRCCS, Milano, Italy.

Introduction: Pulmonary capillary wedge pressure (PCWP) plays a pivotal role in cardiac disease diagnosis and management. Right heart catheterization (RHC) invasively provides accurate PCWP measurement, but it is impractical for widespread use in all patients. The left atrial expansion index (LAEI), measured by transthoracic echocardiography (TTE), describes the relative LA volume increase during the LA reservoir phase. Read More

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Post-COVID-19 rhino-orbito-cerebral mucormycosis: a new addition to challenges in pandemic control.

Eur Arch Otorhinolaryngol 2021 Jul 26. Epub 2021 Jul 26.

Institute of Otorhinolaryngology and Head & Neck Surgery, Institute of Post-Graduate Medical Education & Research, Kolkata, India.

Objective: To document and analyse demographic data, clinical presentation, possible interventions for early clinical detection and management of post-COVID-19 rhino-orbito-cerebral mucormycosis (ROCM).

Method: 32 patients having history of SARS-CoV-2 infection with features of ROCM were observed in terms of their history, presenting features, clinical, microbiological examination, type of surgical intervention, surgical sites of involvement which were subsequently analyzed.

Results: The mean (± S. Read More

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Capillarity and active cell movement at mesendoderm translocation in the Xenopus gastrula.

Development 2021 Sep 29;148(18). Epub 2021 Mar 29.

Department of Cell and Systems Biology, University of Toronto, Toronto M5S 3G5, Canada.

During Xenopus gastrulation, leading edge mesendoderm (LEM) advances animally as a wedge-shaped cell mass over the vegetally moving blastocoel roof (BCR). We show that close contact across the BCR-LEM interface correlates with attenuated net advance of the LEM, which is pulled forward by tip cells while the remaining LEM frequently separates from the BCR. Nevertheless, lamellipodia persist on the detached LEM surface. Read More

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September 2021

[Application of picture archiving and communication systems in lateral wedge osteotomy for cubitus varus deformity in teenagers].

Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi 2021 Jul;35(7):836-840

Department of Orthopedics and Traumatology, Nanfang Hospital, Southern Medical University, Guangzhou Guangdong, 510515, P.R.China.

Objective: To investigate effectiveness of picture archiving and communication systems (PACS) in lateral wedge osteotomy for cubitus varus deformity in teenagers.

Methods: A clinical data of 16 teenagers with cubitus varus deformity between July 2014 and July 2016 was retrospectively analyzed. All patients were treated with lateral wedge osteotomy and fixed with plate. Read More

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Coherent Excitation and Control of Plasmons on Gold Using Two-Dimensional Transition Metal Dichalcogenides.

ACS Photonics 2021 Jun 26;8(6):1607-1615. Epub 2021 May 26.

Department of Physics, Lund University, Box 118, 22100 Lund, Sweden.

The hybrid combination of two-dimensional (2D) transition metal dichalcogenides (TMDs) and plasmonic materials open up novel means of (ultrafast) optoelectronic applications and manipulation of nanoscale light-matter interaction. However, control of the plasmonic excitations by TMDs themselves has not been investigated. Here, we show that the ultrathin 2D WSe crystallites permit nanoscale spatially controlled coherent excitation of surface plasmon polaritons (SPPs) on smooth Au films. Read More

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Postoperative Bone Marrow Lesions (BMLs) Are Associated with Pain Severity in Patients Undergoing Open Wedge High Tibial Osteotomy (OWHTO).

Biomed Res Int 2021 7;2021:9938037. Epub 2021 Jul 7.

Department of Sports Medicine and Arthroscopy, Tianjin Hospital of Tianjin University, Tianjin, China.

The purpose of the study was to investigate the relationship between postoperative bone marrow lesions (BMLs) and pain severity in patients undergoing open wedge high tibial osteotomy (OWHTO). We reviewed the patients undergoing OWHTO between April 2018 and April 2020. The demographic and clinical data of patients were collected. Read More

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(to Test First): Piloting the Feasibility of Using the Growth and Empowerment Measure with Aboriginal Pregnant Women Who Smoke.

J Smok Cessat 2021 13;2021:6610500. Epub 2021 Jan 13.

The University of Newcastle, Callaghan, New South Wales, Australia.

Introduction: Aboriginal pregnant women who smoke experience barriers to quitting, including challenges to social and emotional well-being, but these are infrequently quantified. Finding an appropriate measurement tool in this setting is crucial to increase knowledge for holistic smoking cessation interventions.

Aims: To pilot the Growth and Empowerment Measure (GEM) with a sample of pregnant Aboriginal women who smoke. Read More

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January 2021

Case Report: A Challenging Localization of a Pulmonary Ectopic ACTH-Secreting Tumor in a Patient With Severe Cushing's Syndrome.

Front Endocrinol (Lausanne) 2021 9;12:687539. Epub 2021 Jul 9.

Endocrinology Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico di Milano, Milan, Italy.

Background: Ectopic adrenocorticotropic syndrome (EAS) is a rare cause of endogenous ACTH-dependent Cushing's syndrome, usually associated with severe hypercortisolism as well as comorbidities. Tumor detection is still a challenge and often requires several imaging procedures. In this report, we describe a case of an ectopic ACTH secretion with a misleading localization of the responsible tumor due to a concomitant rectal carcinoma. Read More

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When Is It Safe to Operate for Lung Cancer? Selection of Fiscally Responsible Cardiopulmonary Function Tests for Limited Resection (Wedge Resection and Segmentectomy), Standard Lobectomy, Sleeve Lobectomy, and Pneumonectomy.

Thorac Surg Clin 2021 Aug 9;31(3):255-263. Epub 2021 Jun 9.

Division of Thoracic Surgery, University of Tennessee Health Science Center College of Medicine, 1325 Eastmoreland Avenue, Suite 460, Memphis, TN 38104, USA. Electronic address:

Pulmonary function testing remains the central determinant of candidacy for pulmonary resection and indicator of perioperative risk. For patients with borderline pulmonary function, exercise testing can help determine surgical candidacy either via stair climbing or by obtaining a maximum oxygen consumption. The Thoracic Revised Cardiac Risk Index should be used to select patients for further cardiac testing. Read More

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Importance of left ventricular contraction for left atrial reservoir function.

J Echocardiogr 2021 Jul 25. Epub 2021 Jul 25.

The Cardiology Department of the Internal Medicine and Physiological Laboratory, Osaka Minato Central Hospital, Isoji, 1-7-1, Minato-ku, Osaka, 552-0003, Japan.

Background: The determinants of left atrial (LA) reservoir function have not been clarified.

Methods: To elucidate the effect of left ventricular (LV) contraction on LA reservoir volume (ΔV), volume change due to mitral annular downward motion and aortic root anterior motion, which are related to LV contraction during systole, was calculated in 72 consecutive subjects [42 patients without any cardiac disease (control group), 13 patients with heart failure with reduced ejection fraction (HFrEF group) and 17 with preserved ejection fraction (HFpEF group)]. LA volume was calculated using the modified Simpson's method of bi-plane 2-D echocardiograms. Read More

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Bilateral primary spontaneous pneumothorax with multiple bleb performed by VATS and wedge resection: A rare case in Indonesian adult and review article.

Int J Surg Case Rep 2021 Jul 20;85:106222. Epub 2021 Jul 20.

Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, Universitas Airlangga - Dr. Soetomo General Academic Hospital, Surabaya, Indonesia. Electronic address:

Background: Bilateral primary spontaneous pneumothorax (PSP) is a rare case of lung disease.

Case Presentation: A 20-year-old man with a complaint of shortness of breath is suspected of having PSP and tuberculosis. The patient underwent water seal drainage installation in both lung cavities, but showed no improvement. Read More

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NUDIM: A non-uniform fast Fourier transform based dual-space constraint iterative reconstruction method in biological electron tomography.

J Struct Biol 2021 Jul 22:107770. Epub 2021 Jul 22.

Beijing Synchrotron Radiation Facility, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing, 100049, People's Republic of China; University of Chinese Academy of Sciences, Beijing, 100049, People's Republic of China. Electronic address:

Electron tomography, a powerful imaging tool for studying 3D structures of macromolecular assemblies, always suffers from imperfect reconstruction with limited resolution due to the intrinsic low signal-to-noise ratio (SNR) and inaccessibility to certain tilt angles induced by radiation damage or mechanical limitation. In order to compensate for such insufficient data with low SNR and further improve imaging resolution, prior knowledge constraints about the objects in both real space and reciprocal space are thus exploited during tomographic reconstruction. However, direct Fast Fourier transform (FFT) between real space and reciprocal space remains extraordinarily challenging owing to their inconsistent grid sampling modes, e. Read More

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Clinical findings associated with incomplete hemodynamic left ventricular unloading in patients with a left ventricular assist device.

Rev Esp Cardiol (Engl Ed) 2021 Jul 21. Epub 2021 Jul 21.

Division of Thoracic and Cardiovascular Surgery, Heart and Diabetes Center NRW Bad Oeynhausen, Ruhr-University Bochum, Germany.

Introduction And Objectives: The effect of a centrifugal continuous-flow left ventricular assist device (cfLVAD) on hemodynamic left ventricular unloading (HLVU) and the clinical conditions that interfere with hemodynamic optimization are not well defined.

Methods: We retrospectively evaluated the likelihood of incomplete HLVU, defined as high pulmonary capillary wedge pressure (hPCWP)> 15mmHg in 104 ambulatory cfLVAD patients when the current standard recommendations for cfLVAD rotor speed setting were applied. We also evaluated the ability of clinical, hemodynamic and echocardiographic variables to predict hPCWP in ambulatory cfLVAD patients. Read More

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Pulmonary Hamartoma Associated With Lung Cancer (PHALC Study): Results of a Multicenter Study.

Lung 2021 Jul 24. Epub 2021 Jul 24.

Thoracic Surgery Unit, University of Campania Luigi Vanvitelli, Via Pansini, 7, I-80138, Naples, Italy.

Purpose: Pulmonary hamartoma is the most common benign tumor of the lung. We analyzed a 20-year historical series of patients with pulmonary hamartoma undergoing surgical resection, aiming to evaluate the characteristics, the outcomes, and the association between hamartoma and lung cancer.

Methods: It was a retrospective multicenter study including the data of all consecutive patients with pulmonary hamartoma undergoing surgical resection. Read More

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On the mechanism of droplet rolling and spinning in inclined hydrophobic plates in wedge with different wetting states.

Sci Rep 2021 Jul 23;11(1):15086. Epub 2021 Jul 23.

Mechanical Engineering Department, King Fahd University of Petroleum and Minerals, Dhahran, 31261, Saudi Arabia.

A water droplet rolling and spinning in an inclined hydrophobic wedge with different wetting states of wedge plates is examined pertinent to self-cleaning applications. The droplet motion in the hydrophobic wedge is simulated in 3D space incorporating the experimental data. A high-speed recording system is used to store the motion of droplets in 3D space and a tracker program is utilized to quantify the recorded data in terms of droplet translational, rotational, spinning, and slipping velocities. Read More

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Massive carbon storage in convergent margins initiated by subduction of limestone.

Nat Commun 2021 Jul 22;12(1):4463. Epub 2021 Jul 22.

State Key Laboratory of Geological Processes and Mineral Resources, School of Earth Sciences, China University of Geosciences, Wuhan, China.

Remobilization of sedimentary carbonate in subduction zones modulates arc volcanism emissions and thus Earth's climate over geological timescales. Although limestones (or chalk) are thought to be the major carbon reservoir subducted to subarc depths, their fate is still unclear. Here we present high-pressure reaction experiments between impure limestone (7. Read More

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Mini-invasive Osteotomy for Pediatric Distal Radius Malunion.

Tech Hand Up Extrem Surg 2021 Jul 22. Epub 2021 Jul 22.

Department of Hand Surgery, Turku University Hospital, University of Turku and CoE TYKS ORTO, Turku, Finland.

Although most malunions after pediatric distal radius fractures will remodel as the child grows, adolescent patients with severe malunion and limited growth require reduction to restore alignment. The authors technique for a mini-invasive osteotomy is presented. The apex of the malunion is approached from a single 2 cm volar incision through the flexor carpi radialis sheath. Read More

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Longitudinal analysis of client appointment adherence under Universal Test and Treat strategy: A stepped-wedge trial.

HIV Med 2021 Jul 22. Epub 2021 Jul 22.

Harvard T.H. Chan School of Public Health, Boston, MA, USA.

Objectives: Universal Test and Treat (UTT) strategies are being adopted across sub-Saharan Africa based on clinical benefits to morbidity and mortality and to attain targets of the Joint United Nations Programme on HIV/AIDS (UNAIDS). Universal Test and Treat is expected to change the client population at clinics, due to more asymptomatic HIV clients initiating antiretroviral therapy (ART). We assessed the impact of UTT on client appointment adherence at 14 government-managed health facilities in Eswatini's public sector health system. Read More

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Restrictive cardiomyopathy caused by diffuse calcification of the left ventricle after 20 years of haemodialysis.

Cardiovasc J Afr 2021 Jul 5;32:1-3. Epub 2021 Jul 5.

Division of Cardiovascular Surgery, Department of Surgery, Tri-Service General Hospital, National Defense Medical Centre, Taipei, Taiwan. Email:

Valvular and vascular calcifications are common among patients with end-stage renal disease, but diffuse calcification of the left ventricle is rarely reported. We report on a rare case of restrictive cardiomyopathy resulting from severe myocardial calcification and review the literature. A 77-year-old man was diagnosed with end-stage renal disease after having received regular haemodialysis for 20 years. Read More

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retinopathy: biomarkers assessing vision loss.

Ophthalmic Genet 2021 Jul 22:1-11. Epub 2021 Jul 22.

Save Sight Institute, Faculty of Medicine and Health, The University of Sydney, Sydney, NSW, Australia.

Purpose: Mer tyrosine kinase-retinitis pigmentosa (RP) causes a primary defect in the retinal pigment epithelium, which subsequently affects rod and cone photoreceptors. The study aims to identify the most appropriate -RP biomarkers to measure disease progression for deciding the optimum therapeutic trial intervention time.

Materials And Methods: Patients' data from baseline (BL) and last follow-up (LFU) were reviewed. Read More

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Biomechanical evaluation of an intramedullary clavicle screw in simple oblique and butterfly wedge fractures.

Proc Inst Mech Eng H 2021 Jul 21:9544119211031052. Epub 2021 Jul 21.

Medical College of Georgia at Augusta University, Augusta, GA, USA.

This biomechanical study evaluates the performance of a solid titanium-alloy intra-medullary () clavicular screw in torsion and cantilever bending in cadaveric clavicle specimens with simulated simple oblique and butterfly wedge midshaft fractures. Thirty-two fresh-frozen male clavicles were sorted into six experimental groups: Torsion Control, Torsion Simple Oblique Fracture, Torsion Butterfly Wedge Fracture, Bending Control, Bending Simple Oblique Fracture, and Bending Butterfly Wedge Fracture. The experimental groups were controlled for density, length, diameter, and laterality. Read More

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In vivo relationships between lumbar facet joint and intervertebral disc composition and diurnal deformation.

Clin Biomech (Bristol, Avon) 2021 Jul 14;88:105425. Epub 2021 Jul 14.

Department of Orthopaedic Surgery, Duke University School of Medicine, Durham, NC, USA. Electronic address:

Background: Spinal motion is facilitated by a "three joint complex", two facet joints and one intervertebral disc at each spinal level. Both the intervertebral discs and facet joints are subject to natural age-related degeneration, and while these processes may be linked it is not clear how. As instability in the disc could underlie facet arthritis, we evaluated the hypothesis that the discs and facet joints are mechanically coupled. Read More

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Tibial Sagittal Slope in Anterior Cruciate Ligament Injury and Treatment.

J Am Acad Orthop Surg 2021 Jul 20. Epub 2021 Jul 20.

From the Division of Sports Medicine, Department of Orthopaedic Surgery, New York University Langone Health, New York, NY.

Although anterior cruciate ligament reconstruction (ACLR) is a generally successful procedure, failure is still relatively common. An increased posterior tibial slope (PTS) has been shown to increase the anterior position of the tibia relative to the femur at rest and under load in biomechanical studies. Increased PTS has also been shown to increase forces on the native and reconstructed ACL. Read More

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The importance of adequate diagnosis of pediatric forearm bowing fractures: A case report.

Trauma Case Rep 2021 Aug 1;34:100508. Epub 2021 Jul 1.

AZ St-Blasius Dendermonde, Department of Orthopaedic Surgery and Traumatology, Kroonveldlaan 50, 9200 Dendermonde, Belgium.

Introduction: Correct diagnosis of pediatric bowing fractures has proven to be challenging. Consequently, these entities are often underdiagnosed both at the initial presentation and at further follow-up. We present a case of an ulnar fracture with subsequent non-union and initially missed associated plastic deformity of the radius to highlight the importance of adequate diagnosis of bowing fractures and obtaining appropriate imaging in pediatric forearm trauma to prevent sequelae. Read More

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Laparoscopic gonad-sparing procedure in Ovotesticular disorder of sex development - Case video technique.

J Pediatr Urol 2021 Jul 7. Epub 2021 Jul 7.

Pediatric Surgery Service, Hospital de Clínicas, Porto Alegre, Brazil; Coordinator of the Disorders of Sexual Development (DSD) Multidisciplinary Team, Hospital de Clínicas, Porto Alegre, Brazil. Electronic address:

Introduction: Ovotesticular disorder of sex development (OTD) is a rare condition. There's a lack of literature addressing gonad-sparing surgery for OTD.

Objective: Report the laparoscopic partial gonadectomy technique - gonad-sparing surgery - in an 11-year-old child, 46, XX karyotype with OTD with atypical genitalia. Read More

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