64,934 results match your criteria water soluble


3D interaction homology: Hydropathic interaction environments of serine and cysteine are strikingly different and their roles adapt in membrane proteins.

Curr Res Struct Biol 2021 1;3:239-256. Epub 2021 Oct 1.

Department of Medicinal Chemistry, Virginia Commonwealth University, Richmond, VA, USA.

Atomic-resolution protein structural models are prerequisites for many downstream activities like structure-function studies or structure-based drug discovery. Unfortunately, this data is often unavailable for some of the most interesting and therapeutically important proteins. Thus, computational tools for building native-like structural models from less-than-ideal experimental data are needed. Read More

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October 2021

Photodissociation Dynamics of Nitric Oxide from -Acetylcysteine- or -Acetylpenicillamine-bound Roussin's Red Ester.

ACS Omega 2021 Oct 7;6(41):27158-27169. Epub 2021 Oct 7.

Department of Chemistry and Chemistry Institute for Functional Materials, Pusan National University, Busan 46241, Korea.

The photochemical release of nitric oxide (NO) from a NO precursor is advantageous in terms of spatial, temporal, and dosage control of NO delivery to target sites. To realize full control of the quantitative NO administration from photoactivated NO precursors, it is necessary to have detailed dynamical information on the photodissociation of NO from NO precursors. We synthesized two new water-soluble Roussin's red esters (RREs), [Fe(μ--acetylcysteine)(NO)] and [Fe(μ--acetylpenicillamine)(NO)], which have five times longer lifetime than the well-known [Fe(μ-cysteine)(NO)]. Read More

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October 2021

Physicochemical Characterization and Evaluation of the Binding Effect of Schweinf Gum in Granule and Tablet Formulations.

Biomed Res Int 2021 14;2021:5571507. Epub 2021 Oct 14.

Department of Pharmaceutics, School of Pharmacy, College of Health Sciences, Mekelle University, Ethiopia.

This study is aimed at evaluating the binding effect of gum in granule and tablet formulations using paracetamol as a model drug. Some physicochemical properties of the purified gum such as pH, the presence of tannin and dextrin, solubility, viscosity, loss on drying, total ash value, water solubility index, swelling power, moisture sorption, and powder flow properties were investigated. Paracetamol granules were prepared using wet granulation method at 2%, 4%, 6%, and 8% / of the gum and compared with granules prepared with reference binders (PVP K-30 and Acacia BP) in similar concentrations. Read More

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October 2021

Preparation of MSZ Hydrogel and Its Treatment of Colitis.

Front Pharmacol 2021 8;12:706401. Epub 2021 Oct 8.

School of Basic Medicine, Qingdao University, Qingdao, China.

In order to control the release of mesalazine (MSZ) in the gastrointestinal tract to achieve better pharmacological effects in the colon, in this study, MSZ was added to hydroxypropyl-β-cyclodextrin (HP-β-CD) to form a water-soluble HP-β-CD/MSZ inclusion complex. Then, the inclusion compound was loaded into the structure of the bilayer polyelectrolyte complex microsphere formed by alginate (Alg), chitosan (Cs), and kappa carrageenan (κ-Car) as the hydrogel carrier, and the hydrogel beads with colon-specific release MSZ after oral administration were formed. The formed hydrogel beads have different swelling capabilities in different pH media and have the greatest swelling degree under pH 7. Read More

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October 2021

Synthesis of chitosan/silver nanocomposites by phase inversion with the assistance of carbon dioxide.

Int J Biol Macromol 2021 Oct 21. Epub 2021 Oct 21.

Department of Polymer Science and Engineering, School of Material Science and Chemical Engineering, Ningbo University, Ningbo 315211, Zhejiang, PR China.

Carbon dioxide (CO) assisted synthesis of water-soluble silver nanoparticle with a narrow particle size distribution is reported here based on the phase-inversion procedure. Bio-derived chitosan (CS) is used to stabilize the metal nanoparticles according to its abundant functional groups. Formic acid is employed as both a solvent (for the polymer) and a reductant for in-situ reducing the silver precursor along with the solvent evaporation. Read More

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October 2021

Structural characterization of a water-soluble polysaccharide from Angelica dahurica and its antitumor activity in H22 tumor-bearing mice.

Int J Biol Macromol 2021 Oct 21. Epub 2021 Oct 21.

College of Food Engineering and Biotechnology, Tianjin University of Science and Technology, Tianjin 300457, China.

A novel Angelica dahurica polysaccharide (ADP) with Mw of 6.09 × 10 Da was isolated. The contents of total sugar and uronic acid in ADP were 91. Read More

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October 2021

Activation of CDC48 and acetyltransferase encoding genes contributes to enhanced abiotic stress tolerance and improved productivity traits in rice.

Plant Physiol Biochem 2021 Oct 16;168:329-339. Epub 2021 Oct 16.

Centre for Plant Molecular Biology, Osmania University, Hyderabad, 500 007, India. Electronic address:

World-wide crop productivity is highly impacted by various extreme environmental conditions. In the present investigation, activation tagged (AT) line A10-Ds-RFP6 of rice endowed with improved agronomic attributes was tested for its tolerance ability against drought and salinity stress conditions as well as identification of genes associated with these traits. Under both drought and salinity stress conditions, A10-Ds-RFP6 line exhibited increased seed germination rates and improved plant growth characteristics at seedling, vegetative and reproductive stages as compared to wild-type (WT) plants. Read More

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October 2021

Sequential phenolic acid co-pigmentation pretreatment and contact ultrasound-assisted air drying to intensify blackberry drying and enhance anthocyanin retention: A study on mass transfer and phenolic distribution.

Ultrason Sonochem 2021 Oct 14;80:105788. Epub 2021 Oct 14.

Institute of Agro-product Processing, Jiangsu Academy of Agricultural Sciences, Nanjing 210014, China.

In this work, the spraying of ethanol solution containing phenolic acid (ferulic acid or caffeic acid) was performed before subjecting to contact ultrasound-assisted air drying of blackberry. The mass transfer modeling results revealed that sonication intensified both internal water diffusion and external water exchange during drying, and ethanol pretreatment enhanced the effective diffusivity of water. Compared with air drying alone, the drying time for sequential ferulic acid pretreatment and drying with sonication was shortened by 89. Read More

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October 2021

Ratiometric detection of doxycycline in pharmaceutical based on dual ligands-enhanced copper nanoclusters.

Spectrochim Acta A Mol Biomol Spectrosc 2021 Oct 16;267(Pt 1):120509. Epub 2021 Oct 16.

Chemical Synthesis and Pollution Control Key Laboratory of Sichuan Province, China West Normal University, Nanchong 637002, China; Institute of Applied Chemistry, China West Normal University, Nanchong 637002, China. Electronic address:

A water-soluble, stable, simple and dual ligands (bovine serum albumin and L-histidine)-enhanced copper nanoclusters ([email protected]) was synthesized by one-step wet chemical method. Interestingly, the introduction of L-His ligand could improve evidently the quantum yields (QYs, 3.47%) and stability of BSA-CuNCs due to forming the stronger interaction of L-His and Cu and producing bigger diameter CuNCs by coordination-induced aggregation. Read More

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October 2021

Resuspension and settlement characteristics of lake sediments amended by phosphorus inactivating materials: Implications for environmental remediation.

J Environ Manage 2021 Oct 20;302(Pt A):113892. Epub 2021 Oct 20.

Key Laboratory of Water Pollution Control Technology, Hunan Province, Hunan Research Academy of Environmental Sciences, Changsha 410004, China. Electronic address:

The classical lake internal phosphorus (P) pollution control using P-inactivating materials is typically carried out by reducing the release of soluble P from sediments to overlying water; however, particulate P loading through sediment resuspension could also cause internal P pollution for algae breeding. Therefore, based on lanthanum modified bentonite clay (Phoslock®) and drinking water treatment residues (DWTR), the effect of P inactivating materials on sediment resuspension and settlement were comprehensively investigated to assess the variations in particulate P pollution from sediment. Results showed that both materials could effectively control soluble P pollution from sediment, while both had limited effect on the supplement of particulate P to overlying water. Read More

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October 2021

Formation mechanism of amorphous drug nanoparticles using the antisolvent precipitation method elucidated by varying the preparation temperature.

Int J Pharm 2021 Oct 20:121210. Epub 2021 Oct 20.

Graduate School of Pharmaceutical Sciences, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba 260-8675, Japan.

The present study focuses on the effect of the preparation temperature on the physicochemical properties of amorphous drug nanoparticles to clarify their formation mechanism. Amorphous glibenclamide (GLB) nanoparticles were prepared at 4-40 °C using two antisolvent precipitation methods. In method A, N,N-dimethylformamide (DMF) solution of GLB was added to an aqueous solution containing hydroxypropyl methylcellulose (HPMC) to obtain nano-A suspensions. Read More

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October 2021

Strategy for osteoarthritis therapy: Improved the delivery of triptolide using liposome-loaded dissolving microneedle arrays.

Int J Pharm 2021 Oct 21;609:121211. Epub 2021 Oct 21.

College Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China. Electronic address:

Osteoarthritis (OA) is a chronic disease that seriously impairs people's physical function and quality of life. Triptolide (TP), as a promising anti-inflammatory drug for the treatment of OA, has limited clinical application due to its severe systemic toxicity, poor solubility and rapid elimination in the body. To extend its application prospect for OA treatment. Read More

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October 2021

Gridded distribution of total suspended particulate matter (TSP) and their chemical characterization over Delhi during winter.

Environ Sci Pollut Res Int 2021 Oct 22. Epub 2021 Oct 22.

Environmental Sciences & Biomedical Metrology Division, CSIR - National Physical Laboratory, Dr. K S Krishnan Road, New Delhi, 110012, India.

In the present study, total suspended particulate matter (TSP) samples were collected at 47 different sites (47 grids of 5 × 5 km area) of Delhi during winter (January-February 2019) in campaign mode. To understand the spatial variation of sources, TSP samples were analyzed for chemical compositions including carbonaceous species [organic carbon (OC), elemental carbon (EC), and water-soluble organic carbon (WSOC)], water-soluble total nitrogen (WSTN), water-soluble inorganic nitrogen (WSIN), polycyclic aromatic hydrocarbons (16 PAHs), water-soluble inorganic species (WSIS) (F, Cl, SO, NO, NO, PO, NH, Ca, Mg, Na, and K), and major and minor trace elements (B, Na, Mg, Al, P, S, Cl, K, Ca, Ti, Fe, Zn, Cr, Mn, Cu, As, Pd, F, and Ag). During the campaign, the maximum concentration of several components of TSP (996 μg/m) was recorded at the Rana Pratap Bagh area, representing a pollution hotspot of Delhi. Read More

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October 2021

Modeling lipid-protein interactions for coarse-grained lipid and Cα protein models.

J Chem Phys 2021 Oct;155(15):155101

Department of Biophysics, Graduate School of Science, Kyoto University, Kyoto, Japan.

Biological membranes that play major roles in diverse functions are composed of numerous lipids and proteins, making them an important target for coarse-grained (CG) molecular dynamics (MD) simulations. Recently, we have developed the CG implicit solvent lipid force field (iSoLF) that has a resolution compatible with the widely used Cα protein representation [D. Ugarte La Torre and S. Read More

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October 2021

Accurate prediction of mutation-induced frequency shifts in chlorophyll proteins with a simple electrostatic model.

J Chem Phys 2021 Oct;155(15):151102

Department of Chemistry, Purdue University, West Lafayette, Indiana 47907, USA.

Photosynthetic pigment-protein complexes control local chlorophyll (Chl) transition frequencies through a variety of electrostatic and steric forces. Site-directed mutations can modify this local spectroscopic tuning, providing critical insight into native photosynthetic functions and offering the tantalizing prospect of creating rationally designed Chl proteins with customized optical properties. Unfortunately, at present, no proven methods exist for reliably predicting mutation-induced frequency shifts in advance, limiting the method's utility for quantitative applications. Read More

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October 2021

Evaluation of the Morpho-Physiological, Biochemical and Molecular Responses of Contrasting Lines under Water Deficit Stress.

Plants (Basel) 2021 Oct 6;10(10). Epub 2021 Oct 6.

Centre of Biotechnology of Borj Cedria, Laboratory of Extremophile Plants, B.P. 901, Hammam-Lif 2050, Tunisia.

is a forage crop of choice for farmers, and it is a model species for molecular research. The growth and development and subsequent yields are limited by water availability mainly in arid and semi-arid regions. Our study aims to evaluate the morpho-physiological, biochemical and molecular responses to water deficit stress in four lines (TN6. Read More

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October 2021

Particle Retention Capacity, Efficiency, and Mechanism of Selected Plant Species: Implications for Urban Planting for Improving Urban Air Quality.

Authors:
Huixia Wang Hui Shi

Plants (Basel) 2021 Oct 5;10(10). Epub 2021 Oct 5.

School of Environmental and Municipal Engineering, Xi'an University of Architecture & Technology, Xi'an 710055, China.

Atmospheric particulate matter (PM) has been of concern owing to its negative effects on human health and its role in environmental degradation. For mitigation purposes, it is important to select the most efficient plant species in urban greening. Here, a fast, cost-saving methodology was first added to the conventional method to investigate the size-resolved PM retention capacity and efficiency of twenty plant species. Read More

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October 2021

The Exogenous Application of Micro-Nutrient Elements and Amino Acids Improved the Yield, Nutritional Status and Quality of Mango in Arid Regions.

Plants (Basel) 2021 Sep 29;10(10). Epub 2021 Sep 29.

Horticulture Department, Faculty of Agriculture (Moshtohor), Benha University, Moshtohor, Toukh 13736, Egypt.

The mango is one of the most valuable and appealing tropical fruits due to its color, aroma, tasteful remarkable flavor, and nutritive value; however, improving the yield and quality of mango is an urgent goal in order to combat global population growth. The application of amino acids and a micronutrient mixture might improve the yield and quality features but further research is still required in arid regions. To study the combined effect of a micronutrient mixture (MM) and amino acids (AA) at different rates, twenty-seven Fagri Kalan mango trees (15 years old) were carefully selected. Read More

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September 2021

Roles of Crosstalk between Astrocytes and Microglia in Triggering Neuroinflammation and Brain Edema Formation in 1,2-Dichloroethane-Intoxicated Mice.

Cells 2021 Oct 3;10(10). Epub 2021 Oct 3.

Department of Environmental and Occupational Health, School of Public Health, China Medical University, Shenyang 110122, China.

We have previously reported that the activation of astrocytes and microglia may lead to the overproduction of proinflammatory mediators, which could induce neuroinflammation and cause brain edema in 1,2-dichloroethane (1,2-DCE)-intoxicated mice. In this research, we further hypothesized that astrocyte-microglia crosstalk might trigger neuroinflammation and contribute to brain edema in 1,2-DCE-intoxicated mice. The present research revealed, for the first time, that subacute intoxication with 1,2-DCE might provoke the proinflammatory polarization of microglia, and pretreatment with minocycline, a specific inhibitor of microglial activation, may attenuate the enhanced protein levels of ionized calcium-binding adapter molecule1 (Iba-1), cluster of differentiation 11b (CD11b), glial fibrillary acidic protein (GFAP), soluble calcium-binding protein 100B (S100B), tumor necrosis factor α (TNF-α), interleukin 6 (IL-6), inducible nitric oxide synthase (iNOS), vascular cell adhesion molecule-1 (VCAM-1), intercellular adhesion molecule-1 (ICAM-1), matrix metalloproteinase-9 (MMP-9), Toll-like receptor 4 (TLR4), MyD88, and p-p65, and ameliorate the suppressed protein expression levels of occludin and claudin 5; we also observed changes in water content and made pathological observations on edema in the brains of 1,2-DCE-intoxicated mice. Read More

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October 2021

Hiding in Plain Sight: Modern Thiamine Deficiency.

Cells 2021 Sep 29;10(10). Epub 2021 Sep 29.

Emeritus, Cleveland Clinic, Cleveland, OH 44195, USA.

Thiamine or vitamin B1 is an essential, water-soluble vitamin required for mitochondrial energetics-the production of adenosine triphosphate (ATP). It is a critical and rate-limiting cofactor to multiple enzymes involved in this process, including those at the entry points and at critical junctures for the glucose, fatty acid, and amino acid pathways. It has a very short half-life, limited storage capacity, and is susceptible to degradation and depletion by a number of products that epitomize modern life, including environmental and pharmaceutical chemicals. Read More

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September 2021

Thermocontrolled Reversible Enzyme Complexation-Inactivation-Protection by Poly(-acryloyl glycinamide).

Polymers (Basel) 2021 Oct 19;13(20). Epub 2021 Oct 19.

Department of Chemistry, University of Helsinki, FIN-00014 Helsinki, Finland.

A prospective technology for reversible enzyme complexation accompanied with its inactivation and protection followed by reactivation after a fast thermocontrolled release has been demonstrated. A thermoresponsive polymer with upper critical solution temperature, poly(-acryloyl glycinamide) (PNAGA), which is soluble in water at elevated temperatures but phase separates at low temperatures, has been shown to bind lysozyme, chosen as a model enzyme, at a low temperature (10 °C and lower) but not at room temperature (around 25 °C). The cooling of the mixture of PNAGA and lysozyme solutions from room temperature resulted in the capturing of the protein and the formation of stable complexes; heating it back up was accompanied by dissolving the complexes and the release of the bound lysozyme. Read More

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October 2021

Coaxial Electrospun PLLA Fibers Modified with Water-Soluble Materials for Oligodendrocyte Myelination.

Polymers (Basel) 2021 Oct 19;13(20). Epub 2021 Oct 19.

Department of Cell Biology, Second Military Medical University, Shanghai 200433, China.

Myelin sheaths are essential in maintaining the integrity of axons. Development of the platform for in vitro myelination would be especially useful for demyelinating disease modeling and drug screening. In this study, a fiber scaffold with a core-shell structure was prepared in one step by the coaxial electrospinning method. Read More

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October 2021

Electrospun Polyacrylonitrile/Lignin/Poly(Ethylene Glycol)-Based Porous Activated Carbon Nanofiber for Removal of Nickel(II) Ion from Aqueous Solution.

Polymers (Basel) 2021 Oct 19;13(20). Epub 2021 Oct 19.

Department of Chemistry, Faculty of Science, Universiti Putra Malaysia, UPM, Serdang 43400, Selangor, Malaysia.

The issue of heavy metal contamination has caused a great deal of concern among water quality experts today, as it contributes to water pollution. Activated carbon nanofibers (ACNFs) showed a significant ability in removing heavy metals from the wastewater. In this study, polyacrylonitrile (PAN) was blended and electrospun with an abundant and inexpensive biopolymer, lignin and a water soluble polymer, poly(ethylene glycol) (PEG), by using an electrospinning technique to form nanofibers. Read More

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October 2021

Molecular Dynamics Study of the Conformation, Ion Adsorption, Diffusion, and Water Structure of Soluble Polymers in Saline Solutions.

Polymers (Basel) 2021 Oct 14;13(20). Epub 2021 Oct 14.

Departamento de Ingeniería Química y Procesos de Minerales, Facultad de Ingeniería, Universidad de Antofagasta, Av. Angamos 601, Antofagasta 1240000, Chile.

Polymers have interesting physicochemical characteristics such as charge density, functionalities, and molecular weight. Such attributes are of great importance for use in industrial purposes. Understanding how these characteristics are affected is still complex, but with the help of molecular dynamics (MD) and quantum calculations (QM), it is possible to understand the behavior of polymers at the molecular level with great consistency. Read More

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October 2021

Oligo(Lactic Acid)-Docetaxel Prodrug-Loaded PEG--PLA Micelles for Prostate Cancer.

Nanomaterials (Basel) 2021 Oct 17;11(10). Epub 2021 Oct 17.

Pharmaceutical Sciences Division, School of Pharmacy, University of Wisconsin-Madison, Madison, WI 53705, USA.

Docetaxel (DTX) is among the most frequently prescribed chemotherapy drugs and has recently been shown to extend survival in advanced prostate cancer patients. However, the poor water solubility of DTX prevents full exploitation of this potent anticancer drug. The current marketed formulation, Taxotere, contains a toxic co-solvent that induces adverse reactions following intravenous injection. Read More

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October 2021

Synthesis of a Novel Series of Cu(I) Complexes Bearing Alkylated 1,3,5-Triaza-7-phosphaadamantane as Homogeneous and Carbon-Supported Catalysts for the Synthesis of 1- and 2-Substituted-1,2,3-triazoles.

Nanomaterials (Basel) 2021 Oct 13;11(10). Epub 2021 Oct 13.

Centro de Química Estrutural, Instituto Superior Técnico, Universidade de Lisboa, Av. Rovisco Pais, 1049-001 Lisboa, Portugal.

The -alkylation of 1,3,5-triaza-7-phosphaadamantane (PTA) with , and substituted nitrobenzyl bromide under mild conditions afforded three hydrophilic PTA ammonium salts, which were used to obtain a new set of seven water-soluble copper(I) complexes. The new compounds were fully characterized and their catalytic activity was investigated for the low power microwave assisted one-pot azide-alkyne cycloaddition reaction in homogeneous aqueous medium to obtain disubstituted 1,2,3-triazoles. The most active catalysts were immobilized on activated carbon (AC), multi-walled carbon nanotubes (CNT), as well as surface functionalized AC and CNT, with the most efficient support being the CNT treated with nitric acid and NaOH. Read More

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October 2021

Mechanisms of Chitosan Nanoparticles in the Regulation of Cold Stress Resistance in Banana Plants.

Nanomaterials (Basel) 2021 Oct 11;11(10). Epub 2021 Oct 11.

Department of Soils and Water, Faculty of Agriculture, Assiut University, Assiut 71526, Egypt.

Exposure of banana plants, one of the most important tropical and subtropical plants, to low temperatures causes a severe drop in productivity, as they are sensitive to cold and do not have a strong defense system against chilling. Therefore, this study aimed to improve the growth and resistance to cold stress of banana plants using foliar treatments of chitosan nanoparticles (CH-NPs). CH-NPs produced by nanotechnology have been used to enhance tolerance and plant growth under different abiotic stresses, e. Read More

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October 2021

Preparation and Physicochemical Characterization of Water-Soluble Pyrazole-Based Nanoparticles by Dendrimer Encapsulation of an Insoluble Bioactive Pyrazole Derivative.

Nanomaterials (Basel) 2021 Oct 10;11(10). Epub 2021 Oct 10.

Department of Pharmacy, University of Genoa, Viale Cembrano, 16148 Genoa, Italy.

2-(4-Bromo-3,5-diphenyl-pyrazol-1-yl)-ethanol (BBB4) was synthetized and successfully evaluated concerning numerous biological activities, except for antimicrobial and cytotoxic effects. Due to the antimicrobial effects possessed by pyrazole nucleus, which have been widely reported, and the worldwide need for new antimicrobial agents, we thought it would be interesting to test BBB4 and to evaluate its possible antibacterial effects. Nevertheless, since it is water-insoluble, the future clinical application of BBB4 will remain utopic unless water-soluble BBB4 formulations are developed. Read More

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October 2021

Study on the Preparation and Lipophilic Properties of Polyvinyl Alcohol (PVA) Nanofiber Membranes via Green Electrospinning.

Nanomaterials (Basel) 2021 Sep 27;11(10). Epub 2021 Sep 27.

Division of Mechanical Design Engineering, Jeonbuk National University, Jeonju-si 54896, Korea.

As an environmentally friendly water-soluble polymer, polyvinyl alcohol (PVA) has attracted extensive attention because of its non-toxic, degradable, low cost, and good biocompatibility. Electrospinning is a kind of nanotechnology, and the nanofiber membrane prepared by it has the advantages of large surface area-to-volume ratios, nano- to micron-sized fibers, etc. Herein, a simple and facile one-step green electrospinning method was developed to fabricate various environmentally friendly PVA nanofiber membranes. Read More

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September 2021