261 results match your criteria wasting pew


Comparison of Simplified Creatinine Index and Systemic Inflammatory Markers for Nutritional Evaluation of Hemodialysis Patients.

Nutrients 2021 May 30;13(6). Epub 2021 May 30.

Department of Medicine, Division of Nephrology, Taipei Veterans General Hospital, Taipei 11217, Taiwan.

Protein-energy wasting (PEW) is associated with adverse outcomes in hemodialysis patients. This study compares the simplified creatinine index (SCI) and circulating inflammatory markers as nutritional screening tools for hemodialysis patients. Maintenance hemodialysis patients (230 total patients, 34. Read More

View Article and Full-Text PDF

Maintenance of Skeletal Muscle to Counteract Sarcopenia in Patients with Advanced Chronic Kidney Disease and Especially Those Undergoing Hemodialysis.

Authors:
Katsuhito Mori

Nutrients 2021 May 2;13(5). Epub 2021 May 2.

Department of Nephrology, Osaka City University Graduate School of Medicine 1-4-3, Asahi-Machi, Abeno-ku, Osaka 545-8585, Japan.

Life extension in modern society has introduced new concepts regarding such disorders as frailty and sarcopenia, which has been recognized in various studies. At the same time, cutting-edge technology methods, e.g. Read More

View Article and Full-Text PDF

Chronic Kidney Disease as a Systemic Inflammatory Syndrome: Update on Mechanisms Involved and Potential Treatment.

Life (Basel) 2021 May 5;11(5). Epub 2021 May 5.

Department of Systems Medicine, Nephrology and Dialysis Unit, University of Rome Tor Vergata, via Montpellier 1, 00133 Rome, Italy.

Chronic kidney disease (CKD) is characterized by manifestations and symptoms involving systemic organs and apparatus, associated with elevated cardiovascular morbidity and mortality, bone disease, and other tissue involvement. Arterial hypertension (AH), diabetes mellitus (DM), and dyslipidemia, with glomerular or congenital diseases, are the traditional risk factors recognized as the main causes of progressive kidney dysfunction evolving into uremia. Acute kidney injury (AKI) has recently been considered an additional risk factor for the worsening of CKD or the development of CKD de novo. Read More

View Article and Full-Text PDF

Protein energy wasting and long-term outcomes in nondialysis dependent chronic kidney disease.

J Ren Care 2021 May 30. Epub 2021 May 30.

Department of Medicine, Queen's University, Kingston, Ontario, Canada.

Background: Nutritional status and protein energy wasting (PEW) is prevalent in patients with nondialysis-dependent chronic kidney disease (CKD). The relationship between PEW and long-term development of clinically important outcomes remains to be examined.

Objectives: To investigate the relationships between PEW, as measured by Subjective Global Assessment (SGA 1-7), and progression to important clinical outcomes: mortality and/or kidney failure. Read More

View Article and Full-Text PDF

Optimal Protein Intake in Pre-Dialysis Chronic Kidney Disease Patients with Sarcopenia: An Overview.

Authors:
Yoshitaka Isaka

Nutrients 2021 Apr 6;13(4). Epub 2021 Apr 6.

Department of Nephrology, Osaka University Graduate School of Medicine, Suita 565-0871, Japan.

Multi-factors, such as anorexia, activation of renin-angiotensin system, inflammation, and metabolic acidosis, contribute to malnutrition in chronic kidney disease (CKD) patients. Most of these factors, contributing to the progression of malnutrition, worsen as CKD progresses. Protein restriction, used as a treatment for CKD, can reduce the risk of CKD progression, but may worsen the sarcopenia, a syndrome characterized by a progressive and systemic loss of muscle mass and strength. Read More

View Article and Full-Text PDF

Natriuretic Peptides as Predictors of Protein-Energy Wasting in Hemodialysis Population.

J Ren Nutr 2021 Apr 19. Epub 2021 Apr 19.

Department of Nephrology, Hospices Civils de Lyon, Centre Hospitalier Lyon-Sud, Pierre-Benite, France; University of Lyon, CarMeN lab, INSA-Lyon, INSERM U1060, INRA, Université Claude Bernard Lyon 1, Villeurbanne, France. Electronic address:

Objective: Imbalance between anabolism and catabolism is linked to cachexia and protein-energy wasting (PEW), especially in frail populations such as patients with chronic kidney disease. PEW is responsible of poor outcomes with increased morbidity and mortality. Several causes are involved in PEW such as insulin resistance, acidosis, or hyperparathyroidism. Read More

View Article and Full-Text PDF

Chronic Kidney Disease and Nutrition Support.

Authors:
Winnie Chan

Nutr Clin Pract 2021 Apr 18;36(2):312-330. Epub 2021 Mar 18.

School of Sport, Exercise and Rehabilitation Sciences, The University of Birmingham, Edgbaston, Birmingham, United Kingdom.

Individuals with chronic kidney disease (CKD), particularly those undergoing maintenance dialysis, are prone to protein-energy wasting (PEW), the latter of which can be ameliorated with different methods of nutrition support. Dietary counseling guided by dietitians is the key for preventing and managing PEW in CKD. If dietary counseling per se fails to meet the recommended energy and protein requirements, the addition of oral nutrition supplements (ONSs) would be necessary. Read More

View Article and Full-Text PDF

Resting metabolic rate and its adjustments as predictors of risk protein-energy wasting in hemodialysis patients.

Biosci Rep 2021 Apr;41(4)

Renal Division, Department of Medicine, Guizhou Provincial People's Hospital.

Background: The purpose of the present study was to explore the association between resting metabolic rate (RMR) and protein-energy wasting (PEW) risk in Chinese hemodialysis patients by age and gender subgroup.

Methods: RMR and body composition (body cell mass (BCM) and fat mass) of 774 patients undergoing hemodialysis were estimated by bio-electrical impedance analysis (BIA). Anthropometric data were collected by a standard measurement protocol, and the upper arm muscle circumference (AMC) was calculated. Read More

View Article and Full-Text PDF

Frequency of Intradialytic Hypotension Events Do Not Increase with Oral Nutritional Supplementation during Hemodialysis Treatment: A Randomized Controlled Trial.

J Ren Nutr 2021 Feb 26. Epub 2021 Feb 26.

Nephrology and Mineral Metabolism Department, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City. Electronic address:

Objective: This study aimed to compare the effect of the use of a renal-specific oral nutritional supplement (RS-ONS) during hemodialysis sessions and the use of RS-ONS at home on the incidence of intradialytic hypotension.

Methods: A single-center, 12-week, open-label, randomized controlled clinical trial was conducted. The intervention was a RN-ONS divided into two portions: 100 and 137 mL. Read More

View Article and Full-Text PDF
February 2021

Protein-Energy Wasting and Mortality Risk Prediction Among Peritoneal Dialysis Patients.

J Ren Nutr 2021 Feb 25. Epub 2021 Feb 25.

Department of Internal Medicine-Nephrology, Faculty of Medicine, Chulalongkorn University, King Chulalongkorn Memorial Hospital, Thai Red Cross Society, Bangkok, Thailand; Division of Nephrology, Department of Medicine, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand; Special Task Force for Activating Research in Renal Nutrition (Renal Nutrition Research Group), Office of Research Affairs, Chulalongkorn University, Bangkok, Thailand. Electronic address:

Objectives: Protein-energy wasting (PEW) is defined as the loss of body protein and energy reserves associated with kidney disease. However, the extent to which PEW contributes to increased mortality among peritoneal dialysis (PD) patients remains unclear.

Methods: This is a retrospective cohort study from 2012 to 2020. Read More

View Article and Full-Text PDF
February 2021

Fibroblast growth factor 21 and protein energy wasting in hemodialysis patients.

Clin Nutr 2021 Feb 3. Epub 2021 Feb 3.

Department of Internal Medicine, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands. Electronic address:

Introduction: Protein energy wasting (PEW) is the most important risk factor for morbidity and mortality in hemodialysis patients. Inadequate dietary protein intake is a frequent cause of PEW. Recent studies have identified fibroblast growth factor 21 (FGF21) as an endocrine protein sensor. Read More

View Article and Full-Text PDF
February 2021

Association between the uremic toxins indoxyl-sulfate and p-cresyl-sulfate with sarcopenia and malnutrition in elderly patients with advanced chronic kidney disease.

Exp Gerontol 2021 05 30;147:111266. Epub 2021 Jan 30.

Unit of Nephrology, Dialysis and Kidney Transplantation, Fondazione IRCCS Ca'Granda Ospedale Maggiore Policlinico di Milano, Milan, Italy. Electronic address:

Background: in patients with chronic kidney disease (CKD) indoxyl sulfate (IS) and p-cresyl sulfate (PCs) may induce sarcopenia either directly or via systemic inflammation. We evaluated whether IS and PCs were associated with: sarcopenia, systemic inflammation and nutritional status.

Methods: we examined cross sectionally 93 patients with advanced CKD. Read More

View Article and Full-Text PDF

Comparison of nutritional and hydration status in patients undergoing twice and thrice-weekly hemodialysis: a silent drama in developing countries.

Int Urol Nephrol 2021 Mar 4;53(3):571-581. Epub 2021 Jan 4.

Departamento de Nefrología y Metabolismo Mineral, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Vasco de Quiroga No. 15, Col. Sección XVI, Delegación Tlalpan, Ciudad de México, 14000, México.

Purpose: In low and middle- income countries, due to lack of financial resources, the number of patients receiving one or two hemodialysis (HD) sessions a week has increased, leading to a large number of complications. Protein-energy wasting (PEW) and overhydration (OH) are common complications; nevertheless, the evidence regarding the nutritional status of patients receiving 2 and 3 weekly dialysis sessions is scarce. Thus, our objective was to compare the nutritional and hydration status of patients with two and three HD sessions. Read More

View Article and Full-Text PDF

Evolution of body composition and wasting indicators by time of day of haemodialysis.

Nephrol Dial Transplant 2021 01;36(2):346-354

European Renal Nutrition Working Group, European Renal Association-European Dialysis Transplant Association, London, United Kingdom.

Background: It has been a long-standing clinical concern that haemodialysis (HD) patients on afternoon shifts (ASs) are more prone to protein-energy wasting (PEW) than those on morning shifts (MSs), as their dialysis scheme and post-dialysis symptoms may interfere with meal intake. We evaluated the effect of time of day of HD on the evolution of body composition changes and PEW surrogates.

Methods: We conducted a retrospective study among 9. Read More

View Article and Full-Text PDF
January 2021

Protein intake and renal function in older patients.

Curr Opin Clin Nutr Metab Care 2021 Jan;24(1):10-17

Division of Nephrology, Hypertension and Kidney Transplantation, Harold Simmons Center for Chronic Disease Research and Epidemiology, University of California Irvine, Orange, California.

Purpose Of Review: Chronic kidney disease (CKD) is highly prevalent in elderly patients. There is growing recognition of the importance of attention to dietary protein intake (DPI) in this population given their predisposition to age-related changes in kidney function and coexisting comorbidities (i.e. Read More

View Article and Full-Text PDF
January 2021

Association of Ultrasound-Derived Metrics of the Quadriceps Muscle with Protein Energy Wasting in Hemodialysis Patients: A Multicenter Cross-Sectional Study.

Nutrients 2020 Nov 23;12(11). Epub 2020 Nov 23.

School of BioSciences, Faculty of Health and Medical Sciences, Taylor's University Lakeside Campus, No 1, Jalan Taylor's, Subang Jaya 47500, Selangor, Malaysia.

This study aimed to assess muscle wasting and risk of protein energy wasting (PEW) in hemodialysis (HD) patients using an ultrasound (US) imaging method. PEW was identified using the ISRNM criteria in 351 HD patients. Quadriceps muscle thickness of (RF) and (VI) muscles and cross-sectional area (CSA) of the RF muscle (RF) were measured using US and compared with other physical measures. Read More

View Article and Full-Text PDF
November 2020

Efficacy of intradialytic amino acids on nutritional status in children with stage 5 chronic kidney disease.

Pediatr Nephrol 2021 Jun 18;36(6):1561-1569. Epub 2020 Nov 18.

Faculty of Medicine, Pediatric Department, Mansoura University, Elgomhoria Street, Mansoura, Egypt.

Background: Protein energy wasting (PEW) is a common cause of morbidity and mortality in patients with stage 5 chronic kidney disease (CKD 5). Intradialytic parenteral nutrition (IDPN) has been used as a therapy for preventing and treating PEW in children with CKD 5 when other conventional modalities fail. However, not enough data is available to define its effectiveness in treating malnutrition in children. Read More

View Article and Full-Text PDF

Protein-Energy Wasting and Associated Factors Among Chronic Kidney Disease Patients at St. Paul's Hospital Millennium Medical College, Addis Ababa, Ethiopia.

Int J Nephrol Renovasc Dis 2020 2;13:307-318. Epub 2020 Nov 2.

Department of Nutrition and Dietetics, Faculty of Public Health, Health Institute, Jimma University, Jimma, Ethiopia.

Background: Protein-energy wasting is a major issue in patients with chronic kidney disease (CKD), adversely affecting morbidity, mortality, functional activity, and quality of life. Assessment of nutritional status in CKD patients is important to ensure patient's normal protein stores and avoid metabolic complications. However, in Ethiopia, there were very few studies done to assess the prevalence of protein-energy wasting (PEW) and its associated factors among CKD patients. Read More

View Article and Full-Text PDF
November 2020

The effect of protein-enriched snacks on serum albumin concentration in non-selected haemodialysis patients.

J Nephrol 2020 Nov 2. Epub 2020 Nov 2.

Nephrology and Dialysis Centre, Nephrocare Tassin Charcot, 7 Avenue Marechal Foch, 69110, Sainte-Foy-Les-Lyon, France.

Objective: Serum albumin level is not only one of the protein-energy wasting criteria but also a powerful marker of mortality in patients on haemodialysis (HD) treatment. The study aimed to assess the effect of a protein-enriched snack given during HD treatment on serum albumin level.

Design And Methods: This prospective, single-centre, observational, non-randomized 16-month study was sub-divided into four 4-month periods. Read More

View Article and Full-Text PDF
November 2020

Bioelectrical impedance analysis-derived phase angle as a determinant of protein-energy wasting and frailty in maintenance hemodialysis patients: retrospective cohort study.

BMC Nephrol 2020 10 19;21(1):438. Epub 2020 Oct 19.

Meiseikai Toyo Clinic Yachimata, Chiba, Japan.

Background: Phase angle (PA), measured by bioelectrical impedance analysis (BIA) has been studied as indicator of nutritional status or muscle function in hemodialysis (HD) patients. It remains unclear if the phase angle is associated protein-energy wasting (PEW) or frailty, which are common complication in hemodialysis patients. The aim of this study is to determine whether BIA-derived PA is a marker of PEW or frailty in HD patients. Read More

View Article and Full-Text PDF
October 2020

Assessment of nutritional status in maintenance hemodialysis patients: A multicenter cross-sectional study in Iran.

Semin Dial 2021 Jan 14;34(1):77-82. Epub 2020 Oct 14.

Department of Nutrition, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.

Introduction: Protein-energy wasting (PEW) is common in hemodialysis patients and is linked with a high rate of morbidity and mortality. Regarding importance of nutrition in these patients, a recent study was administered to evaluate the nutritional status of hemodialysis patients.

Materials: In this cross-sectional study 540 HD patients from 15 dialysis centers were evaluated. Read More

View Article and Full-Text PDF
January 2021

Frailty phenotype and multi-domain impairments in older patients with chronic kidney disease.

BMC Geriatr 2020 09 29;20(1):371. Epub 2020 Sep 29.

Unit of Nephrology, Dialysis and Kidney Transplantation Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico di Milano, Via della Commenda 15, 20122, Milan, Italy.

Background: Older subjects with chronic kidney disease (CKD) are often affected by multiple geriatric impairments that may benefit from a comprehensive geriatric assessment (CGA). However, ordinary execution of CGA in all these individuals would be unaffordable. We evaluated if Frailty Phenotype (FP) could identify older CKD-patients that may benefit the most from a CGA. Read More

View Article and Full-Text PDF
September 2020

Impact of malnutrition on health-related quality of life in patients on maintenance hemodialysis.

Ther Apher Dial 2020 Sep 25. Epub 2020 Sep 25.

Mansoura Nephrology and Dialysis Unit (MNDU), Mansoura University, Mansoura, Egypt.

Malnutrition is considered as one of the most important risk factors that adversely affect the quality of life (QOL) in maintenance hemodialysis (MHD) patients. Many clinically useful nutrition assessment techniques are now available, but the usefulness of such techniques in predicting QOL in MHD patients had not been sufficiently tested. The aim of this study was to explore the relation between different nutritional assessment methods, and QOL and identify nutritional parameter that can best predict physical and mental domains of QOL in MHD patients. Read More

View Article and Full-Text PDF
September 2020

Protein Energy Wasting in Children With Chronic Kidney Disease and End-Stage Kidney Disease: An Observational Study.

J Ren Nutr 2021 May 18;31(3):270-277. Epub 2020 Sep 18.

Department of Pediatric Nephrology, St John's National Academy of Health Sciences, Bangalore, Karnataka, India.

Objectives: Protein energy wasting (PEW), a specific nutritional comorbidity associated with increased mortality, is underrecognized in children with chronic kidney disease (CKD). The aim of this study was to determine the burden and factors associated with PEW and assess the utility of parameters used to diagnose PEW in children with CKD and End stage kidney disease (ESKD).

Methods: Children between 2 and 18 years of age with CKD stages 2-5 were recruited over 30 months. Read More

View Article and Full-Text PDF

Protein-Energy Wasting Assessment and Clinical Outcomes in Patients with Acute Kidney Injury: A Systematic Review with Meta-Analysis.

Nutrients 2020 Sep 13;12(9). Epub 2020 Sep 13.

Department of Medicine, Faculty of Medicine, Universiti Kebangsaan Malaysia, Cheras, Kuala Lumpur 56000, Malaysia.

Nutritional assessment is essential to identify patients with acute kidney injury (AKI) who are protein-energy wasting (PEW) and at risk of poor clinical outcomes. This systematic review aimed to investigate the relationship of nutritional assessments for PEW with clinical outcomes in patients with AKI. A systematic search was performed in PubMed, Scopus, and Cochrane Library databases using search terms related to PEW, nutrition assessment, and AKI to identify prospective cohort studies that involved AKI adult patients with at least one nutritional assessment performed and reported relevant clinical outcomes, such as mortality, length of stay, and renal outcomes associated with the nutritional parameters. Read More

View Article and Full-Text PDF
September 2020

Effects of fish oil during hemodialysis on nutritional status and quality of life: a randomized double-blinded trial.

Food Nutr Res 2020 3;64. Epub 2020 Aug 3.

Department of Nephrology, Xuzhou Medical University, Jiangsu, China.

Background: Supplementation of fish oil has been shown to exert beneficial effects in patients undergoing hemodialysis. The aim of this study was to investigate the efficacy of fish oil in improving the quality of life of these patients through a randomized, double-blinded clinical trial.

Methods: Among the 103 patients enrolled in the study, a total of 74 patients were randomized to receive fish oil (intervention group) or placebo (=37 per group). Read More

View Article and Full-Text PDF

Protein energy-wasting associated with nephrotic syndrome - the comparison of metabolic pattern in severe nephrosis to different stages of chronic kidney disease.

BMC Nephrol 2020 08 14;21(1):346. Epub 2020 Aug 14.

Department of Internal Medicine, Nephrology and Dialysis, Military Institute of Medicine, Szaserów Street 128, 04-141, Warsaw, Poland.

Background: Nephrotic syndrome (NS) is associated with a hypercatabolic state expressed as an exacerbated degradation of muscle mass. However, the clinical significance of this phenomenon has not yet been investigated. The aim of the study was to evaluate the nutritional status of patients with severe NS (defined as nephrotic range proteinuria with hypoalbuminemia ≤2. Read More

View Article and Full-Text PDF

Circulating 20S proteasome for assessing protein energy wasting syndrome in hemodialysis patients.

PLoS One 2020 31;15(7):e0236948. Epub 2020 Jul 31.

Nephrology, Dialysis and Transplantation Department, Gabriel Montpied University Hospital, Clermont-Ferrand, France.

Protein energy wasting (PEW) including muscle atrophy is a common complication in chronic hemodialysis patients. The ubiquitin proteasome system (UPS) is the main proteolytic system causing muscle atrophy in chronic kidney disease and proteasome 20S is the catalytic component of the UPS. Circulating proteasome 20S (c20S proteasome) is present in the blood and its level is related to disease severity and prognosis in several disorders. Read More

View Article and Full-Text PDF
September 2020

Relationship of dietary and serum zinc and leptin levels with protein energy wasting in haemodialysis patients.

Int Urol Nephrol 2020 Oct 28;52(10):1969-1977. Epub 2020 Jul 28.

RFM Dialysis Units, Ankara, Turkey.

Objective: This study was carried out to evaluate the relationship between dietary and serum zinc and leptin levels with protein-energy wasting (PEW) in haemodialysis patients.

Methods: The study was conducted on 80 volunteer patients aged 19-65 years who received haemodialysis treatment three times a week for at least 1 year. Anthropometric measurements and body composition analyses were performed. Read More

View Article and Full-Text PDF
October 2020

Exploring Metabolic Signature of Protein Energy Wasting in Hemodialysis Patients.

Metabolites 2020 Jul 16;10(7). Epub 2020 Jul 16.

Department of Dietetics, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Serdang 43400, Malaysia.

End-stage renal disease patients undergoing maintenance hemodialysis (HD) are vulnerable to the protein energy wasting (PEW) syndrome. Identification and diagnosis of PEW relies on clinical processes of judgment dependent on fulfilling multiple criteria drawn from serum biochemistry, weight status, predictive muscle mass, dietary energy and protein intakes. Therefore, we sought to explore the biomarkers' signature with plasma metabolites of PEW by using H-nuclear magnetic resonance for an untargeted metabolomics approach in the HD population, to understand metabolic alteration of PEW. Read More

View Article and Full-Text PDF