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Impact of riboflavin and curcumin mediated photodynamic therapy and Er,Cr:YSGG on microleakage of class V resin glass ionomer restorations in permanent molar teeth.

Photodiagnosis Photodyn Ther 2021 Jul 26:102462. Epub 2021 Jul 26.

Department of Restorative Dental Sciences, College of Dentistry, King Saud University, Riyadh 11545, Saudi Arabia. Electronic address:

Purpose: The present study aimed to evaluate the impact of PDT using curcumin and riboflavin as photosensitizers and Er,Cr:YSGG on microleakage in class V RMGIC restorations in permanent teeth.

Materials And Methods: Eighty permanent molars were investigated and randomly divided into 4 groups: control group: resin-modified glass ionomer restoration with no treatment, R-PDT: PDT with riboflavin, Cu-PDT: PDT with curcumin (Cu) and, Er,Cr:YSGG: laser application. All the teeth in each group were restored with the help of RMGIC. Read More

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Reconnection Sites in Redo Ablation after Cryoballoon Pulmonary Vein Isolation in Patients with Paroxysmal Atrial Fibrillation.

Arq Bras Cardiol 2021 Jul;117(1):100-105

Centro Medico Nacional 20 de Noviembre - Hemodinamia y Electrofisiologua, Ciudad de México - México.

Background: In paroxysmal atrial fibrillation (PAF), pulmonary vein isolation using cryoballoon (CB-PVI) has similar efficacy as radiofrequency ablation (RF-PVI) has. In redo ablation procedures following RF-PVI, PV reconnection is high, whereas in patients with redo following CB-PVI, information is scarce.

Objective: To determine the sites of PV reconnection in patients who underwent redo ablation after initial CB-PVI. Read More

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Commensal Streptococcus mitis produces two different lipoteichoic acids of type I and type IV.

Glycobiology 2021 Jul 26. Epub 2021 Jul 26.

Department of Microbiology, University of Kaiserslautern, 67663 Kaiserslautern, Germany.

The opportunistic pathogen Streptococcus mitis possesses, like other members of the Mitis group of viridans streptococci, phosphorylcholine (P-Cho)-containing teichoic acids (TAs) in its cell wall. Bioinformatic analyses predicted the presence of TAs that are almost identical with those identified in the pathogen S. pneumoniae, but a detailed analysis of S. Read More

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Defining successful non-invasive ventilation initiation: Data from a real-life cohort.

Respirology 2021 Jul 26. Epub 2021 Jul 26.

Institute for Research and Innovation in Biomedicine (IRIB), Normandie University, UNIRouen, Rouen, France.

Background And Objective: When home non-invasive ventilation (NIV) is initiated, five goals need to be achieved: a daily use >4 h/day, an improvement in gas exchange, health-related quality of life (HRQL) and sleep quality without side effects. Our aim was to assess how frequently these five goals were reached and the factors predictive of achievement.

Methods: We conducted a monocentric cohort study that included patients electively established on home NIV over 2 years. Read More

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Chemometric analysis on ATR-FT-IR spectra of spray paint samples for forensic purposes.

J Forensic Sci 2021 Jul 23. Epub 2021 Jul 23.

Department of Forensic Science, Punjabi University, Patiala, Punjab, India.

Forensic investigation of cases involving spray paints requires comparison of paint such as those recovered from graffiti with the references sample seized from the suspect's possession site. This study describes the use of Attenuated Total Reflectance Fourier Transform Infrared (ATR-FT-IR) spectroscopy for nondestructive analysis of 20 red spray paints of different manufactures, which could be encountered at a crime scene, particularly in case of vandalism. Spray paints could be encountered on a number of different substrates, and therefore, the samples were placed on simulated substrates and were analyzed in order to check the effect of substrates on sample analysis. Read More

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Breakage of sliding hip screw after fixation of pertrochanteric hip fracture: A rare complication.

Int J Surg Case Rep 2021 Jul 22;85:106226. Epub 2021 Jul 22.

Division of Orthopedic Surgery, Lebanese University, Faculty of Medical Sciences, Beirut, Lebanon.

Introduction: The authors report a rare case of lag screw breakage in a patient treated using locking DHS with home-made trochanteric stabilizing plate (TSP) for pertrochanteric hip fracture.

Case Presentation: A 67 year-old female was operated for pertrochanteric hip fracture with incompetent lateral wall using locking DHS with home-made TSP. At seven months postoperative, there was radiographic nonunion with breakage of the sliding lag screw. Read More

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A Comparative Study of the Accuracy of Dental CAD Programs in Designing a Fixed Partial Denture.

J Prosthodont 2021 Jul 26. Epub 2021 Jul 26.

Department of Prosthodontics, Yonsei University College of Dentistry, Seoul, Republic of Korea.

Purpose: Error testing at each stage of prosthetic manufacturing remains relatively underdeveloped for computer-aided design/computer-aided manufacturing methods, and no experimental studies have validated the computer-aided design programs. This study aimed to test the accuracy and trueness of the computer-aided design of a three-unit fixed prosthesis.

Materials & Methods: Three computer-aided design programs (Exocad, Dental System™, and inLab 16) were tested on the designs of a three-unit fixed partial denture, and a three-dimensional analysis program was used to calculate the internal clearance error for the computer-aided design prostheses. Read More

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Mature trichome is the earliest sequestration site of Cd ions in leaves.

Heliyon 2021 Jul 8;7(7):e07501. Epub 2021 Jul 8.

Hebei Key Laboratory of Plant Physiology and Molecular Pathology, Hebei Agricultural University, 071001, Baoding, China.

Sequestration of heavy metals by plants in non-glandular leaf trichomes is important for survival in toxic soils and has the potential for environmental remediation. Although heavy metals are particularly toxic to many plants during development, the integration of sequestration into the developmental timecourse is unknown. We tested the hypothesis that plants preferentially sequester heavy metals into mature trichomes by investigating the timecourse of Cd ions into the leaves of the model plant . Read More

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Nanoparticle-Assisted Diagnosis and Treatment for Abdominal Aortic Aneurysm.

Front Med (Lausanne) 2021 7;8:665846. Epub 2021 Jul 7.

Department of Vascular Surgery, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China.

An abdominal aortic aneurysm (AAA) is a localized dilatation of the aorta related to the regional weakening of the wall structure, resulting in substantial morbidity and mortality with the aortic ruptures as complications. Ruptured AAA is a dramatic catastrophe, and aortic emergencies constitute one of the leading causes of acute death in older adults. AAA management has been centered on surgical repair of larger aneurysms to mitigate the risks of rupture, and curative early diagnosis and effective pharmacological treatments for this condition are still lacking. Read More

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Incidence of Complications in Chest Wall Masculinization for the Obese Female-to-Male Transgender Population: A Case Series.

World J Plast Surg 2021 May;10(2):14-24

Plastic and Reconstructive Surgery, MedStar Franklin Square Medical Center; Baltimore, Maryland.

Background: Chest masculinization is aimed at aligning physical appearance of female-to-male (FtM) transgender patients to their identifying gender. Despite limited evidence, obese FtM patients have historically been denied this procedure due to concerns of complications. We reviewed chest masculinization in the high body mass index (BMI) population to analyze the outcomes. Read More

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Skull Base Invasion Patterns of Malignant Head and Neck Tumors: A Neurosurgical Perspective.

J Neurol Surg B Skull Base 2021 Jul 8;82(Suppl 3):e120-e130. Epub 2020 Jan 8.

Department of Neurosurgery, Fukushima Medical University, Fukushima, Japan.

 Craniofacial resection (CFR) and temporal bone resection (TBR) on malignant head and neck tumors (MHNTs) invading skull base require accurate and precise determination of the tumor invasion. We investigated tumor skull base invasion patterns and surgical results in CFR and TBR cases.  We performed either CFR or TBR for 75 selected patients with the possibility of en bloc resection over the period between 2011 and 2018. Read More

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Two cases of gastric penetration by fish bones with differing courses.

Oxf Med Case Reports 2021 Jul 21;2021(7):omab060. Epub 2021 Jul 21.

Department of Gastroenterology, Dokkyo Medical University Saitama Medical Center, Koshigaya City, Japan.

Most foreign bodies swallowed accidentally are naturally excreted. Gastric penetration by a fish bone is rare due to anatomical and physiological features such as the thick stomach wall, wide lumen and gastric acid. The most common penetration site is the antral region. Read More

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Lymphocutaneous sporotrichosis of the abdominal wall: A lesson in lymphatic drainage.

Med J Malaysia 2021 Jul;76(4):583-584

University Kebangsaan Malaysia Medical Center, Department of Medicine, Kuala Lumpur, Malaysia.

Cutaneous sporotrichosis (CS) presents as asymptomatic lesions of varied morphology. The most common variant is the lymphocutaneous type which typically progresses from a papule to an ulcer and then forms nodules along the superficial lymphatic channels. Diagnosis CS may be challenging when the lesion presents at an uncommon site where the superficial lymphatic drainage is unfamiliar. Read More

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[Clinical analysis of the vascular pulsatile tinnitus associated with sigmoid sinus-mastoid].

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2021 May;35(5):410-415

Department of Otorhinolaryngology Head and Neck Surgery,the 980th Hospital of Joint Logistics Support Force of PLA,Shijiazhuang,050082,China.

To probe the clinical characteristics of diagnosis and therapy of vascular pulsatile tinnitus(PT) associated with sigmoid sinus-mastoid. Retrospectively analyzed the clinical data of the hospitalized 45 PT patients of an ear surgeon in one hospital between January 2013 to January 2020, and observed the effectiveness with surgery and non-surgery therapy. Surgical procedures include reconstruction the bone wall of sigmoid sinus by transmastoid approach and ligation of mastoid emissary vein. Read More

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Yeast Ssd1 is a non-enzymatic member of the RNase II family with an alternative RNA recognition site.

Nucleic Acids Res 2021 Jul 24. Epub 2021 Jul 24.

Wellcome Centre for Cell Biology, School of Biological Sciences, University of Edinburgh, Edinburgh EH9 3BF, UK.

Ssd1, a conserved fungal RNA-binding protein, is important in stress responses, cell division and virulence. Ssd1 is closely related to Dis3L2 of the RNase II family of nucleases, but lacks catalytic activity and likely suppresses translation of bound mRNAs. Previous studies identified RNA motifs enriched in Ssd1-associated transcripts, yet the sequence requirements for Ssd1 binding are not defined. Read More

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Feeding gastrostomy stoma site cutaneous myiasis: a rare entity.

BMJ Case Rep 2021 Jul 22;14(7). Epub 2021 Jul 22.

Surgery, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, India

Infestation of any dead or necrotic tissues by the larvae of flies (maggots) is myiasis. This form of habitation is not restricted to any particular tissues in the body and can occur anywhere. However, myiasis at the surgical stoma site is very rare. Read More

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Persistent Atrial Fibrillation: The Role of Left Atrial Posterior Wall Isolation and Ablation Strategies.

J Clin Med 2021 Jul 15;10(14). Epub 2021 Jul 15.

Cardiovascular Clinical Academic Group, Molecular and Clinical Sciences Institute, St. George's University of London and St. George's University Hospitals NHS Foundation Trust, London SW17 0QT, UK.

Atrial fibrillation (AF) is a global disease with rapidly rising incidence and prevalence. It is associated with a higher risk of stroke, dementia, cognitive decline, sudden and cardiovascular death, heart failure and impairment in quality of life. The disease is a major burden on the healthcare system. Read More

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The Lysozyme Inhibitor Thionine Acetate Is Also an Inhibitor of the Soluble Lytic Transglycosylase Slt35 from .

Molecules 2021 Jul 9;26(14). Epub 2021 Jul 9.

School of Chemistry, Cardiff University, Park Place, Cardiff CF10 3AT, UK.

Lytic transglycosylases such as Slt35 from are enzymes involved in bacterial cell wall remodelling and recycling, which represent potential targets for novel antibacterial agents. Here, we investigated a series of known glycosidase inhibitors for their ability to inhibit Slt35. While glycosidase inhibitors such as 1-deoxynojirimycin, castanospermine, thiamet G and miglitol had no effect, the phenothiazinium dye thionine acetate was found to be a weak inhibitor. Read More

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Optimal clamping time in meatotomy procedure for children with meatal stenosis: Experience with 120 cases.

Arch Ital Urol Androl 2021 Jun 29;93(2):244-247. Epub 2021 Jun 29.

Urology Research Center, Al-Thora General Hospital, Department of Urology, Ibb University of Medical Since, Ibb.

Objective: During meatotomy procedure for children with meatal stenosis (MS), a straight clamp used as a hemostat on the ventrum of the meatus before incised with scissors for clamping and holding bleeding from the site of operation. The aim of this study was to evaluate the optimum clamping time for meatotomy in children with MS.

Materials And Methods: All the patients with MS between 2014 to 2019 were enrolled in this retrospective study. Read More

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Microbiological Monitoring of the Environment Using the "Association Rules" Approach and Disinfection Procedure Evaluation in a Hospital Center in Morocco.

J Environ Public Health 2021 5;2021:7682042. Epub 2021 Jul 5.

Laboratory of Microbial Biotechnology and Bioactive Molecules, Science and Technologies Faculty, Sidi Mohamed Ben Abdellah University, Fez, Morocco.

Background: The hospital environment, especially surfaces and medical devices, is a source of contamination for patients.

Objective: This study carried out, to the best of our knowledge, for the first time at Taza Hospital in Morocco aimed to assess the microbiological quality of surfaces and medical devices in surgical departments and to evaluate the disinfection procedure in time and space.

Methods: Samples were taken by swabbing after cleaning the hospital surface or medical device, to isolate and identify germs which were inoculated on semiselective culture media then identified by standard biochemical and physiological tests, using the analytical profile index (API) galleries. Read More

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Effect of polymyxin B on ex vivo tumor necrosis factor-alpha responsiveness of blood leukocytes in Danish Holstein Friesian cows.

Vet Immunol Immunopathol 2021 Aug 15;238:110293. Epub 2021 Jul 15.

Aarhus University, Faculty of Science and Technology, Department of Animal Science, Blichers Allé 20, P.O. Box 50, DK-8300, Tjele, Denmark; Christine Røntved, CMR On-Site RD, Graverhusvej 53, Langholt, 9310, Vodskov, Denmark. Electronic address:

Whole blood stimulation assay (WBA) with killed gram-positive and gram-negative udder pathogens were used to investigate the interference of the endotoxin-binding antibiotic polymyxin B (PMB) on the ex vivo TNF-α response. Blood samples were collected from first to third lactating dairy cows in their early lactation (<50 days in milk, n = 32) period. The WBA was stimulated with both inactivated bacteria (e. Read More

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Structural and mechanistic investigations of protein S-glycosyltransferases.

Cell Chem Biol 2021 Jul 14. Epub 2021 Jul 14.

Howard Hughes Medical Institute and Roger Adams Laboratory, Department of Chemistry, University of Illinois at Urbana-Champaign, 600 South Mathews Avenue, Urbana, IL 61801, USA; Department of Biochemistry, University of Illinois at Urbana-Champaign, 600 South Mathews Avenue, Urbana, IL 61801, USA. Electronic address:

Attachment of sugars to nitrogen and oxygen in peptides is ubiquitous in biology, but glycosylation of sulfur atoms has only been recently described. Here, we characterize two S-glycosyltransferases SunS and ThuS that selectively glycosylate one of five Cys residues in their substrate peptides; substitution of this Cys with Ser results in a strong decrease in glycosylation activity. Crystal structures of SunS and ThuS in complex with UDP-glucose or a derivative reveal an unusual architecture in which a glycosyltransferase type A (GTA) fold is decorated with additional domains to support homodimerization. Read More

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Magnetic Resonance Imaging Detects Progression of Lung Disease and Impact of Newborn Screening in Preschool Children with Cystic Fibrosis.

Am J Respir Crit Care Med 2021 Jul 20. Epub 2021 Jul 20.

Charité Universitätsmedizin Berlin, 14903, Department of Pediatric Pulmonology, Immunology and Critical Care Medicine, Berlin, Germany.

Rationale: Previous cross-sectional studies demonstrated that chest magnetic resonance imaging (MRI) is sensitive to detect early lung disease in infants and preschool children with cystic fibrosis (CF) without radiation exposure. However, the ability of MRI to detect progression of lung disease and the impact of early diagnosis in preschool children with CF remains unknown.

Objectives: To investigate the potential of MRI to detect progression of early lung disease and impact of early diagnosis by CF newborn screening (NBS) in preschool children with CF. Read More

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Anterior wall adenocarcinoma of bladder with similar clinicopathological and prognostic characteristics as common bladder carcinomas should not be treated as or classified into urachal adenocarcinomas.

Cancer Med 2021 Jul 18. Epub 2021 Jul 18.

Department of Biotherapy, Cancer Center, West China Hospital of Sichuan University, Chengdu, China.

Purpose: To discuss whether the dome or anterior wall of bladder adenocarcinoma (BAC) should be classified into urachal carcinoma (UrC) and the relationship of primary tumor location (PTL) as well as treatment with survival.

Methods: Surveillance, Epidemiology, and End Results 18 database was examined for eligible patients from 1975 to 2016. Patients were classified into adenocarcinoma originating from the urachus (UAC), the dome (D-BAC), the anterior wall (A-BAC), and the other sites adenocarcinoma of the bladder (O-BAC). Read More

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Cell Wall Permeability Model Generation Using Chemoinformatics and Machine Learning Approaches.

ACS Omega 2021 Jul 25;6(27):17472-17482. Epub 2021 Jun 25.

Advanced Computation and Data Sciences Division, CSIR - North East Institute of Science and Technology, Jorhat, Assam 785 006, India.

The drug-resistant strains of () are evolving at an alarming rate, and this indicates the urgent need for the development of novel antitubercular drugs. However, genetic mutations, complex cell wall system of , and influx-efflux transporter systems are the major permeability barriers that significantly affect the drugs activity. Thus, most of the small molecules are ineffective to arrest the cell growth, even though they are effective at the cellular level. Read More

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Uterine scar rupture at the site of the placenta accreta presenting as a case of sudden death.

Autops Case Rep 2021 8;11:e2020226. Epub 2020 Dec 8.

All India Institute of Medical Sciences, Department of Forensic Medicine and Toxicology, Raipur, Chhattisgarh, India.

Uterine rupture during pregnancy is a known complication of placenta accreta. This paper presents a case of sudden maternal death in the 27 week of gestation due to a ruptured uterine scar at the site of placenta accreta with a short inter-pregnancy period of 6 months with previous two C-sections. Autopsy findings revealed a massive hemoperitoneum and a thinned out anterolateral uterine wall. Read More

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December 2020

Features Suggesting Preferential Conduction in Pulmonary Artery Ventricular Arrhythmia for Identification of Successful Ablation Sites.

Int Heart J 2021 Jul 17. Epub 2021 Jul 17.

Department of Cardiology, Tsuchiura Kyodo Hospital.

Radiofrequency catheter ablation (RFCA) for pulmonary artery ventricular arrhythmia (PAVA) can be difficult because of the occasional existence of PAVA with preferential conduction.This study described the characteristics of PAVA that demonstrate preferential conduction.We analyzed electrocardiographic and electrophysiological data from 8 patients found to have PAVAs with preferential conduction out of 183 patients (4. Read More

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Association of Snoring Characteristics with Predominant Site of Collapse of Upper Airway in Obstructive Sleep Apnoea Patients.

Sleep 2021 Jul 16. Epub 2021 Jul 16.

School of Biomedical Engineering, Faculty of Engineering, The University of Sydney, Sydney, Australia.

Study Objectives: Acoustic analysis of isolated events and snoring by previous researchers suggests a correlation between individual acoustic features and individual site of collapse events. In this study, we hypothesised that multi-parameter evaluation of snore sounds during natural sleep would provide a robust prediction of the predominant site of airway collapse.

Methods: The audio signals of 58 OSA patients were recorded simultaneously with full night polysomnography. Read More

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Therapeutic Computed Tomography-Guided Pericardiocentesis: Lessons Learned Based on a 7-Year Single-Center Experience.

J Comput Assist Tomogr 2021 Jul 13. Epub 2021 Jul 13.

From the Department of Radiology, Asaf Ha Rophe Medical Center, Rishon LeTzion, Israel Soroka Medical Center, Beer Sheva, Israel Ben Gurion Negev University, Beer Sheva, Israel.

Objective: Pericardiocentesis is a well-known procedure commonly performed by either image-guided intervention or surgical approaches. Computed tomography (CT)-guided pericardiocentesis is not widely used, but provides certain advantages. In the article we will discuss our technique of CT-guided therapeutic pericardiocentesis, including advantages and disadvantages, patient selection, possible approaches, and complications. Read More

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Pattern of local recurrence after mastectomy and reconstruction in breast cancer patients: a systematic review.

Gland Surg 2021 Jun;10(6):2037-2046

Department of Plastic and Reconstructive Surgery, Pusan National University School of Medicine, Yangsan, Korea.

Background: This study aimed to describe the locations of local recurrences based on the mastectomy and reconstruction type in breast cancer patients.

Methods: In November 2020, a systematic literature review was performed through MEDLINE/PubMed and the Cochrane Centre Register of Controlled Trials. Publications that included skin-sparing or nipple-sparing mastectomy followed by breast reconstruction and described the location of local recurrences were analyzed. Read More

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