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The Relationship Between Walking Speed and the Energetic Cost of Walking in Persons With Multiple Sclerosis and Healthy Controls: A Systematic Review.

Neurorehabil Neural Repair 2021 Apr 13:15459683211005028. Epub 2021 Apr 13.

Rehabilitation Research Center, REVAL, Faculty of Rehabilitation Sciences, Hasselt University, Belgium.

Background: Persons with multiple sclerosis (pwMS) experience walking impairments, characterized by decreased walking speeds. In healthy subjects, the self-selected walking speed is the energetically most optimal. In pwMS, the energetically most optimal walking speed remains underexposed. Read More

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[Prevalence of frailty among Chilean older people].

Rev Med Chil 2020 Oct;148(10):1418-1426

Institute of Health and Wellbeing, University of Glasgow, Glasgow, United Kingdom.

Background: The assessment of frailty among older people could help to reduce its social and health burden.

Aim: To determine and characterize the prevalence of frailty in Chilean older adults.

Material And Methods: We studied 233 participants, aged > 60 years, participating in the Chilean National Health Survey 2016-2017. Read More

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October 2020

Lactoferrin for the treatment of age-associated inflammation - A pilot study.

Physiol Int 2021 Apr 9. Epub 2021 Apr 9.

Division of Geriatric Medicine and Gerontology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

Background: Chronic inflammation (CI) is a common trait of aging associated with adverse outcomes including mortality. We hypothesized that recombinant human Lactoferrin (rhLf) would reduce chronic inflammation of aging.

Methods: Thirty-six community dwelling older adults were randomly assigned to rhLf or placebo treatment in 1:1 ratio for 3 months. Read More

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Towards Improving the Prediction of Functional Ambulation after Spinal Cord Injury Though the Inclusion of Limb Accelerations During Sleep and Personal Factors.

Arch Phys Med Rehabil 2021 Apr 8. Epub 2021 Apr 8.

Rehab Neural Engineering Labs, University of Pittsburgh, Pittsburgh PA; Human Engineering Research Laboratories, Veterans Affairs Pittsburgh Healthcare System, Pittsburgh, PA; Department of Bioengineering; Physical Medicine and Rehabilitation; Physical Therapy, University of Pittsburgh, Pittsburgh, PA. Electronic address:

Objective: To determine if functional measures of ambulation can be accurately classified using clinical measures, demographics, personal, psychosocial, and environmental factors (PPEF), and limb accelerations (LA) obtained during sleep, among individuals with chronic, motor incomplete spinal cord injury (SCI) in an effort to guide future, longitudinal predictions models.

Design: Cross-sectional, 1-5 days of data collection SETTING: Community-based data collection PARTICIPANTS: Adults with chronic (>1 year), motor incomplete SCI (n=27) INTERVENTIONS: Not applicable MAIN OUTCOME MEASURES: Ambulatory ability based on the 10-Meter (10mWT) or 6-Minute Walk Tests (6MWT) categorized as non-ambulatory, household ambulator (0.01-0. Read More

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Centrally sensitized patients undergoing total knee arthroplasty have higher expectations than do non-centrally sensitized patients.

Knee Surg Sports Traumatol Arthrosc 2021 Apr 10. Epub 2021 Apr 10.

Department of Orthopaedic Surgery, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, 222, Banpo-daero, Seocho-gu, Seoul, 06591, Republic of Korea.

Purpose: The goal of this retrospective observational study is to determine whether patients with and without central sensitization (CS) undergoing total knee arthroplasty (TKA) have similar preoperative expectations. It was hypothesized that the degree of preoperative expectations is higher in patients with CS than in those without.

Methods: The data of 324 patients who underwent primary unilateral TKA for knee osteoarthritis were reviewed and CS was measured using the Central Sensitization Inventory (CSI), which is a validated self-reported questionnaire consisting of a total of 25 questions. Read More

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Appetite and Energy Intake Regulation in Response to Acute Exercise.

Med Sci Sports Exerc 2021 Apr 7. Epub 2021 Apr 7.

Division of Endocrinology, Metabolism, and Diabetes, Department of Medicine, University of Colorado, Anschutz Medical Campus, Aurora, CO Department of Health and Kinesiology, College of Health, University of Utah, Salt Lake City, UT Anschutz Health & Wellness Center at the University of Colorado, Anschutz Medical Campus, Aurora, CO Division of General Internal Medicine, Department of Internal Medicine, University of Utah, Salt Lake City, UT Division of Geriatric Medicine, Department of Medicine, University of Colorado, Anschutz Medical Campus, Aurora, CO Rocky Mountain Regional Veterans Administration, Aurora, CO.

Purpose: To determine if energy intake and appetite regulation differ in response to an acute bout of resistance exercise (REx) vs aerobic exercise (AEx).

Methods: Physically inactive adults (n=24, 35±2% body fat, 50% female) completed 3 conditions: AEx (walking at 65-70% heart rate max for 45 minutes); REx (1-set to failure of 12 exercises); and sedentary control (SED). Each condition was initiated in the post-prandial state (35 minutes post breakfast). Read More

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Evaluation of the labrum on postoperative magnetic resonance images: a predictor of acetabular development in developmental dysplasia of the hip.

Hip Int 2021 Apr 8:11207000211004917. Epub 2021 Apr 8.

Department of Orthopaedic Surgery, Okayama University, Okayama, Japan.

Introduction: Residual acetabular dysplasia of the hip after open reduction can complicate the treatment of developmental dysplasia of the hip (DDH) due to the potential need for corrective surgery. This retrospective study aimed to determine the predictive factors for acetabular development using postoperative radiographs and magnetic resonance imaging (MRI).

Methods: We retrospectively investigated 74 hips of patients with DDH who underwent open reduction after reaching walking age and were followed up radiologically until skeletal maturity. Read More

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Effect of Low-Intensity vs High-Intensity Home-Based Walking Exercise on Walk Distance in Patients With Peripheral Artery Disease: The LITE Randomized Clinical Trial.

JAMA 2021 04;325(13):1266-1276

Wake Forest University, Winston-Salem, North Carolina.

Importance: Supervised high-intensity walking exercise that induces ischemic leg symptoms is the first-line therapy for people with lower-extremity peripheral artery disease (PAD), but adherence is poor.

Objective: To determine whether low-intensity home-based walking exercise at a comfortable pace significantly improves walking ability in people with PAD vs high-intensity home-based walking exercise that induces ischemic leg symptoms and vs a nonexercise control.

Design, Setting, And Participants: Multicenter randomized clinical trial conducted at 4 US centers and including 305 participants. Read More

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Differences in Physical Activity During Walking and Two Pokémon Go Playing Styles.

Games Health J 2021 Apr;10(2):130-138

Department of Health Sciences and Outdoor Studies, Maryville College, Maryville, Tennessee, USA.

Two self-selected playing styles of Pokémon Go (PG) have been observed: intermittent and continuous. However, it is unknown how playing style impacts volume and pattern of physical activity (PA) compared with a traditional walking bout. Twenty experienced PG players followed a 1. Read More

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Social Anxiety and Obsessive-Compulsive Disorder Are Common Among Persons With Multiple Sclerosis at King Abdulaziz Medical City, Riyadh.

Cureus 2021 Feb 28;13(2):e13619. Epub 2021 Feb 28.

Neurology, Oakland University William Beaumont School of Medicine, Royal Oak, USA.

Background Multiple sclerosis (MS) is associated with a physical disability and disturbed psychosocial functioning in young people. Many psychological and psychiatric comorbidities have been reported in MS. Objective To determine the frequency of social anxiety disorder (SAD) and obsessive-compulsive disorder (OCD) among MS patients and their relation to MS severity. Read More

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February 2021

The influence of physiologic and atmospheric variables on spasticity after spinal cord injury.

NeuroRehabilitation 2021 Mar 29. Epub 2021 Mar 29.

Spinal Cord Injury Research Laboratory, Crawford Research Institute, Shepherd Center, Atlanta, GA, USA.

Background: A number of physiological and atmospheric variables are believed to increase spasticity in persons with spinal cord injury (SCI) based on self-reported measures, however, there is limited objective evidence about the influence of these variables on spasticity.

Objective: We investigated the relationship between physiological/ atmospheric variables and level of spasticity in individuals with SCI.

Methods: In 53 participants with motor-incomplete SCI, we assessed the influence of age, time since injury, sex, injury severity, neurological level of injury, ability to walk, antispasmodic medication use, temperature, humidity, and barometric pressure on quadriceps spasticity. Read More

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Middle-age people with multiple sclerosis demonstrate similar mobility characteristics to neurotypical older adults.

Mult Scler Relat Disord 2021 Mar 25;51:102924. Epub 2021 Mar 25.

Department of Health & Exercise Science, Colorado State University, Fort Collins, Colorado, USA; Molecular, Cellular, and Integrative Neuroscience Program, Colorado State University, Fort Collins, Colorado, USA.

Background: Clinical trials often report significant mobility differences between neurotypical and atypical groups, however, these analyses often do not determine which measures are capable of discriminating between groups. Additionally, indirect evidence supports the notion that some mobility impaired populations demonstrate similar mobility deficits. Thus, the current study aimed to provide a comprehensive analysis of three distinct aspects of mobility (walking, turning, and balance) to determine which variables were significantly different and were also able to discriminate between neurotypical older adults (OA) and middle-aged people with multiple sclerosis (PwMS), and between middle-aged neurotypical adults and PwMS. Read More

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Externally validated model predicting gait independence after stroke showed fair performance and improved after updating.

J Clin Epidemiol 2021 Mar 31. Epub 2021 Mar 31.

University of Technology Sydney, Graduate School of Health, Discipline of Physiotherapy, Sydney, Australia. Electronic address:

Objective: To externally validate recent prognostic models that predict independent gait following stroke.

Study Design And Setting: A systematic search identified recent models (<10 years) that predicted independent gait in adult stroke patients, using easily obtainable predictors. Predictors from the original models were assigned proxies when required, and model performance was evaluated in the validation cohort (n=957). Read More

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A Phase II study of autologous mesenchymal stromal cells and c-kit positive cardiac cells, alone or in combination, in patients with ischaemic heart failure: the CCTRN CONCERT-HF trial.

Eur J Heart Fail 2021 Apr 3. Epub 2021 Apr 3.

University of Kansas, School of Medicine, Kansas City, KS, USA.

Aims: CONCERT-HF is an NHLBI-sponsored, double-blind, placebo-controlled, Phase II trial designed to determine whether treatment with autologous bone marrow-derived mesenchymal stromal cells (MSCs) and c-kit positive cardiac cells (CPCs), given alone or in combination, is feasible, safe, and beneficial in patients with heart failure (HF) caused by ischaemic cardiomyopathy.

Methods And Results: Patients were randomized (1:1:1:1) to transendocardial injection of MSCs combined with CPCs, MSCs alone, CPCs alone, or placebo, and followed for 12 months. Seven centres enrolled 125 participants with left ventricular ejection fraction of 28. Read More

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Effect of Tai Chi on Markers of Oxidative Stress: Systematic Review and Meta-Analysis.

Int J Environ Res Public Health 2021 Mar 26;18(7). Epub 2021 Mar 26.

Research Unit on Gerontology, Facultad de Estudios Superiores Zaragoza, Universidad Nacional Autónoma de México, Ciudad de México P.C. 09230, Mexico.

Background: This study aimed to synthesize the evidence of the effect of practicing Tai Chi on oxidative stress markers (OxSM).

Methods: This systematic review and meta-analysis was conducting using the MEDLINE, Cochrane Library, ScienceDirect, Scopus, Epistemonikos, Lilacs, and Ovid databases to identify randomized (RCT) and non-randomized (NRCT) clinical trials that evaluated the Tai Chi effect on OxSM compared to sedentary behavior, walking or yoga. Pooled mean differences (MDs) with 95% confidence intervals (95%CI) were estimated using the inverse variance method to determine the effect of Tai Chi on OxSM. Read More

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Quantifying Step Count and Oxygen Consumption with Portable Technology during the 2-Min Walk Test in People with Lower Limb Amputation.

Sensors (Basel) 2021 Mar 16;21(6). Epub 2021 Mar 16.

Sirindhorn School of Prosthetics and Orthotics, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok 10700, Thailand.

Step counts and oxygen consumption have yet to be reported during the 2-min walk test (2MWT) test in persons with lower-limb amputations (LLA). The purpose of this study was to determine step counts and oxygen consumption during the 2MWT in LLA. Thirty-five men and women walked for two minutes as quickly as possible while wearing activity monitors (ActiGraph Link on the wrist (LW) and ankle (LA), Garmin vivofit3 on the wrist (VW) and ankle (VA), and a modus StepWatch on the ankle (SA), and a portable oxygen analyzer. Read More

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Psychosocial and Social Environmental Factors as Moderators in the Relation between the Objective Environment and Older Adults' Active Transport.

Int J Environ Res Public Health 2021 Mar 5;18(5). Epub 2021 Mar 5.

Department of Movement and Sport Sciences, Faculty of Medicine and Health Sciences, Ghent University, Watersportlaan 2, B-9000 Ghent, Belgium.

In order to develop tailored interventions aiming to encourage active transport among older adults, it is important to gain insights into the modifiable moderators affecting active transport behavior considering the neighborhood in which one lives. Therefore, this study aimed to determine which objective physical environmental factors have an impact on the active transport behavior of Belgian older adults (≥65 years old) and which psychosocial and social environmental moderators influence those relationships. Data from 503 independent living older adults who participated the Belgian Environmental Physical Activity Study in Seniors were included. Read More

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