423 results match your criteria vzv vasculopathy


Ischemic Cerebellar Stroke in a 4-Year-Old Boy After Chickenpox: An Atypical Vascular Involvement.

J Stroke Cerebrovasc Dis 2021 Apr 1;30(6):105719. Epub 2021 Apr 1.

Child Development Centre, Pediatric Hospital, Centro Hospitalar e Universitário de Coimbra, Coimbra, Portugal. Electronic address:

Cerebrovascular events in pediatric population are very rare. Up to 30% may result from varicella zoster (VZV) arteriopathy, usually as a delayed complication of varicella primary infection. The most typical pattern includes involvement of anterior brain circulation arteries, probably by VZV migration from the trigeminal ganglia. Read More

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Chronic Headache and Cerebral Venous Sinus Thrombosis Due to Varicella Zoster Virus Infection: A Case Report and Review of the Literature.

Am J Case Rep 2021 Mar 17;22:e927699. Epub 2021 Mar 17.

Department of Medicine, Hamad General Hospital, Doha, Qatar.

BACKGROUND Varicella zoster virus (VZV) infection causes 2 clinically distinct forms of the disease: varicella (chickenpox) and herpes zoster (shingles). Primary VZV infection results in the diffuse vesicular rash of varicella, or chickenpox. Endogenous reactivation of latent VZV typically results in a localized skin infection known as herpes zoster, or shingles. Read More

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Detection of varicella zoster virus antigen and DNA in two cases of cerebral amyloid angiopathy.

J Neurol Sci 2021 Mar 9;422:117315. Epub 2021 Jan 9.

Department of Neurology, University of Colorado School of Medicine, Aurora, CO 80045, United States; Department of Ophthalmology, University of Colorado School of Medicine, Aurora, CO 80045, United States. Electronic address:

Objective: Varicella zoster virus (VZV) vasculopathy and cerebral amyloid angiopathy (CAA) have similar clinical presentations: both affect cerebrovasculature in the elderly, produce hemorrhage, and can have a protracted course of cognitive decline and other neurological deficits. The cause of CAA is unknown, but amyloid-beta (Aβ) is found within arterial walls. Recent studies show that VZV induces Aβ and amylin expression and an amyloid-promoting environment. Read More

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Acute Stroke Caused by Progressive Intracranial Artery Stenosis due to Varicella Zoster Virus Vasculopathy After Chemotherapy for Malignant Lymphoma.

Intern Med 2020 Dec 29. Epub 2020 Dec 29.

Department of Stroke and Cerebrovascular Medicine, Kyorin University Faculty of Medicine, Japan.

Decreased cell-mediated immunity can reactivate Varicella zoster virus (VZV), which can lead to various neurological complications, including vasculopathy. We herein report the case of a patient with acute stroke with progressive internal carotid artery stenosis due to VZV vasculopathy after chemotherapy for malignant lymphoma. Treatment for VZV vasculopathy improved the stenosis and prevented recurrent stroke. Read More

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December 2020

[Multiple cerebral hemorrhages due to varicella-zoster virus vasculopathy presenting as cranial nerve palsy].

Rinsho Shinkeigaku 2020 Dec 20;60(12):861-864. Epub 2020 Nov 20.

Department of Neurology, Hiroshima Red Cross Hospital & Atomic-bomb Survivors Hospital.

A 72-year-old man was admitted to our hospital because of right facial muscle weakness and diplopia. He had been treated for aplastic anemia with cyclosporin for 2 years. Thirteen days before admission, a diagnosis of herpes zoster was made and treated with amenamevir. Read More

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December 2020

Varicella Zoster Virus Meningoencephalitis With an Atypical Presentation of Chest Pain, Impaired Memory, and Seizure.

J Emerg Med 2020 Nov 21;59(5):e175-e178. Epub 2020 Sep 21.

Department of Emergency Medicine, Western Michigan University Homer Stryker M.D. School of Medicine, Kalamazoo, Michigan.

Background: Neurologic complications of varicella zoster virus (VZV) reactivation can be associated with considerable mortality and morbidity. Aseptic meningitis associated with VZV infection is rare, occurring in 0.5% of immunocompetent individuals. Read More

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November 2020

[Systemic varicella-zoster infection during ixazomib-containing multiagent chemotherapy for multiple myeloma].

Rinsho Ketsueki 2020 ;61(8):870-873

Division of Hematology, Department of Medicine, Keio University School of Medicine.

A 58-year-old man received high-dose melphalan with autologous peripheral blood stem cell transplantation for multiple myeloma in stringent complete response (sCR). Relapse occurred 4 years after the transplantation, and he was placed on ixazomib, lenalidomide, and dexamethasone (IRd) and achieved sCR. On the 10th day of the 10th course of IRd, he developed fever followed by generalized skin eruption with vesicles, headache, and dizziness. Read More

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October 2020

Primary and Acquired Immunodeficiencies Associated with Severe Varicella-Zoster Infections.

Clin Infect Dis 2020 Aug 28. Epub 2020 Aug 28.

Laboratory of Infectious Diseases, National Institutes of Health, Bethesda, Maryland.

Background: While most cases of varicella or zoster are self-limited, patients with certain immune deficiencies may develop severe or life-threatening disease.

Methods: We studied a patient with varicella-zoster virus (VZV) CNS vasculopathy and as part of the evaluation, tested his plasma for antibodies to cytokines. We reviewed the literature for cases of varicella or zoster associated with primary and acquired immunodeficiencies. Read More

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Amylin, Aβ42, and Amyloid in Varicella Zoster Virus Vasculopathy Cerebrospinal Fluid and Infected Vascular Cells.

J Infect Dis 2021 Apr;223(7):1284-1294

Department of Neurology, University of Colorado School of Medicine, Aurora, Colorado, USA.

Background: Varicella zoster virus (VZV) vasculopathy is characterized by persistent arterial inflammation leading to stroke. Studies show that VZV induces amyloid formation that may aggravate vasculitis. Thus, we determined if VZV central nervous system infection produces amyloid. Read More

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Meningoradiculitis due to varicella zoster virus reactivation in a patient treated with ixekizumab.

Ann Dermatol Venereol 2020 Oct 30;147(10):667-671. Epub 2020 Jun 30.

Dermatology department, Jean-Bernard hospital, Valenciennes, France.

Introduction: Ixekizumab is a recently developed biopharmaceutical used since 2016 in the US and Europe for the treatment of plaque psoriasis. Few adverse effects have been reported in the literature and ixekizumab is not known to increase the risk of viral reactivation. Herein we report the case of an immunocompetent female patient treated with ixekizumab who presented meningoradiculitis due to varicella zoster virus (VZV) reactivation. Read More

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October 2020

Polyneuritis cranialis and vasculopathy caused by varicella zoster virus without rash.

Acta Neurol Belg 2020 Aug 10;120(4):1029-1032. Epub 2020 Jun 10.

Al-Assad University Hospital of Damascus, Damascus, Syria.

The neurological disorders caused by Varicella Zoster Virus (VZV) in the absence of skin rash are a challenge to the clinician. The presentation varies from acute to subacute to chronic. Reactivation of VZV usually produces zoster (shingles), meningitis or meningoencephalitis, cerebellitis, isolated or multiple cranial nerve palsies (polyneuritis cranialis), myelitis, and vasculopathy. Read More

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Determinants of neurological syndromes caused by varicella zoster virus (VZV).

J Neurovirol 2020 08 3;26(4):482-495. Epub 2020 Jun 3.

Departments of Infectious Diseases and Clinical Medicine, Aarhus University Hospital, Aarhus, Denmark.

Varicella zoster virus (VZV) is a pathogenic human herpes virus which causes varicella as a primary infection, following which it becomes latent in peripheral autonomic, sensory, and cranial nerve ganglionic neurons from where it may reactivate after decades to cause herpes zoster. VZV reactivation may also cause a wide spectrum of neurological syndromes, in particular, acute encephalitis and vasculopathy. While there is potentially a large number of coding viral mutations that might predispose certain individuals to VZV infections, in practice, a variety of host factors are the main determinants of VZV infection, both disseminated and specifically affecting the nervous system. Read More

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Central nervous system infections produced by varicella zoster virus.

Curr Opin Infect Dis 2020 06;33(3):273-278

Department of Neurology.

Purpose Of Review: Varicella zoster virus (VZV) causes varicella, establishes latency, then reactivates to produce herpes zoster. VZV reactivation can also cause central nervous system (CNS) disease with or without rash. Herein, we review these CNS diseases, pathogenesis, diagnosis, and treatment. Read More

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Cutaneous Vasculitis and Central Nervous System Infarctions due to Varicella Zoster Virus Vasculopathy in an Immunocompromised Patient.

Case Rep Transplant 2020 6;2020:5049627. Epub 2020 Apr 6.

Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX, USA.

Varicella zoster virus (VZV) infection commonly presents as varicella during childhood, and zoster, later in life. Here, we present a rare and interesting case of VZV infection that manifested with both cerebral and spinal infarctions and cutaneous vasculitis in the absence of a classic vesicular rash in an immunocompromised patient. Read More

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[An autopsied case of severe varicella zoster virus-associated encephalomyelitis under immunosuppressant therapy].

Rinsho Shinkeigaku 2020 May 18;60(5):351-357. Epub 2020 Apr 18.

Department of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University.

The patient was a 40-year-old woman who was previously diagnosed with systemic lupus erythematosus and myasthenia gravis and had received prednisolone and tacrolimus for more than 7 years. In February 2017, she noticed pain in her lower back and weakness of the lower limbs, and was referred to our hospital on day 5. She had shingles in the right lower thoracic dermatomes and Brown-Séquard syndrome with right-sided dominant weakness in her lower limbs and left-sided superficial sensory disturbance below the L1 level. Read More

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Zoster Sine Herpete Masquerading as Central Nervous System Vasculitis.

Cureus 2020 Mar 10;12(3):e7231. Epub 2020 Mar 10.

Rheumatology, Einstein Medical Center, Philadelphia, USA.

Central nervous system (CNS) vasculopathy caused by varicella zoster virus (VZV) is a rare condition. Rarer still is the development of CNS vasculopathy in the absence of a typical zoster rash, a phenomenon known as zoster sine herpete. We report a case of a 34-year-old male with HIV, non-compliant with highly active antiretroviral therapy (HAART), who presented with left-sided temporal headaches and numbness without rash. Read More

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Anti-varicella Zoster Virus IgG and hsCRP Levels Correlate with Progression of Coronary Artery Atherosclerosis.

Iran J Allergy Asthma Immunol 2019 Oct 23;18(5):543-553. Epub 2019 Oct 23.

Department of Immunology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.

The relationship between high levels of anti-Varicella Zoster Virus (VZV) IgG in cerebrospinal fluid (CSF) and cerebrovascular atherosclerosis commends a possible similar association in other vessels. We aimed to investigate the association of VZV-seropositivity with coronary artery atherosclerosis. We recruited 88 newly diagnosed patients with more than 50% stenosis in at least one of the main coronary arteries. Read More

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October 2019

An Autopsy Case of Varicella Zoster Virus Encephalitis with Multiple Brain Lesions.

Intern Med 2020 Jul 2;59(13):1643-1647. Epub 2020 Apr 2.

Department of Neurology, International University of Health and Welfare Hospital, Japan.

Varicella-zoster virus (VZV) encephalitis in the absence of vasculopathy may rarely occur in association with herpes zoster. We herein report the case of a 67-year-old woman with non-Hodgkin's lymphoma undergoing chemotherapy who presented with an acute alteration in consciousness. Magnetic resonance imaging of the brain revealed multiple and nonspecific lesions of hyperintensity with mild edema in the cortex and subcortex. Read More

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Focal Cerebral Arteriopathy in Young Adult Patients With Stroke.

Stroke 2020 05 26;51(5):1596-1599. Epub 2020 Mar 26.

From the Department of Neurology (M.C.M., S.C.), Cork University Hospital, Ireland.

Background and Purpose- Focal cerebral arteriopathy is monophasic inflammatory stenosis of the distal internal carotid artery or the proximal segment of the middle cerebral artery. It is one of the most common causes of acute arterial ischemic stroke in young children but is a less familiar entity for adult neurologists. Methods- We retrospectively reviewed stroke service radiology records at a tertiary referral center from January 2013 to December 2014. Read More

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Acute Herpes Zoster Followed by Cerebral Venous Sinus Thrombosis.

Neurol India 2020 Jan-Feb;68(1):219-221

Department of Neurology, The Second Affiliated Hospital of Anhui Medical University, Hefei, Anhui, People's Republic of China.

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December 2020

Atypical vasculopathic varicella-zoster infection mimicking cutaneous small-vessel vasculitis.

Int J Dermatol 2020 Jun 12;59(6):e214-e216. Epub 2020 Feb 12.

Department of Dermatology, Hospital Clínico Universitario "Lozano Blesa", Zaragoza, Spain.

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Behçet's Disease with Severe Autonomic Disorders Developing after Herpes Zoster.

Intern Med 2020 Apr 1;59(8):1099-1104. Epub 2020 Feb 1.

Department of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences, Japan.

A 58-year-old Japanese woman with herpes zoster developed Behçet's disease (BD) with symptoms including orthostatic intolerance as an autonomic disorder. Multiple immune-suppressive therapies and a β-blocker successfully controlled both the disease activity of BD and the autonomic disorders. A cytokine multiplex analysis of her serum revealed the elevation of proinflammatory cytokines [interleukin (IL)-1, IL-6, IL-12, tumor necrosis factor alfa (TNFα), and interferon gamma (IFN-γ)] and a low IL-10 concentration. Read More

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Disseminated cutaneous herpes zoster and multiple cerebral infarcts in an adult with diabetes mellitus.

J Neurovirol 2020 02 15;26(1):130-132. Epub 2020 Jan 15.

Department of Neurology, Shuang Ho Hospital, Taipei Medical University, No. 291, Zhongzheng Rd., Zhonghe District, New Taipei City, 23561, Taiwan.

Ischemic stroke is a rare complication of varicella-zoster virus (VZV) infection. We present the case of a patient with a medical history of type 2 diabetes mellitus (DM) who experienced disseminated cutaneous VZV infection followed by multiple cerebral infarcts associated with VZV vasculopathy. Brain magnetic resonance imaging revealed multiple hyperintense lesions over the bilateral deep white matter and basal ganglia. Read More

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February 2020

Microparticle-mediated VZV propagation and endothelial activation: Mechanism of VZV vasculopathy.

Neurology 2020 02 31;94(5):e474-e480. Epub 2019 Dec 31.

From the Infection, Immunology and Rheumatology Section (D.E., E.M., Y.H., C.V., J.B., N.K., P.B.) and Clinical Neurosciences (V.G.), University College London GOS Institute of Child Health; Arthritis Research UK Centre for Adolescent Rheumatology (D.E.); and Department of Cell and Developmental Biology (M.T.), University College London, UK.

Objective: Varicella zoster virus (VZV) can spread anterogradely and infect cerebral arteries causing VZV vasculopathy and arterial ischemic stroke. In this study, we tested the hypothesis that virus-infected cerebrovascular fibroblasts undergo phenotypic changes that promote vascular remodeling and facilitate virus transmission in an in vitro model of VZV vasculopathy. The aims of this project were therefore to examine the changes that virus-infected human brain adventitial vascular fibroblasts (HBVAFs) undergo in an in vitro model of VZV vasculopathy and to identify disease biomarkers relating to VZV-related vasculopathy. Read More

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February 2020

The darker side of varicella zoster infection: Arterial ischemic stroke.

Neurology 2020 02 31;94(5):193-194. Epub 2019 Dec 31.

From the Department of Neurology (S.P.), SUNY Downstate, Brooklyn; and Center for Neurotherapeutics Discovery (H.A.G.), University of Rochester Medical Center, NY.

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February 2020

Assessment for varicella zoster virus in patients newly suspected of having giant cell arteritis.

Rheumatology (Oxford) 2020 08;59(8):1992-1996

Northern Clinical School, University of Sydney, St Leonards, Sydney, New South Wales, Australia.

Objectives: There is uncertainty if varicella zoster virus (VZV) triggers GCA. This is based on discordant reports of VZV detection in GCA temporal artery biopsies. We conducted a multimodal evaluation for VZV in the inception Giant Cell Arteritis and PET Scan (GAPS) cohort. Read More

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Cerebral Venous Thrombosis and Acute Pulmonary Embolism following Varicella Infection.

Eur J Case Rep Intern Med 2019 20;6(10):001171. Epub 2019 Sep 20.

Department of Cardiology, Belhoul Speciality Hospital, Dubai, UAE.

Varicella infection is caused by varicella-zoster virus (VZV) and commonly presents as a self-limiting skin manifestation in children. VZV also causes cerebral arterial vasculopathy and antibody-mediated hypercoagulable states leading to thrombotic complications in children, although there are very few such reports in adults. Postulated causal factors include vasculitis, direct endothelial damage, or acquired protein S deficiency secondary to molecular mimicry. Read More

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September 2019

HIV vasculopathy versus VZV vasculitis in an HIV patient with multiple brain ischaemic infarcts.

BMJ Case Rep 2019 Jul 16;12(7). Epub 2019 Jul 16.

Lyerly Neurosurgery, Baptist Neurological Institute, Jacksonville, Florida, USA.

We report the case of a 56-year-old man who presented to the emergency department with a 3-day onset of left limb weakness and feeling intoxicated with poor balance. Stroke hospitalisations in the USA decreased from 2000 to 2010, however the number of hospitalised patients with ischaemic stroke and HIV infection has increased significantly. Herein, we discuss the management of this unique case to highlight the importance of a broad differential diagnosis when approaching HIV/AIDS patients presenting with acute or subacute neurological focalisation. Read More

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Varicella-zoster virus vasculopathy in a multiple sclerosis patient on fingolimod.

J Neurol Sci 2019 Aug 26;403:119-121. Epub 2019 Jun 26.

Division of Neurology, Department of Medicine, Centre Hospitalier de l'Université de Montréal (CHUM), University of Montreal, Montreal, Québec, Canada.

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Cerebrovascular events after herpes zoster infection: a risk that should be not underestimated.

J Neurovirol 2019 08 8;25(4):439-447. Epub 2019 May 8.

Division of Neurology, Stroke Center, SacroCuore-Don Calabria Hospital, Negrar, Italy.

The occurrence of a cerebrovascular event after a herpes zoster (HZ) infection represents a nightmare in clinical practice, especially in those patients with concomitant cardiovascular comorbidities/risk factors and disease related per se to a higher risk of zoster infection. Moreover, the absence of a consensus opinion regarding a specific and adequate prevention of cerebrovascular events in these patients further complicates the treatment. Accumulating evidences demonstrated that HZ and HZ ophtalmicus (HZO) increase the risk of cerebrovascular events in the short-and long-term periods. Read More

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