118 results match your criteria vss derived


Simultaneous recovery of phosphorus and alginate-like exopolysaccharides from two types of aerobic granular sludge.

Bioresour Technol 2021 Nov 25:126411. Epub 2021 Nov 25.

Department of Chemical Engineering, National Taiwan University, Taipei 106, Taiwan; Department of Mechanical Engineering, City University of Hong Kong, Kowloon Tang, Hong Kong.

Wastewater treatment plants are expected to realize not only pollutants removal from wastewater but also resources recovery such as phosphorus (P) and alginate-like exopolysaccharides (ALE) from the produced sludge. In this study, ALE extraction and fractionation from the same activated sludge-derived bacterial aerobic granular sludge (AGS) and algal-bacterial AGS were performed in addition to P fate examination during ALE recovery. Results showed that the ALE content recovered from algal-bacterial AGS was 8. Read More

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November 2021

Single-Examination Risk Prediction of Severe Retinopathy of Prematurity.

Pediatrics 2021 Dec;148(6)

Departments of Ophthalmology.

Background And Objectives: Retinopathy of prematurity (ROP) is a leading cause of childhood blindness. Screening and treatment reduces this risk, but requires multiple examinations of infants, most of whom will not develop severe disease. Previous work has suggested that artificial intelligence may be able to detect incident severe disease (treatment-requiring retinopathy of prematurity [TR-ROP]) before clinical diagnosis. Read More

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December 2021

Lifetime Cost and Quality-Adjusted Life-Years Across Management Options for Small- and Medium-Sized Sporadic Vestibular Schwannoma.

Otol Neurotol 2021 10;42(9):e1369-e1375

Department of Otolaryngology-Head and Neck Surgery.

Objective: Despite the growing emphasis on healthcare costs, limited data address this aspect of care within the vestibular schwannoma (VS) literature. We sought to determine which strategy confers the lowest lifetime cost and greatest quality-adjusted life-years (QALYs) for patients with small- to medium-sized sporadic VS tumors.

Study Design: A Markov model was created to determine the most cost-effective management algorithm. Read More

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October 2021

Losartan prevents tumor-induced hearing loss and augments radiation efficacy in NF2 schwannoma rodent models.

Sci Transl Med 2021 07;13(602)

Edwin L. Steele Laboratories, Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.

Hearing loss is one of the most common symptoms of neurofibromatosis type 2 (NF2) caused by vestibular schwannomas (VSs). Fibrosis in the VS tumor microenvironment (TME) is associated with hearing loss in patients with NF2. We hypothesized that reducing the fibrosis using losartan, an FDA-approved antihypertensive drug that blocks fibrotic and inflammatory signaling, could improve hearing. Read More

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Role of Catalyst in Optimizing Fluid Catalytic Cracking Performance During Cracking of H-Oil-Derived Gas Oils.

ACS Omega 2021 Mar 12;6(11):7626-7637. Epub 2021 Mar 12.

University Prof. Dr. Assen Zlatarov, Professor Yakimov 1, 8010 Burgas, Bulgaria.

Three H-Oil gas oils, heavy atmospheric gas oil (HAGO), light vacuum gas oil (LVGO), heavy vacuum gas oil (HVGO), and two their blends with hydrotreated straight run vacuum gas oils (HTSRVGOs) were cracked on two high unit cell size (UCS) lower porosity commercial catalysts and two low UCS higher porosity commercial catalysts. The cracking experiments were performed in an advanced cracking evaluation fluid catalytic cracking (FCC) laboratory unit at 527 °C, 30 s catalyst time on stream, and catalyst-to-oil (CTO) variation between 3.5 and 7. Read More

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Improving the "second generation Daugirdas equation" to estimate Kt/V on the once-weekly haemodialysis schedule.

J Nephrol 2021 06 30;34(3):907-912. Epub 2021 Jan 30.

Division of Nephrology, Miulli General Hospital, Strada Provinciale Santeramo, 70121, Acquaviva delle Fonti, Puglia, Italy.

Introduction: The haemodialysis (HD) dose, as expressed by Kt/V urea, is currently routinely estimated with the second generation Daugirdas (D2) equation (Daugirdas in J Am Soc Nephrol 4:1205-1213, 1993). This equation, initially devised for a thrice-weekly schedule, was modified to be used for all dialysis schedules (Daugirdas et al. in Nephrol Dial Transplant 28:2156-2160, 2013), by adopting a variable factor that adjusts for the urea generation (GFAC) over the preceding inter-dialysis interval (PIDI, days). Read More

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Disrupted connectivity within visual, attentional and salience networks in the visual snow syndrome.

Hum Brain Mapp 2021 05 15;42(7):2032-2044. Epub 2021 Jan 15.

Headache Group, Department of Basic and Clinical Neuroscience, King's College London, London, United Kingdom.

Here we investigate brain functional connectivity in patients with visual snow syndrome (VSS). Our main objective was to understand more about the underlying pathophysiology of this neurological syndrome. Twenty-four patients with VSS and an equal number of gender and age-matched healthy volunteers attended MRI sessions in which whole-brain maps of functional connectivity were acquired under two conditions: at rest while watching a blank screen and during a visual paradigm consisting of a visual-snow like stimulus. Read More

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Insights into pathophysiology and treatment of visual snow syndrome: A systematic review.

Prog Brain Res 2020 15;255:311-326. Epub 2020 Jun 15.

Department of Neurology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland. Electronic address:

Background: Visual snow syndrome is a debilitating disorder characterized by tiny flickering dots (like TV static) in the entire visual field and a set of accompanying visual (palinopsia, enhanced entoptic phenomena, photophobia, nyctalopia), nonvisual (e.g. tinnitus) and nonperceptional (e. Read More

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Autologous mesenchymal stem cells application in post-burn scars treatment: a preliminary study.

Cell Tissue Bank 2021 Mar 30;22(1):39-46. Epub 2020 Aug 30.

Department of Burns and Reconstructive Surgery, Faculty of Medicine, Comenius University, University Hospital, Pazitkova 4, 821 01, Bratislava, Slovakia.

Mesenchymal stem cells (MSCs) are multi-potent cells characterized by long term self-renewal and by potential for differentiation into cells of different mesenchymal tissue types such as fibroblasts, osteocytes, chondrocytes, and adipocytes. Their unique properties offer broad therapeutic potentials. Bone marrow has been used as the most common MSCs source, but it is gradually going to be replaced by adipose tissue which showed to contain more MSCs per unit than the bone marrow and clinical application of MSCs procured from the adipose tissue have been demonstrating at least similar results. Read More

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Ligand and Structure-based Virtual Screening of Lamiaceae Diterpenes with Potential Activity against a Novel Coronavirus (2019-nCoV).

Curr Top Med Chem 2020 ;20(24):2126-2145

Laboratory of Cheminformatics, Program of Natural and Synthetic Bioactive Products (PgPNSB), Health Sciences Center, Federal University of Paraiba, Joao Pessoa-PB, Brazil.

Background: The emergence of a new coronavirus (CoV), named 2019-nCoV, as an outbreak originated in the city of Wuhan, China, has resulted in the death of more than 3,400 people this year alone and has caused worldwide an alarming situation, particularly following previous CoV epidemics, including the Severe Acute Respiratory Syndrome (SARS) in 2003 and the Middle East Respiratory Syndrome (MERS) in 2012. Currently, no exists for infections caused by CoVs; however, some natural products may represent potential treatment resources, such as those that contain diterpenes.

Objective: This study aimed to use computational methods to perform a virtual screening (VS) of candidate diterpenes with the potential to act as CoV inhibitors. Read More

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November 2020

The microenvironment in sporadic and neurofibromatosis type II-related vestibular schwannoma: the same tumor or different? A comparative imaging and neuropathology study.

J Neurosurg 2020 May 29;134(5):1419-1429. Epub 2020 May 29.

1Department of Neurosurgery, Manchester Centre for Clinical Neurosciences, Salford Royal NHS Foundation Trust, Manchester Academic Health Science Centre.

Objective: Inflammation and angiogenesis may play a role in the growth of sporadic and neurofibromatosis type 2 (NF2)-related vestibular schwannoma (VS). The similarities in microvascular and inflammatory microenvironment have not been investigated. The authors sought to compare the tumor microenvironment (TME) in sporadic and NF2-related VSs using a combined imaging and tissue analysis approach. Read More

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Combined intralesional triamcinolone acetonide and platelet rich plasma versus intralesional triamcinolone acetonide alone in treatment of keloids.

J Dermatolog Treat 2020 Mar 4:1-7. Epub 2020 Mar 4.

Dermatology and Venereology Department, Faculty of Medicine, Tanta University, Tanta, Egypt.

Keloids are benign fibro-proliferative growths occurring after skin injury or spontaneously. Intralesional triamcinolone acetonide (TA) is their first-line therapy, but commonly associated with side effects or recurrence. Platelet rich plasma (PRP) is an autologous blood-derived product with promising results in improving wound healing with lower keloid occurrence. Read More

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Body Mass Index Best Predicts Recovery of Recombinant Factor VIII in Underweight to Obese Patients with Severe Haemophilia A.

Thromb Haemost 2020 Feb 30;120(2):277-288. Epub 2019 Dec 30.

Novo Nordisk A/S, Søborg, Denmark.

Background:  Factor VIII (FVIII) products are usually dosed according to body weight (BW). This may lead to under- or over-dosing in underweight or obese patients, respectively.

Objective:  This article evaluates the pharmacokinetics (PK) of recombinant FVIII concentrate, particularly recovery, in relation to body mass index (BMI) and other body composition descriptors. Read More

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February 2020

Pharmacokinetic studies of nanoparticles as a delivery system for conventional drugs and herb-derived compounds for cancer therapy: a systematic review.

Int J Nanomedicine 2019 23;14:5659-5677. Epub 2019 Jul 23.

Graduate Studies, Chulabhorn International College of Medicine, Thammasat University, Pathumthani, Thailand.

The poor pharmacokinetic characteristics of most anticancer drugs have limited their clinical effectiveness. The application of nanoparticles as a novel drug delivery system has provided opportunities to tackle the current challenges facing conventional drug delivery systems such as poor pharmacokinetics, lack of specificity to tumor cells, multidrug resistance, and toxicity. This systematic review aims to examine the application of pharmacokinetic studies of nanoparticles loaded in conventional drugs and herb-derived compounds for cancer therapy. Read More

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December 2019

Multicenter, Prospective, Phase II and Biomarker Study of High-Dose Bevacizumab as Induction Therapy in Patients With Neurofibromatosis Type 2 and Progressive Vestibular Schwannoma.

J Clin Oncol 2019 12 18;37(35):3446-3454. Epub 2019 Oct 18.

New York University, New York, NY.

Purpose: Bevacizumab treatment at 7.5 mg/kg every 3 weeks results in improved hearing in approximately 35%-40% of patients with neurofibromatosis type 2 (NF2) and progressive vestibular schwannomas (VSs). However, the optimal dose is unknown. Read More

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December 2019

Growth kinetics of Candidatus 'Methanoperedens nitroreducens' enriched in a laboratory reactor.

Sci Total Environ 2019 Apr 27;659:442-450. Epub 2018 Dec 27.

The University of Queensland, Advanced Water Management Centre, St Lucia, QLD 4072, Australia. Electronic address:

Recently it has been shown that Candidatus 'Methanoperedens nitroreducens', an anaerobic methanotrophic archaea (ANME), can reduce nitrate to nitrite using electrons derived from anaerobic oxidation of methane. In this study, the growth kinetics of 'M. nitroreducens' enriched in a laboratory reactor were studied. Read More

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Validity of Pulmonary Valve -Scores in Predicting Valve-Sparing Tetralogy Repairs-Systematic Review †.

Children (Basel) 2019 May 4;6(5). Epub 2019 May 4.

Division of Pediatric and Congenital Cardiac Surgery, UT-Houston McGovern Medical School, Children's Memorial Hermann Hospital, 6431 Fannin Street, MSB 6.264, Houston, TX 77030, USA.

There is a lack of consensus regarding the preoperative pulmonary valve (PV) -score "cut-off" in tetralogy of Fallot (ToF) patients to attempt a successful valve sparing surgery (VSS). Therefore, the aim of this study was to review the available evidence regarding the association between preoperative PV -score and rate of re-intervention for residual right ventricular outflow tract (RVOT) obstruction, i.e. Read More

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Gas Mixing and Final Mixture Composition Control in Simple Geometry Micro-mixers via DSMC Analysis.

Micromachines (Basel) 2019 Mar 7;10(3). Epub 2019 Mar 7.

Department of Mechanical Engineering, University of Thessaly-Pedion Areos, 38334 Volos, Greece.

The mixing process of two pressure driven steady-state rarefied gas streams flowing between two parallel plates was investigated via DSMC (Direct Simulation Monte Carlo) for different combinations of gases. The distance from the inlet, where the associated relative density difference of each species is minimized and the associated mixture homogeneity is optimized, is the so-called mixing length. In general, gas mixing progressed very rapidly. Read More

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Vector uncoating limits adeno-associated viral vector-mediated transduction of human dendritic cells and vector immunogenicity.

Sci Rep 2019 03 6;9(1):3631. Epub 2019 Mar 6.

Institute of Experimental Hematology, Hannover Medical School, Hannover, Germany.

AAV vectors poorly transduce Dendritic cells (DC), a feature invoked to explain AAV's low immunogenicity. However, the reason for this non-permissiveness remained elusive. Here, we performed an in-depth analysis using human monocyte-derived immature DC (iDC) as model. Read More

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Voluntary sustainability standards could significantly reduce detrimental impacts of global agriculture.

Proc Natl Acad Sci U S A 2019 02 22;116(6):2130-2137. Epub 2019 Jan 22.

Institute on the Environment, University of Minnesota, St. Paul, MN 55108;

Voluntary sustainability standards (VSS) are stakeholder-derived principles with measurable and enforceable criteria to promote sustainable production outcomes. While institutional commitments to use VSS to meet sustainable procurement policies have grown rapidly over the past decade, we still have relatively little understanding of the () direct environmental benefits of large-scale VSS adoption; () potential perverse indirect impacts of adoption; and () implementation pathways. Here, we illustrate and address these knowledge gaps using an ecosystem service modeling and scenario analysis of Bonsucro, the leading VSS for sugarcane. Read More

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February 2019

Preclinical pharmacokinetic evaluation to facilitate repurposing of tyrosine kinase inhibitors nilotinib and imatinib as antiviral agents.

BMC Pharmacol Toxicol 2018 Dec 4;19(1):80. Epub 2018 Dec 4.

James L. Winkle College of Pharmacy, University of Cincinnati, Cincinnati, OH, USA.

Background: Several tyrosine kinase inhibitors (TKIs) developed as anti-cancer drugs, also have anti-viral activity due to their ability to disrupt productive replication and dissemination in infected cells. Consequently, such drugs are attractive candidates for "repurposing" as anti-viral agents. However, clinical evaluation of therapeutics against infectious agents associated with high mortality, but low or infrequent incidence, is often unfeasible. Read More

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December 2018

Development of an Intracranial Dural Arteriovenous Fistula after Venous Sinus Stenting for Idiopathic Intracranial Hypertension.

J Neurointerv Surg 2018 Jul 21;10(7):e15. Epub 2018 Mar 21.

Department of Neurosurgery, University of Virginia, Charlottesville, Virginia, USA.

We report a case in which an intracranial dural arteriovenous fistula (DAVF) developed after endovascular treatment of a patient with idiopathic intracranial hypertension with venous sinus stenting (VSS). The pathogenesis may involve hemodynamic alterations secondary to increased poststenting venous sinus pressure, which may cause new arterial ingrowth into the fistulous sinus wall without capillary interposition. Despite administration of dual antiplatelet therapy, there may also be subclinical cortical vein thrombosis that contributed to DAVF formation. Read More

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Development of biochemical sulfide potential (BSP) test for sulfidogenic biotechnology application.

Water Res 2018 05 9;135:231-240. Epub 2018 Feb 9.

Department of Civil and Environmental Engineering, The Hong Kong University of Science and Technology, Hong Kong, China; Water Technology Center, The Hong Kong University of Science and Technology, Hong Kong, China; Hong Kong Branch of Chinese National Engineering Research Center for Control & Treatment of Heavy Metal Pollution, The Hong Kong University of Science and Technology, Hong Kong, China; Wastewater Treatment Laboratory, FYT Graduate School, The Hong Kong University of Science and Technology, Nansha, Guangzhou, China. Electronic address:

The determination of organics biodegradability and corresponding biodegradation kinetics provides valuable information on the optimal design and operation of anaerobic biotechnology especially for sulfidogenesis. This study proposes a deterministic method, i.e. Read More

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Prediction of Human Pharmacokinetics of Ulixertinib, a Novel ERK1/2 Inhibitor from Mice, Rats, and Dogs Pharmacokinetics.

Eur J Drug Metab Pharmacokinet 2018 Aug;43(4):453-460

Drug Metabolism and Pharmacokinetics, Jubilant Biosys, Industrial Suburb, Yeshwanthpur, Bangalore, 560 022, India.

Background And Objectives: Ulixertinib (BVD-523) is a novel and selective reversible inhibitor of ERK1/ERK2. The primary objectives of the study were to evaluate the pharmacokinetics of ulixertinib in mice, rats, and dogs followed by prediction of human pharmacokinetic profile by allometric equations with/without correction factors.

Methods: Oral and intravenous pharmacokinetic profiles of ulixertinib were generated in mice, rats, and dogs. Read More

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Pharmacokinetics and Scintigraphic Imaging of the Hypoxia-Imaging Agent [I]IAZA in Healthy Adults Following Exercise-Based Cardiac Stress †.

Pharmaceutics 2018 Feb 22;10(1). Epub 2018 Feb 22.

PET Centre, Department of Oncology, University of Alberta, 11560 University Ave, Edmonton, AB T6B 1Z2, Canada.

The objective of this work is to evaluate the potential effect of cardiac stress exercise on the accumulation of [I]IAZA, a radiopharmaceutical used to image focal tissue hypoxia, in otherwise normal myocardium in healthy volunteers, and to determine the impact of exercise on [I]IAZA pharmacokinetics. The underlying goal is to establish a rational basis and a baseline for studies of focal myocardial hypoxia in cardiac patients using [I]IAZA. Three healthy male volunteers ran the 'Bruce' treadmill protocol, a clinically-accepted protocol designed to expose myocardial ischemia in patients. Read More

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February 2018

Targeting the cMET pathway augments radiation response without adverse effect on hearing in NF2 schwannoma models.

Proc Natl Acad Sci U S A 2018 02 9;115(9):E2077-E2084. Epub 2018 Feb 9.

Edwin L. Steele Laboratories, Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114;

Neurofibromatosis type II (NF2) is a disease that needs new solutions. Vestibular schwannoma (VS) growth causes progressive hearing loss, and the standard treatment, including surgery and radiotherapy, can further damage the nerve. There is an urgent need to identify an adjunct therapy that, by enhancing the efficacy of radiation, can help lower the radiation dose and preserve hearing. Read More

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February 2018

Development of an intracranial dural arteriovenous fistula after venous sinus stenting for idiopathic intracranial hypertension.

BMJ Case Rep 2017 Sep 26;2017. Epub 2017 Sep 26.

Department of Neurosurgery, University of Virginia, Charlottesville, Virginia, USA.

We report a case in which an intracranial dural arteriovenous fistula (DAVF) developed after endovascular treatment of a patient with idiopathic intracranial hypertension with venous sinus stenting (VSS). The pathogenesis may involve hemodynamic alterations secondary to increased poststenting venous sinus pressure, which may cause new arterial ingrowth into the fistulous sinus wall without capillary interposition. Despite administration of dual antiplatelet therapy, there may also be subclinical cortical vein thrombosis that contributed to DAVF formation. Read More

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September 2017

HBK-15 protects mice from stress-induced behavioral disturbances and changes in corticosterone, BDNF, and NGF levels.

Behav Brain Res 2017 08 23;333:54-66. Epub 2017 Jun 23.

Chair and Department of Toxicology, Faculty of Pharmacy, Jagiellonian University Medical College, Medyczna 9, 30-688 Krakow, Poland; Jagiellonian Centre for Experimental Therapeutics, Bobrzyńskiego 14, 30-348 Krakow, Poland.

Unlike majority of current antidepressants, HBK-15-a 5-HT and 5-HT receptor antagonist - showed memory-enhancing properties. In this study, we aimed to further characterize pharmacological profile of HBK-15 and investigate its antidepressant- and anxiolytic-like activity in the mouse model of unpredictable chronic mild stress. We used sucrose consumption test, forced swim test and elevated plus maze test as behavioral endpoints. Read More

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Simplified empirical model for phosphorous removal in a facultative wastewater lagoon.

J Environ Manage 2017 Oct 19;201:1-5. Epub 2017 Jun 19.

University of Manitoba, Department of Civil Engineering, Winnipeg, MB, R3T 5V6, Canada. Electronic address:

Nutrient removal in a facultative lagoon in Manitoba, Canada, was monitored from May 2015 to April 2016. According to the 12-month data, phosphorous concentration in the effluent did not meet the regulatory requirement. Various models have been developed to predict nitrogen removal from lagoon through the years; however, not much effort has been deployed to model phosphorous removal from lagoons. Read More

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October 2017

Municipal wastewater biological nutrient removal driven by the fermentation liquid of dairy wastewater.

Environ Technol 2017 Nov 6;38(21):2639-2649. Epub 2017 Jan 6.

b College of Architecture and Urban Planning , Tongji University , Shanghai , People's Republic of China.

Carbon substrate is required by biological nutrient removal (BNR) microorganism, but it is usually insufficient in the influent of many municipal wastewater treatment plants. In this study the use of ethanol-enriched fermentation liquid, which was derived from dairy wastewater, as the preferred carbon substrate of BNR was reported. First, the application of dairy wastewater and food processing wastewater and their fermentation liquid as the carbon substrate of BNR was compared in the short-term tests. Read More

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November 2017