Molecules 2021 Jun 16;26(12). Epub 2021 Jun 16.
Arbuzov Institute of Organic and Physical Chemistry, Federal Research Center "Kazan Scientific Center of Russian Academy of Sciences", Arbuzov 8, 420088 Kazan, Russia.
A series of 1,2,3-triazolyl nucleoside analogues in which 1,2,3-triazol-4-yl-β-d-ribofuranosyl fragments are attached via polymethylene linkers to both nitrogen atoms of the heterocycle moiety (uracil, 6-methyluracil, thymine, quinazoline-2,4-dione, alloxazine) or to the C-5 and -3 atoms of the 6-methyluracil moiety was synthesized. All compounds synthesized were evaluated for antiviral activity against influenza virus A/PR/8/34/(H1N1) and coxsackievirus B3. Antiviral assays revealed three compounds, , , , which showed moderate activity against influenza virus A H1N1 with IC values of 57. Read More