Am J Ther 2021 Jul 16. Epub 2021 Jul 16.
Department of Medical and Surgical Specialties, Faculty of Medicine, Transilvania University of Brasov, Brasov, Romania; Department of Fundamental, Prophylactic and Clinical Disciplines, Faculty of Medicine, Transilvania University of Brasov, Brasov, Romania; Department of Cardiology, Clinical County Emergency Hospital Brasov, Brasov, Romania; and Faculty of Sociology and Communication, Faculty of Economic Sciences and Business Administration, Transilvania University of Brasov, Brasov, Romania.
Background: In coronary artery disease (CAD), reduction of perfusion in coronary arteries is followed by increases of oxidative stress and decreases of adenosine triphosphate reserve. In this condition, trimetazidine (TMZ), a metabolic anti-ischemic agent, seems to be an ideal therapeutic agent because it increases mitochondrial adenosine triphosphate production.
Study Question: To evaluate the impact of TMZ on oxidative stress, inflammation, endothelial dysfunction, and long-term prognosis in CAD. Read More