302 results match your criteria volumes midline

Morphological changes of intervertebral disc in relation with curve severity of patients with Adolescent Idiopathic Scoliosis - a T2-weighted MRI study.

Stud Health Technol Inform 2021 Jun;280:37-39

Department of Imaging and Interventional Radiology, Faculty of Medicine, The Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong SAR, China.

The purpose of this study was to evaluate the morphological changes of intervertebral discs (IVD) and vertebral bodies (VB) in AIS girls according to the subgroups with different curve severity by magnetic resonance imaging (MRI). This study included 33 age-matched female controls and 76 AIS girls with a right-sided thoracic curvature. Wedge angle, height ratio and distance ratio of VB and IVD were measured on the best midline coronal and sagittal planes from reformatted MRI spine. Read More

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Droplet digital PCR-based detection of circulating tumor DNA from pediatric high grade and diffuse midline glioma patients.

Neurooncol Adv 2021 Jan-Dec;3(1):vdab013. Epub 2021 Jan 27.

Division of Molecular Pathology, Institute of Cancer Research, London, UK.

Background: The use of liquid biopsy is of potential high importance for children with high grade (HGG) and diffuse midline gliomas (DMG), particularly where surgical procedures are limited, and invasive biopsy sampling not without risk. To date, however, the evidence that detection of cell-free DNA (cfDNA) or circulating tumor DNA (ctDNA) could provide useful information for these patients has been limited, or contradictory.

Methods: We optimized droplet digital PCR (ddPCR) assays for the detection of common somatic mutations observed in pediatric HGG/DMG, and applied them to liquid biopsies from plasma, serum, cerebrospinal fluid (CSF), and cystic fluid collected from 32 patients. Read More

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January 2021

Association of Lesion Pattern and Dysphagia in Acute Intracerebral Hemorrhage.

Stroke 2021 May 18:STROKEAHA120032615. Epub 2021 May 18.

Department of Neurology, Goethe University, Frankfurt am Main, Germany. (F.H., C.F., A.S., S.L.).

Background And Purpose: Dysphagia is a common and severe symptom of acute stroke. Although intracerebral hemorrhages (ICHs) account for 10% to 15% of all strokes, the occurrence of dysphagia in this subtype of stroke has not been widely investigated. The aim of this study was to evaluate the overall frequency and associated lesion locations and clinical predictors of dysphagia in patients with acute ICH. Read More

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Automated Midline Estimation for Symmetry Analysis of Cerebral Hemispheres in FLAIR MRI.

Front Aging Neurosci 2021 29;13:644137. Epub 2021 Apr 29.

Electrical, Computer and Biomedical Engineering Department, Ryerson University, Toronto, ON, Canada.

To perform brain asymmetry studies in large neuroimaging archives, reliable and automatic detection of the interhemispheric fissure (IF) is needed to first extract the cerebral hemispheres. The detection of the IF is often referred to as mid-sagittal plane estimation, as this plane separates the two cerebral hemispheres. However, traditional planar estimation techniques fail when the IF presents a curvature caused by existing pathology or a natural phenomenon known as brain torque. Read More

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Tumor-associated epilepsy in patients with brain metastases: necrosis-to-tumor ratio forecasts postoperative seizure freedom.

Neurosurg Rev 2021 May 14. Epub 2021 May 14.

Department of Neurosurgery, Center of Integrated Oncology (CIO) Bonn, University Hospital Bonn, Venusberg-Campus 1, 53127, Bonn, Germany.

Surgical resection is highly effective in the treatment of tumor-related epilepsy (TRE) in patients with brain metastases (BM). Nevertheless, some patients suffer from postoperative persistent epilepsy which negatively impacts health-related quality of life. Therefore, early identification of patients with potentially unfavorable seizure outcome after BM resection is important. Read More

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MRI-based radiomics for prognosis of pediatric diffuse intrinsic pontine glioma: an international study.

Neurooncol Adv 2021 Jan-Dec;3(1):vdab042. Epub 2021 Mar 5.

Department of Medical Biophysics, Western University, London, Onatrio, Canada.

Background: Diffuse intrinsic pontine gliomas (DIPGs) are lethal pediatric brain tumors. Presently, MRI is the mainstay of disease diagnosis and surveillance. We identify clinically significant computational features from MRI and create a prognostic machine learning model. Read More

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Predictors of Brain Natriuretic Peptide Serum Level Elevation in Patients with Symptomatic Chronic Subdural Hematoma: A Prospective Study.

J Clin Med 2021 Apr 20;10(8). Epub 2021 Apr 20.

Department of Orthopedics and Trauma Surgery, St Vinzenz Hospital Dinslaken, University of Duisburg-Essen, 46537 Dinslaken, Germany.

Background: Brain natriuretic peptide serum levels (BNP) on admission are frequently elevated in patients with symptomatic chronic subdural hematoma (cSDH) and predict unfavorable long-term functional outcomes. However, the reasons for these elevated levels remain unclear. Therefore, we aimed to identify the predictors of BNP elevation. Read More

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Intracisternal administration of tanshinone IIA-loaded nanoparticles leads to reduced tissue injury and functional deficits in a porcine model of ischemic stroke.

IBRO Neurosci Rep 2021 Jun 5;10:18-30. Epub 2021 Jan 5.

Regenerative Bioscience Center, University of Georgia, Athens, GA 30602, United States.

Background: The absolute number of new stroke patients is annually increasing and there still remains only a few Food and Drug Administration (FDA) approved treatments with significant limitations available to patients. Tanshinone IIA (Tan IIA) is a promising potential therapeutic for ischemic stroke that has shown success in pre-clinical rodent studies but lead to inconsistent efficacy results in human patients. The physical properties of Tan-IIA, including short half-life and low solubility, suggests that Poly (lactic-co-glycolic acid) (PLGA) nanoparticle-assisted delivery may lead to improve bioavailability and therapeutic efficacy. Read More

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Internet gaming disorder impacts gray matter structural covariance organization in the default mode network.

J Affect Disord 2021 06 31;288:23-30. Epub 2021 Mar 31.

Center for Cognition and Brain Disorders, The Affiliated Hospital of Hangzhou Normal University, Hangzhou, Zhejiang Province, China; Zhejiang Key Laboratory for Research in Assessment of Cognitive Impairments, Hangzhou, Zhejiang Province, China. Electronic address:

Introduction: Although previous studies have revealed that dysfunctional brain organization is associated with internet gamingdisorder (IGD), the neuroanatomical basis that underlies IGD remains elusive. In this work, we aimed to investigate gray matter (GM) volume alterations and structural covariance patterns in relation to IGD severity.

Methods: Structural magnetic resonance imaging data were acquired from two hundred and thirty young adults encompassing a wide range of IGD severity. Read More

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Gray matter volume differences between transgender men and cisgender women: A voxel-based morphometry study.

Aust N Z J Psychiatry 2021 Mar 16:4867421998801. Epub 2021 Mar 16.

Department of Psychiatry and Psychotherapy, Gifu University Graduate School of Medicine, Gifu, Japan.

Objective: Gender dysphoria (GD) is characterized by distress due to inconsistency between gender identity and biological sex. Individuals with GD often desire to be the other gender, which is called transgender. Although altered brain volumes in transgender people, particularly transgender women, have been reported, the particular brain regions have been inconsistent among studies. Read More

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Individualized elective irradiation of the clinically node-negative neck in definitive radiotherapy for head and neck squamous cell carcinoma.

Cancer Commun (Lond) 2021 Apr 26;41(4):303-315. Epub 2021 Feb 26.

Department of Radiation Oncology, Sun Yat-sen University Cancer Center; State Key Laboratory of Oncology in South China; Collaborative Innovation Center for Cancer Medicine, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Guangzhou, Guangdong, 510060, P. R. China.

Background: Oral cavity (OC), oropharyngeal (OP), hypopharyngeal (HP), and laryngeal (LA) squamous cell carcinoma (SCC) have a high incidence of regional lymph node metastasis (LNM). Elective irradiation for clinically node-negative neck is routinely administered to treat lymph nodes harboring occult metastasis. However, the optimal elective irradiation schemes are still inconclusive. Read More

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Exploring the predictive value of lesion topology on motor function outcomes in a porcine ischemic stroke model.

Sci Rep 2021 Feb 15;11(1):3814. Epub 2021 Feb 15.

Regenerative Bioscience Center, University of Georgia, Athens, GA, USA.

Harnessing the maximum diagnostic potential of magnetic resonance imaging (MRI) by including stroke lesion location in relation to specific structures that are associated with particular functions will likely increase the potential to predict functional deficit type, severity, and recovery in stroke patients. This exploratory study aims to identify key structures lesioned by a middle cerebral artery occlusion (MCAO) that impact stroke recovery and to strengthen the predictive capacity of neuroimaging techniques that characterize stroke outcomes in a translational porcine model. Clinically relevant MRI measures showed significant lesion volumes, midline shifts, and decreased white matter integrity post-MCAO. Read More

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February 2021

Brain Magnetic Resonance Imaging Volumetric Measures of Functional Outcome after Severe Traumatic Brain Injury in Adolescents.

J Neurotrauma 2021 Jun 24;38(13):1799-1808. Epub 2021 Feb 24.

Waisman Center, University of Wisconsin, Madison, Wisconsin, USA.

Adolescent traumatic brain injury (TBI) is a major public health concern, resulting in >35,000 hospitalizations in the United States each year. Although neuroimaging is a primary diagnostic tool in the clinical assessment of TBI, our understanding of how specific neuroimaging findings relate to outcome remains limited. Our study aims to identify imaging biomarkers of long-term neurocognitive outcome after severe adolescent TBI. Read More

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Radiotherapy for Oropharyngeal Carcinoma With an Uninvolved Contralateral Neck: The Safety of Omission of Contralateral High Level II and Retropharyngeal Lymph Nodes From Elective Target Volumes.

Clin Oncol (R Coll Radiol) 2021 May 23;33(5):331-339. Epub 2020 Dec 23.

Department of Clinical Oncology, Leeds Cancer Centre, Leeds, UK. Electronic address:

Aims: To analyse outcomes and patterns of failure in patients with oropharyngeal carcinoma (OPC) treated with definitive volumetric modulated arc therapy with omission of contralateral high level II lymph nodes (HLII) and retropharyngeal lymph nodes (RPLN) in the contralateral uninvolved neck.

Materials And Methods: Patients with OPC treated between January 2016 and July 2019 were retrospectively identified. In the absence of contralateral neck disease, institutional protocols allowed omission of contralateral HLII and contralateral RPLN in the additional absence of ipsilateral RPLN, soft palate/posterior pharyngeal wall primary. Read More

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A rater agreement study on measurements in cross-sectional CBCT images exploring the association between alveolar bone morphology and craniofacial height.

Oral Radiol 2020 Dec 3. Epub 2020 Dec 3.

Faculty of Odontology, Oral-and Maxillofacial Radiology, Malmö University, 205 06, Malmö, Sweden.

Objectives: To investigate rater agreement regarding measurements of height and width of the maxilla and mandible using cross-sectional images from CBCT examinations. Furthermore, to explore the association between vertical craniofacial height and alveolar bone morphology.

Methods: Pre-treatment CBCT scans from 450 patients referred for treatment to a private clinic for orthodontics and oral surgery in Scandinavia were available and of these, 180 were selected. Read More

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December 2020

Duration-dependent extensive volume and shape changes of mesolimbic structures in surgically treated unilateral patients with temporal lobe epilepsy.

Epilepsy Behav 2021 01 27;114(Pt A):107517. Epub 2020 Nov 27.

The Department of Neurosurgery, Guro Hospital, Korea University Medicine, Republic of Korea. Electronic address:

Purpose: Although surgical treatment of drug-resistant mesial temporal lobe epilepsy (MTLE) has proven efficacy, surgical referrals are often delayed. Knowledge of the abnormalities of mesolimbic structures beyond the hippocampus may be important for patients with MTLE because of its usefulness in the understanding of progressive disabilities in affected structures. This study aimed to identify volume and shape changes of mesolimbic structures in surgically treated patients with unilateral MTLE and their correlation with various clinical parameters. Read More

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January 2021

The spatiotemporal spread of cervical spinal cord contusion injury pathology revealed by 3D in-line phase contrast synchrotron X-ray microtomography.

Exp Neurol 2021 02 19;336:113529. Epub 2020 Nov 19.

King's College London, Wolfson Centre for Age Related Diseases, Institute of Psychiatry, Psychology & Neuroscience, Guy's Campus, London Bridge, London SE1 1UL, UK. Electronic address:

Extensive structural changes occur within the spinal cord following traumatic injury. Acute tissue debris and necrotic tissue are broken down, proliferating local glia and infiltrating leukocytes remodel tissue biochemical and biophysical properties, and a chronic cavity surrounded by a scar forms at the injury epicentre. Serial-section 2D histology has traditionally assessed these features in experimental models of spinal cord injury (SCI) to measure the extent of tissue pathology and evaluate efficacy of novel therapies. Read More

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February 2021

A novel lower bound for tip-apex distance.

Eur J Trauma Emerg Surg 2020 Oct 10. Epub 2020 Oct 10.

Manufacturing and Automation Research Center, Koc University, Istanbul, 34450, Turkey.

Purpose: The cut-out of the cephalomedullary nail is among the most common post-surgery complications for intertrochanteric fractures. As a risk predictor, a tip-apex distance (TAD) below 25 mm, observed from orthogonal fluoroscopic views, is recommended in the literature. This study aims to demonstrate that TAD < 25 mm is a mathematically insufficient risk definition and to complement the TAD upper bound with an appropriate lower bound, with the introduction of a novel distance parameter, TADX, based on the orthogonal projection of the nail tip on the central femoral midline. Read More

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October 2020

Benefits of the Subdural Evacuating Port System (SEPS) Procedure Over Traditional Craniotomy for Subdural Hematoma Evacuation.

Neurohospitalist 2020 Oct 4;10(4):257-265. Epub 2020 May 4.

Department of Neurosurgery, NYU School of Medicine, NYU Langone Health, New York, NY, USA.

Background: There remains no consensus on the optimal primary intervention for subdural hematoma (SDH). Although historically favored, craniotomy carries substantial morbidity and incurs significant costs. Contrastingly, the subdural evacuating port system (SEPS) is a minimally invasive bedside procedure. Read More

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October 2020

Bedside Catheter Hematoma Evacuation in Vitamin K Antagonist-Related Intracerebral Hemorrhage: A Safe and Feasible Approach.

Front Neurol 2020 14;11:807. Epub 2020 Aug 14.

Department of Neurology, University of Freiburg, Freiburg im Breisgau, Germany.

Although outcome in intracerebral hemorrhage (ICH) patients is generally not improved by surgical intervention, the use of minimally invasive surgery (MIS) has shown promising results. However, vitamin K antagonist (VKA)-related ICH patients are underrepresented in surgical treatment trials. We therefore assessed the safety and efficacy of a bedside MIS approach including local application of urokinase in VKA-related ICH. Read More

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Diffusion Tensor Imaging-Based Analysis of Baseline Neurocognitive Function and Posttreatment White Matter Changes in Pediatric Patients With Craniopharyngioma Treated With Surgery and Proton Therapy.

Int J Radiat Oncol Biol Phys 2021 02 6;109(2):515-526. Epub 2020 Sep 6.

Department of Radiation Oncology, St. Jude Children's Research Hospital, Memphis, Tennessee.

Purpose: To determine the preirradiation baseline association of white matter integrity with neurocognitive function and to assess posttreatment changes in pediatric patients with craniopharyngioma treated with proton therapy.

Methods And Materials: Ninety children and adolescents (2-20 years old) with craniopharyngioma were treated with proton therapy (54 Gy[RBE]) in a prospective therapeutic trial. Neurocognitive performance at the postoperative baseline before proton therapy and diffusion tensor imaging (DTI) data acquired at baseline and at annual follow-up were analyzed. Read More

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February 2021

Normal cavum veli interpositi at 14-17 gestational weeks: three-dimensional and Doppler transvaginal neurosonographic study.

Ultrasound Obstet Gynecol 2021 07;58(1):19-25

Ob-Gyn Ultrasound Unit, Lis Maternity Hospital, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel.

Objectives: To provide evidence to support the hypothesis that the midline cyst-like fluid collection that is frequently observed on fetal brain ultrasound (US) imaging during the early second trimester represents a normal transient cavum veli interpositi (CVI).

Methods: This was a retrospective analysis of 89 three-dimensional normal fetal brain volumes, acquired by transvaginal US imaging in 87 pregnant women between 14 and 17 gestational weeks. The midsagittal view was studied using multiplanar imaging, and the maximum length of the fluid collection located over (dorsal to) the tela choroidea of the third ventricle was measured. Read More

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Altered structural and functional connectivity in CSF1R-related leukoencephalopathy.

Brain Imaging Behav 2021 Jun;15(3):1655-1666

Department of Neurology, Rui Jin Hospital & Rui Jin Hospital North, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China.

CSF1R-related leukoencephalopathy is a rare white-matter encephalopathy characterized by motor and neuropsychiatric symptoms due to colony-stimulating factor 1 receptor (CSF1R) gene mutation. Few studies have investigated the intrinsic brain alternations of patients with CSF1R-related leukoencephalopathy. We aim to evaluate the structural and functional changes in those patients. Read More

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Histological, molecular, clinical and outcomes characteristics of Multiple Lesion Glioblastoma. A retrospective monocentric study and review of literature.

Neurocirugia (Astur : Engl Ed) 2021 May-Jun;32(3):114-123. Epub 2020 Jun 18.

Human Neurosciences Department Neurosurgery Division "Sapienza" University, Italy.

Background: Multiple lesion glioblastoma (M-GBM) represent a group of GBM patients in which there exist multiple foci of tumor enhancement. The prognosis is poorer than that of single-lesion GBM patients, but this actually is a controversial data. Is unknown whether multifocality has a genetic and molecular basis. Read More

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Craniometric and Volumetric Analyses of Cranial Base and Cranial Vault Differences in Patients With Nonsyndromic Single-Suture Sagittal Craniosynostosis.

J Craniofac Surg 2020 Jun;31(4):1010-1014

Division of Plastic and Reconstructive Surgery, Children's Hospital of Philadelphia, Philadelphia, PA.

Purpose: How different from "normal" are the cranial base and vault of infants with nonsyndromic, single-suture sagittal synostosis (NSSS)? This study quantitatively addresses this question utilizing computed tomography (CT) analytic technology.

Method: Head CT scans of infants with NSSS and normocephalic controls were analyzed using Mimics to calculate craniometric angles, distances, and segmented volumes. Craniometric measurements and asymmetry indices were compared between NSSS and control groups using linear regressions controlling for age. Read More

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Selection of single-isocenter for multiple-target stereotactic brain radiosurgery to minimize total margin volume.

Phys Med Biol 2020 09 16;65(18):185012. Epub 2020 Sep 16.

Department of Radiation and Cellular Oncology, University of Chicago, Chicago, IL, United States of America. Department of Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, United States of America.

Treating multiple brain metastases with a single isocenter improves efficiency but requires margins to account for rotation induced shifts that increase with target-to-isocenter distance. A method to select the single isocenter position that minimizes the total volume of normal tissue treated during multi-target stereotactic radiosurgery (SRS) is presented. A statistical framework was developed to quantify the impact of uncertainties on planning target volumes (PTV). Read More

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September 2020

Three-Dimensional Identification of the Medial Longitudinal Fasciculus in the Human Brain: A Diffusion Tensor Imaging Study.

J Clin Med 2020 May 4;9(5). Epub 2020 May 4.

Department of Physical Therapy, College of Health Sciences, Dankook University, Cheonan 31116, Korea.

Background: The medial longitudinal fasciculus (MLF) interacts with eye movement control circuits involved in the adjustment of horizontal, vertical, and torsional eye movements. In this study, we attempted to identify and investigate the anatomical characteristics of the MLF in human brain, using probabilistic diffusion tensor imaging (DTI) tractography.

Methods: We recruited 31 normal healthy adults and used a 1. Read More

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A Novel Rat Model to Test Intra-Abdominal Anti-adhesive Therapy.

Front Surg 2020 8;7:12. Epub 2020 Apr 8.

Department of Surgery - Otolaryngology Head and Neck Surgery, The University of Adelaide, Adelaide, SA, Australia.

Adhesion formation after abdominal surgery is considered almost inevitable and a major cause of morbidity. Novel treatments have been proposed, however there is a lack of suitable small animal models for pre-clinical evaluation, mainly due to inconsistency in adhesion formation in positive control animals. Here, we propose a new rat model of abdominal adhesions using Kaolin as the adhesion-inducing agent at an optimized dosage for testing newer agents in respect to their anti-adhesive property. Read More

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Intracranial Effects of Microgravity: A Prospective Longitudinal MRI Study.

Radiology 2020 Jun 14;295(3):640-648. Epub 2020 Apr 14.

From the Department of Diagnostic and Interventional Imaging, University of Texas Health Science Center at Houston, McGovern Medical School, 6431 Fannin St, MSB 2.100 Houston, TX 77030 (L.A.K., K.M.H., R.F.R.); Cardiovascular and Vision Laboratory, NASA Johnson Space Center, Houston, Tex (M.B.S.); Kellogg Brown & Root (KBR), Houston, Tex (A.S., S.S.L., K.M., B.R.M.); Department of Teleoncology, Memorial Sloan-Kettering Cancer Center, New York, NY (C.O.); and School of Nursing, University of Michigan, Ann Arbor, Mich (R.J.P.S.).

Background Astronauts on long-duration spaceflight missions may develop changes in ocular structure and function, which can persist for years after the return to normal gravity. Chronic exposure to elevated intracranial pressure during spaceflight is hypothesized to be a contributing factor, however, the etiologic causes remain unknown. Purpose To investigate the intracranial effects of microgravity by measuring combined changes in intracranial volumetric parameters, pituitary morphologic structure, and aqueductal cerebrospinal fluid (CSF) hydrodynamics relative to spaceflight and to establish a comprehensive model of recovery after return to Earth. Read More

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Estimating brain volume loss after radiation therapy in children treated for posterior fossa tumors (Corpus callosum and whole brain volume changes following radiotherapy in children).

Adv Clin Exp Med 2020 03;29(3):331-337

CRUK Imaging Centre at The Institute of Cancer Research, Sutton, London, UK.

Background: More than half of pediatric tumors of central nervous system (CNS) primarily originate in the posterior fossa and are conventionally treated with radiation therapy (RT).

Objectives: The objective of this study was to establish whether corpus callosum volumes (CCV) and whole brain volumes (WBV) are correlated and to determine the impact of whole-brain lowvs high-dose RT on brain parenchymal volume loss as assessed using each technique.

Material And Methods: Of the 30 identified children (6-12 years) with newly diagnosed posterior fossa tumors treated with cranial RT, including focal and whole-brain RT, suitable imaging was obtained for 23. Read More

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