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Assessing exposure to Kilkari: a big data analysis of a large maternal mobile messaging service across 13 states in India.

BMJ Glob Health 2021 Jul;6(Suppl 5)

School of Public Health and Family Medicine, University of Cape Town, Cape Town, South Africa.

The Kilkari programme is being implemented by the Government of India in 13 states. Designed by BBC Media Action and scaled in collaboration with the Ministry of Health and Family Welfare from January 2016, Kilkari had provided mobile health information to over 10 million subscribers by the time BBC Media Action transitioned the service to the government in April 2019. Despite the reach of Kilkari in terms of the absolute number of subscribers, no longitudinal analysis of subscriber exposure to health information content over time has been conducted, which may underpin effectiveness and changes in health outcomes. Read More

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[Study on the gelatin methacryloyl composite scaffold with exogenous transforming growth factor β to promote the repair of skull defects].

Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi 2021 Jul;35(7):904-912

Department of Orthopedics, the First Affiliated Hospital of Bengbu Medical College, Bengbu Anhui, 233000, P.R.China.

Objective: To prepare a bone tissue engineering scaffold for repairing the skull defect of Sprague Dawley (SD) rats by combining exogenous transforming growth factor β (TGF-β ) with gelatin methacryloyl (GelMA) hydrogel.

Methods: Firstly, GelMA hydrogel composite scaffolds containing exogenous TGF-β at concentrations of 0, 150, 300, 600, 900, and 1 200 ng/mL (set to groups A, B, C, D, E, and F, respectively) were prepared. Cell counting kit 8 (CCK-8) method was used to detect the effect of composite scaffold on the proliferation of bone marrow mesenchymal stem cells (BMSCs) in SD rats. Read More

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[Study of modified subcutaneous lumbar spine index as a predictor for short-term effectiveness in transforaminal lumbar interbody fusion].

Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi 2021 Jul;35(7):878-885

Department of Spine Surgery, Zhongda Hospital Affiliated to Southeast University, Nanjing Jiangsu, 210009, P.R.China.

Objective: To explore the value of modified subcutaneous lumbar spine index (MSLSI) as a predictor for short-term effectiveness of transforaminal lumbar interbody fusion (TLIF) in treatment of lumbar degenerative disease (LDD).

Methods: Between February 2014 and October 2019, 450 patients who were diagnosed as LDD and received single-segment TLIF were included in the study. Based on the MSLSI measured by preoperative lumbar MRI, the patients were sorted from small to large and divided into three groups ( =150). Read More

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[Study on the safety and effectiveness of low-dose tranexamic acid in operation of multi-level continuous thoracic ossification of ligament flavum].

Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi 2021 Jul;35(7):873-877

Department of Orthopedics, Affiliated Hospital of North Sichuan Medical College, Nanchong Sichuan, 637000, P.R.China.

Objective: To investigate the safety and effectiveness of low-dose tranexamic acid (TXA) in operation of multi-level continuous thoracic ossification of ligament flavum (TOLF).

Methods: A clinical data of 26 patients who underwent operation for multi-level continuous TOLF and met the selection criteria between July 2015 and January 2019 was retrospectively analyzed. Among them, 13 cases (group A) were received intravenous infusion of TXA (10 mg/kg) at 15 minutes before operation, and maintained the infusion at 1 mg/(kg·h) until the end of the operation; 13 cases (group B) were received the same dose of normal saline before and during operation. Read More

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[Study on the structural changes of pharyngeal cavity after bariatric surgery in obese patients with obstructive sleep apnea].

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2021 Jun;35(6):538-542

Department of Otorhinolaryngology,the Second Hospital of Hebei Medical University,Shijiazhuang,050000,China.

To study whether and how bariatric surgery changes the structure of the pharyngeal cavity in obese patients with obstructive sleep apnea(OSA). Forty-two patients who underwent laparoscopic sleeve gastrectomy were recruited. Morphological indicators(BMI, neck and waist circumference), PSG and acoustic pharyngometry indicators were evaluated pre-operatively and 3, 6, and 12 months post-operatively. Read More

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[Advances in etiology and mechanism of structural nasal obstruction].

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2021 Jul;35(7):666-672

Structural nasal obstruction(SNO) is a series of diseases caused by congenital or acquired structural anatomical abnormalities of nasal airway and its surrounding tissues, which leads to increased nasal ventilation resistance. The effect of medication drugs for SNO is poor and surgical intervention is often needed. However, the abnormal structure of nasal airway is very complex, including the periphery of nasal airway, internal nasal airway, the front and rear of nasal airway and complex factors. Read More

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[The prognostic value of myocardial infarct size measured by cardiovascular magnetic resonance in patients with acute ST-segment elevation myocardial infarction].

Zhonghua Nei Ke Za Zhi 2021 Aug;60(8):751-756

Department of Cardiology, Shengjing Hospital, China Medical University, Shenyang 110022, China.

To investigate the prognostic value of infarct size (IS) in patients with acute ST-segment elevation myocardial infarction (STEMI) underwent primary percutaneous coronary intervention (PCI). A total of 104 patients with acute STEMI who underwent primary PCI treatment in Shengjing Hospital of China Medical University from February 2017 to November 2018 were included in the present study. All patients underwent cardiovascular magnetic resonance (CMR) within one week after primary PCI treatment. Read More

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[Expressions of MPV, P-LCR and NLR in patients with novel coronavirus disease 2019].

Zhonghua Yu Fang Yi Xue Za Zhi 2021 Jul;55(7):890-895

Department of Laboratory Medicine, the Third Central Hospital of Tianjin, Tianjin Key Laboratory of Extracorporeal Life Support for Critical Diseases,Artificial Cell Engineering Technology Research Center, Tianjin Institute of Hepatobiliary Disease, Tianjin 300170, China.

To provide new ideas for clinical diagnosis and treatment of coronavirus disease 2019 (COVID-19), this study explore the expression level and prognostic value of platelet parameters in mild, moderate and severe COVID-19. This is a retrospective analysis. From January to May 2020, a total of 69 patients who were diagnosed with COVID-19 in the Third Central Hospital and the Jinnan Hospital (both situated in Tianjin) were enrolled in the disease group. Read More

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[Clinical efficacy of the combined diagnosis and management for children with airway allergic diseases].

Zhonghua Yu Fang Yi Xue Za Zhi 2021 Jul;55(7):818-826

Key Laboratory of Major Diseases in Children, Ministry of Education, Department of Otolaryngology Head and Neck Surgery, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing 100045, China.

To evaluate the clinical efficacy of the combined diagnosis and management in children with airway allergic diseases(bronchial asthma, allergic rhinitis). This observational study belongs to cluster sampling cases, which included the clinical data from children with airway allergic diseases in Allergy Department and Otorhinolaryngology Department of Beijing Children's Hospital from April to December in 2015. They were followed up every three months during 12 months. Read More

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Preclinical In Vivo-Models to Investigate HIPEC; Current Methodologies and Challenges.

Cancers (Basel) 2021 Jul 8;13(14). Epub 2021 Jul 8.

Department of Radiation Oncology, Amsterdam UMC, University of Amsterdam, Cancer Center Amsterdam, 1105 AZ Amsterdam, The Netherlands.

Hyperthermic intraperitoneal chemotherapy (HIPEC) is a treatment modality for patients with peritoneal metastasis (PM) of various origins which aims for cure in combination with cytoreductive surgery (CRS). Efficacy of CRS-HIPEC depends on patient selection, tumor type, delivery technique, and treatment parameters such as temperature, carrier solution, type of drug, dosage, volume, and treatment duration. Preclinical research offers a powerful tool to investigate the impact of these parameters and to assist in designing potentially more effective treatment protocols and clinical trials. Read More

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[Effect of therapies for kidney-tonifying and blood-activating in treatment of anovulatory infertility in eugenics].

Zhongguo Zhong Yao Za Zhi 2021 Jun;46(11):2634-2638

Xiyuan Hospital, China Academy of Chinese Medical Sciences Beijing 100091, China.

In the context of the new era, paying attention to maternal and child health and advocating prenatal and postnatal care can effectively improve the quality of the birth population. Traditional Chinese medicine has a long history of prenatal and postnatal healthcare with rich content, which is the theoretical basis of modern related services. With the social development and the improvement of people's awareness of prenatal and postnatal healthcare, people have gradually shifted the focus of prenatal and postnatal healthcare to the peri-pregnancy stage at present, namely that couples of childbearing age are guided to prepare for pregnancy under the premise of solving their basic diseases. Read More

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[Value of (18)F-FDG PET-CT imaging to predict epidermal growth factor receptor mutations in patients with lung squamous cell carcinoma].

Zhonghua Zhong Liu Za Zhi 2021 Jul;43(7):795-800

Department of Nuclear Medicine, the First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China.

To investigate the value of (18)F-fluorodeoxy glucose ((18)F-FDG) positron emission tomography/computed tomography (PET-CT) in predicting the epidermal growth factor receptor (EGFR) mutations in patients with lung squamous cell carcinoma. We retrospectively analyzed the clinical data and (18)F-FDG PET-CT imaging data of 206 patients with lung squamous cell carcinoma confirmed by pathology and underwent EGFR mutation test in the First Affiliated Hospital of Nanjing Medical University from June 2013 to October 2018. Receiver operating characteristic (ROC) curve analysis was performed to quantify the predictive value of maximum standard uptake value (SUV(max)), metabolic tumor volume (MTV), total lesion glycolysis (TLG). Read More

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[Value of ATP synthase C subunit in predicting cardiac function and outcomes of sepsis].

Zhonghua Yi Xue Za Zhi 2021 Jul;101(27):2140-2146

Emergency Department, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, China.

To investigate the value of serum mitochondrial ATP synthase C subunit level in the evaluation of cardiac functional status and prognosis in patients with sepsis. A total of 165 sepsis patients admitted to the Emergency Intensive Care Unit (EICU) of the First Affiliated Hospital of Wenzhou Medical University from January 1, 2017 to December 31, 2018 were included, there were 103 males (62.4%) and 62 females (37. Read More

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[Resting-state functional magnetic resonance imaging analysis of abnormal directional functional connectivity of the nucleus accumbens in patients with chronic tinnitus].

Zhonghua Yi Xue Za Zhi 2021 Jul;101(27):2127-2132

Department of Radiology, Nanjing First Hospital, Nanjing Medical University, Nanjing 210006, China.

To investigate abnormal directional functional connectivity of the nucleus accumbens (NAc) in chronic tinnitus patients using resting-state functional magnetic resonance imaging (fMRI), and to determine the relationship between the degree of this connectivity and tinnitus characteristics. The resting-state fMRI data of 40 patients with bilateral chronic tinnitus (12 males and 28 females, aged from 26 to 63(50.6±11. Read More

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[Clinical diagnosis and treatment analysis of 553 cases of acoustic neuroma in a single center].

Zhonghua Yi Xue Za Zhi 2021 Jul;101(26):2077-2080

Department of Surgery, District 11, the First Affiliated Hospital of Soochow University, Suzhou 215006, China.

To explore the relationship between microsurgery and prognosis of acoustic neuroma. A total of 553 acoustic neuroma surgical cases admitted to the First Affiliated Hospital of Soochow University from January 1, 1986 to September 30, 2016, were collected retrospectively. They were divided into 1986-1995 group, 1996-2005 group, and 2006-2016 group. Read More

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[Different revascularization strategies for patients with coronary artery disease complicating reduced ejection fraction].

Zhonghua Yi Xue Za Zhi 2021 Jul;101(26):2071-2076

Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University, Beijing 100029, China.

To explore the short and long term outcomes of coronary artery disease(CAD) patients with heart failure with reduced ejection fraction (HFrEF) after two different revascularization strategies. The CAD patients with HFrEF who had undegone successful revascularization from January 1, 2005 to December 31, 2014 in Anzhen Hospital were analyzed based on registries. The baseline characteristics, changes of left heart function and the MACCE after a mean follow-up of 3. Read More

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[Clinical features of Kasabach-Merritt syndrome: an analysis of 16 neonates].

Zhongguo Dang Dai Er Ke Za Zhi 2021 Jul;23(7):696-701

Department of Neonatology, Anhui Children's Hospital, Anhui Medical University, Hefei 230000, China.

Objective: To study the clinical features, treatment, and prognosis of neonates with Kasabach-Merritt syndrome (KMS), and to provide a reference for optimizing the diagnosis and treatment of this disease.

Methods: A retrospective analysis was performed for the clinical and follow-up data of 16 neonates with KMS who were admitted to the Anhui Children's Hospital, Anhui Medical University, from January 2016 to December 2020.

Results: Of the 16 neonates, there were 13 boys (81%) and 3 girls (19%), with an age of 1 hour to 10 days on admission. Read More

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[Comparative study of short-term efficacy,effectiveness and safety at different stages of the laparoscopic pancreaticoduodenectomy learning curve].

Zhonghua Wai Ke Za Zhi 2021 Jul;59(7):618-623

Department of Biliary-Pancreatic Surgery,Affiliated Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030,China.

To compare short-term efficacy,effectiveness and safety of laparoscopic pancreaticoduodenectomy(LPD) learning curve at different stages and at the same time with open pancreaticoduodenectomy(OPD). Clinical data of 488 patients who underwent pancreaticoduodenectomy at Department of Biliary-Pancreatic Surgery,Affiliated Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology from July 2014 to December 2016 were collected. There were 40 cases at the groping stage of LPD surgery(100 cases at the same time of OPD),64 cases at the stable stage (89 cases at the same time of OPD),and 118 cases at the mature stage(77 cases at the same time of OPD). Read More

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[Preliminary clinical observation of omalizumab therapy for moderate to severe asthma].

Zhonghua Jie He He Hu Xi Za Zhi 2021 Jul;44(7):611-618

Pulmonary and Critical Care Medicine, Guangzhou Institute of Respiratory Health, National Clinical Research Center for Respiratory Disease, National Center for Respiratory Medicine, State Key Laboratory of Respiratory Diseases, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou 510120, China.

To observe the effectiveness, safety and management of omalizumab therapy for moderate to severe asthma in real-world clinical practice in China. This retrospective analysis involved 79 patients with moderate to severe asthma who received omalizumab therapy for at least 4 months in the First Affiliated Hospital of Guangzhou Medical University from March 2018 to April 2020. All participants were between 14 to 76 years old(median 50 years),including 30 males and 49 females. Read More

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[Diagnostic value of FNDC5 in patients with subclinical diabetic cardiomyopathy].

Zhonghua Xin Xue Guan Bing Za Zhi 2021 Jul 24;49(7):687-693. Epub 2021 Jul 24.

Department of Endocrinology, Third Affiliated Hospital of Soochow University, Suzhou 213000, China.

To estimate the diagnostic value of fibronectin type Ⅲ-domain containing protein 5 (FNDC5) in subclinical diabetic cardiomyopathy. A total of 94 patients with type 2 diabetes (T2DM), who were hospitalized from April 2018 to June 2019 in the Third Affiliated Hospital of Soochow University, were enrolled in this study. Patients were divided into T2DM with cardiac dysfunction (subclinical DCM) group (=47) and T2DM without cardiac dysfunction (non-DCM) group (=47) according to echocardiography and gated myocardial perfusion imaging results. Read More

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Operational characteristics of 30 lateral flow immunoassays used to identify COVID-19 immune response.

J Immunol Methods 2021 Jul 6;496:113096. Epub 2021 Jul 6.

National Health Laboratory Services, Johannesburg, South Africa; Department of Immunology, Faculty of Health Sciences, University of Witwatersrand, South Africa. Electronic address:

Serology or antibody tests for COVID-19 are designed to detect antibodies (mainly Immunoglobulin M (IgM) and Immunoglobulin G (IgG) produced in response to Severe Acute Respiratory Syndrome Coronavirus 2 (SARS CoV-2) infection. In this study, 30 lateral flow immunoassays were tested using serum or plasma from patients with confirmed SARS CoV-2 infection. Negative serological controls were accessed from a well-characterised bank of sera which were stored prior to February 2020. Read More

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[Induction of mouse T lymphocyte differentiation in vitro by thymic organoids].

Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 2021 Aug;37(8):679-686

Center for Clinical Molecular Medicine, Children's Hospital, Chongqing Medical University, Ministry of Education Key Laboratory of Child Development and Disorders, National Clinical Research Center for Child Health and Disorders (Chongqing), China International Science and Technology Cooperation Base of Child Development and Critical Disorders, Chongqing Engineering Research Center for Stem Cell Therapy, Chongqing 400014, China. *Corresponding author, E-mail:

Objective To induce the differentiation of hematopoietic stem progenitor cells (HSPCs) into T cell by creating thymic organoids and simulating the three-dimensional structure of thymus tissue in vitro. Methods The retroviral vector expressing the DLL1 and Green fluorescent protein (GFP) was constructed, and the OP9-DLL1 cell line was established in OP9 cells with the aid of retroviral infection. The mRNA and protein level of DLL1 in OP9-DLL1 cells was detected by quantitative real-time PCR and Western blot respectively. Read More

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Macro- and microelements in serum and seminal plasma as biomarkers for bull sperm cryotolerance.

Acta Vet Scand 2021 Jul 5;63(1):25. Epub 2021 Jul 5.

Clinic for Reproduction and Large Animals, Veterinary Faculty, University of Ljubljana, Gerbičeva 60, 1000, Ljubljana, Slovenia.

Background: Wide variation in fertility rates is observed when using frozen bull semen, even when the bulls have met quality standards for semen production. Therefore, a simple and reliable test to assess the freezing potential of bull semen based on the analysis of fresh semen or blood would be of great value. Attention is now turning to assessment of seminal plasma components such as proteins and elements. Read More

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[Preliminary study of the changes in blood system in pyrrolizidine alkaloid-related liver damage].

Zhonghua Gan Zang Bing Za Zhi 2021 Jun;29(6):533-538

Department of Gastroenterology and Hepatology, Zhongshan Hospital, Fudan University, Shanghai 200032, China Evidence-based Medicine Center of Fudan University, Shanghai 200032, China.

To preliminary explore the changes in blood system in pyrrolizidine alkaloids (PAs)-related liver damage. General situation, liver function, biochemical blood test, routine blood test, coagulation function markers, etc., of 77 cases with drug-induced liver damage admitted to the Zhongshan Hospital Affiliated to Fudan University from 2012 to 2019 were retrospectively analyzed. Read More

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[Impact of combined nerve blocks on the outcome of hip replacement in elderly patients with acute cerebral infarction].

Zhonghua Yi Xue Za Zhi 2021 Jul;101(25):1968-1972

Department of Anesthesiology, Renmin Hospital of Wuhan University, Wuhan 430060, China.

To investigate the impact of ultrasound-guided lumbar plexus, sciatic nerve and L paravertebral combined nerve blocks on the outcomes of elderly acute cerebral infarction patients with femoral neck fracture who underwent hip replacement. The clinical data of 114 elderly acute cerebral infarction patients with femoral neck fracture and underwent artificial hip replacement surgery from May 2013 to September 2018 in Renmin Hospital of Wuhan University were retrospectively analyzed. The patients were divided into two groups based on the different anesthetic methods they received: general anesthesia (G group, =48), lumbar plexus, sciatic nerve and L paravertebral combined nerve blocks (N group, =66). Read More

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[Research on the short-term effects of welding fumes on workers' lung function: a panel study].

Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi 2021 Jun;39(6):469-471

Tianjin Centers for Disease Control and Prevention, Tianjin 300011 Public Health Department, Tianjin Medical University, Tianjin 300070, China.

To explore the short-term effects of welding fumes on workers' lung function in the welding environment preliminarily, and provide reference for future research. In October 2020, the lung function of the subjects was repeatedly measured before and after the working shift with a panel study. The paired test was used to compare the lung function before and after the shift, and the linear mixed effects model was used to analyze the short-term changes of lung function. Read More

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Renal sinus fat volume in type 2 diabetes mellitus is associated with glycated hemoglobin and metabolic risk factors.

J Diabetes Complications 2021 Jun 15:107973. Epub 2021 Jun 15.

Department of Radiology, Leiden University Medical Center, Albinusdreef 2, 2333, ZA, Leiden, the Netherlands.

Aims: We aimed to compare renal sinus fat volume assessed by MRI between patients with type 2 diabetes and healthy volunteers, and investigate the association between renal sinus fat and metabolic traits.

Methods: In this cross-sectional study, renal sinus fat and parenchyma volumes measured on abdominal MRI were compared between patients and controls using analysis of covariance. Associations of renal parameters with clinical characteristics were analyzed using linear regression analysis. Read More

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The Oleofobization of Paper via Plasma Treatment.

Polymers (Basel) 2021 Jun 29;13(13). Epub 2021 Jun 29.

Department of Surface Engineering, Jožef Stefan Institute, Jamova 39, 1000 Ljubljana, Slovenia.

Cellulose is a promising biomass material suitable for high volume applications. Its potential lies in sustainability, which is becoming one of the leading trends in industry. However, there are certain drawbacks of cellulose materials which limit their use, especially their high wettability and low barrier properties, which can be overcome by applying thin coatings. Read More

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[Clinical effects of expanded flap in repair of the exposed wounds of titanium mesh after cranioplasty with titanium mesh].

Zhonghua Shao Shang Za Zhi 2021 Jun 25;37:1-6. Epub 2021 Jun 25.

Department of Burns and Cutaneous Surgery, Burn Center of PLA, the First Affiliated Hospital of Air Force Medical University, Xi'an 710032, China.

To explore the clinical effects of using skin and soft tissue expander (hereinafter referred to as expander) expanded flap in repair of the exposed wounds of titanium mesh after cranioplasty with titanium mesh. A retrospective cohort study was conducted. From April 2015 to October 2019, 13 patients with exposed wounds of titanium mesh after cranioplasty with titanium mesh were admitted to the First Affiliated Hospital of Air Force Medical University, including 10 males and 3 females, aged 18 to 70 years. Read More

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Tumor perfusion evaluation using dynamic contrast-enhanced ultrasound after electrochemotherapy and IL-12 plasmid electrotransfer in murine melanoma.

Sci Rep 2021 Jun 29;11(1):13446. Epub 2021 Jun 29.

Clinic for Small Animals, Veterinary Faculty, University of Ljubljana, Gerbičeva 60, Ljubljana, Slovenia.

Electrochemotherapy with bleomycin (ECT BLM) is an effective antitumor treatment already used in clinical oncology. However, ECT alone is still considered a local antitumor therapy because it cannot induce systemic immunity. When combined with adjuvant gene electrotransfer of plasmid DNA encoding IL-12 (GET pIL-12), the combined therapy leads to a systemic effect on untreated tumors and distant metastases. Read More

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