Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi 2021 Jul;35(7):904-912
Department of Orthopedics, the First Affiliated Hospital of Bengbu Medical College, Bengbu Anhui, 233000, P.R.China.
Objective: To prepare a bone tissue engineering scaffold for repairing the skull defect of Sprague Dawley (SD) rats by combining exogenous transforming growth factor β (TGF-β ) with gelatin methacryloyl (GelMA) hydrogel.
Methods: Firstly, GelMA hydrogel composite scaffolds containing exogenous TGF-β at concentrations of 0, 150, 300, 600, 900, and 1 200 ng/mL (set to groups A, B, C, D, E, and F, respectively) were prepared. Cell counting kit 8 (CCK-8) method was used to detect the effect of composite scaffold on the proliferation of bone marrow mesenchymal stem cells (BMSCs) in SD rats. Read More