22 results match your criteria volume hdv

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Dosimetric evaluation of different planning techniques based on flattening filter-free beams for central and peripheral lung stereotactic body radiotherapy.

Biomed Phys Eng Express 2021 Oct 12. Epub 2021 Oct 12.

Department of Radiotherapy, Government Medical College Patiala, Sangrur Road, Patiala, Punjab, 147001, INDIA.

This study aimed to dosimetrically compare and evaluate the flattening filter-free (FFF) photon beam-based three-dimensional conformal radiotherapy (3DCRT), intensity-modulated radiation therapy (IMRT), and volumetric modulated arc therapy (VMAT) for lungstereotactic body radiotherapy (SBRT). RANDO phantom computed tomography (CT) images were used for treatment planning. Gross tumor volumes (GTVs) were delineated in the central and peripheral lung locations. Read More

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October 2021

Hepatitis B/D-Related Hepatocellular Carcinoma. A Clinical Literature Review.

J Gastrointest Cancer 2021 Oct 6. Epub 2021 Oct 6.

Department of General Surgery, Faculty of Medicine, Inonu University Turgut Ozal Medical Center, Institute of Liver Transplantation, Malatya, Turkey.

Aim: Given the current literature data, this article aims to shed light on the epidemiological and clinical effects of HBV, as well as its impact on the development of hepatocellular carcinoma (HCC).

Methods: A review of the English language literature based on a MEDLINE (PubMed) database was searched. The keywords were cirrhosis, hepatocellular carcinoma, epidemiology, hepatitis delta virus, hepatitis B virus, and co-infection. Read More

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October 2021

Association of quantitative computed tomography ındices with lung function and extent of pulmonary fibrosis in patients with systemic sclerosis.

Clin Rheumatol 2021 Sep 16. Epub 2021 Sep 16.

Department of Rheumatology, Kocaeli University Faculty of Medicine, Kocaeli, Turkey.

Objectives: The aim was to investigate the discriminative value of a wide range of quantitative computed tomography (qCT) parameters in systemic sclerosis (SSc) patients with and without pulmonary fibrosis (PF) and their association with pulmonary function tests (PFTs) and visual fibrosis scores (VFS).

Method: Thoracic high-resolution computed tomography (HRCT) images of SSc patients with and without PF were analyzed with Vitrea® Advanced Visualization software. The mean lung attenuation (MLA), skewness, kurtosis, and threshold-based volumes [low-density volume (LDV), medium-density volume (MDV), and high-density volume (HDV)] derived from the attenuation histograms of the right and left lungs were evaluated separately. Read More

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September 2021

Impact of [F]FDG-PET and [F]FLT-PET-Parameters in Patients with Suspected Relapse of Irradiated Lung Cancer.

Diagnostics (Basel) 2021 Feb 11;11(2). Epub 2021 Feb 11.

Department of Clinical Physiology, Nuclear Medicine & PET, Copenhagen University Hospital, Rigshospitalet, 2100 Copenhagen Ø, Denmark.

Radiation-induced changes may cause a non-malignant high 2-deoxy-2-[F]fluoro-d-glucose (FDG)-uptake. The 3'-deoxy-3'-[F]fluorothymidine (FLT)-PET/CT performs better in the differential diagnosis of inflammatory changes and lung lesions with a higher specificity than FDG-PET/CT. We investigated the association between post-radiotherapy FDG-PET-parameters, FLT-PET-parameters, and outcome. Read More

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February 2021

Degenerative changes in the elbow joint after radial head excision for fracture: quantitative 3-dimensional analysis of bone density, stress distribution, and bone morphology.

J Shoulder Elbow Surg 2021 May 2;30(5):e199-e211. Epub 2020 Nov 2.

Department of Orthopaedic Surgery, Hand and Upper Extremity Service, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.

Hypothesis And Background: Some investigators speculate that excision may lead to elbow arthritis and associated problems; however, evidence supporting this theory is limited. It is hypothesized that radial head excision causes bone density changes as a result of asymmetrical stress distributions, consequently leading to osteophyte formation. In this study, we sought to quantitatively compare the 3-dimensional (3D) bone density and stress distributions between operative and nonoperative elbows in patients who underwent radial head excision. Read More

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F-FLT PET/CT Adds Value to F-FDG PET/CT for Diagnosing Relapse After Definitive Radiotherapy in Patients with Lung Cancer: Results of a Prospective Clinical Trial.

J Nucl Med 2021 05 9;62(5):628-635. Epub 2020 Oct 9.

Department of Clinical Physiology, Nuclear Medicine, and PET, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.

Diagnosing relapse after radiotherapy for lung cancer is challenging. The specificity of both CT and F-FDG PET/CT is low because of radiation-induced changes. 3'-deoxy-3'-F-fluorothymidine (F-FLT) PET has previously demonstrated higher specificity for malignancy than F-FDG PET. Read More

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Altered bone density and stress distribution patterns in long-standing cubitus varus deformity and their effect during early osteoarthritis of the elbow.

Osteoarthritis Cartilage 2018 01 14;26(1):72-83. Epub 2017 Oct 14.

Department of Orthopaedic Surgery, Osaka University, Graduate School of Medicine, 2-2 Yamada-oka, Suita, Osaka 565-0871, Japan. Electronic address:

Objective: To quantify the bone density and stress distribution patterns in long-standing cubitus varus and clarify the effects of the deformity on bone density.

Design: We created three-dimensional computed tomography (CT) elbow models from 21 patients with long-standing cubitus varus deformities without advanced osteoarthritis (OA) and assessed the deformity by superimposing the affected humerus onto a mirror-image of the contralateral normal. Elbows were divided into 13 regions before measuring the bone density of each region and comparing the percentage of high-density volume (%HDV) between affected and normal sides. Read More

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January 2018

Telomere Dynamics in Immune Senescence and Exhaustion Triggered by Chronic Viral Infection.

Viruses 2017 10 5;9(10). Epub 2017 Oct 5.

Department of Pathology, Center for Viral Pathogenesis, University of Kansas Medical Center, Kansas City, KS 66160, USA.

The progressive loss of immunological memory during aging correlates with a reduced proliferative capacity and shortened telomeres of T cells. Growing evidence suggests that this phenotype is recapitulated during chronic viral infection. The antigenic volume imposed by persistent and latent viruses exposes the immune system to unique challenges that lead to host T-cell exhaustion, characterized by impaired T-cell functions. Read More

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October 2017

Prevalence and predictors for compensated Advanced Chronic Liver Disease (c-ACLD) in patients with chronic Hepatitis Delta Virus (HDV) infection.

PLoS One 2017 22;12(3):e0174453. Epub 2017 Mar 22.

Laboratório de Pesquisa Clínica em DST/AIDS (LAPCLIN-AIDS), Instituto Nacional de Infectologia Evandro Chagas - Fundação Oswaldo Cruz (FIOCRUZ), Rio de Janeiro, Brazil.

Objective: The study aimed to evaluate the prevalence and predictor factors for compensated advanced chronic liver disease (c-ACLD) in patients with hepatitis Delta virus (HDV) infection.

Methods: This cross-sectional study included consecutive HDV-infected patients defined by positive anti-HDV. Patients with hepatitis C coinfection, liver transplantation or presence of conditions that limit liver (LSM) or spleen stiffness measurement (SSM) were excluded. Read More

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Simulation Model of Microsphere Distribution for Selective Internal Radiation Therapy Agrees With Observations.

Int J Radiat Oncol Biol Phys 2016 10 13;96(2):414-421. Epub 2016 May 13.

Department of Radiation Physics, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden; Department of Medical Physics and Biomedical Engineering, Sahlgrenska University Hospital, Gothenburg, Sweden.

Purpose: To perform a detailed analysis of microsphere distribution in biopsy material from a patient treated with (90)Y-labeled resin spheres and characterize microsphere distribution in the hepatic artery tree, and to construct a novel dichotomous bifurcation model for microsphere deposits and evaluate its accuracy in simulating the observed microsphere deposits.

Methods And Materials: Our virtual model consisted of arteries that successively branched into 2 new generations of arteries at 20 nodes. The artery diameter exponentially decreased from the lowest generation to the highest generation. Read More

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October 2016

Development and application of an aerosol screening model for size-resolved urban aerosols.

Res Rep Health Eff Inst 2014 Jun(179):3-79

Predictive models of vehicular ultrafine particles less than 0.1 microm in diameter (UFPs*) and other urban pollutants with high spatial and temporal variation are useful and important in applications such as (1) decision support for infrastructure projects, emissions controls, and transportation-mode shifts; (2) the interpretation and enhancement of observations (e.g. Read More

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A comparative assessment of PM2.5 exposures in light-rail, subway, freeway, and surface street environments in Los Angeles and estimated lung cancer risk.

Environ Sci Process Impacts 2013 Jan;15(1):234-43

According to the U.S. Census Bureau, 570000+ commuters in Los Angeles travel for over 60 minutes to work. Read More

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January 2013

Development of a reverse transcription-loop-mediated isothermal amplification (RT-LAMP) system for rapid detection of HDV genotype 1.

Lett Appl Microbiol 2013 Mar 22;56(3):229-35. Epub 2013 Jan 22.

Department of Gastroenterology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.

Unlabelled: The object of this study was to develop a reverse transcription-loop-mediated isothermal amplification (RT-LAMP) assay for detecting hepatitis D virus (HDV) genotype 1. With an alignment analysis, a highly conserved sequence (nt 820-1020) was chosen as a suitable target to design LAMP primers. The optimal condition of RT-LAMP was a 25-μl reaction volume, which consists of the following components: 1·6 μmol l⁻¹ each of FIP and BIP, 0·2 μmol l⁻¹ each of F3 and B3, 1·5 μmol l⁻¹ dNTPs, 4 mmol l⁻¹ MgSO₄, 8 U Bst DNA polymerase, 2U M-MLV and 2 μl extracted RNA sample. Read More

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Manufacturing of adenovirus vectors: production and purification of helper dependent adenovirus.

Methods Mol Biol 2011 ;737:139-56

Biotechnology Research Institute, NRC, Montreal, QC, Canada.

Adenoviral vector (AdV) of the third generation also known as helper-dependent adenoviral vector (HDV) is an attractive delivery system for gene therapy applications. However, obtaining high quality-grade HDV in sufficient amount remains a challenge that hampers the extensive use of this vector in preclinical and clinical studies. Here we review recent progress in the large-scale manufacturing of HDV. Read More

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September 2011

Internal mammary lymph node irradiation contributes to heart dose in breast cancer.

Med Dosim 2010 6;35(3):163-8. Epub 2009 Jun 6.

Department of Radiotherapy, Institut Gustave Roussy, Villejuif, France.

We assessed the impact of internal mammary chain radiotherapy (IMC RT) to the radiation dose received by the heart in terms of heart dose-volume histogram (DVH). Thirty-six consecutive breast cancer patients presenting with indications for IMC RT were enrolled in a prospective study. The IMC was treated by a standard conformal RT technique (50 Gy). Read More

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November 2010

Structure and replication of hepatitis delta virus RNA.

Authors:
J M Taylor

Curr Top Microbiol Immunol 2006 ;307:1-23

Fox Chase Cancer Center, Philadelphia, PA 19111-2497, USA.

While this volume covers many different aspects of hepatitis delta virus (HDV) replication, the focus in this chapter is on studies of the structure and replication of the HDV RNA genome. An evaluation of such studies is not only an integral part of our understanding of HDV infections but it also sheds new light on some important aspects of cell biology, such as the fidelity of RNA transcription by a host RNA polymerase and on various forms of post-transcriptional RNA processing. Representations of the replication of the RNA genome are frequently simplified to a form of rolling-circle model, analogous to what have been described for plant viroids. Read More

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Damage assessment in gastric cancer treatment with adjuvant radiochemotherapy: calculation of the NTCP's from the differential HDV of the organs at risk.

Clin Transl Oncol 2006 Apr;8(4):271-8

Department of Radiation Oncology, Hospital Regional Universitario Carlos Haya, Málaga.

Objective: To calculate the Normal Tissue Complication Probabilities (NTCP) for the liver, right kidney, left kidney and spinal cord, as well as the global Uncomplicated Tumour Control Probability (UTCP) in gastric cancer patients who underwent a treatment with radiotherapy after radical surgery in our environment.

Material And Method: In April 2000, a postoperative chemotherapy (QT-RT) protocol started in the province of Malaga for Gastric Adenocarcinomas with postsurgical stage II or higher (pT3-4 and/or pN+). This clinical protocol served as a base for our NTCP and UTCP retrospective theorical study. Read More

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Real-world emission factors of fine and ultrafine aerosol particles for different traffic situations in Switzerland.

Environ Sci Technol 2005 Nov;39(21):8341-50

Paul Scherrer Institut, Laboratory of Atmospheric Chemistry, CH-5232 Villigen, Switzerland.

Extended field measurements of particle number (size distribution of particle diameters, D, in the range between 18 nm and 10 microm), surface area concentrations, and PM1 and PM10 mass concentrations were performed in Switzerland to determine traffic emissions using a comprehensive set of instruments. Measurements took place at roads with representative traffic regimes: at the kerbside of a motorway (120 km h(-1)), a highway (80-100 km h(-1)), and in an urban area with stop-and-go traffic (0-50 km h(-1)) regulated by light signals. Mean diurnal variations showed that the highest pollutant concentrations were during the morning rush hours, especially of the number density in the nanoparticle size range (D <50 nm). Read More

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November 2005

Acute toxicity in pelvic radiotherapy; a randomised trial of conformal versus conventional treatment.

Radiother Oncol 1997 Feb;42(2):121-36

Department of Radiotherapy, Royal Marsden NHS Trust, Sutton, UK.

Background: A prospective, randomized clinical trial to assess the effect of reducing the volume of irradiated normal tissue on acute reactions in pelvic radiotherapy accured 266 evaluable patients between 1988 and 1993.

Purpose: This is the definitive analysis to assess the differences between the conformal and conventional arms of the trial.

Materials And Methods: In both arms, patients were treated with 6 MV X-rays using a 3-field technique (in all but 5 cases) consisting of an anterior and two wedged lateral or posterior oblique fields; in the conventional arm, rectangular fields were employed, whereas in the conformal arm, the fields were shaped with customized blocks drawn according to the beam's-eye-view of the target volume. Read More

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February 1997

The effects of using recombinant vaccinia viruses expressing either large or small HDAg to protect woodchuck hepadnavirus carriers from HDV superinfection.

Prog Clin Biol Res 1993 ;382:201-5

Chiron Corporation, Emeryville, CA 94608.

Live rVVs expressing either p24 delta or p27 delta were produced and used to immunize woodchuck hepadnavirus carriers. Upon challenge with infectious HDV, circulating HDV RNA levels appeared to be similar in both controls and vaccinees. Although extended follow-up studies of these animals is necessary before making firm conclusions, including an analysis of circulating HDAg levels, these preliminary results provide no evidence for a protective immunity conferred by the rVVs. Read More

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Hepatitis delta virus pathogenicity.

Authors:
E J Gowans F Bonino

Prog Clin Biol Res 1993 ;382:125-30

Division of Medical Virology, Institute of Medical and Veterinary Science, Adelaide, Australia.

This review has presented data consistent with the hypothesis that HDV may be directly cytopathic or non-cytopathic depending on the stage of infection. Nevertheless, although a majority of HDV-infected patients show evidence of liver disease, healthy carriers of the virus lead to the suggestion that different healthy carriers of HDV can exist, but particularly in the absence of a florid HBV replication. These results lead to the suggestion that different strains of HDV may result in different disease outcomes. Read More

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Hepatitis delta virus: protein composition of delta antigen and its hepatitis B virus-derived envelope.

J Virol 1986 Jun;58(3):945-50

Hepatitis delta virus (HDV)-associated particles were purified from the serum of an experimentally infected chimpanzee by size chromatography and by density centrifugation. Hepatitis delta antigen (HDAg) was detected after mild detergent treatment at a column elution volume corresponding to 36-nm particles and banded at a density of 1.25 g/ml. Read More

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