3,377 results match your criteria voiding decreased


Implementation of a clinical guideline for nonoperative management of isolated blunt renal injury in children.

Surg Open Sci 2021 Jul 3;5:19-24. Epub 2021 May 3.

Washington University in St. Louis School of Medicine, 1 Barnes Jewish Hospital Plaza, St. Louis, MO 63110.

Background: The aim was to evaluate the impact of a standardized nonoperative management protocol by comparing patients with isolated blunt renal injury before and after implementation.

Methods: We retrospectively reviewed the trauma registry at our Level 1 pediatric trauma center. We compared consecutive patients (≤ 18 years) managed nonoperatively for blunt renal injury Pre (1/2010-9/2014) and Post (10/2014-3/2020) implementation of a clinical guideline. Read More

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[Sacral neuromodulation as treatment of non-neurological vesical emptying disorders].

Prog Urol 2021 Jul 28. Epub 2021 Jul 28.

Service d'urologie andrologie et transplantation rénale, CHRU Minjoz, Besançon, France; Université de Franche Comte, Besançon, France; Nanomedicine Lab, Imagery and Therapeutics", EA 4662, Besancon, France.

Goal: The goal was to evaluate the results of sacral neuromodulation (SNM) in non-neurological vesical emptying disorders.

Patients And Methods: From February 2010 to October 2017, 28 patients presenting voiding symptoms or a non-obstructive chronic urine retention without neurological cause have been operated for an SNM (test phase). The test was positive in case of decreased number of proper intermittent self-catheterization (SC) or post-voiding residual urine (PVR) of at least 50 %. Read More

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Monitoring Severity of Respiratory Syncytial Virus (RSV) in Infants and Young Children Using the Pediatric RSV Electronic Severity and Outcome Rating System (PRESORS): Results of Initial Quantitative Validation.

Patient Relat Outcome Meas 2021 23;12:247-265. Epub 2021 Jul 23.

Janssen Global Services LLC, High Wycombe, UK.

Purpose: PRESORS ClinRO completed by clinicians and ObsRO completed by caregivers were developed to characterize the clinical course of respiratory syncytial virus (RSV) infection. This study describes preliminary analysis of PRESORS' measurement properties using clinical trial data.

Patients And Methods: PRESORS ClinRO and ObsRO data were collected in a 28-day randomized, double-blind, Phase 1b trial of JNJ-53718678 or placebo in infants and children ≤24 months of age treated for RSV infection in hospitals. Read More

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Urodynamic effects of prostatic urethral lift procedure for male voiding LUTS.

J Endourol 2021 Jul 27. Epub 2021 Jul 27.

Radboudumc, 6034, Urology, Nijmegen, Gelderland, Netherlands;

Aims: Primary objective is to investigate whether prostatic urethral lift (PUL) results in an improvement of urodynamic parameters that define bladder outlet obstruction (urethral resistance algorithm [URA], Schäfer grade, PdetQmax, PdetOpen).

Methods: 20 patients (main inclusion criteria: ≥ 50 years of age, BPO, IPSS ≥ 13, prostate volume ≤ 60 mL, no middle prostate lobe) were enrolled in the study and a PUL was performed. Patients underwent urodynamic investigation and filled out the IPSS and QoL before and after PUL. Read More

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[Comparison on efficacy between fascia-oriented versus vascular-oriented lateral lymph node dissection in patients with rectal cancer].

Zhonghua Wei Chang Wai Ke Za Zhi 2021 Jul;24(7):611-618

National Cancer Center, National Clinical Research Center for Cancer, Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China.

To compare the postoperative function, the short-term and long-term outcomes between fascia-oriented and vascular-oriented lateral lymph node dissection (LLND) in patients with rectal cancer. A retrospective cohort study was performed. Clinical data of patients who received total mesorectal excision (TME) with LLND at National Cancer Center, Cancer Hospital of Chinese Academy of Medical Science from January 2014 to December 2019 were retrospectively collected. Read More

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Interventional benefit of Pilates using Oov and mat on middle-aged women with lower urinary tract symptoms: emphasis on abdominal muscle thickness and muscular function.

J Exerc Rehabil 2021 Jun 30;17(3):192-197. Epub 2021 Jun 30.

School of Global Sport Studies, Korea University, Sejong, Korea.

Lower urinary tract symptoms (LUTS) have been considered as clinically prevalent symptom in women, and can be ameliorated by the change of abdominal muscles and pelvic floor muscle (PFM). This study investigated the efficacy of Pilates program using Oov and mat on the change of abdominal muscle thickness, PFM function, and LUTS clinical score. 53 women experiencing LUTS were randomly assigned to Oov Pilates exercise group (OPEG) (n=20), mat Pilates exercise group (MPEG) (n= 16), and symptomatic control group (SCG) (n=17), respectively, and two groups using Oov and mat participated in 8-week Pilates program. Read More

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Efficacy of vibegron, a novel β3-adrenoreceptor agonist, for lower urinary tract dysfunction in mice with spinal cord injury.

Int J Urol 2021 Jul 17. Epub 2021 Jul 17.

Department of Urology, Kindai University Faculty of Medicine, Osakasayama, Osaka, Japan.

Objectives: To investigate the effect of vibegron, a new clinically approved β3-adrenoceptor agonist in lower urinary tract dysfunction in mice with spinal cord injury.

Methods: Investigators performed cystometry under awake conditions in 4-week spinal cord injury female mice. Two weeks after spinal cord injury, saline or vibegron (30 mg/kg) was orally administered for 2 weeks prior to the urodynamic study. Read More

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Endovascular embolization as a treatment for symptomatic adenomyosis - results of preliminary study.

Ginekol Pol 2021 Jul 15. Epub 2021 Jul 15.

3rd Chair and Department of Gynecology, Medical University in Lublin, Poland.

Objectives: To present preliminary results of minimally invasive endovascular embolization as a treatment of symptomatic adenomyosis or adenomyosis with fibroids and to assess the long-term clinical outcome.

Material And Methods: Between 2015 and 2020 twelve patients with symptomatic adenomyosis or adenomyosis with fibroids underwent uterine artery embolization (UAE). All patients were evaluated in terms of patient's overall satisfaction, relief of clinical symptoms, reintervention and hysterectomy as well as menopause rates. Read More

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Pycnogenol® Supplementation Prevents Recurrent Urinary Tract Infections/Inflammation and Interstitial Cystitis.

Evid Based Complement Alternat Med 2021 23;2021:9976299. Epub 2021 Jun 23.

IRVINE3 Vascular/Circulation Labs CH-PE University, Pescara, Italy.

This open pilot registry study aimed to evaluate and compare the prophylactic effects of Pycnogenol® or cranberry extract in subjects with previous, recurrent urinary tract infections (UTI) or interstitial cystitis (IC). . Inclusion criteria were recurrent UTI or IC. Read More

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CHANGES IN THE KIDNEY AND LIVER STRUCTURE AND FUNCTIONS DURING THE EXPERIMENTAL, NON-LETHAL LOAD OF CARBON TETRACHLORIDE (CCL₄).

Georgian Med News 2021 May(314):150-155

¹National Pirogov Memorial Medical University, Vinnitsa; ²International Humanities University, Odessa; ³Ukrainian Research Institute of Medical Rehabilitation and Balneology of the Ministry of Health of Ukraine, Odessa.

Objective - to evaluate changes in the structure and function of the liver and kidneys under non-lethal carbon tetrachloride intragastric administration. Experimental studies were performed on 46 white Wistar male rats. Within 7 days, the experimental group of animals underwent intoxication with the introduction of 0. Read More

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Deciphering Spinal Endogenous Dopaminergic Mechanisms That Modulate Micturition Reflexes in Rats with Spinal Cord Injury.

eNeuro 2021 Jul-Aug;8(4). Epub 2021 Jul 29.

Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261.

Spinal neuronal mechanisms regulate recovered involuntary micturition after spinal cord injury (SCI). It was recently discovered that dopamine (DA) is synthesized in the rat injured spinal cord and is involved in lower urinary tract (LUT) activity. To fully understand the role of spinal DAergic machinery in micturition, we examined urodynamic responses in female rats during pharmacological modulation of the DA pathway. Read More

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Improving Drinking and Micturition Habits in Preschool Children: An Educational Project.

Urol Int 2021 Jul 8:1-9. Epub 2021 Jul 8.

Department of Urology and Pediatric Urology, District Hospital Garmisch-Partenkirchen, Garmisch-Partenkirchen, Germany.

Introduction: Children worldwide often do not drink enough. However, sufficient fluids are essential for physical and cognitive health. A regular and adequate supply of fluids also supports bladder maturation in the context of acquiring urinary continence. Read More

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Efficacy of Transcutaneous Electrical Nerve Stimulation in the Management of Neurogenic Overactive Bladder: A Randomized Controlled Trial.

Am J Phys Med Rehabil 2021 Jul 3. Epub 2021 Jul 3.

Department of Rehabilitation Medicine, Shanghai Tenth People's Hospital, Tongji University, Shanghai, China. Department of Urology, Shanghai Tenth People's Hospital, Tongji University, Shanghai, China.

Objective: To investigate the therapeutic effect of transcutaneous electrical nerve stimulation (TENS) on neurogenic overactive bladder (NOAB) that is refractory to pharmacotherapy.

Methods: This randomized trial recruited 83 participants with NOAB that were non-responsive to 3 months first-line anticholinergic drug treatment. Participants were randomized into treatment and control groups. Read More

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Hidrox and Chronic Cystitis: Biochemical Evaluation of Inflammation, Oxidative Stress, and Pain.

Antioxidants (Basel) 2021 Jun 29;10(7). Epub 2021 Jun 29.

Department of Biomedical and Biotechnological Sciences, University of Catania, 95123 Catania, Italy.

Interstitial cystitis/painful bladder syndrome (IC/PBS) is a chronic bladder condition characterized by frequent urination, inflammation, oxidative stress, and pain. The aim of the study was to evaluate the anti-inflammatory and antioxidant effects of an oral administration of Hidrox (10 mg/kg) in the bladder and spinal cord in a rodent model of IC/BPS. The chronic animal model of cystitis was induced by repeated intraperitoneal injections of cyclophosphamide (CYP) for five consecutive days. Read More

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Identifying Patterns of Symptom Distress in Pregnant Women: A Pilot Study.

Int J Environ Res Public Health 2021 06 11;18(12). Epub 2021 Jun 11.

School of Nursing, College of Medicine, National Taiwan University, Taipei City 10051, Taiwan.

During pregnancy, a woman's enlarged uterus and the developing fetus lead to symptom distress; in turn, physical and psychological aspects of symptom distress are often associated with adverse prenatal and birth outcomes. This study aimed to identify the trends in the trajectory of these symptoms. This longitudinal study recruited 95 pregnant women, with a mean age of 32 years, from the prenatal wards of two teaching hospitals in northern Taiwan. Read More

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Therapeutic Efficacy of Urethral Sphincteric Botulinum Toxin Injections for Female Sphincter Dysfunctions and a Search for Predictive Factors.

Toxins (Basel) 2021 06 2;13(6). Epub 2021 Jun 2.

Institute of Clinical Medicine, College of Medicine, National Cheng Kung University, Tainan 704, Taiwan.

External urethral sphincter (EUS) dysfunction is a common, bothersome female voiding dysfunction. This study aims to analyze the characteristics of different types of female EUS dysfunction, as well as to determine the outcome predictors of sphincteric botulinum toxin A (BoNT-A) injection. Women receiving sphincteric BoNT-A injections for refractory EUS dysfunction were retrospectively reviewed. Read More

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Corticotropin-releasing hormone from the pontine micturition center plays an inhibitory role in micturition.

J Neurosci 2021 Jun 28. Epub 2021 Jun 28.

Division of Urology, Children's Hospital of Philadelphia, 3rd Floor, Wood Building, 34th and Civic Center Blvd., Philadelphia, PA 19104.

Lower urinary tract or voiding disorders are prevalent across all ages and affect over 40% of adults over 40 years old leading to decreased quality of life and high healthcare costs. The pontine micturition center (PMC; ie, Barrington's nucleus) contains a large population of neurons that localize the stress-related neuropeptide, corticotropin-releasing hormone (CRH) and project to neurons in the spinal cord to regulate micturition. How the PMC and CRH-expressing neurons in the PMC control volitional micturition is of critical importance for human voiding disorders. Read More

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Therapeutic effects of traditional Thai herbal blood and wind tonic formulations for treatment of menopausal symptoms.

Explore (NY) 2021 Jun 12. Epub 2021 Jun 12.

Traditional Thai Medical Research and Innovation Center, Faculty of Traditional Thai Medicine, Prince of Songkla University, Hat Yai, Songkhla 90110, Thailand.

Introduction: Traditional Thai herbal medicine formulations have been used as alternative therapies for menopausal symptoms due to concerns from adverse effects associated with hormone therapy. This study aimed to demonstrate the effects of traditional Thai herbal blood and wind tonic formulations used by a traditional Thai medicine doctor, Mr. Somporn Chanwanitsakul, in postmenopausal women. Read More

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A Preclinical Study of Human Embryonic Stem Cell-Derived Mesenchymal Stem Cells for Treating Detrusor Underactivity by Chronic Bladder Ischemia.

Stem Cell Rev Rep 2021 Jun 29. Epub 2021 Jun 29.

Department of Urology, Asan Medical Center, University of Ulsan College of Medicine, 88 Olympic-ro 43-gil, Songpa-gu, Seoul, 05505, South Korea.

Background: The therapeutic effects of human embryonic stem cell-derived multipotent mesenchymal stem cells (M-MSCs) were evaluated for detrusor underactivity (DUA) in a rat model with atherosclerosis-induced chronic bladder ischemia (CBI) and associated mechanisms.

Methods: Sixteen-week-old male Sprague-Dawley rats were divided into five groups (n = 10). The DUA groups underwent 30 bilateral repetitions of endothelial injury to the iliac arteries to induce CBI, while the sham control group underwent a sham operation. Read More

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Acute urinary retention in pediatric cerebral palsy: Is there an optimal management strategy?

J Pediatr Urol 2021 Jun 5. Epub 2021 Jun 5.

Department of Urology, University of California San Diego, 200 West Arbor Drive MC 7897, San Diego, CA 92103, USA; Rady Children's Hospital - San Diego, 3020 Childrens Way MC 5120, San Diego, CA 92123, USA.

Introduction And Objective: Cerebral palsy (CP) patients commonly have lower urinary tract dysfunction. Urinary retention (UR), which has been associated with dysfunctional voiding in CP can correlate to chronic upper tract dysfunction. We sought to provide insight into the pediatric presentation of acute UR in patients with CP and subsequent outcomes in this at-risk population. Read More

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Botulinum toxin A improves neurogenic bladder fibrosis by suppressing transforming growth factor β1 expression in rats.

Transl Androl Urol 2021 May;10(5):2000-2007

Department of Urology, Xuanwu Hospital Capital Medical University, National Clinical Research Center for Geriatric Diseases, Beijing, China.

Background: Intradetrusor botulinum toxin A injection is recommended for the treatment of refractory detrusor overactivity (DO) in patients with neurogenic bladder, however, whether it could inhibit neurogenic bladder fibrosis is uncertain. This study aimed to investigate the effect of botulinum toxin A on neurogenic bladder fibrosis and the underlying mechanism.

Methods: Forty eight Female Wistar rats were evenly randomized into 4 groups: Sham, T10 transection, Early and Late groups. Read More

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Intermediate-term results of a prospective, multicenter study on remote programming sacral neuromodulation for refractory overactive bladder.

Transl Androl Urol 2021 May;10(5):1966-1975

Urology Department, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences Beijing, China.

Background: To evaluate the efficacy and safety of a novel remote programming sacral neuromodulation (SNM) system (BetterStim system) in the treatment of patients with refractory overactive bladder (OAB) for 3 years.

Methods: A total of 8 centers in China enrolled 84 patients with OAB. Following test stimulation 70 patients underwent implantation using BetterStim. Read More

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Voiding behavior in awake unrestrained untethered spontaneously hypertensive and Wistar control rats.

Am J Physiol Renal Physiol 2021 Aug 21;321(2):F195-F206. Epub 2021 Jun 21.

Department of Biomedical Engineering, grid.26009.3dDuke University, Durham, North Carolina.

The spontaneously hypertensive rat (SHR), a genetic model of high blood pressure, has also been studied as a potential model of overactive bladder. In vivo studies have confirmed the presence of surrogate markers of overactive bladder, including detrusor overactivity, increased urinary frequency, decreased bladder capacity and voided volume (VV), and afferent hypersensitivity to bladder irritation. However, these observations were during awake cystometry using implanted bladder catheters tethered to an infusion pump and artificially filled. Read More

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Autologous Fascial Slings for Surgical Management of Stress Urinary Incontinence: A Come Back.

J Obstet Gynaecol India 2021 Apr 2;71(2):106-114. Epub 2021 Jan 2.

Department of Obstetrics, Gynecology and Urogynecology, All India Institute of Medical Sciences, Ansari Nagar, New Delhi, 110029 India.

Stress urinary incontinence (SUI) is a common type of urinary incontinence adversely affecting the quality of life of women. For mild SUI, life style changes, pelvic floor exercises and medical treatment with duloxetine may help. Most patients of moderate to severe SUI usually require surgical treatment. Read More

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Solifenacin/Mirabegron Induces an Acute Compliance Increase in the Filling Phase of the Capacity-Reduced Urinary Bladder: A Pressure-Volume Analysis in Rats.

Front Pharmacol 2021 26;12:657959. Epub 2021 May 26.

Department of Physiology, School of Medicine, College of Medicine, Taipei Medical University, Taipei City, Taiwan.

Pressure in the bladder, which is a high compliance organ, is only slightly elevated to a considerable filling volume during storage. Although cystometry off-line offers mean compliance, no protocol is available for real-time assays of the dynamics of bladder compliance, and the potential impact of solifenacin and mirabegron on dynamic bladder compliance has not been established. Along with constantly infused cystometry, a pressure-volume analysis (PVA) was performed by plotting intra-vesical volume against pressure in Sprague-Dawley rats. Read More

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Clinical efficacy and therapeutic value of delayed surgery in patients with symptomatic old thoracolumbar fractures.

BMC Surg 2021 Jun 11;21(1):290. Epub 2021 Jun 11.

Department of Orthopaedics, Xijing Hospital, Air Force Medical University, 127 West Changle Road, Xi'an, 710032, China.

Background: To investigate the clinical efficacy and therapeutic value of posterior decompression reduction, bone grafting fusion, and internal fixation for treatment of symptomatic old thoracolumbar fractures.

Method: Retrospective analysis was conducted for 14 patients (9 men, 5 women; average age 40.1 years) with old thoracolumbar fractures who underwent posterior operation. Read More

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A comparison of Kinesio taping and external electrical stimulation in addition to pelvic floor muscle exercise and sole pelvic floor muscle exercise in women with overactive bladder: a randomized controlled study.

Disabil Rehabil 2021 Jun 7:1-9. Epub 2021 Jun 7.

Department of Urology, Ankara Gazi Mustafa Kemal Hospital, Ankara, Turkey.

Purpose: To compare the effects of Kinesio taping® (KT) and external electrical stimulation (ES) in addition to pelvic floor muscle exercise (PFME) and sole PFME in women with overactive bladder (OAB).

Material And Methods: Patients with OAB were randomly allocated into PFME, PFME + KT, PFME + ES groups. All treatments were carried out for 6 weeks. Read More

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Rapid hypercalciuria induction with bone formation marker reduction during immobilization in children.

Endocr Pract 2021 Jun 4. Epub 2021 Jun 4.

Endocrinology and Metabolism Department, Tokyo Metropolitan Children's Medical Center. Electronic address:

Objective: The present study aimed to examine prospectively the occurrence of hypercalciuria and changes in bone metabolite markers in pediatric patients during immobilization.

Methods: In total, 13 children with an orthopedic disease requiring immobilization longer than two weeks were enrolled. Blood samples were collected after breakfast. Read More

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Evaluation of the 24-h pad weight test as continence rate assessment tool after artificial urinary sphincter implantation for postprostatectomy urinary incontinence: A Swedish retrospective cohort study.

Neurourol Urodyn 2021 Aug 3;40(6):1585-1592. Epub 2021 Jun 3.

Section of Urology, Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden.

Aim: Patient-reported pad-count as continence rate assessment tool after artificial urinary sphincter (AUS) implantation is common. However, lack of standardized continence definition using this method results in heterogeneous published efficacy outcomes. Data on 24-h pad weight tests (PWT) after primary AUS implantation for postprostatectomy urinary incontinence (PPUI) is scarce. Read More

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[Prevalence and risk factors for lower urinary tract symptoms after robotic sacrocolpopexy.]

Arch Esp Urol 2021 Jun;74(5):494-502

Servicio de Urología. Hospital Nacional de Parapléjicos. Toledo. España.

Objectives: To analyse the outcomes of Robotic Sacrocolpopexy (RSC) on resolution of Lower urinary tract Symptoms (LUTS) associated to pelvic organ prolapses (POP) and to determine the risk factors for preoperative LUTS presence.

Material And Methods: A longitudinal study was carried out on 51 females mean aged (± standard deviation) 66 ± 9 years, who underwent RSC. A preoperative evaluation was made on the degree and type of POP, and the presence of the LUTS stress urinary incontinence (SUI), urgency and voiding difficulty. Read More

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