18,039 results match your criteria vmat


Efficient uncertainty quantification for Monte Carlo dose calculations using importance (re-)weighting.

Phys Med Biol 2021 Sep 20. Epub 2021 Sep 20.

Department of Medical Physics in Radiation Oncology, Deutsches Krebsforschungszentrum, Heidelberg, GERMANY.

To present an efficient uncertainty quantification method for range and set-up errors in Monte Carlo (MC) dose calculations. Further, we show that uncertainty induced by interplay and other dynamic influences may be approximated using suitable error correlation models.We introduce an importance (re-)weighting method in MC history scoring to concurrently construct estimates for error scenarios, the expected dose and its variance from a single set of MC simulated particle histories. Read More

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September 2021

Increasing demand on human capital and resource utilization in radiotherapy: The past decade.

Int J Radiat Oncol Biol Phys 2021 Sep 17. Epub 2021 Sep 17.

Department of Oncology, University of Calgary, Calgary AB, Canada; Department of Physics & Astronomy, University of Calgary, Calgary AB, Canada; Tom Baker Cancer Centre, Calgary AB, Canada.

Purpose: To quantify the change resource utilization in radiotherapy in the context of advancing technologies and techniques over the last decade.

Methods And Materials: Prospectively, the time to complete radiotherapy workflow tasks was captured between January 1, 2020 and December 31, 2020. The institutional task workflows are specific to each technique and broadly organized into four categories: 3D conformal radiotherapy (3DCRT), IMRT, VMAT simple, and VMAT complex. Read More

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September 2021

A phase I/II study of acute and late physician assessed and patient-reported morbidity following whole pelvic radiation in high-risk prostate cancer patients.

Acta Oncol 2021 Sep 20:1-6. Epub 2021 Sep 20.

Department of Oncology, Aarhus University Hospital, Aarhus, Denmark.

Background: The aim of this study was to assess acute and late morbidity measured by the physician and patient-reported outcomes (PROs) in high-risk prostate cancer (PC) patients receiving whole pelvic intensity-modulated radiotherapy (IMRT) in the setting of a national clinical trial.

Material And Methods: A total of 88 patients with adenocarcinoma of the prostate and high-risk parameters were enrolled from 2011 to 2013. All patients received 78 Gy in 39 fractions of IMRT delivering simultaneous 78 Gy to the prostate and 56 Gy to the seminal vesicles and lymph nodes. Read More

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September 2021

Clinical impact of anisotropic analytical algorithm and Acuros XB dose calculation algorithms for intensity modulated radiation therapy in lung cancer patients.

J Xray Sci Technol 2021 Sep 15. Epub 2021 Sep 15.

Biophysics Department, Faculty of Science, Cairo University, Giza, Egypt.

Objective: To evaluate dose differences predicted between using Anisotropic Analytical Algorithm (AAA) and Acuros XB (AXB) in patients diagnosed with locally advanced non-small cell lung cancer (NSCLC) treated with intensity modulated radiation therapy (IMRT).

Methods: A phantom study was done to evaluate the dose prediction accuracy of AXB and AAA beyond low-density medium by comparing the calculated measurement results. Thirty-two advanced NSCLC patients were subjected to IMRT. Read More

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September 2021

Re-evaluation of the prognostic significance of retropharyngeal node metastasis in nasopharyngeal carcinoma patients treated with intensity-modulated radiotherapy.

Asia Pac J Clin Oncol 2021 Sep 19. Epub 2021 Sep 19.

Department of Radiotherapy, Fujian Medical University Cancer Hospital, Fujian Cancer Hospital, Fuzhou, China.

Background And Purpose: To investigate the prognostic value of retropharyngeal lymphadenopathy in nasopharyngeal carcinoma (NPC) after intensity-modulated radiotherapy.

Materials And Methods: Retrospective studies were performed in a total of 1197 patients. We evaluated the incidence of the retropharyngeal node (RPN) metastasis and the characteristics of the metastatic RPN including laterality, size, necrosis, and extranodal neoplastic spread. Read More

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September 2021

Dosimetric Comparison, Treatment Efficiency Estimation, and Biological Evaluation of Popular Stereotactic Radiosurgery Options in Treating Single Small Brain Metastasis.

Front Oncol 2021 5;11:716152. Epub 2021 Aug 5.

Department of Radiation Oncology, Shanghai Chest Hospital, Shanghai Jiao Tong University, Shanghai, China.

Objectives: This study aimed to show the advantages of each stereotactic radiosurgery (SRS) treatment option for single small brain metastasis among Gamma Knife (GK), Cone-based VMAT (Cone-VMAT), and MLC-based CRT (MLC-CRT) plans.

Materials And Methods: GK, Cone-VMAT, and MLC-CRT SRS plans were retrospectively generated for 11 patients with single small brain metastasis whose volume of gross tumor volume (GTV) ranged from 0.18 to 0. Read More

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Treatment planning comparison between dynamic wave arc and volumetric modulated arc therapies for prostate-cancer treatment.

Med Dosim 2021 Sep 16. Epub 2021 Sep 16.

Hiroshima High-Precision Radiotherapy Cancer Center, 3-2-2, Futabanosato, Higashi-ku Hiroshima 732-0057, Japan; Department of Radiation Oncology, Graduate School of Biomedical & Health Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima 734-8551, Japan.

The aim of this study was to compare the quality of dynamic wave arc (DWA) and coplanar volumetric modulated arc therapy (co-VMAT) plans for the treatment of localized prostate cancer. The planning target volume (PTV)-rectum, a section of the PTV comprising the PTV minus that of the rectum, received 78 Gy in 39 fractions as the mean dose to the PTV-rectum. The DWA and co-VMAT plans were generated for each patient using the RayStation treatment planning system for the Vero4DRT system. Read More

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September 2021

MRI-guided focal boost to dominant intraprostatic lesion using volumetric modulated arc therapy in prostate cancer. Results of a phase II trial.

Br J Radiol 2021 Sep 19:20210683. Epub 2021 Sep 19.

Radiation Oncology Department, Hospital Universitario de la Princesa, Health Research Institute IIS-IP, Madrid, Spain.

Objective: To determine morphological and biological control as well as toxicity and quality of life (QoL) of men with localized prostate cancer (PCa) treated with MRI-guided focal boost radiotherapy.

Material And Methods: 30 patients with PCa and a visible dominant intraprostatic lesion (DIL) identified on mpMRI were included in a prospective Phase II trial. Matching point registration of planning CT and T2W, diffusion-weighted and a gradient-recalled echo (GRE) MRI images made in treatment position was used for prostate and tumour delineation. Read More

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September 2021

Long term results of a phase II trial of hypofractionated adjuvant radiotherapy for early-stage breast cancer with volumetric modulated arc therapy and simultaneous integrated boost.

Radiother Oncol 2021 Sep 16. Epub 2021 Sep 16.

IRCCS Humanitas Research Hospital -Department of Radiotherapy and Radiosurgery, via Manzoni 56, 20089 Rozzano, Milan, Italy; Department of Biomedical Sciences, Humanitas University, Via Rita Levi Montalcini 4, 20090 Pieve Emanuele, Milan, Italy.

Purpose: to report toxicity and cosmetic outcome with a median follow-up of 6 years of a phase II trial of hypofractionated radiotherapy with volumetric modulated arc therapy (VMAT) and simultaneous integrated boost (SIB) for early-stage breast cancer after conservative surgery.

Materials And Methods: from August 2010 to September 2014, patients requiring adjuvant radiotherapy for early-stage breast cancer were treated according to a phase I-II protocol with SIB to 40.5 and 48 Gy to the breast and the boost region, respectively, with VMAT technique. Read More

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September 2021

Treatment outcome and compliance to dose-intensified linac-based SBRT for unfavorable prostate tumors using a novel real-time organ-motion tracking.

Radiat Oncol 2021 Sep 17;16(1):180. Epub 2021 Sep 17.

Department of Radiation Oncology, School of Medicine and Surgery, University of Milan Bicocca, Milan, Italy.

Purpose/objectives: To report preliminary data on treatment outcome and compliance to dose-intensified organ sparing SBRT for prostate cancer using a novel electromagnetic transmitter-based tracking system (RayPilotÒ System) to account for intra-fractional organ motion.

Material/methods: Thirteen patients with intermediate unfavorable (9) and selected high-risk (4) prostate cancer underwent dose-escalated SBRT in 4 or 5 fractions (BED = 279 Gy and 253 Gy, respectively). The VMAT treatment consisted in two 6FFF or 10FFF full arcs optimized to have the 95% isodose covering at least 95% of the PTV (2 mm isotropic expansion of the CTV). Read More

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September 2021

Online MR evaluation of inter- and intra-fraction uterus motions and bladder volume changes during cervical cancer external beam radiotherapy.

Radiat Oncol 2021 Sep 17;16(1):179. Epub 2021 Sep 17.

Department of Radiation Oncology Physics and Technology, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, No.440 Jiyan road, Huaiyin district, Jinan City, 250117, Shandong Province, China.

Purpose/objective(s): The purpose of the study was to assess the uterus motions and bladder volume changes of fractional movements in cervical sites throughout the external beam radiotherapy (EBRT) treatment.

Materials/methods: A prospective online MR imaging tracking study was conducted in EBRT 43 patients with at least 4 scans during each treatment (before: ultrasound scan, MRI scan, CBCT scan, after: MRI scan) were included. In order to improve the treatment repeatability, each patient was instructed to empty the bladder and drink 500 ml water 1 h before CT simulation and each treatment. Read More

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September 2021

Impact of RBE variations on risk estimates of temporal lobe necrosis in patients treated with intensity-modulated proton therapy for head and neck cancer.

Acta Oncol 2021 Sep 17:1-8. Epub 2021 Sep 17.

Department of Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, USA.

Background: Temporal lobe necrosis (TLN) is a potential late effect after radiotherapy for skull base head and neck cancer (HNC). Several photon-derived dose constraints and normal tissue complication probability (NTCP) models have been proposed, however variation in relative biological effectiveness (RBE) may challenge the applicability of these dose constraints and models in proton therapy. The purpose of this study was therefore to investigate the influence of RBE variations on risk estimates of TLN after Intensity-Modulated Proton Therapy for HNC. Read More

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September 2021

Long-term outcomes of induction chemotherapy followed by intensity-modulated radiotherapy and adjuvant chemotherapy in nasopharyngeal carcinoma patients with N3 disease.

Transl Oncol 2021 Sep 13;14(12):101216. Epub 2021 Sep 13.

Department of Radiation Oncology, Fudan University Shanghai Cancer Center, Shanghai 200032, China; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, China; Shanghai Key Laboratory of Radiation Oncology, Shanghai 200032, China. Electronic address:

Objectives: To evaluate long-term outcomes of induction chemotherapy (IC) followed by intensity-modulated radiotherapy (IMRT) and adjuvant chemotherapy (AC) in nasopharyngeal carcinoma (NPC) patients with N3 disease.

Materials And Methods: From September 2005 to August 2016, 143 patients confirmed NPC with the 8th AJCC/UICC staging criteria N3 were reviewed. All patients received IC followed by IMRT and AC. Read More

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September 2021

Diaphragm Based Position Verification to Improve Daily Target Dose Coverage in Proton and Photon Radiotherapy Treatment of Distal Esophageal Cancer.

Int J Radiat Oncol Biol Phys 2021 Sep 13. Epub 2021 Sep 13.

Department of Radiation Oncology, University Medical Center Groningen, University of Groningen, The Netherlands.

Purpose: In modern conformal radiotherapy of distal esophageal cancer, target coverage can be affected by variations in the diaphragm position. We investigated if daily position verification (PV) extended by a diaphragm position correction would optimize target dose coverage for esophageal cancer treatment.

Materials And Methods: For fifteen esophageal cancer patients, intensity modulated proton therapy (IMPT) and volumetric modulated arc therapy (VMAT) plans were computed. Read More

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September 2021

Determining tolerance levels for quality assurance of 3D printed bolus for modulated arc radiotherapy of the nose.

Phys Eng Sci Med 2021 Sep 16. Epub 2021 Sep 16.

Cancer Care Services, Royal Brisbane and Women's Hospital, Brisbane, QLD, Australia.

Given the existing literature on the subject, there is obviously a need for specific advice on quality assurance (QA) tolerances for departments using or implementing 3D printed bolus for radiotherapy treatments. With a view to providing initial suggested QA tolerances for 3D printed bolus, this study evaluated the dosimetric effects of changes in bolus geometry and density, for a particularly common and challenging clinical situation: specifically, volumetric modulated arc therapy (VMAT) treatment of the nose. Film-based dose verification measurements demonstrated that both the AAA and the AXB algorithms used by the Varian Eclipse treatment planning system (Varian Medical Systems, Palo Alto, USA) were capable of providing sufficiently accurate dose calculations to allow this planning system to be used to evaluate the effects of bolus errors on dose distributions from VMAT treatments of the nose. Read More

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September 2021

Intensity modulated radiotherapy in anal canal squamous cell carcinoma: Implementation and outcomes.

J Cancer Res Ther 2021 Jul-Sep;17(4):975-981

Department of Radiation Oncology, Tata Medical Center, Kolkata, West Bengal, India.

Objective: Concurrent chemoradiotherapy (CCRT) is the standard curative treatment option for nonmetastatic anal squamous cell carcinoma (SCC). Intensity modulated radiotherapy (IMRT) can reduce doses delivered to bowel and skin and reduce toxicities associated with conventional fields. Here, we present our institutional data on dosimetry, toxicity, and clinical outcomes with IMRT for anal cancer. Read More

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September 2021

Dosimetric analysis of three-dimensional conformal radiotherapy, intensity-modulated radiotherapy-step and shoot, helical tomotherapy, and volumetric modulated arc therapy in prostate cancer radiotherapy.

J Cancer Res Ther 2021 Jul-Sep;17(4):893-900

Radiation Oncology Department, Rumah Sakit Cipto Mangunkusumo, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia.

Introduction: There is limited study comparing dosimetry parameters in detail. In regard to prostate cancer, there are four different techniques, namely three-dimensional conformal radiotherapy (3D-CRT), intensity-modulated radiotherapy-step and shoot (IMRT-SS), IMRT-helical tomotherapy (HT), and volumetric-modulated arc therapy (VMAT).

Materials And Methods: Experimental study with intervention on ten prostate cancer patients' computed tomography planning data. Read More

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September 2021

Validation of absolute point dosimetry by the analytical anisotropic algorithm and Acuros XB algorithm employing intensity-modulated radiotherapy technique on an in-house develop cost-effective heterogeneous thorax phantom.

J Cancer Res Ther 2021 Jul-Sep;17(4):859-864

School of Studies in Physics, Vikram University, Ujjain, Madhya Pradesh, India.

Introduction: Dose validation inside the human body needs a medium which can simulate the actual heterogeneities of a specific body site. The aim of the present work is to study the properties of a cost-effective heterogeneous thorax phantom (HTP) developed in-house by the author and its application for the evaluation of patient-specific absolute point dosimetry by employing analytic anisotropic algorithm (AAA) and Acuros XB (AXB) algorithm.

Materials And Methods: HTP was made from the dust of porous pinewood, rib cage, and honeybee's wax. Read More

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September 2021

Single-isocenter stereotactic non-coplanar arc treatment of 200 patients with brain metastases: multileaf collimator size and setup uncertainties.

Strahlenther Onkol 2021 Sep 15. Epub 2021 Sep 15.

Department of Oncology, Radiotherapy Research Unit (52AA), Herlev & Gentofte Hospital, University of Copenhagen, Borgmester Ib Juuls vej 7, 2730, Herlev, Denmark.

Purpose: The purpose of this study was to evaluate our 2 years' experience with single-isocenter, non-coplanar, volumetric modulated arc therapy (VMAT) for brain metastasis (BM) stereotactic radiosurgery (SRS).

Methods: A total of 202 patients treated with the VMAT SRS solution were analyzed retrospectively. Plan quality was assessed for 5 mm (120) and 2. Read More

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September 2021

Clinical Profile and Treatment Outcomes in Patients Treated with Intensity-Modulated Radiotherapy (IMRT) for Carcinoma Nasopharynx: A Retrospective Analysis.

J Oncol 2021 30;2021:9932749. Epub 2021 Aug 30.

Department of Radiation Oncology, Regional Cancer Centre, Thiruvananthapuram, Kerala, India.

Objective: To retrospectively evaluate the clinical outcome of carcinoma nasopharynx patients treated with the IMRT technique.

Methods: Eighty-one nasopharyngeal carcinoma patients who were treated with IMRT with or without chemotherapy between the period January 2011 and December 2014 at a comprehensive tertiary cancer center, Kerala, India, were included in the study. The mean age was 43 years (range 13-77 years), and majority of the patients were males (67. Read More

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Influence of eye movement on lens dose and optic nerve target coverage during craniospinal irradiation.

Clin Transl Radiat Oncol 2021 Nov 29;31:28-33. Epub 2021 Aug 29.

Department of Radiation Oncology, University Medical Center Utrecht, Utrecht, the Netherlands.

Purpose: Optic nerves are part of the craniospinal irradiation (CSI) target volume. Modern radiotherapy techniques achieve highly conformal target doses while avoiding organs-at-risk such as the lens. The magnitude of eye movement and its influence on CSI target- and avoidance volumes are unclear. Read More

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November 2021

Efficacy and Prognostic Analysis of 315 Stage I-IVa Esophageal Cancer Patients Treated with Simultaneous Integrated Boost-Intensity-Modulated Radiation Therapy.

Cancer Manag Res 2021 7;13:6969-6975. Epub 2021 Sep 7.

Department of Radiotherapy, The First Affiliated Hospital of Bengbu Medical College, Bengbu, 233004, People's Republic of China.

Purpose: Use of simulated integrated boost-intensity-modulated radiation therapy (SIB-IMRT) is rarely reported in the treatment of esophageal cancer. This study was performed to observe the curative effect and prognostic factors associated with concurrent chemoradiotherapy for esophageal cancer using modern radiotherapy (RT) techniques.

Patients And Methods: In total, 315 patients with esophageal squamous cell carcinoma who received SIB-IMRT between 2015 and 2018 were included in this retrospective study. Read More

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September 2021

Retrospective comparison of rectal toxicity between carbon-ion radiotherapy and intensity-modulated radiation therapy based on treatment plan, normal tissue complication probability model, and clinical outcomes in prostate cancer.

Phys Med 2021 Sep 11;90:6-12. Epub 2021 Sep 11.

Department of Radiation Oncology, Gunma University Graduate School of Medicine, Gunma, Japan; Gunma University Heavy Ion Medical Center, Gunma, Japan.

This retrospective study assessed the treatment planning data and clinical outcomes for 152 prostate cancer patients: 76 consecutive patients treated by carbon-ion radiation therapy and 76 consequtive patients treated by moderate hypo-fractionated intensity-modulated photon radiation therapy. These two modalities were compared using linear quadratic model equivalent doses in 2 Gy per fraction for rectal or rectal wall dose-volume histogram, 3.6 Gy per fraction-converted rectal dose-volume histogram, normal tissue complication probability model, and actual clinical outcomes. Read More

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September 2021

Dose rate correction for a silicon diode detector array.

J Appl Clin Med Phys 2021 Sep 14. Epub 2021 Sep 14.

Department of Radiation Oncology, University of Wuerzburg, Wuerzburg, Germany.

Purpose: A signal dependence on dose rate was reported for the ArcCHECK array due to recombination processes within the diodes. The purpose of our work was to quantify the necessary correction and apply them to quality assurance measurements.

Methods: Static 10 × 10 cm 6-MV fields delivered by a linear accelerator were applied to the detector array while decreasing the average dose rate, that is, the pulse frequency, from 500 to 30 MU/min. Read More

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September 2021

Fully automated noncoplanar radiation therapy treatment planning.

Med Phys 2021 Sep 14. Epub 2021 Sep 14.

Department of Radiation Oncology, Stanford University, Stanford, USA.

Purpose: To perform fully automated noncoplanar treatment planning, we propose a method called NC-POPS to produce noncoplanar (NC) plans using the Pareto Optimal Projection Search (POPS) algorithm.

Methods: Noncoplanar radiation therapy treatment planning has the potential to improve dosimetric quality as compared to traditional coplanar techniques. Likewise, automated treatment planning algorithms can reduce a planner's active treatment planning time and remove inter-planner variability. Read More

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September 2021

Predicting personalised optimal arc parameter using knowledge-based planning model for inoperable locally advanced lung cancer patients to reduce organ at risk doses.

Biomed Phys Eng Express 2021 Sep 13. Epub 2021 Sep 13.

Radiation Physics Department, Hull University Teaching Hospitals NHS Trust, Queens Centre For Oncology And Hematology, Castle Hill Hospital, Castle Hill Hospital, Cottingham, Hull, Kingston upon Hull, HU16 5JQ, UNITED KINGDOM OF GREAT BRITAIN AND NORTHERN IRELAND.

Volumetric modulated arc therapy (VMAT) allows for reduction of organs at risk (OAR) volumes receiving higher doses, but increases OAR volumes receiving lower radiation doses and can subsequently increasing associated toxicity. Therefore, reduction of this low-dose-bath is crucial. This study investigates personalizing the optimization of VMAT arc parameters (gantry start and stop angles) to decrease OAR doses. Read More

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September 2021

Radiation Therapy Planning of Thoracic Tumors: A Review of Challenges Associated With Lung Toxicities and Potential Perspectives of Gallium-68 Lung PET/CT Imaging.

Front Med (Lausanne) 2021 27;8:723748. Epub 2021 Aug 27.

Service de médecine nucléaire, CHRU de Brest, EA3878 (GETBO), Université de Brest, Brest, France.

Despite the introduction of new radiotherapy techniques, such as intensity modulated radiation therapy or stereotactic body radiation therapy, radiation induced lung injury remains a significant treatment related adverse event of thoracic radiation therapy. Functional lung avoidance radiation therapy is an emerging concept in the treatment of lung disease to better preserve lung function and to reduce pulmonary toxicity. While conventional ventilation/perfusion (V/Q) lung scintigraphy is limited by a relatively low spatial and temporal resolution, the recent advent of Gallium V/Q lung PET/CT imaging offers a potential to increase the accuracy of lung functional mapping and to better tailor lung radiation therapy plans to the individual's lung function. Read More

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Use of a Biodegradable, Contrast-Filled Rectal Spacer Balloon in Intensity-Modulated Radiotherapy for Intermediate-Risk Prostate Cancer Patients: Dosimetric Gains in the BioPro-RCMI-1505 Study.

Front Oncol 2021 26;11:701998. Epub 2021 Aug 26.

Academic Department of Radiation Oncology, Centre Oscar Lambret, Lille, France.

Background/purpose: Dose-escalated external beam radiotherapy (RT) is effective in the control of prostate cancer but is associated with a greater incidence of rectal adverse events. We assessed the dosimetric gain and safety profile associated with implantation of a new biodegradable rectal spacer balloon.

Materials/methods: Patients scheduled for image-guided, intensity-modulated RT for intermediate-risk prostate cancer were prospectively included in the French multicenter BioPro-RCMI-1505 study (NCT02478112). Read More

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Role of MRI-Based Functional Imaging in Improving the Therapeutic Index of Radiotherapy in Cancer Treatment.

Front Oncol 2021 27;11:645177. Epub 2021 Aug 27.

Department of Gynecology and Obstetrics, Key Laboratory of Birth Defects and Related Diseases of Women and Children, Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu, China.

Advances in radiation technology, such as intensity-modulated radiation therapy (IMRT), have largely enabled a biological dose escalation of the target volume (TV) and reduce the dose to adjacent tissues or organs at risk (OARs). However, the risk of radiation-induced injury increases as more radiation dose utilized during radiation therapy (RT), which predominantly limits further increases in TV dose distribution and reduces the local control rate. Thus, the accurate target delineation is crucial. Read More

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Online Magnetic Resonance-Guided Radiotherapy (oMRgRT) for Gynecological Cancers.

Front Oncol 2021 27;11:628131. Epub 2021 Aug 27.

Department of Radiation Oncology, University Medical Center Utrecht, University Utrecht, Utrecht, Netherlands.

Radiation therapy (RT) is increasingly being used in gynecological cancer management. RT delivered with curative or palliative intent can be administered alone or combined with chemotherapy or surgery. Advanced treatment planning and delivery techniques such as intensity-modulated radiation therapy, including volumetric modulated arc therapy, and image-guided adaptive brachytherapy allow for highly conformal radiation dose delivery leading to improved tumor control rates and less treatment toxicity. Read More

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