2,505 results match your criteria vlbw preterm

The microbiome, guard or threat to infant health.

Trends Mol Med 2021 Sep 10. Epub 2021 Sep 10.

Department of Pediatrics, The University of Chicago, Chicago, IL, USA. Electronic address:

Despite improvements in survival for very low birthweight (VLBW) premature infants, there continues to be significant morbidity for these infants at remarkable cost to the healthcare system. Concurrent development of the preterm infant intestine alongside the gut microbiome in the clinical setting rather than in the protected in utero environment where it would usually occur creates significant vulnerabilities for the infant's immature intestine and immune system, resulting in devastating illness and neurological injury. However, the microbiome also has the capacity to promote healthy development. Read More

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September 2021

Survival Status and Predictors of Mortality Among Preterm Neonates Admitted to Mizan Tepi University Teaching Hospital, South West Ethiopia.

Pediatric Health Med Ther 2021 1;12:439-449. Epub 2021 Sep 1.

Department of Nursing, Mizan Tepi University, Mizan Tepi, South Nations, Nationalities and People Region, Ethiopia.

Objective: The main objective of this study was to assess survival status and predictors of mortality among preterm neonates admitted to Mizan Tepi University Teaching Hospital.

Materials And Methods: A retrospective cohort study was conducted on 568 randomly selected neonates. All preterm neonates admitted in NICU from May 9, 2016 to December 30, 2019 were the source population. Read More

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September 2021

The influence of parenteral protein intake on electrolyte disturbances in premature infants.

An Pediatr (Engl Ed) 2021 Sep 24;95(3):139-146. Epub 2020 Oct 24.

Pharmacy Service, Vall d'Hebron Barcelona Hospital Campus, Barcelona, Spain.

Introduction: Aggressive parenteral nutrition with delivery of high amino acid and energy doses is used to improve growth and neurodevelopmental outcomes in very low birth weight (VLBW) preterm infants. Recent findings, however, suggest that this approach may cause electrolyte imbalances. The aim of our study was to compare the prevalence of hypercalcaemia, hypophosphataemia, and hypokalaemia in 2 groups of preterm infants that received parenteral nutrition with different amounts of amino acids and to analyse perinatal and nutritional variables associated with the development of electrolyte imbalances. Read More

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September 2021

Physical growth and brain MRI predict the neurodevelopmental outcomes in very low birth weight infants at 2-year-old.

Neuro Endocrinol Lett 2021 Sep 10;42(5):321-330. Epub 2021 Sep 10.

Department of NICU, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou 510080, China.

Objective: The purpose of the current study was to determine the predictive effect of physical growth and brain magnetic resonance imaging (MRI) on neurodevelopmental outcomes in very low birth weight infants (VLBW) infants.

Materials And Methods: A total of 85 VLBW infants were included in the current study. They were cared according to the guideline of preterm management during hospitalization, and to planned follow-up rules after discharged strictly. Read More

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September 2021

Prevalence and Initial Diagnosis of Cerebral Palsy in Preterm and Term-Born Children in Taiwan: A Nationwide, Population-Based Cohort Study.

Int J Environ Res Public Health 2021 Aug 26;18(17). Epub 2021 Aug 26.

Division of Neonatology, Department of Pediatrics, Chi Mei Medical Center, Tainan 71004, Taiwan.

The aim of this long-term longitudinal study in Taiwan was to estimate and compare the prevalence of cerebral palsy (CP) and to identify the age of CP diagnosis of term-born and preterm children with different birthweights. Records of 1494 extremely low birth weight (ELBW, <1000 g), 3961 very low birth weight (VLBW, 1000-1499 g), 19,612 low birth weight (LBW, 1500-2499 g) preterm, and 100,268 matched term-born children were retrieved from Taiwan's National Health Insurance Research Database. According to a 12-year retrospective data review, the results showed the highest prevalence of CP in preterm ELBW children (147. Read More

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Reduced Exercise Capacity in Adults Born Very Low Birth Weight: A Population-Based Cohort Study.

Am J Respir Crit Care Med 2021 Sep 9. Epub 2021 Sep 9.

University of Otago Christchurch, 2494, Department of Pediatrics, Christchurch, New Zealand.

Rationale: Population-based data regarding the consequences of very low birth weight (VLBW) and bronchopulmonary dysplasia (BPD) on adult exercise capacity is limited.

Objectives: To compare exercise capacity in a national VLBW cohort with term-born controls and explore factors contributing to the differences.

Methods: At 26-30 years of age, 228 VLBW survivors and 100 controls underwent lung function tests, cardiopulmonary exercise testing and assessment of resting cardiac structure/function using echocardiography. Read More

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September 2021

Vitamin D and bone minerals in neonates.

Steven A Abrams

Early Hum Dev 2021 Sep 2:105461. Epub 2021 Sep 2.

Department of Pediatrics, Dell Medical School at the University of Texas, Austin, TX, USA. Electronic address:

Osteopenia and rickets remain a problem for high-risk infants, especially preterm infants <1500 g birthweight (very low birth weight, VLBW). The primary cause of osteopenia in VLBW infants is a low intake of calcium and phosphorus compared to requirements for the rapidly growing skeleton. Human milk is a relatively low mineral containing substance and cannot meet the bone mineral needs of very low birth weight infants. Read More

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September 2021

Obstetric and neonatal outcomes of pregnancies resulting from preimplantation genetic testing: a systematic review and meta-analysis.

Hum Reprod Update 2021 Sep 2. Epub 2021 Sep 2.

Center for Reproductive Medicine, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, China.

Background: Preimplantation genetic testing (PGT) includes methods that allow embryos to be tested for severe inherited diseases or chromosomal abnormalities. In addition to IVF/ICSI and repeated freezing and thawing of the embryos, PGT requires a biopsy to obtain embryonic genetic material for analysis. However, the potential effects of PGT on obstetric and neonatal outcomes are currently uncertain. Read More

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September 2021

Impact of very preterm birth and post-discharge growth on cardiometabolic outcomes at school age: a retrospective cohort study.

BMC Pediatr 2021 08 31;21(1):373. Epub 2021 Aug 31.

Department of Pediatrics, Seoul National University Children's Hospital, Seoul National University College of Medicine, 101, Daehak-ro, Jongno-gu, Seoul, Republic of Korea.

Background: Adverse metabolic outcomes later in life have been reported among children or young adults who were born as preterm infants. This study was conducted to examine the impact of very preterm/very low birth weight (VP/VLBW) birth and subsequent growth after hospital discharge on cardiometabolic outcomes such as insulin resistance, fasting glucose, and systolic and diastolic blood pressure (BP) among children at 6-8 years of age.

Methods: This retrospective cohort study included children aged 6-8 years and compared those who were born at < 32 weeks of gestation or weighing < 1,500 g at birth (n = 60) with those born at term (n = 110). Read More

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Outbreak of late-onset Group B Streptococcal disease with serotype Ib in a Neonatal Intensive Care Unit.

Turk J Pediatr 2021 ;63(4):697-702

Division of Neonatology, Department of Pediatrics, Saitama City Hospital, Saitama, Japan.

Background: Hospital outbreaks of invasive group B streptococcus (GBS) infection are rare. There are only a few published reports of late-onset GBS outbreaks in neonatal intensive care units (NICUs). We report here three cases of late-onset GBS in our NICU. Read More

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January 2021

Enablers and barriers for enteral feeding with mother`s own milk in preterm very low birth weight infants in a tertiary care neonatal intensive care unit.

Turk J Pediatr 2021 ;63(4):564-574

Department of Neonatology, Fernandez Hospital, Hyderguda, Hyderabad, Telangana, India.

Background: The management of lactation in preterm mothers is a real challenge for Neonatal Intensive Care Unit (NICU) care, providers. The study aimed to evaluate the enablers and barriers for enteral feeding with mothers` own milk (MOM) in preterm very low birth weight (VLBW) infants in a tertiary care neonatal unit.

Methods: This prospective observational study took place at a tertiary level NICU of a high-risk obstetric unit in a private hospital. Read More

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January 2021

Protein Enrichment of Donor Breast Milk and Impact on Growth in Very Low Birth Weight Infants.

Nutrients 2021 Aug 20;13(8). Epub 2021 Aug 20.

Perinatal Institute, Division of Neonatology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA.

Protein content is often inadequate in donor breast milk (DBM), resulting in poor growth. The use of protein-enriched target-pooled DBM (DBM+) has not been examined. We compared three cohorts of very low birth weight (VLBW) infants, born ≤ 1500 g: DBM cohort receiving > 1-week target-pooled DBM (20 kcal/oz), MBM cohort receiving ≤ 1-week DBM, and DBM+ cohort receiving > 1-week DBM+. Read More

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Slow advancement of enteral feed volumes to prevent necrotising enterocolitis in very low birth weight infants.

Cochrane Database Syst Rev 2021 08 24;8:CD001241. Epub 2021 Aug 24.

Centre for Reviews and Dissemination, University of York, York, UK.

Background: Early enteral feeding practices are potentially modifiable risk factors for necrotising enterocolitis (NEC) in very preterm or very low birth weight (VLBW) infants. Observational studies suggest that conservative feeding regimens, including slowly advancing enteral feed volumes, reduce the risk of NEC. However, it is unclear whether slow feed advancement may delay establishment of full enteral feeding, and if it could be associated with infectious morbidities secondary to prolonged exposure to parenteral nutrition. Read More

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Questioning the adequacy of standardized vitamin D supplementation protocol in very low birth weight infants: a prospective cohort study.

J Pediatr Endocrinol Metab 2021 Aug 20. Epub 2021 Aug 20.

Department of Pediatrics, Division of Neonatology, Eskisehir Osmangazi University Faculty of Medicine, Eskisehir, Turkey.

Objectives: Preterm infants are at increased risk for vitamin D deficiency (VDD). We aimed to assess the adequacy of standardized vitamin D supplementation protocol in very low birth weight (VLBW) infants. Additionally, vitamin D status of mother/infant couples and the associations between vitamin D status at birth and morbidities of the infants were investigated. Read More

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Very preterm birth and trajectories of domain-specific self-concept from childhood into adulthood.

Dev Psychopathol 2021 Aug 20:1-12. Epub 2021 Aug 20.

Department of Psychology, University of Warwick, Coventry, UK.

Self-concept refers to individuals' perceptions of themselves in specific domains and is closely related with their overall self-esteem. Lower self-esteem has been reported in those born preterm (<37 weeks gestation), but the development of self-concept has not been studied in this population. This study investigates whether differences in trajectories of domain-specific self-concepts are explained by premature birth or other risk factors, using the Bavarian Longitudinal Study (N = 460), a population-based study of very preterm (VP; <32 weeks gestation)/very low birth weight (VLBW; <1500 g) cohort and term-born controls. Read More

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Long-Term Outcomes after Early Neonatal Hyperglycemia in VLBW Infants: A Systematic Review.

Neonatology 2021 Aug 19:1-13. Epub 2021 Aug 19.

Department of Pediatrics, University of Minnesota Medical School, Minneapolis, Minnesota, USA.

Introduction: Long-term effects of early hyperglycemia in VLBW infants are poorly characterized. The objective of this study was to systematically review the effect of early hyperglycemia on growth, metabolic health, and neurodevelopment after neonatal intensive care unit discharge in VLBW infants.

Methods: The systematic review was conducted in accordance with the PRISMA guidelines. Read More

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Umbilical Cord Blood Use for Admission Blood Tests of VLBW Preterm Neonates: A Randomized Control Trial.

Am J Perinatol 2021 Aug 18. Epub 2021 Aug 18.

Department of Pediatrics, Brooke Army Medical Center, San Antonio, Texas.

Objective:  Umbilical cord blood (UCB) for admission laboratories is an approach to decrease anemia risk in very low birth weight (VLBW) neonates. We hypothesized that UCB use results in higher hemoglobin concentration [HgB] around 24 hours of life.

Study Design:  A randomized control trial among VLBW infants whose admission laboratories were drawn from UCB ( = 39) or the infant ( = 41) in three U. Read More

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Postnatal glucocorticoid use impacts renal function in VLBW neonates.

Pediatr Res 2021 Aug 16. Epub 2021 Aug 16.

MetroHealth Medical Center, Department of Pediatrics, Division of Neonatology, Cleveland, OH, USA.

Background: Preterm neonates often require glucocorticoids to manage refractory hypotension, prevent, and treat bronchopulmonary dysplasia. We have investigated the effect of cumulative dose and duration of glucocorticoids on blood pressure and renal function in VLBW infants.

Methods: In this retrospective cohort study, medical records of infants (GA ≤ 35 weeks) born January 2015 to December 2019 were reviewed to extract demographic and clinical characteristics, dose and duration of steroids, blood pressure (BP), and creatinine at the time of discharge from the neonatal intensive care unit. Read More

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Impact of preimplantation genetic testing on obstetric and neonatal outcomes: a systematic review and meta-analysis.

Fertil Steril 2021 Aug 6. Epub 2021 Aug 6.

Reproductive Medical Center, Henan Province Key Laboratory for Reproduction and Genetics, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, People's Republic of China. Electronic address:

Objective: To investigate whether preimplantation genetic testing (PGT) increases the risk of adverse obstetric and neonatal outcomes.

Design: Systematic review and meta-analysis.

Setting: Not applicable. Read More

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Covariation of changing patent ductus arteriosus management and preterm infant outcomes in Pediatrix neonatal intensive care units.

J Perinatol 2021 Aug 5. Epub 2021 Aug 5.

Division of Neonatology, Department of Pediatrics, Duke University Medical Center, Durham, NC, USA.

Objective: To test the hypothesis that NICU-specific preterm infant outcomes co-vary with changes in local patent ductus arteriosus (PDA) management.

Study Design: This retrospective multicenter study examined NICU-specific aggregated data for infants born 400-1499 g (VLBW) in the Pediatrix Clinical Data Warehouse. For each NICU and each year 2006-2016 we calculated proportion of infants receiving cyclooxygenase inhibitor (COXI) and/or PDA ligation and determined NICU-specific changes in these therapies between consecutive years. Read More

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[Real world research on the growth pattern of preterm children with different birth weight].

Zhonghua Er Ke Za Zhi 2021 Aug;59(8):665-671

Department of Child Health Care, Children's Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, China International Science and Technology Cooperation Base of Child Development and Critical Disorders, Chongqing Key Laboratory of Pediatrics, Chongqing 400014, China.

To investigate the physical indices and growth status of preterm children aged 0 to 4 years with different birth weight. Following the real world research approach, the current study retrospectively collected e-chart information of 8 496 preterm children from the child health care system of the Children's Hospital of Chongqing Medical University from December 2010 to December 2017, with 203 123 full-term children followed up during the same period as controls. Premature children were divided into normal birth weight (NBW) group, low birth weight (LBW) group, and very low birth weight (VLBW) group based on their birth weights. Read More

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More than Just a Fad: Building and Maintaining a Small Baby Program.

Neonatal Netw 2021 Jul;40(4):224-232

Survival rate for preterm infants has improved significantly in the last decade because of advancements in care provided by NICUs. Yet, a large proportion of extremely low birth weight (ELBW) infants continue to be at risk of being discharged home from NICUs with long-term co-morbidities. Several centers have introduced and described the concept of a focused program on the care of micro-preemies and demonstrated improved processes as well as outcomes utilizing a continuous improvement approach with adoption of standardized guidelines, checklists, and shared team values. Read More

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The Association between Ovarian Hyperstimulation Syndrome and Pregnancy Complications following Fertility Treatments.

Am J Perinatol 2021 Jul 29. Epub 2021 Jul 29.

Department of Public Health, Faculty of Health Sciences Ben Gurion University of the Negev, Givatayim, Israel.

Objective:  This study was aimed to assess the association between ovarian hyperstimulation syndrome (OHSS) and pregnancy complications among women who conceived following fertility treatment.

Study Design:  A retrospective population-based cohort study, including all singleton deliveries of patients conceived following ovulation induction (OI) or in vitro fertilization (IVF) between 1988 and 2016, was conducted. All births occurred in a single tertiary medical center. Read More

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Impact of parenteral nutrition guideline implementation on growth of very low-birth-weight infants in a neonatal intensive care unit.

JPEN J Parenter Enteral Nutr 2021 Jul 23. Epub 2021 Jul 23.

Department of Pharmacy, Nemours Children's Hospital, Orlando, Florida, USA.

Background: In preterm neonates, parenteral nutrition (PN) is utilized to provide adequate energy and maintain the expected growth rate of a fetus. To optimize growth, our institution implemented comprehensive guidelines for prescribing PN. This study compared the effect of this change on growth outcomes of very low-birth-weight (VLBW) infants at 28 days' postnatal age (PNA). Read More

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Determinants of fatty acid content and composition of human milk fed to infants born weighing <1250 g.

Am J Clin Nutr 2021 Jul 13. Epub 2021 Jul 13.

Translational Medicine Program, The Hospital for Sick Children, Toronto, Ontario, Canada.

Background: Infants born at very low birth weight (VLBW) are vulnerable to deficits in fatty acids (FAs) but little is known of factors that influence the intakes or composition of their human milk feeds.

Objectives: We aimed to identify sources of variability in the fat composition of human milk fed to VLBW infants and examine the impact of milk source (mother's own or donor) on fat and FA intakes.

Methods: Serial samples of mother's milk (n = 476) and donor milk (n = 53) fed to infants born weighing <1250 g (n = 114 infants from 100 mothers) were collected [Optimizing Mothers' Milk for Preterm Infants (OptiMoM) randomized clinical trial]. Read More

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Immature Platelet Counts and Thrombopoietin Plasma Concentrations in Thrombocytopenic and Non-thrombocytopenic Preterm Infants.

Front Pediatr 2021 25;9:685643. Epub 2021 Jun 25.

Department of Neonatology, Charité - Universitätsmedizin Berlin, Berlin, Germany.

Immature platelet counts (IPC) may prove useful in guiding platelet transfusion management in preterm neonates. However, the relationship between IPCs and thrombopoietin (Tpo) concentrations has not been evaluated in preterm neonates. Prospective cohort study in thrombocytopenic ( = 31) and non-thrombocytopenic very low birth weight (VLBW) infants ( = 38), and healthy term neonates (controls; = 41). Read More

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The impact of neonatal morbidities on child growth and developmental outcomes in very low birth weight infants: a nationwide cohort study.

Eur J Pediatr 2021 Jul 8. Epub 2021 Jul 8.

Department of Pediatrics, Yonsei University College of Medicine, 211 Eonjuro Gangnamgu, Seoul, 06273, Korea.

Growth in preterm infants has long-term implications for neurodevelopmental outcomes. We aimed to estimate the nationwide growth outcomes from birth to 5 years in infants born under 1500 g and to analyze the effects of major morbidities in preterm infants on growth. In total, 2961 children born in 2013 with a birth weight under 1500 g who underwent an infant health checkup between 2013 and 2018 according to the National Health Insurance Service database were included. Read More

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Extrauterine Growth Restriction in Very Low Birth Weight Infants: Concordance Between Fenton 2013 and INTERGROWTH-21 Growth Charts.

Front Pediatr 2021 21;9:690788. Epub 2021 Jun 21.

Central University Hospital of Asturias, Oviedo, Spain.

Postnatal growth restriction has high prevalence in very low birth weight (VLBW) preterm neonates, and this could affect their long-term prognosis. Nowadays, there is no consensus on how to monitor growth in these neonates. This study aimed to compare prevalence of intra- and extrauterine growth restriction (IUGR and EUGR) in a sample of VLBW infants according to the Fenton 2013 charts and INTERGROWTH-21st (IW-21) standards and to analyze concordance between both in the different EUGR definitions criteria (cross-sectional, dynamic, and true). Read More

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Optimizing parenteral nutrition to achieve an adequate weight gain according to the current guidelines in preterm infants with birth weight less than 1500 g: a prospective observational study.

BMC Pediatr 2021 07 7;21(1):303. Epub 2021 Jul 7.

Department of Pediatric Gastroenterology, Hepatology and Nutrition, Henan Provincial People's Hospital, People's Hospital of Zhengzhou University, 7 Wei Wu Road, Zhengzhou, 450003, Henan, China.

Aim: European Society for Clinical Nutrition and Metabolism released the guidelines on pediatric parenteral nutrition in 2018. We aimed to compare the parenteral nutrition (PN) regimen with the current guidelines, evaluate weight gain and explore the correlation of parenteral macronutrient and energy intakes with weight gain outcome in preterm infants with birth weight less than 1500 g.

Methods: A prospective observational study was conducted. Read More

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Comparison of growth curves in very low birth weight preterm infants after hospital discharge.

Eur J Pediatr 2021 Jul 6. Epub 2021 Jul 6.

Fernandes Figueira Institute, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil.

Monitoring preterm infants' growth is essential to ensure the best prognosis for their growth and development. We aimed to compare growth curves in very low birth weight preterm infants after hospital discharge. In this retrospective longitudinal study, 178 preterm infants' growth was assessed by z-scores for weight for age and length to age and compared between Fenton and Kim and Intergrowth-21st charts from hospital discharge until 50 weeks postnatal, and between Intergrowth-21st and WHO charts, 50 and 64 weeks postnatal. Read More

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