Neoplasia 2021 Jul 25;23(9):898-911. Epub 2021 Jul 25.
Laboratory of Cancer Pathology, Center for Advanced Studies and Technology (CAST), "G. d' Annunzio" University of Chieti-Pescara, 66100 Chieti, Italy; Oncoxx Biotech, 66034 Lanciano (Chieti), Italy; Unit of Medical Genetics, Department of Biomedical Sciences - BIOMORF, University of Messina, 98125 Messina, Italy. Electronic address:
We recently reported that activation of Trop-2 through its cleavage at R87-T88 by ADAM10 underlies Trop-2-driven progression of colon cancer. However, the mechanism of action and pathological impact of Trop-2 in metastatic diffusion remain unexplored. Through searches for molecular determinants of cancer metastasis, we identified TROP2 as unique in its up-regulation across independent colon cancer metastasis models. Read More