385,444 results match your criteria vivo assay


Chemicalome and metabolome profiling of Chai-Gui Decoction using an integrated strategy based on UHPLC-Q-TOF-MS/MS analysis.

J Chromatogr B Analyt Technol Biomed Life Sci 2021 Oct 6;1185:122979. Epub 2021 Oct 6.

Nanjing University of Chinese Medicine Wuxi Affiliated Hospital: Wuxi Hospital of Traditional Chinese Medicine, Wuxi 214000, China. Electronic address:

Traditional Chinese medicine prescriptions are widely believed to exert therapeutic benefits via a multiple-component and multiple-target mode. The systemic profiling of their in vitro chemicalome and in vivo metabolome is of great importance for further understanding their clinical value. Herein, an integrated strategy using ultra-performance liquid chromatography coupled with quadruple time-of-flight mass spectrometry was proposed to profile the chemicalome and metabolome of Chai-Gui Decoction. Read More

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October 2021

High protein diet-induced metabolic changes are transcriptionally regulated via KLF15-dependent and independent pathways.

Biochem Biophys Res Commun 2021 Oct 15;582:35-42. Epub 2021 Oct 15.

Nutrigenomics Research Group, Faculty of Medicine, University of Tsukuba, Ibaraki, Japan; Department of Internal Medicine (Endocrinology and Metabolism), Faculty of Medicine, University of Tsukuba, Ibaraki, Japan. Electronic address:

High protein diet (HPD) is an affordable and positive approach in prevention and treatment of many diseases. It is believed that transcriptional regulation is responsible for adaptation after HPD feeding and Kruppel-like factor 15 (KLF15), a zinc finger transcription factor that has been proved to perform transcriptional regulation over amino acid, lipid and glucose metabolism, is known to be involved at least in part in this HPD response. To gain more insight into molecular mechanisms by which HPD controls expressions of genes involved in amino acid metabolism in the liver, we performed RNA-seq analysis of mice fed HPD for a short period (3 days). Read More

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October 2021

Design, synthesis, and biological evaluation of N-(3-cyano-1H-indol-5/6-yl)-6-oxo-1,6-dihydropyrimidine-4-carboxamides and 5-(6-oxo-1,6-dihydropyrimidin-2-yl)-1H-indole-3-carbonitriles as novel xanthine oxidase inhibitors.

Eur J Med Chem 2021 Oct 19;227:113928. Epub 2021 Oct 19.

Key Laboratory of Structure-Based Drugs Design & Discovery of Ministry of Education, School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, 103 Culture Road, Shenhe District, Shenyang 110016, China. Electronic address:

Xanthine oxidase (XO) has been an important target for the treatment of hyperuricemia and gout. The analysis of potential interactions of pyrimidinone and 3-cyano indole pharmacophores present in the corresponding reported XO inhibitors with parts of the XO active pocket indicated that they both can be used as effective fragments for the fragment-based design of nonpurine XO inhibitors. In this paper, we adopted the fragment-based drug design strategy to link the two fragments with an amide bond to design the type 1 compounds 13a-13w,14c, 14d, 14f, 14g, 14j, 14k, and 15g. Read More

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October 2021

Oral administration of berberine limits post-traumatic osteoarthritis development and associated pain via AMP-activated protein kinase (AMPK) in mice.

Osteoarthritis Cartilage 2021 Oct 20. Epub 2021 Oct 20.

VA San Diego Healthcare System, San Diego, USA; Department of Medicine, University of California San Diego, La Jolla, USA. Electronic address:

Objective: We investigated the effect of berberine, a natural plant product that can activate AMP-activated protein kinase (AMPK), on OA development and associated pain in mice.

Design: Human primary knee chondrocytes were utilized to investigate how AMPK is activated by berberine. Both global knockout (KO) of AMPKα1 and congenic wild type (WT) mice were subjected to the post-traumatic OA through destabilization of medial meniscus (DMM) surgery. Read More

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October 2021

Molecular characterization and chemotaxis assay of a CC motif chemokine ligand 25 from Japanese sea bass (Lateolabrax japonicus).

Fish Shellfish Immunol 2021 Oct 20. Epub 2021 Oct 20.

State Key Laboratory for Managing Biotic and Chemical Threats to the Quality and Safety of Agro-products, Ningbo University, Ningbo, 315211, China; Laboratory of Biochemistry and Molecular Biology, School of Marine Sciences, Meishan Campus, Ningbo University, Ningbo, 315832, China; Key Laboratory of Applied Marine Biotechnology of Ministry of Education, Meishan Campus, Ningbo University, Ningbo, 315832, China. Electronic address:

CC motif chemokine ligand 25 (CCL25) is a key chemokine that attracts various types of leukocytes, such as activated peritoneal macrophages. However, information on CCL25 in fish is limited. Here, a CCL25 gene (LjCCL25) was identified from Japanese sea bass (Lateolabrax japonicus), showing upregulation in multiple tissues against Vibrio harveyi infection. Read More

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October 2021

Glucose metabolism in Pseudomonas aeruginosa is cyclic when producing Polyhydroxyalkanoates and Rhamnolipids.

J Biotechnol 2021 Oct 20. Epub 2021 Oct 20.

Department of Microbiology, Institute of Biomedical Sciences,University of São Paulo, Brazil.

Pseudomonas aeruginosa is an important chassis for production of polyhydroxyalkanoates (PHA) and rhamnolipids (RHL). Advances in the understanding of the biosynthesis metabolism of these biocompounds are crucial for increasing yield. C-Metabolic Flux Ratio Analysis (C-MFA) is a technique to estimate in vivo metabolic fluxes ratios. Read More

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October 2021

A novel bioavailable curcumin-galactomannan complex modulates the genes responsible for the development of chronic diseases in mice: A RNA sequence analysis.

Life Sci 2021 Oct 20:120074. Epub 2021 Oct 20.

Cancer Biology Laboratory, Department of Biosciences and Bioengineering, Indian Institute of Technology-Guwahati, Guwahati 781 039, Assam, India; DBT-AIST International Center for Translational and Environmental Research, Indian Institute of Technology-Guwahati, Guwahati 781 039, Assam, India. Electronic address:

Background: Chronic diseases or non-communicable diseases are a major burden worldwide due to the lack of highly efficacious treatment modalities and the serious side effects associated with the available therapies.

Purpose/study Design: A novel self-emulsifying formulation of curcumin with fenugreek galactomannan hydrogel scaffold as a water-dispersible non-covalent curcumin-galactomannan molecular complex (curcumagalactomannosides, CGM) has shown better bioavailability than curcumin and can be used for the prevention and treatment of chronic diseases. However, the exact potential of this formulation has not been studied, which would pave the way for its use for the prevention and treatment of multiple chronic diseases. Read More

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October 2021

Vemurafenib drives EMT gene expression in BRAFi-resistant BRAF/NRAS melanoma enhancing tumor growth and metastasis in a bioluminescent murine model.

J Invest Dermatol 2021 Oct 20. Epub 2021 Oct 20.

University of Arizona, Department of Pharmacology and Toxicology, College of Pharmacy and UA Cancer Center, 1515 N. Campbell Ave., Tucson, AZ 85724, USA. Electronic address:

BRAF-inhibitor (BRAFi)-resistance compromises long term survivorship of malignant melanoma patients, and mutant NRAS is a major mediator of BRAFi-resistance. Here, employing phenotypic and transcriptomic analysis of isogenic melanoma cells that differ only by NRAS mutational status (BRAFi-sensitive A375-BRAF/NRAS versus BRAFi-resistant A375-BRAF/NRAS) we demonstrate that BRAFi (vemurafenib) treatment selectively targets BRAF/NRAS cells upregulating epithelial-to-mesenchymal transition (EMT) gene expression, paradoxically promoting invasiveness and metastasis in vitro and in vivo. First, NanoString nCounter transcriptomic analysis identified upregulation of specific gene expression networks ('EMT' and 'EMT to Metastasis') as a function of NRAS-status. Read More

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October 2021

Systematically characterize the absorbed components of Ligustri Lucidi Fructus and their metabolic pathways in rat plasma by ultra-high-performance liquid chromatography-Q-Exactive Orbitrap tandem mass spectrometry combined with network pharmacology.

J Sep Sci 2021 Oct 23. Epub 2021 Oct 23.

Shandong Provincial Collaborative Innovation Center for Quality Control and Construction of the Whole Industrial Chain of Traditional Chinese Medicine, Jinan, 250355, China.

Ligustri Lucidi Fructus is dried and mature fruit of Ligubtrum lucidum Ait., which has the effects of nourishing liver and kidney. Herein, an accurate and sensitive method was established for separation and identification of the absorbed constituents and metabolites of Ligustri Lucidi Fructus in rat plasma based on ultra-high-performance liquid chromatography-Q-Exactive Orbitrap tandem mass spectrometry. Read More

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October 2021

LncRNA NEAT1 aggravates lipopolysaccharide-induced acute lung injury by regulating the miR-98-5p/TLR4 axis.

J Biochem Mol Toxicol 2021 Oct 23:e22927. Epub 2021 Oct 23.

Department of Respiratory Medicine, Huai'an Second People's Hospital and The Affiliated Huai'an Hospital of Xuzhou Medical University, Huai'an, Jiangsu, P. R. China.

Although long noncoding RNA nuclear paraspeckle assembly transcript 1 (NEAT1) was reported to be associated with acute lung injury (ALI), its specific mechanism has not been well studied. Mouse and cell ALI models were constructed by lipopolysaccharide (LPS). Cell viability was evaluated by 3-(4,5)-dimethylthiahiazo (-z-y1)-3,5-di- phenytetrazoliumromide assay. Read More

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October 2021

DNMT3A epigenetically regulates key microRNAs involved in epithelial-to-mesenchymal transition in prostate cancer.

Carcinogenesis 2021 Oct 23. Epub 2021 Oct 23.

Department of Biotechnology and Life Sciences, University of Insubria, 21052 Busto Arsizio (VA), Italy.

Epithelial-to-Mesenchymal Transition (EMT) is involved in prostate cancer metastatic progression, and its plasticity suggests epigenetic implications. Deregulation of DNMTs and several miRNAs plays a relevant role in EMT, but their interplay has not been clarified yet. In this study we provide evidence that DNMT3A interaction with several miRNAs has a central role in an ex-vivo EMT prostate cancer model obtained via exposure of PC3 cells to conditioned media from cancer-associated fibroblasts (CM-CAFs). Read More

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October 2021

SC66 inhibits the proliferation and induces apoptosis of human bladder cancer cells by targeting the AKT/β-catenin pathway.

J Cell Mol Med 2021 Oct 22. Epub 2021 Oct 22.

Department of Urology, Renmin Hospital of Wuhan University, Wuhan, China.

Bladder cancer (BC) is a major disease of the genitourinary tract, and chemotherapy is one of the main treatments commonly used at present. SC66 is a new type of allosteric AKT inhibitor that is reported to play an effective inhibitory role in the progression of many other types of tumours, but there is no reported research on its role in BC. In this study, we found that SC66 significantly inhibited the proliferation and EMT-mediated migration and invasion of T24 and 5637 cells. Read More

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October 2021

Characterisation and mode of action analysis of black soldier fly (Hermetia illucens) larva derived haemocytes.

Insect Sci 2021 Oct 23. Epub 2021 Oct 23.

Technische Universität Dresden, Fakultät Biologie, Institut für Zoologie, Professur für angewandte Zoologie, Zellescher Weg 20 b, Dresden, 01217, Germany.

With the growing importance of the black soldier fly (Hermetia illucens) for both sustainable food production and waste management as well as for science, a great demand of understanding its immune system arises. Here, we present the first description of the circulating larval haemocytes with special emphasis on uptake of microorganisms and distinguishing haemocyte types. With histological, zymographic, and cytometric methods and with a set of haemocyte binding lectins and antibodies, the haemocytes of H. Read More

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October 2021

In Vivo Monitoring of Cytosolic pH Using the Ratiometric pH Sensor pHluorin.

Methods Mol Biol 2022 ;2391:99-107

Departamento de Genética, Campus de Excelencia Internacional Agroalimentario ceiA3, Universidad de Córdoba, Córdoba, Spain.

Cytosolic pH (pH) is a key factor controlling cell fate. The genetically encoded pH-sensor pHluorin has proven highly valuable for studies on pH in many living organisms. pHluorin displays a bimodal excitation spectrum with peaks at 395 nm and 475 nm, which is dependent on pH. Read More

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January 2022

In vitro and in vivo assessment of a CLD sequestration strategy in Nitisol using contrasted carbonaceous materials.

Environ Geochem Health 2021 Oct 22. Epub 2021 Oct 22.

Université de Lorraine, INRAE, UR AFPA , F-54000 , Nancy, France.

Chlordecone (Kepone) (CLD) is a highly persistent pesticide formerly used in the French West Indies. High levels of this pesticide may be found in soils and constitute a subsequent source of contamination for outdoor-reared animals due to involuntary ingestion of consistent amounts of soil. In that context, carbonaceous materials may be used to amend soil to efficiently decrease the bioavailability of such organic pollutants. Read More

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October 2021

Bone regeneration capacity of newly developed spherical magnesium phosphate cement granules.

Clin Oral Investig 2021 Oct 23. Epub 2021 Oct 23.

Department for Functional Materials in Medicine and Dentistry, University Hospital Würzburg, Pleicherwall 2, 97070, Würzburg, Germany.

Objectives: Magnesium phosphate-based cements begin to catch more attention as bone substitute materials and especially as alternatives for the more commonly used calcium phosphates. In bone substitutes for augmentation purposes, atraumatic materials with good biocompatibility and resorbability are favorable. In the current study, we describe the in vivo testing of novel bone augmentation materials in form of spherical granules based on a calcium-doped magnesium phosphate (CaMgP) cement. Read More

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October 2021

Simultaneous serotonin and dopamine monitoring across timescales by rapid pulse voltammetry with partial least squares regression.

Anal Bioanal Chem 2021 Oct 23. Epub 2021 Oct 23.

Department of Chemistry & Biochemistry, University of California, Los Angeles, Los Angeles, CA, 90095, USA.

Many voltammetry methods have been developed to monitor brain extracellular dopamine levels. Fewer approaches have been successful in detecting serotonin in vivo. No voltammetric techniques are currently available to monitor both neurotransmitters simultaneously across timescales, even though they play integrated roles in modulating behavior. Read More

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October 2021

TBC1D10C is a cytoskeletal functional linker that modulates cell spreading and phagocytosis in macrophages.

Sci Rep 2021 Oct 22;11(1):20946. Epub 2021 Oct 22.

Laboratorio de Investigación en Inmunología y Proteómica, Hospital Infantil de México, Federico Gómez, Ciudad de México, Mexico.

Cell spreading and phagocytosis are notably regulated by small GTPases and GAP proteins. TBC1D10C is a dual inhibitory protein with GAP activity. In immune cells, TBC1D10C is one of the elements regulating lymphocyte activation. Read More

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October 2021

An ELISA-based method for rapid genetic screens in .

Proc Natl Acad Sci U S A 2021 Oct;118(43)

Vollum Institute, Oregon Health and Science University, Portland, OR 97239.

is a powerful model in which to perform genetic screens, but screening assays that are both rapid and can be used to examine a wide variety of cellular and molecular pathways are limited. offer an extensive toolbox of GFP-based transcriptional reporters, GFP-tagged proteins, and driver lines, which can be used to express GFP in numerous subpopulations of cells. Thus, a tool that can rapidly and quantitatively evaluate GFP levels in tissue would provide a broadly applicable screening platform. Read More

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October 2021

CAR T-cell entry into tumor islets is a two-step process dependent on IFNγ and ICAM-1.

Cancer Immunol Res 2021 Oct 22. Epub 2021 Oct 22.

Department of Immunology, Inflammation and Infection, Institut Cochin, INSERM U1016, CNRS UMR8104, Université Paris Descartes

Adoptive transfer of T cells expressing chimeric antigen receptors (CARs) has shown remarkable clinical efficacy against advanced B-cell malignancies but not yet against solid tumors. Here, we used fluorescent imaging microscopy and ex vivo assays to compare the early functional responses (migration, Ca2+, and cytotoxicity) of CD20 and EGFR CAR T cells upon contact with malignant B cells and carcinoma cells. Our results indicated that CD20 CAR T cells rapidly form productive ICAM-1-dependent conjugates with their targets. Read More

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October 2021

A pilot study investigating the effect of extended contact lens wear on limbal and central corneal morphology.

Cont Lens Anterior Eye 2021 Oct 19:101524. Epub 2021 Oct 19.

School of Optometry and Vision Science, University of New South Wales, Sydney, NSW, Australia. Electronic address:

Purpose: To investigate the effect of long-term extended soft contact lens wear on limbal and central corneal cell morphology, and limbal architecture.

Methods: Each participant attended a study visit involving in vivo confocal microscopy of central corneal and limbal epithelium. Scans were graded by five masked graders for three features: central epithelial irregularity, limbal epithelial irregularity and the prominence of palisades of Vogt. Read More

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October 2021

Ex vivo expanded allogeneic natural killer cells have potent cytolytic activity against cancer cells through different receptor-ligand interactions.

J Exp Clin Cancer Res 2021 Oct 23;40(1):333. Epub 2021 Oct 23.

Department of Pathology, CHA Bundang Medical Center, CHA University, 59 Yatapro Sungnam, Gyeonggi-do, Seongnam, Republic of Korea.

Background: Recently, allogeneic natural killer (NK) cells have gained considerable attention as promising immunotherapeutic tools due to their unique biological functions and characteristics. Although many NK expansion strategies have been reported previously, a deeper understanding of cryopreserved allogeneic NK cells is needed for specific therapeutic approaches.

Methods: We isolated CD3CD56 primary natural killer (pNK) cells from healthy donors and expanded them ex vivo using a GMP-compliant method without any feeder to generate large volumes of therapeutic pNK cells and cryopreserved stocks. Read More

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October 2021

Engineering of Lu-labeled gold encapsulated into dendrimeric nanomaterials for the treatment of lung cancer.

J Biomater Sci Polym Ed 2021 Oct 22:1-15. Epub 2021 Oct 22.

Operating Room, Taizhou Hospital of Zhejiang Province, Taizhou, China.

As a novel type of theranostic radioactive agents, Lu-labeled nanomaterials conjugated to macromolecules have been described. The study aimed to fabricate PAMAM-G4-(Lu-dendrimer)-bombesin-folate in the dendrimeric cavity, assess the radiopharmaceutical ability for specifically targeted radiotherapy and simultaneously detects gastrin-releasing peptide receptors (GRPR) and folate receptors (FRs) overexpressed in lung carcinoma cells, respectively. In an aqueous-basic media, p-SCN-benzyl-DOTA was conjugated to the dendrimer. Read More

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October 2021

Nutrients Profile of 52 Browse Species Found in Semi-Arid Areas of South Africa for Livestock Production: Effect of Harvesting Site.

Plants (Basel) 2021 Oct 7;10(10). Epub 2021 Oct 7.

Department of Chemistry, School of Physical and Chemical Sciences, Faculty of Natural and Agricultural Sciences, North West University, Mmabatho 2735, South Africa.

The use of these browse plant species as feed supplements to livestock is restricted due to a lack of knowledge about their nutritional status. This study was conducted to evaluate the nutritive value of woody browse species found in a semi-arid, as influenced by harvesting, site (Limpopo and North West Province). Limpopo had a Glenrosa, Mispah and Lithosols (GM-L) soil type and North West sites had an Aeolian Kalahari sand, Clovelly and Hutton (AKS-CH) soil type. Read More

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October 2021

The Arabidopsis Rho of Plants GTPase ROP1 Is a Potential Calcium-Dependent Protein Kinase (CDPK) Substrate.

Plants (Basel) 2021 Sep 29;10(10). Epub 2021 Sep 29.

Institute of Plant Biology, Biological Research Centre of the Eötvös Lóránd Research Network, 6726 Szeged, Hungary.

Plant Rho-type GTPases (ROPs) are versatile molecular switches involved in a number of signal transduction pathways. Although it is well known that they are indirectly linked to protein kinases, our knowledge about their direct functional interaction with upstream or downstream protein kinases is scarce. It is reasonable to suppose that similarly to their animal counterparts, ROPs might also be regulated by phosphorylation. Read More

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September 2021

Immunomodulatory Effect of Waldst. & Kit.

Plants (Basel) 2021 Sep 23;10(10). Epub 2021 Sep 23.

National Institute for Chemical-Pharmaceutical Research and Development-ICCF Bucharest, Calea Vitan No. 112, 3rd District, 031299 Bucharest, Romania.

(1) Background: Waldst. & Kit. (hellebore) is a plant species found mainly in Balkans and the Carpathians, and it is traditionally used for a variety of ailments since the time of Hippocrates. Read More

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September 2021

siRNA Nanoparticle Targeting PD-L1 Activates Tumor Immunity and Abrogates Pancreatic Cancer Growth in Humanized Preclinical Model.

Cells 2021 Oct 13;10(10). Epub 2021 Oct 13.

Department of Biomedical Sciences, University of Ulsan College of Medicine, Seoul 05505, Korea.

Pancreatic cancer is characterized by late detection, frequent drug resistance, and a highly metastatic nature, leading to poor prognosis. Antibody-based immunotherapy showed limited success for pancreatic cancer, partly owing to the low delivery rate of the drug into the tumor. Herein, we describe a poly(lactic-co-glycolic acid;PLGA)-based siRNA nanoparticle targeting PD-L1 ([email protected]). Read More

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October 2021

Analysis of Gene Expression Patterns of Epigenetic Enzymes , and in Murine Chondrogenic Models.

Cells 2021 Oct 6;10(10). Epub 2021 Oct 6.

Department of Anatomy, Histology and Embryology, Faculty of Medicine, University of Debrecen, 4032 Debrecen, Hungary.

We investigated the gene expression pattern of selected enzymes involved in DNA methylation and the effects of the DNA methylation inhibitor 5-azacytidine during in vitro and in vivo cartilage formation. Based on the data of a PCR array performed on chondrifying BMP2-overexpressing C3H10T1/2 cells, the relative expressions of (tet methylcytosine dioxygenase 1), (DNA methyltransferase 3), and (O-linked -acetylglucosamine transferase) were further examined with RT-qPCR in murine cell line-based and primary chondrifying micromass cultures. We found very strong but gradually decreasing expression of throughout the entire course of in vitro cartilage differentiation along with strong signals in the cartilaginous embryonic skeleton using specific RNA probes for in situ hybridization on frozen sections of 15-day-old mouse embryos. Read More

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October 2021

Neuron-Specific IMP2 Overexpression by Synapsin Promoter-Driven AAV9: A Tool to Study Its Role in Axon Regeneration.

Cells 2021 Oct 5;10(10). Epub 2021 Oct 5.

Department of Bio-Medical Sciences, Philadelphia College of Osteopathic Medicine, 4170 City Avenue, Philadelphia, PA 19131, USA.

Insulin-like growth factor II mRNA-binding protein (IMP) 2 is one of the three homologues (IMP1-3) that belong to a conserved family of mRNA-binding proteins. Its alternative splice product is aberrantly expressed in human hepatocellular carcinoma, and it is therefore identified as HCC. Previous works have indicated that IMP1/ZBP1 (zipcode binding protein) is critical in axon guidance and regeneration by regulating localization and translation of specific mRNAs. Read More

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October 2021

Mutation of the EPHA2 Tyrosine-Kinase Domain Dysregulates Cell Pattern Formation and Cytoskeletal Gene Expression in the Lens.

Cells 2021 Sep 30;10(10). Epub 2021 Sep 30.

Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St. Louis, MO 63110, USA.

Genetic variations in ephrin type-A receptor 2 (EPHA2) have been associated with inherited and age-related forms of cataract in humans. Here, we have characterized the eye lens phenotype and transcript profile of germline knock-in mutant mice homozygous for either a missense variant associated with age-related cataract in humans (-Q722) or a novel insertion-deletion mutation (-indel722) that were both located within the tyrosine-kinase domain of EPHA2. Confocal imaging of ex vivo lenses from -indel722 mice on a fluorescent reporter background revealed misalignment of epithelial-to-fiber cell meridional-rows at the lens equator and severe disturbance of Y-suture formation at the lens poles, whereas -Q722 lenses displayed mild disturbance of posterior sutures. Read More

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September 2021