432,745 results match your criteria vitamin supplementation

Natural diversity in the carotene, tocochromanol and fatty acid composition of crude palm oil.

Food Chem 2021 Jul 21;365:130638. Epub 2021 Jul 21.

DIADE, Univ Montpellier, CIRAD, IRD, Montpellier, France. Electronic address:

Crude palm oil (CPO) is extracted from the mesocarp of oil palm (Elaeis guineensis) fruits. CPO is widely consumed in many African countries. Due to its high provitamin A carotenoid content, it is also widely used in programmes designed to prevent vitamin A deficiency. Read More

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Benefits of safe sunlight exposure: vitamin D and beyond.

J Steroid Biochem Mol Biol 2021 Jul 27:105957. Epub 2021 Jul 27.

Department of Pathology, Lake Erie College of Osteopathic Medicine, Erie, Pennsylvania, USA. Electronic address:

This review examines the beneficial effects of ultraviolet radiation on systemic autoimmune diseases, including multiple sclerosis and type I diabetes, where the epidemiological evidence for the vitamin D-independent effects of sunlight is most apparent. Ultraviolet radiation, in addition to its role in the synthesis of vitamin D, stimulates anti-inflammatory pathways, alters the composition of dendritic cells, T cells, and T regulatory cells, and induces nitric oxide synthase and heme oxygenase metabolic pathways, which may directly or indirectly mitigate disease progression and susceptibility. Recent work has also explored how the immune-modulating functions of ultraviolet radiation affect type II diabetes, cancer, and the current global pandemic caused by SARS-CoV-2. Read More

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Letter to the editor regarding megaloblastic anemia with elevated vitamin B12.

Clin Biochem 2021 Jul 27. Epub 2021 Jul 27.

Hematology Research Laboratory, Department of Hematology, West China Hospital of Sichuan University, Chengdu 610041, Sichuan, China. Electronic address:

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Parental resistance to oral vitamin K prophylaxis was much more common in Swiss birthing centres than private or public hospitals.

Acta Paediatr 2021 Jul 30. Epub 2021 Jul 30.

Faculty of Biology and Medicine, University of Lausanne, Lausanne, Switzerland.

Vitamin K deficiency bleeding is a haemorrhagic condition that puts newborn infants at increased risk of bleeding during the first six months of life. The consequences can be disastrous, including lifelong disabling neurological sequelae or death, and can be prevented by a single intramuscular injection of vitamin K at birth. This is regularly cited as the prophylaxis gold standard for its simplicity of administration and efficacy when patients have cholestasis, although repeated oral vitamin K doses have comparable efficacy. Read More

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Fresh pomegranate juices from cultivars and local ecotypes grown in southeastern Italy: comparison of physicochemical properties, antioxidant activity and bioactive compounds.

J Sci Food Agric 2021 Jul 30. Epub 2021 Jul 30.

Department of Soil, Plant and Food Science (DISSPA), University of Bari Aldo Moro, via Amendola, 165/a, I-70126, Bari, Italy.

Background: Pomegranate juice has gained attention for its health properties, becoming consequently a highly demanded product. The revival of the pomegranate in Italy, as in other Mediterranean countries, starts with the planting of new intensive orchards characterized by both the new cultivation technique and new varieties. Thanks to growing demand and high productivity, pomegranate can become an interesting crop to diversify farm income. Read More

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Cutaneous concentrations of 7-dehydrocholesterol in Hoffmann's two-toed sloths (Choloepus hoffmanni) in managed care.

Zoo Biol 2021 Jul 30. Epub 2021 Jul 30.

Department of Clinical Sciences, Cornell University, Ithaca, New York, USA.

Hoffmann's two-toed sloths (Choloepus hoffmanni) are unique animals popular in zoological settings. The role of vitamin D in the maintenance of calcium homeostasis in this species is unexplored, although disorders of calcium homeostasis have been reported in managed sloths, including urolithiasis and soft tissue mineralization. This study assessed cutaneous concentrations of 7-dehydrocholesterol (7-DHC) in nine indoor-housed Hoffmann's two-toed sloths, as a means of evaluating the potential for cutaneous photobiosynthesis of vitamin D . Read More

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Development of an artificial neural network as a tool for predicting the chemical attributes of fresh peach fruits.

PLoS One 2021 30;16(7):e0251185. Epub 2021 Jul 30.

Food Science and Technology Department, Faculty of Agriculture, Alexandria University, Alexandria, Egypt.

This investigation aimed to develop a method to predict the total soluble solids (TSS), titratable acidity, TSS/titratable acidity, vitamin C, anthocyanin, and total carotenoids contents using surface color values (L*, Hue and chroma), single fruit weight, juice volume, and sphericity percent of fresh peach fruit. Multiple regression analysis (MLR) and an artificial neural network (ANN) were employed. An ANN model was developed with six inputs and 15 neurons in the first hidden layer for the prediction of six chemical composition parameters. Read More

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Slipped Capital Femoral Epiphysis in an Adult with Panhypopituitarism: A Case Report.

JBJS Case Connect 2021 Jul 30;11(3). Epub 2021 Jul 30.

Tallahassee Primary Care Associates, Tallahassee, Florida.

Case: Our patient was a 31-year-old woman with previously undiagnosed panhypopituitarism who presented with bilateral slipped capital femoral epiphysis (SCFE). Together with endocrinology, her treatment plan involved medical management of her panhypopituitarism and surgical correction with femoral neck osteotomy. Hormone deficiencies were corrected 6 weeks after replacement therapy began, and the patient was cleared for surgery. Read More

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Classroom microbiome, functional pathways and sick-building syndrome (SBS) in urban and rural schools - Potential roles of indoor microbial amino acids and vitamin metabolites.

Sci Total Environ 2021 Jul 7;795:148879. Epub 2021 Jul 7.

Guangdong Provincial Key Laboratory of Protein Function and Regulation in Agricultural Organisms, College of Life Sciences, South China Agricultural University, Guangzhou, Guangdong 510642, PR China; Key Laboratory of Zoonosis of Ministry of Agriculture and Rural Affairs, South China Agricultural University, Guangzhou, Guangdong 510642, PR China; Guangdong Laboratory for Lingnan Modern Agriculture, South China Agricultural University, Guangzhou, Guangdong 510642, PR China. Electronic address:

Sick building symptoms (SBS) are defined as non-specific symptoms related to indoor exposures, including mucosal symptoms in eye, nose, throat, and skin, and general symptoms as headache and tiredness. Indoor microbial composition is associated with SBS symptoms, but the impact of microbial functional genes and potential metabolic products has not been characterized. We conducted a shotgun microbial metagenomic sequencing for vacuum dust collected in urban and rural schools in Shanxi province, China. Read More

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Vitamin D supplementation in people with IBS has no effect on symptom severity and quality of life: results of a randomised controlled trial.

Eur J Nutr 2021 Jul 30. Epub 2021 Jul 30.

Molecular Gastroenterology Research Group, Department of Oncology & Metabolism, The Medical School, The University of Sheffield, Beech Hill Road, Sheffield, S10 2RX, UK.

Purpose: Several small trials suggest a benefit of vitamin D supplementation in irritable bowel syndrome (IBS). The generalisability of these reports is limited by their design and scale. This study aimed to assess whether vitamin D supplementation improved IBS symptoms in a UK community setting. Read More

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The enigma of vitamin D supplementation in aging with obesity.

Simone Perna

Minerva Gastroenterol (Torino) 2021 Jul 30. Epub 2021 Jul 30.

Department of Biology, College of Science, University of Bahrain, Sakhir, Bahrain -

Introduction: The American Geriatrics Society recommends a minimum daily supplement of 1,000 IU and underlines that a dosage lower than 600 IU do not prevent falls in elderly people.

Evidence Acquisition: Review author searched on PubMed, Medline, Embase, Scopus database (last search May 30, 2021), with the MeSH terms and keywords of vitamin D, (25(OH)D), elderly and obesity. This review article aims to support the rationale on the correct vitamin D supplementation in elderly people with obesity and overweight. Read More

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Clinical Image: Magnetic Resonance Imaging Appearance of Scurvy.

Arthritis Rheumatol 2021 Jul 30. Epub 2021 Jul 30.

B. Shine Rheumatology Institute, Rambam Health Care Campus, Haifa, Israel.

A 40-year-old previously healthy woman presented to the Rheumatology department with suspected arthritis because of bilateral lower limb pain, swelling, and difficulty walking for the last six months. Physical examination revealed multiple subcutaneous hematomas, gingival hyperplasia, bilateral knee effusion, lower extremities muscle weakness, and right hip joint movement limitation. The laboratory tests were remarkable only for iron and folate deficiency normocytic anemia (Hemoglobin 9 mg/dl). Read More

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[Deficient micronutrient status of the population of various countries as a risk factor in COVID-19].

Probl Sotsialnoi Gig Zdravookhranenniiai Istor Med 2021 Jun;29(Special Issue):593-597

N. A. Semashko National Research Institute of Public Health, 105064, Moscow, Russia.

The article provides an overview of scientific information on the modern features of the micronutrient status of the population of different countries of the world. It is emphasized that in conditions of epidemiological risk, it is necessary to take into account the provision of micronutrients for various social groups of the population: children, elderly people with a low socio-economic status, as well as those with chronic diseases. As a result of the analysis, it is determined that the deficient micronutrient status contributes not only to a high risk of the body's susceptibility to infectious agents, but also negatively affects the course and outcome of an infectious disease. Read More

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A prospective longitudinal study to evaluate bone health, implication of FRAX tool and impact on quality of life (FACT-P) in advanced prostate cancer patients.

Am J Clin Exp Urol 2021 15;9(3):211-220. Epub 2021 Jun 15.

King George's Medical University Lucknow, India.

Background: Androgen-deprivation therapy (ADT) as a treatment modality in advanced prostate cancer has deleterious effect on bone mineral density (BMD) and quality of life (QOL). Using FRAX (Fracture Risk Assessment) model, candidates at high risk of fractures can be predicted and appropriate treatment can be initiated at early step to prevent skeletal-related events. Objectives of the present study were to evaluate bone health, implication of FRAX tool in advanced prostate cancer and to see the impact of ADT and Bone-directed therapy (BDT) on FRAX and FACT-P QOL scores. Read More

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Effects of 12-Week Multivitamin and Omega-3 Supplementation on Micronutrient Levels and Red Blood Cell Fatty Acids in Pre-menopausal Women.

Front Nutr 2021 13;8:610382. Epub 2021 Jul 13.

School of Kinesiology, Auburn University, Auburn, AL, United States.

The purpose of this study was to validate the efficacy of a customized vitamin-mineral supplement on blood biomarkers in pre-menopausal females. Women (21-40 years old) who were apparently healthy were recruited from the local community (ClinicalTrials.gov trial registration NCT03828097). Read More

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Pubic Osteolysis in an Elderly Masquerading as Malignancy: A Case Report and Review of Literature.

J Orthop Case Rep 2021 Apr;11(4):18-22

Department of Radiation Oncology, Indraprastha Apollo Hospitals, New Delhi, India.

Introduction: A rapidly progressive destructive lesion characterizes pubic osteolysis (PO) in the pubic bone due to an inadequate fracture healing response. It may be seen in pelvic insufficiency fractures (IF) secondary to radiation therapy (RT) of pelvic malignancies, occurring even in the absence of significant trauma. Such a radiological picture may distract the clinician towards a malignant etiology and may affect the management. Read More

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Structural Dynamics and Perspectives of Vitamin B6 Biosynthesis Enzymes in : Advances and Open Questions.

Front Cell Infect Microbiol 2021 13;11:688380. Epub 2021 Jul 13.

Pólo TerRa, São Carlos Institute of Physics, University of São Paulo, São Carlos, Brazil.

Malaria is still today one of the most concerning diseases, with 219 million infections in 2019, most of them in Sub-Saharan Africa and Latin America, causing approx. 409,000 deaths per year. Despite the tremendous advances in malaria treatment and prevention, there is still no vaccine for this disease yet available and the increasing parasite resistance to already existing drugs is becoming an alarming issue globally. Read More

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The Role of Vitamin C in Reducing Pain Associated With Diabetic Neuropathy.

Cureus 2021 Jun 24;13(6):e15895. Epub 2021 Jun 24.

Neurology, Jinnah Sindh Medical University, Karachi, PAK.

Introduction: Neuropathic pain is a painful condition that arises after a lesion or an insult to the somatosensory nervous system, either in a central or peripheral location. The most common cause of neuropathic pain is diabetes. Controlled trials have been conducted on recent advancements in medicine to investigate the effect of vitamin C in the treatment of neuropathic pain. Read More

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Evaluation of Nutrients Intake for a Group of Jordanian Older Adults with Sarcopenia Syndrome in Amman: An Explorative and Pilot Study.

J Aging Res 2021 16;2021:6641967. Epub 2021 Jul 16.

Physical Education Department, School of Sport Science, University of Jordan, Amman, Jordan.

Aim: Sarcopenia is an age-related syndrome that is characterized by a progressive loss of muscle mass, strength, and function. This study was performed in order to evaluate nutrients intake and physical activity level and to investigate the effect of sarcopenia syndrome on food intake for a group of Jordanian older adults with sarcopenia syndrome in Amman. . Read More

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Anthropometric Measurements and Correlations to Glucometabolic and Cardiovascular Risk in Obese Patients Undergoing Gastric Bypass Surgery.

J Obes 2021 16;2021:6647328. Epub 2021 Jul 16.

Bariatric Clinic, Department of Surgery, Falun Hospital, Falun, Sweden.

Abdominal obesity is associated with hypertension, increased fasting glucose, HbA1c, and cholesterol. Body mass index (BMI) is frequently used to measure and define obesity and as inclusion criteria for bariatric surgery. Sagittal abdominal diameter (SAD) has been suggested to predict the amount of visceral fat, metabolic traits, and cardiometabolic risk superior to BMI. Read More

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The relationship between preoperative serum vitamin D deficiency and postoperative atrial fibrillation: A systematic review and meta-analysis.

J Cardiovasc Thorac Res 2021 18;13(2):102-108. Epub 2021 Mar 18.

Research Center for Evidence-based Medicine, Iranian EBM Centre: A Joanna Briggs Institute (JBI) Centre of Excellence, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.

Postoperative atrial fibrillation (POAF) is the most common arrhythmia seen in the first days following cardiac surgeries. Recently, there is a growing discussion regarding the link between vitamin D deficiency and POAF development. This systematic review and meta-analysis of the observational studies aimed at evaluating the association between preoperative vitamin D deficiency and Postoperative atrial fibrillation. Read More

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Long-term metformin therapy and vitamin B12 deficiency: An association to bear in mind.

World J Diabetes 2021 Jul;12(7):916-931

Diabetes Research Institute Federation (DRIF), Division of Endocrinology and Diabetes, CTO Alesini Hospital, Department of Systems Medicine, University of Rome Tor Vergata, Rome 00145, Italy.

To date, metformin remains the first-line oral glucose-lowering drug used for the treatment of type 2 diabetes thanks to its well-established long-term safety and efficacy profile. Indeed, metformin is the most widely used oral insulin-sensitizing agent, being prescribed to more than 100 million people worldwide, including patients with prediabetes, insulin resistance, and polycystic ovary syndrome. However, over the last decades several observational studies and meta-analyses have reported a significant association between long-term metformin therapy and an increased prevalence of vitamin B12 deficiency. Read More

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Protective Effect of L. Seeds against Paracetamol-Induced Hepatotoxicity in Rats: A Comparison with Vitamin C.

ScientificWorldJournal 2021 6;2021:6618273. Epub 2021 Jul 6.

Biochemistry of Natural Products Team, Faculty of Sciences and Techniques, Moulay Ismail University, Errachidia, Morocco.

L. (date palm) seeds have been mentioned in the Moroccan pharmacopoeia as efficient remedies against a wide range of diseases including hepatic and gastrointestinal disorders and countless infections. The current work was performed to assess the phenolic profile and hepatoprotective potential of two date seed varieties, locally known as and , aqueous extracts against paracetamol- (PCM-) driven liver toxicity in 42 Wistar rats. Read More

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Safety and efficacy of subcutaneous alpha-tocopherol in healthy adult horses.

Equine Vet Educ 2021 Apr 4;33(4):215-219. Epub 2020 Jun 4.

William R. Pritchard Veterinary Medical Teaching Hospital.

Vitamin E is essential for neuromuscular function. The primary treatment, oral supplementation with natural ('RRR') α-tocopherol, is not effective in all horses. The objectives of this pilot study were to evaluate the safety and efficacy of a subcutaneously administered RRR-α-tocopherol preparation. Read More

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Investigating the causality of metabolites involved in one-carbon metabolism with the risk and age at onset of Parkinson's disease: A two-sample mendelian randomization study.

Neurobiol Aging 2021 Jul 4. Epub 2021 Jul 4.

Department of Cell Biology, Key Laboratory of Cell Biology, Ministry of Public Health, China; Key Laboratory of Medical Cell Biology, Ministry of Education, China Medical University, Shenyang 110122, China. Electronic address:

With the aging population and increasing life expectancy, Parkinson's disease (PD), a neurological disorder rapidly increasing in morbidity and mortality, is causing a huge burden on society and the economy. Several studies have suggested that one-carbon metabolites, including homocysteine, vitamin B6, vitamin B12 and folate acid, are associated with PD risk. However, the results remain inconsistent and controversial. Read More

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Hyperemesis gravidarum and vitamin K deficiency: a systematic review.

Br J Nutr 2021 Jul 30:1-31. Epub 2021 Jul 30.

Amsterdam University Medical Centers, University of Amsterdam, department of Obstetrics and Gynaecology, Amsterdam Reproduction & Development research institute, Meibergdreef 9, Amsterdam, the Netherlands.

Hyperemesis gravidarum (HG), severe nausea and vomiting in pregnancy, can lead to vitamin deficiencies. Little is known about HG-related vitamin K deficiency. We aim to summarize available evidence on the occurrence of HG-related vitamin K deficiency and corresponding maternal and neonatal complications. Read More

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Circulating vitamin C concentration and risk of cancers: a Mendelian randomization study.

BMC Med 2021 Jul 30;19(1):171. Epub 2021 Jul 30.

Key Laboratory of Growth Regulation and Translational Research of Zhejiang Province, School of Life Sciences, Westlake University, 18 Shilongshan Rd, Cloud Town, Hangzhou, 310024, China.

Background: Circulating vitamin C concentrations have been associated with several cancers in observational studies, but little is known about the causal direction of the associations. This study aims to explore the potential causal relationship between circulating vitamin C and risk of five most common cancers in Europe.

Methods: We used summary-level data for genetic variants associated with plasma vitamin C in a large vitamin C genome-wide association study (GWAS) meta-analysis on 52,018 Europeans, and the corresponding associations with lung, breast, prostate, colon, and rectal cancer from GWAS consortia including up to 870,984 participants of European ancestry. Read More

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Relationship between maternal vitamin D status in the first trimester of pregnancy and maternal and neonatal outcomes: a retrospective single center study.

BMC Pediatr 2021 Jul 29;21(1):330. Epub 2021 Jul 29.

International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University, 910# Hengshan Road, Shanghai, 20030, China.

Background: This study aimed to investigate the relationship between maternal serum vitamin D status in the first trimester of pregnancy and maternal as well as neonatal outcomes, considered the prevalence of vitamin D deficiency (serum 25(OH)D < 50 nmol/L) around the world, especially in the pregnant women.

Methods: From January 2015 to December 2016, in this cross-sectional retrospective study, we enrolled women receiving regular prenatal examinations and giving birth in the International Peace Maternity and Child Health Hospital. Cases confirmed as multiple pregnancy, incomplete medical records, and vitamin D level recorded after 13 weeks of gestation were excluded. Read More

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Vitamin D affects the Warburg effect and stemness maintenance of non-small-cell lung cancer cells by regulating PI3K/AKT/mTOR signaling pathway.

Curr Cancer Drug Targets 2021 Jul 28. Epub 2021 Jul 28.

Department of Emergency, Renmin Hospital of Wuhan University, Wuhan 430060, China.

Background: Non-small-cell lung cancer (NSCLC) is the most prevalent form of lung cancer, accounting for approximately 85% of all lung cancer cases and resulting in high morbidity and mortality. Previous studies have demonstrated that 1,25-dihydroxy-vitamin-D3 (vitamin D) exhibited anti-cancer activity against breast and prostate cancer.

Objectives: The aim of the current study is to investigate the effect of vitamin D on NSCLC and its underlying mechanism. Read More

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